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Hire Dr. Prabhu M.

United States

USD 50 /hr

Senior Organic & Medicinal Chemist | Synthetic Chemistry, Drug Development & Scientific Editing

Profile Summary

I am a PhD organic chemist with over fifteen years of research experience spanning synthetic organic chemistry, medicinal chemistry, materials science, and specialized molecule design. My work has produced 46 peer-reviewed publications, three book chapters, and 13 awarded U.S. patents. I bring deep, hands-on expertise across the full innovation cycle: molecular design and synthesis, synthetic-route optimization, structural characterization, and process development. My experience extends from active pharmaceutical ingredient (API) process development and CNS drug discovery to the design of porphyrins, metalloporphyrins, corroles, and nanoscale molecular architectures. During my postdoctoral research at the University of Akron, I contributed to the creation of the first synthetic nanoscale fractal molecule. Alongside my laboratory work, I have twelve years of experience as a scientific editor, reviewing and refining manuscripts across the physical sciences and engineering. This combination of bench expertise and critical review skill allows me to deliver work that is scientifically rigorous, well-documented, and publication-ready. Areas of Expertise Synthetic Organic Chemistry — multi-step synthesis, methodology development, route optimization for yield and purity Medicinal Chemistry & Drug Discovery — CNS therapeutics, structure–activity relationships, API process development Specialty & Materials Chemistry — porphyrins, metalloporphyrins, corroles, supramolecular and nanoscale architectures, self-assembly Structural Characterization — NMR (including ³¹P NMR), UV-Vis spectroscopy, mass spectrometry Catalysis & Reaction Systems — biomimetic oxidation, reverse micelles, ionic liquids, photooxidation chemistry Patent Development — invention disclosure, patent-relevant innovation, IP-protectable molecule design Scientific Editing & Peer Review — manuscript editing, language and technical review, publication preparation Selected Experience Senior Scientist — Frontier Scientific Designed and synthesized porphyrins, metalloporphyrins, corroles, and specialized small molecules for industrial, pharmaceutical, and materials-science applications. Optimized synthetic pathways to enhance yield, purity, and functional performance, and confirmed molecular integrity using NMR, UV-Vis, and mass spectrometry. Scientist, Medicinal Chemistry — Reviva Pharmaceuticals Contributed to the development of Brilaroxazine (RP5063), a novel serotonin-dopamine stabilizer investigated for schizophrenia and pulmonary arterial hypertension. This work is reflected in several awarded patents on arylpiperazine and piperazine-based antipsychotic agents. Research Associate — Ranbaxy Developed multiple commercially viable processes for the production of active pharmaceutical ingredients. Postdoctoral & Academic Research — University of Akron, University of Florida, Acadia University, Augusta University, Brooklyn College (CUNY) Conducted research across organic synthesis, N-acyliminium chemistry, medicinal chemistry, and photochemistry. Contributed novel methodologies and analytical approaches, including the use of ³¹P NMR to track photooxidation intermediates in lipid emulsion systems. Findings published in journals including Tetrahedron Letters, Synthesis, Langmuir, The Journal of Physical Chemistry A, and Photochemistry and Photobiology. Scientific Editor — Cactus Communications Proofread and edited scientific manuscripts in the physical sciences and engineering, performing both language and technical editing to ensure accuracy, clarity, and compliance with style guidelines. Services Offered Synthetic route design and optimization Medicinal chemistry and drug-discovery consulting Specialty molecule and materials synthesis guidance Structural characterization and data interpretation (NMR, UV-Vis, MS) Literature review and feasibility assessment Patent and invention-disclosure support Scientific manuscript editing, proofreading, and peer review Independent scientific review and quality oversight of technical deliverables Education PhD, Organic Chemistry — University of Delhi Postdoctoral Research — University of Florida; The University of Akron; Indian Institute of Technology, Delhi Why Work With Me Clients come to me when they need scientific work done rigorously and explained clearly. My patent record reflects a proven ability to take ideas from concept to protectable innovation, my characterization expertise ensures every claim is backed by data, and my editing background means deliverables arrive clear, accurate, and ready to use. Whether you need a synthetic route designed, a molecule characterized, a manuscript polished, or expert review of technical work, I bring precision, depth, and a results-driven approach.

