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Hire Dr. Rosa D.
Portugal
USD 85 /hr
Scientific Consultant with 25+ years of laboratory and research experience
Profile Summary
Subject Matter Expertise
Services
Writing
Medical Writing
Research
Scientific and Technical Research,
Systematic Literature Review
Consulting
Scientific and Technical Consulting
Work Experience
Scientific Director
Prime Matter Consulting Lda
July 2020 - Present 
Researcher
Universidade de Lisboa Faculdade de Farmácia
June 2012 - Present
Post-Doctoral Fellow
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical
July 2021 - July 2022
Masters' Thesis Researcher
Universidade de Coimbra Faculdade de Medicina
September 2007 - September 2009
Academic Internship in Biochemistry
Instituto Portugues de Oncologia Fransisco Gentil
September 2004 - July 2005
Education
Post-graduate Degree on Higher Education Pedagogy (Instituto de Educação (Education Institute))
Universidade de Lisboa
July 2021 - July 2022
PhD in Pharmacy (specialty in Food Science) (Faculty of Pharmacy)
University of Lisbon
September 2012 - July 2019
M.S. Biochemistry (Faculty of Sciences and Technology)
University of Coimbra
September 2007 - September 2009
B.S. Biochemistry (Faculty of Sciences and Technology)
University of Coimbra
2000 - 2005
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Rosa Direito, Lucas Fornari Laurindo, Gabriel Magno de Carvalho, Bárbara de Oliveira Zanuso, Maria Eduardo Figueira, Ricardo de Alvares Goulart, Daiene Santos Buglio, Sandra Maria Barbalho (2023). Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review . Pharmaceutics.
Rosa Direito, Daniela Franceschi Nishikito, Ana Claudia Abdalla Borges, Lucas Fornari Laurindo, Alda M. M. Bueno Otoboni, Ricardo de Alvares Goulart, Claudia C. T. Nicolau, Adriana M. R. Fiorini, Renata Vargas Sinatora, Sandra M. Barbalho (2023). Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds . Pharmaceutics.
Daniela Franceschi Nishikito, Ana Claudia Abdalla Borges, LUCAS FORNARI LAURINDO, Alda M. M. Bueno Otoboni, Direito R, Ricardo de Alvares Goulart, Claudia C. T. Nicolau, Adriana M. R. Fiorini, Renata Vargas Sinatora, sandra barbalho (2023). Anti-inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds . Pharmaceutics.
LUCAS FORNARI LAURINDO, Gabriel Magno de Carvalho, Bárbara de Oliveira Zanuso, Figueira, ME, Direito R, Ricardo de Alvares Goulart, Daiene Santos Buglio, sandra barbalho (2023). Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review . Pharmaceutics.
Rosa Direito, Huseyin Ayvaz, Turgut Cabaroglu, Asiye Akyildiz, Cigdem Uysal Pala, Riza Temizkan, Erdal Ağçam, Zayde Ayvaz, Alessandra Durazzo, Massimo Lucarini, et al. (2022). Anthocyanins: Metabolic Digestion, Bioavailability, Therapeutic Effects, Current Pharmaceutical/Industrial Use, and Innovation Potential . Antioxidants.
Huseyin Ayvaz, TURGUT CABAROGLU, Asiye Akyildiz, Cigdem Uysal Pala, Riza Temizkan, erdal ağçam, Zayde Ayvaz, Alessandra Durazzo, Massimo Lucarini, Direito R, et al. (2022). Anthocyanins: Metabolic Digestion, Bioavailability, Therapeutic Effects, Current Pharmaceutical/Industrial Use, and Innovation Potential . Antioxidants.
Rosa Direito, Sandra Maria Barbalho, Lucas Fornari Laurindo, Ledyane Taynara Marton, Elen Landgraf Guiguer, Ricardo de Alvares Goulart, Ricardo José Tofano, Antonely C. A. Carvalho, Uri Adrian Prync Flato, Viviane Alessandra Capelluppi Tofano, et al.(2022). Ginkgo biloba in the Aging Process: A Narrative Review . Antioxidants. 11. (3). p. 525. {MDPI} {AG}
sandra barbalho, Direito R, Lucas Fornari Laurindo, Ledyane Taynara Marton, Elen Landgraf Guiguer, Ricardo de Alvares Goulart, Ricardo José Tofano, Antonely C. A. Carvalho, Uri Adrian Prync Flato, Viviane Alessandra Capelluppi Tofano, et al. (2022). <i>Ginkgo biloba</i> in the Aging Process: A Narrative Review . Antioxidants.
Rosa Direito, Joana Mota, João Rocha, João Fernandes, Bruno Sepodes, Maria Eduardo Figueira, Anabela Raymundo, Ana Lima, Ricardo Boavida Ferreira (2021). Lupinus albus Protein Components Inhibit MMP-2 and MMP-9 Gelatinolytic Activity In Vitro and In Vivo . International Journal of Molecular Sciences.
Joana Mota, Direito R, Joao Rocha, João Fernandes, Bruno Sepodes, Figueira, ME, A. Raymundo, Ana Lima, Ricardo Boavida Ferreira (2021). <i>Lupinus albus</i> Protein Components Inhibit MMP-2 and MMP-9 Gelatinolytic Activity In Vitro and In Vivo . International Journal of Molecular Sciences.
Rosa Direito, João Rocha, Bruno Sepodes, Maria Eduardo-Figueira (2021). From Diospyros kaki L. (Persimmon) Phytochemical Profile and Health Impact to New Product Perspectives and Waste Valorization . Nutrients.
Direito R, Joao Rocha, Bruno Sepodes, Figueira, ME (2021). From <i>Diospyros kaki</i> L. (Persimmon) Phytochemical Profile and Health Impact to New Product Perspectives and Waste Valorization . Nutrients.
Rosa Direito, João Rocha, Bruno Sepodes, Maria Eduardo-Figueira(2021). Phenolic Compounds Impact on Rheumatoid Arthritis, Inflammatory Bowel Disease and Microbiota Modulation . Pharmaceutics. 13. (2). p. 145. {MDPI} {AG}
Direito R, Joao Rocha, Bruno Sepodes, Figueira, ME (2021). Phenolic Compounds Impact on Rheumatoid Arthritis, Inflammatory Bowel Disease and Microbiota Modulation . Pharmaceutics.
Rosa Direito, João Rocha, Raquel Leandro, Margarida Gonçalves, Maria Paula Duarte, Adelaide Fernandes, Bruno Sepodes, Maria-Eduardo Figueira(2020). Attenuation of Colonic Injury and Inflammation by Administration of a Phenolic Extract of Summer Savory (Satureja hortensis L.) in Experimental Inflammatory Bowel Disease in Mice . Applied Sciences. 10. (23). p. 8465. {MDPI} {AG}
Rosa Direito, João Rocha, Ana-Teresa Serra, Adelaide Fernandes, Marisa Freitas, Eduarda Fernandes, Rui Pinto, Rosário Bronze, Bruno Sepodes, Maria-Eduardo Figueira(2020). Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis . Journal of Dietary Supplements. p. 1--21. Informa {UK} Limited
Joao Rocha, Raquel Leandro, Direito R, Maria Margarida Gonçalves, Maria Paula Duarte, Fernandes A, Bruno Sepodes, Maria-Eduardo Figueira (2020). Attenuation of Colonic Injury and Inflammation by Administration of a Phenolic Extract of Summer Savory (<i>Satureja hortensis</i> L.) in Experimental Inflammatory Bowel Disease in Mice . Applied Sciences.
Direito, R., Rocha, J., Serra, A.-T., Fernandes, A., Freitas, M., Fernandes, E., Pinto, R., Bronze, R., Sepodes, B., Figueira, M.-E.(2020). Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis . Journal of Dietary Supplements. 17. (6). p. 663-683.
(2019). Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices . Journal of Functional Foods.
Rosa Direito, Catarina Reis, Luís Roque, Margarida Gonçalves, Ana Sanches-Silva, Maria Manuela Gaspar, Rui Pinto, João Rocha, Bruno Sepodes, Maria Rosário Bronze, et al. (2019). Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability . Pharmaceutics.
Rosa Direito, João Rocha, Ana Lima, Maria Margarida Gonçalves, Maria Paula Duarte, Vanessa Mateus, Catarina Sousa, Adelaide Fernandes, Rui Pinto, Ricardo Boavida Ferreira, et al.(2019). Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice . Medicines. 6. (2). p. 65. {MDPI} {AG}
Direito R, João Rocha, Ana Lima, Maria Margarida Gonçalves, Maria Paula Duarte, Vanessa Mateus, Catarina Sousa, Adelaide Fernandes, Rui Pinto, Ricardo Boavida Ferreira, et al. (2019). Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice . Medicines.