Subject Matter Expertise

• ★ Chemistry
• ★ Organic Chemistry
• ★ Medicinal Chemistry
• ☆ Chemical Reagent Development
• ☆ Dispersion Chemistry
• ☆ Materials Science & Engineering
• ☆ Nanotechnology & Nanomaterials
• ☆ Marine Chemistry
• ☆ Inorganic Chemistry
• ☆ Natural Product Chemistry
• ☆ Physical Chemistry
• ☆ Chemoinformatics
• ☆ Polymer Chemistry
• ☆ Analytical Chemistry
• ☆ Liquid Chromatography/HPLC
• ☆ Gas Chromatography
• ☆ Electrochemistry
• ☆ Agricultural Chemistry
• ☆ Cosmochemistry
• ☆ Surface Chemistry
• ☆ Structural Chemistry
• ☆ Supramolecular Chemistry
• ☆ Nanotechnology
• ☆ Radiochemistry
• ☆ Astrochemistry
• ☆ Petrochemistry
• ☆ Solid-State Chemistry
• ☆ Flow Chemistry
• ☆ Green Chemistry
• ☆ Photochemistry
• ☆ Quantum Chemistry
• ☆ Theoretical Chemistry
• ☆ Thermochemistry
• ☆ Computational Chemistry
• ☆ Mechanochemistry
• ☆ Sonochemistry
• ☆ Physical Organic Chemistry
• ☆ Phytochemistry
• ☆ Biochemistry
• ☆ Neurochemistry
• ☆ Basic Immunology
• ☆ Biotechnology & Bioengineering
• ☆ Nanobiotechnology
• ☆ Plant Biotechnology
• ☆ Mechanical Engineering
• ☆ Chemical Engineering
• ☆ Biogeochemistry
• ☆ Geochemistry
• ☆ Atmospheric Chemistry
• ☆ Environmental Chemistry
• ☆ Flavor & Fragrance Chemistry
• ☆ Food Chemistry
• ☆ Quantum Mechanics
• ☆ Applied Chemistry
• ☆ Chemical Biology
• ☆ Clinical Biochemistry
• ☆ Cancer Research
• ☆ Formulation

Services

• Writing
• Research
• Data & AI

Writing Medical Writing, Technical Writing

Research User Research, Meta-Research, Gap Analysis, Systematic Literature Review

Data & AI Statistical Analysis

Work Experience

Director of Finance

Maryland Department of Human Services

July 2017 - Present

Education

PhD

University of Delhi

December 1994 - March 1999

Certifications

• Career Essentials in Generative AI by Microsoft and LinkedIn

  Microsoft and LinkedIn

  https://www.linkedin.com/learning/certificates/8123d16e6c0694b0f2f769052406d9335de27f7896a2c469701dd0643e58ba3c

  November 2023 - Present

Publications

BOOK CHAPTER

Durantini, A.M., Mohapatra, P.P., Ashaque, M., Zatoulovski, M.E., Kim, M.M., Cengel, K.A., Busch, T.M., Zhu, T.C., Greer, A.(2021). Photooxidative vulnerability to intralipid in photodynamic therapy . Photochemistry. 48. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 411-422.

Mishra, B.B., Kumar, D., Mishra, A., Mohapatra, P.P., Tiwari, V.K.(2012). Cyclo-Release Strategy in Solid-Phase Combinatorial Synthesis of Heterocyclic Skeletons . Advances in Heterocyclic Chemistry. 107. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 41-99.

JOURNAL ARTICLE

Prasad, V., Mishra, N., Agrahari, A.K., Singh, S.K., Mohapatra, P.P., Tiwari, V.K.(2019). Cycloelimination-assisted combinatorial synthesis of diverse heterocyclic scaffolds of chemotherapeutic values . Current Organic Chemistry. 23. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 768-808.

Mohapatra, P.P., Chiemezie, C.O., Kligman, A., Kim, M.M., Busch, T.M., Zhu, T.C., Greer, A.(2017). ³¹P NMR Evidence for Peroxide Intermediates in Lipid Emulsion Photooxidations: Phosphine Substituent Effects in Trapping . Photochemistry and Photobiology. 93. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1430-1438.

O’Brien, M., Weagle, R., Corkum, D., Kuanar, M., Mohapatra, P.P., Jha, A.(2017). Convenient access to 5-arylisoindolo[2,1- a]quinolin-11(6a H)-ones . Molecular Diversity. 21. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 455-462.

Jha, A., Mohapatra, P.P., Alharbi, S.A., Jahan, N.(2017). Curcumin: Not so spicy after all . Mini-Reviews in Medicinal Chemistry. 17. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1425-1434.

Ghogare, A.A., Debaz, C.J., Silva Oliveira, M., Abramova, I., Mohapatra, P.P., Kwon, K., Greer, E.M., Prado, F.M., Valerio, H.P., Di Mascio, P., et al.(2017). Experimental and DFT Computational Insight into Nitrosamine Photochemistry - Oxygen Matters . Journal of Physical Chemistry A. 121. (32). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5954-5966.