Direito R, Catarina Pinto Reis, Luís Roque, Margarida Gonçalves, Ana Sanches-Silva, Maria Manuela Gaspar, Rui Pinto, João Rocha, Bruno Sepodes, Maria Rosário Bronze, et al. (2019). Phytosomes with Persimmon (<i>Diospyros kaki</i> L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability . Pharmaceutics.
(2019). Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice . Medicines.
Mendes, C., Rocha, J., Direito, R., Fernandes, A., Sepodes, B., Figueira, M.-E., Ribeiro, M.H.(2019). Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices . Journal of Functional Foods. 63.
Mota, A.H., Direito, R., Carrasco, M.P., Rijo, P., Ascensão, L., Viana, A.S., Rocha, J., Eduardo-Figueira, M., Rodrigues, M.J., Custódio, L., et al.(2019). Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis . International Journal of Pharmaceutics. 559. p. 13-22.
Rocha, J., Direito, R., Lima, A., Mota, J., Gonçalves, M., Duarte, M.P., Solas, J., Peniche, B.F., Fernandes, A., Pinto, R., et al.(2019). Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice . Biomedicine and Pharmacotherapy. 118.
Direito, R., Reis, C., Roque, L., Gonçalves, M., Sanches-Silva, A., Gaspar, M.M., Pinto, R., Rocha, J., Sepodes, B., Bronze, M.R., et al.(2019). Phytosomes with persimmon (Diospyros kaki l.) extract: Preparation and preliminary demonstration of in vivo tolerability . Pharmaceutics. 11. (6).
Vieira da Silva, S.A., Clemente, A., Rocha, J., Direito, R., Marques, H.C., Sepodes, B., Figueira, M.-E., Ribeiro, M.H.(2018). Anti-inflammatory effect of limonin from cyclodextrin (un)processed orange juices in in vivo acute inflammation and chronic rheumatoid arthritis models . Journal of Functional Foods. 49. p. 146-153.
Direito R, Lima A, Rocha J, Ferreira RB, Mota J, Rebelo P, Fernandes A, Pinto R, Alves P, Bronze R, et al.(2017). Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities . The Journal of nutritional biochemistry.
Direito, R., Lima, A., Rocha, J., Ferreira, R.B., Mota, J., Rebelo, P., Fernandes, A., Pinto, R., Alves, P., Bronze, R., et al.(2017). Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities . Journal of Nutritional Biochemistry. 46. p. 100-108.
Rosa Direito, Maria-Eduardo Figueira, Mónica Oliveira, João Rocha, Paula Alves, Ana-Teresa Serra, Catarina Duarte, Rosário Bronze, Adelaide Fernandes, Dora Brites, et al. (2016). Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat . Biomedicine & Pharmacotherapy.
Figueira, M.-E., Oliveira, M., Direito, R., Rocha, J., Alves, P., Serra, A.-T., Duarte, C., Bronze, R., Fernandes, A., Brites, D., et al.(2016). Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat . Biomedicine and Pharmacotherapy. 83. p. 1191-1202.
Silva, S., Sepodes, B., Rocha, J., Direito, R., Fernandes, A., Brites, D., Freitas, M., Fernandes, E., Bronze, M.R., Figueira, M.E.(2015). Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis . Journal of Nutritional Biochemistry. 26. (4). p. 360-368.
Figueira, M.E., Câmara, M.B., Direito, R., Rocha, J., Serra, A.T., Duarte, C.M.M., Fernandes, A., Freitas, M., Fernandes, E., Marques, M.C., et al.(2014). Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis . Food and Function. 5. (12). p. 3241-3251.
Rocha, J., Barateiro, A., Fernandes, A., Raposo, J., Direito, R., Eduardo-Figueira, M., Pinto, R., Thiemermann, C., Mota-Filipe, H., Sepodes, B. (2013). GLYCOGEN SYNTHASE KINASE-3 INHIBITION REDUCES LIVER, NEUROMUSCULAR, AND LUNG INJURY CAUSED BY BURN INJURY IN THE RAT . Shock.
Alves, G., Fortuna, A., Sousa, J., Direito, R., Almeida, A., Rocha, M., Falcão, A., Soares-Da-Silva, P.(2010). Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: No interference with carbamazepine and its metabolites . Therapeutic Drug Monitoring. 32. (4). p. 512-516.
CONFERENCE ABSTRACT
(2020). Reduction of inflammation and colon injury by a Satureja hortensis L. (Savory) phenolic extract in experimental inflammatory bowel disease in mice. Iberphenol International Conference.