Panda, S.S., Jones, R.A., Bachawala, P., Mohapatra, P.P.(2017). Spirooxindoles as potential pharmacophores . Mini-Reviews in Medicinal Chemistry. 17. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1515-1536.

Panda, S.S., Detistov, O.S., Girgis, A.S., Mohapatra, P.P., Samir, A., Katritzky, A.R.(2016). Synthesis and molecular modeling of antimicrobial active fluoroquinolone-pyrazine conjugates with amino acid linkers . Bioorganic and Medicinal Chemistry Letters. 26. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2198-2205.

Al-Jaroudi, Z., Mohapatra, P.P., Jha, A.(2016). Facile synthesis of 3-substituted isoindolinones Dedicated to the memory of Professor Sharon Roscoe, a colleague and mentor instrumental in shaping the careers of many chemists . Tetrahedron Letters. 57. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 772-777.

Al-Jaroudi, Z., Mohapatra, P.P., Cameron, T.S., Jha, A.(2016). Expedient and Diastereoselective Synthesis of Substituted 6,6a-Dihydroisoindolo[2,1-a]quinolin-11(5H)-ones . Synthesis (Germany). 48. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4477-4488.

Mukherjee, C., Mohapatra, P.P., Youssef, D., Jha, A.(2016). Optical enrichment in enzyme-catalyzed resolution of 1-aryl-2,2-dimethyl-1,3-propanediols . Canadian Journal of Chemistry. 95. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-6.

Kale, R.R., Prasad, V., Mohapatra, P.P., Tiwari, V.K.(2010). Recent developments in benzotriazole methodology for construction of pharmacologically important heterocyclic skeletons . Monatshefte fur Chemie. 141. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1159-1182.

Singh, S., Bharti, N., Mohapatra, P.P.(2009). Chemistry and biology of synthetic and naturally occurring antiamoebic agents . Chemical Reviews. 109. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1900-1947.

Katritzky, A.R., Mohapatra, P.P., Huang, L.(2008). 1, 3, 4-Oxadiazoles from functionalized N-acylbenzotriazoles and acyl hydrazides . Arkivoc. 2008. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 62-68.

Katritzky, A.R., Fedoseyenko, D., Mohapatra, P.P., Steel, P.J.(2008). Reactions of p-benzoquinone with sulfur nucleophiles . Synthesis. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 777-787.

Katritzky, A.R., Mohapatra, P.P., Fedoseyenko, D., Duncton, M., Steel, P.J.(2007). 1-Benzotriazol-1-yl-3,3,3-trifluoro-2-methoxy-2-phenylpropan-1-ones: Mosher-Bt reagents . Journal of Organic Chemistry. 72. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4268-4271.

Katritzky, A.R., Khelashvili, L., Le, K.N.B., Mohapatra, P.P., Steel, P.J.(2007). Synthesis of o-sulfamidotriazobenzenes from 1,1′- sulfonylbis(benzotriazole) . Journal of Organic Chemistry. 72. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5805-5808.

Katritzky, A.R., Khelashvili, L., Mohapatra, P.P., Steel, P.J.(2007). Efficient N-aroylation of substituted indoles with N-aroylbenzotriazoles . Synthesis. (23). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3673-3677.

Katritzky, A.R., Akhmedov, N.G., Doskocz, J., Mohapatra, P.P., Hall, C.D., Güven, A.(2007). NMR spectra, GIAO and charge density calculations of five-membered aromatic heterocycles . Magnetic Resonance in Chemistry. 45. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 532-543.

Katritzky, A.R., Rogers, J.W., Witek, R.M., Vakulenko, A.V., Mohapatra, P.P., Steel, P.J., Damavarapu, R.(2007). Synthesis and characterization of blowing agents and hypergolics . Journal of Energetic Materials. 25. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 79-109.

Katritzky, A.R., Le, K.N.B., Mohapatra, P.P.(2007). Synthesis of aliphatic hydroxyaryl ketones or (hetero)aryl hydroxyaryl ketones by acylation of organometallic reagents . Synthesis. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3141-3146.

Newkome, G.R., Wang, P., Moorefield, C.N., Cho, T.J., Mohapatra, P.P., Li, S., Hwang, S.-H., Lukoyanova, O., Echegoyen, L., Palagallo, J.A., et al.(2006). Nanoassembly of a fractal polymer: A molecular "Sierpinski hexagonal gasket" . Science. 312. (5781). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1782-1785.

Katritzky, A.R., Le, K.N.B., Khelashvili, L., Mohapatra, P.P.(2006). Alkyl, unsaturated, (hetero)aryl, and N-protected α-amino ketones by acylation of organometallic reagents . Journal of Organic Chemistry. 71. (26). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9861-9864.