(2020). Nanocarriers with Sambucus nigra L. extract for anti-inflammatory activity. 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology.
(2020). Skin Delivery of Sambucus nigra L. extracts through nanocarriers. 5th World Congress & Expo on Pharmaceutics & Drug Delivery Systems.
(2019). Phytosomes with Persimmon (Diospyros kaki, L.) Extract: Preparation and Preliminary Demonstration of in vivo Tolerability. 13th World Congress on Polyphenols Applications.
(2019). Deflamin, a Non-Toxic Oglimer from Lupinus Albus Seeds, Resists Digestion and Inhibits Colitis by Targeting MMP-9 Activity in vitro and in vivo. World Congress of Gastroenterology.
(2019). Evaluation of the Anti-Inflammatory Activity of a Persimmon (Diospyros kaki, L.) Extract in Colitis and Rheumatoid Arthritis Rodent Models. Natural Products in Drug Discovery and Human Health conference organized by Portuguese Chemistry Society.
(2019). Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation, Characterization and In Vivo Preliminary Tolerability. 3rd Edition of the Master activity of the Lusophone Academy of Pharmaceutical Sciences.
(2018). Phytosomes with Diospyros kaki Phenolic Extract: Preparation and Characterization. 10th iMed.ULisboa and 3rd i3du Postgraduate Students Meeting.
(2017). Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities . Annual Reunion of the Portuguese Pharmacology Society.
(2014). Transient and Lasting Neurodegenerative Effects of Chronic Systemic Inflammation in Early Neonatal Mice. 6th iMed.UL Postgraduate Students Meeting.
(2013). Evaluation of the anti-inflammatory activity of a persimmon (Diospyros kaki, L.) extract in an animal (Wistar rats) model of rheumatoid arthritis. XLIII Annual Meeting of the Portuguese Pharmacological Society; XXXI Clinical Pharmacology Meeting; XII Toxicology Meeting, UMIB, ICBAS-University of Porto.
(2013). Glycogen synthase kinase-3 inhibition reduces liver, neuromuscular and lung injury caused by burn injury in the rat. The European Shock Society’s 15th biannual conference.
(2011). The effect of raspberry in the postprandial inflammation in healthy humans.
(2011). Phenolic compounds in raspberry samples – possible contribution to biological activity. Iberoamerican Conference from the Faculty of Pharmacy, Lisbon.
CONFERENCE POSTER
(2019). Nanocarriers with Sambucus nigra L. Extracts for Skin Applications. 26th International Conference on Bioencapsulation.
(2016). Intestinal Anti-inflammatory Activity of Grapefruit Juice in a Model of Rat Colitis.
(2014). Inflammation associated events and neurovascular disruption in neonatal sepsis. Barriers of the CNS Gordon Research Conference Expanding the Understanding of CNS Barriers in Health and Disease.
(2013). Neonatal sepsis changes the pattern of microvascular coverage by astrocytes and microglia. 5th Post-Graduate iMed.UL Students Meeting, Lisbon, Portugal.
(2013). Neonatal Systemic Inflammation Differently Alters Regional Brain Microvasculature. Workshop Beating the blood-brain & other blood barriers.
(2011). Phenolic compounds in raspberry samples – possible contribution to biological activity. Iberoamerican Conference from the Faculty of Pharmacy, Lisbon.
(2010). Morphological evaluation of rat liver tissue after the subcutaneous injection of 1,2-dimethylhydrazine. 16th World Congress of Basic and Clinical Pharmacology”, Copenhagen.
BOOK CHAPTER
(2019). CARACTERIZAÇÃO QUÍMICA E AVALIAÇÃO DA ATIVIDADE BIOLÓGICA DA FRAMBOESA (RUBUS IDAEUS L.). CONTRIBUIÇÃO PARA O DESENVOLVIMENTO DE UMA ALEGAÇÃO DE SAÚDE . A produção do Conhecimento nas Ciências Agrárias e Ambientais 2.
CONFERENCE PAPER
(2013). Neonatal Exposure to LPS Alters Microvascular and Glial Patterns in Different Brain Regions. ESNI Course, Porto.
(2012). Systemic Inflammation in the Neonatal Period Causes Microvasculature Alterations that May Differ Between Brain Regions and Neonatal Age. 4th Postgraduate iMed.UL Students Meeting, Lisbon.
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