Katritzky, A.R., Singh, S., Mohapatra, P.P., Clemens, N., Kirichenko, K.(2005). Synthesis of functionalized dithiocarbamates via N-(1-benzotriazolylalkyl) dithiocarbamates . Arkivoc. 2005. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 63-79.

Katritzky, A.R., Mohapatra, P.P., Singh, S., Clemens, N., Kirichenko, K.(2005). Synthesis of α-amino amides via α-amino imidoylbenzotriazoles . Journal of the Serbian Chemical Society. 70. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 319-327.

Katritzky, A.R., Witek, R.M., Rodriguez-Garcia, V., Mohapatra, P.P., Rogers, J.W., Cusido, J., Abdel-Fattah, A.A.A., Steel, P.J.(2005). Benzotriazole-assisted thioacylation . Journal of Organic Chemistry. 70. (20). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7866-7881.

Katritzky, A.R., Kirichenko, K., Mohapatra, P.P., Prakash, I.(2004). The synthesis of α-benzotriazolyl ketones from acid halides . Arkivoc. 2004. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 22-28.

Newkome, G.R., Cho, T.J., Moorefield, C.N., Mohapatra, P.P., God&#237;nez, L.A.(2004). Towards Ordered Architectures: Self-Assembly and Stepwise Procedures to the Hexameric Metallomacrocycles [Arylbis(terpyridinyl)<inf>6</inf>Fe ^II<inf>6-n</inf>-Ru^II<inf>n</inf>] (n = 0,2,3,5) . Chemistry - A European Journal. 10. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1493-1500.

Newkome, G.R., Cho, T.J., Moorefield, C.N., Cush, R., Russo, P.S., God&#237;nez, L.A., Saunders, M.J., Mohapatra, P.(2002). Hexagonal terpyridine-ruthenium and -iron macrocyclic complexes by stepwise and self-assembly procedures . Chemistry - A European Journal. 8. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2946-2954.

Chauhan, S.M.S., Sahoo, B., Mohapatra, P.P., Kalra, B., Gulati, A.(2001). Formation of 6-formyl-7-hydroxy-8-methoxycoumarin and 5,8-dioxopsoralen by reaction of 8-methoxypsoralen with H<inf>2</inf>O<inf>2</inf> and potassium superoxide (KO<inf>2</inf>) catalyzed by halogenated or perhalogenated 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides . Chemical and Pharmaceutical Bulletin. 49. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1232-1233.

Chauhan, S.M.S., Mohapatra, P.P., Mamta, Parkash, S., Azam, M.(2000). Biomimetic oxidation of 3β-hydroxy-olean-12-ene and its acetoxy derivative with monooxygen donors catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides in dichloromethane . Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry. 39. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 183-189.

Chauhan, S.M.S., Kalra, B., Mohapatra, P.P.(1999). Oxidation of 1-naphthol and related phenols with hydrogen peroxide and potassium superoxide catalysed by 5,10,15,20- tetraarylporphyrinatoiron(III)chlorides in different reaction conditions . Journal of Molecular Catalysis A: Chemical. 137. (1-3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 85-92.

Chauhan, S.M.S., Srinivas, K.A., Mohapatra, P.P.(1999). Oxidation of phenylbutazone with hydrogen peroxide catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides in dichloromethane . Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry. 38. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 724-725.

Chauhan, S.M.S., Parkash, S., Mohapatra, P.P.(1997). Oxidation of geraniol and related volatile terpenoids with iodosylbenzene catalysed by 5,10,15,20-tetrakis(2′,6′-dichlorophenyl)porphyrinatoiron(III) chloride in dichloromethane, aqueous SDS and CTAB micelles . Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry. 36. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 312-317.

Chauhan, S.M.S., Mohapatra, P.P., Visweswara Rao, K., Vijayaraghavan, B., Shahi, S.P.(1996). Formation of 21-alkyl and aryl-5, 10, 15, 20-tetraphenylporphyrins in the oxidation of 1,1-dialkyl-and 1-alkyl-1-arylhydrazines with cumene hydroperoxide catalysed by 5, 10, 15, 20-tetraphenylporphyrinatoiron (III) chloride . Indian Journal of Heterocyclic Chemistry. 5. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 181-184.

Chauhan, S.M.S., Mohapatra, P.P., Kalra, B., Kohli, T.S., Satapathy, S.(1996). Biomimetic oxidation of indole-3-acetic acid and related substrates with hydrogen peroxide catalysed by 5,10,15,20-tetrakis 2',6'-dichloro-3'- sulfonatophenyl) porphyrinatoiron(III) hydrate in aqueous solution and AOT reverse micelles . Journal of Molecular Catalysis A: Chemical. 113. (1-2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 239-247.