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Hire Sharoon A.

United States

USD 110 /hr

PhD Biochemist | Oncology & Protease Biology | Translational & Computational Research Expert

Profile Summary

I am a PhD candidate in Biochemistry and Molecular Biology at Mayo Clinic, specializing in serine proteases and translational oncology. My research focuses on enzymes such as PRSS23 and HTRA3, integrating biochemical experimentation, structural modeling, and in-silico simulations to elucidate molecular mechanisms of tumor progression and therapeutic response. Alongside my pre-clinical expertise in recombinant protein design, purification, enzymology, and molecular docking/MD simulation, I bring hands-on experience supporting clinical research, including Phase I/II oncology trials and human-tissue analyses. This dual background enables me to design scientifically rigorous studies that maintain clinical relevance and regulatory awareness. I deliver complete, reproducible workflows—from assay optimization and structural analysis to high-quality figures, statistical validation, and concise technical documentation suitable for publication or regulatory submission. I work seamlessly across academia, biotech, and CRO collaborations while maintaining GLP standards and confidentiality. Core expertise: protein expression, purification & enzymology; molecular docking, MD simulations & structural analysis; homology modeling & mutant comparison (WT vs variant); data processing & visualization in R/Python (tidyverse, ggplot2, matplotlib); pre-clinical study design & translation to early-phase (I/II) clinical context; scientific writing—methods, results, publication-ready figures.

Subject Matter Expertise

• ☆ Biocatalysis
• ☆ Natural Product Chemistry
• ☆ Peptide Synthesis
• ☆ Computational Biology
• ☆ Phytochemistry
• ☆ Medicinal Plants
• ☆ Biostatistics
• ☆ Data Analysis
• ☆ Image Processing
• ☆ Computer Simulation/Computational Modeling
• ☆ Predictive Modeling & Analytics
• ☆ Data Processing
• ☆ Data Collection
• ☆ Machine Learning
• ☆ Artificial Intelligence
• ☆ Deep Learning
• ☆ Pharmacy
• ☆ Clinical Pharmacy
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Pharmaceutical Manufacturing
• ☆ Bioprocess Development
• ☆ In vitro Diagnostics
• ☆ In vitro Diagnostic Validation
• ☆ In vitro Diagnostic Design
• ☆ Biomarker Analysis
• ☆ Pharmacovigilance/Drug Safety Monitoring
• ☆ Precision Medicine
• ☆ Hematology
• ☆ Hematology-Oncology
• ☆ Leukemia & Lymphoma
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Drug Delivery Technologies
• ☆ Liposomes
• ☆ Quality Assurance & Quality Control (QA/QC)
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ Meta-Research
• ☆ Literature Search
• ☆ Regulatory Writing
• ☆ NDA/BLA Applications
• ☆ Nonclinical Study Documentation
• ☆ Clinical Trial Documentation
• ☆ Clinical Trial Protocol Writing
• ☆ Clinical Study Reports
• ☆ Medical Writing
• ☆ Medical Content Writing
• ☆ Research Summaries & Abstracts
• ☆ Investigational New Drug (IND) Application Writing
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Spec Sheets
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Language Translation
• ☆ Creative Writing
• ☆ Speechwriting
• ☆ Grant Writing
• ☆ Small Business
• ☆ Data-Driven Decision Making
• ☆ Entrepreneurship

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Business & Legal Writing, Copywriting, Creative Writing, Newswriting, General Proofreading & Editing, Translation

Research User Research, Meta-Research, Feasibility Study, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Business Strategy Consulting, Scientific and Technical Consulting, Regulatory Consulting, Manufacturing Consulting

Data & AI Predictive Modeling, Statistical Analysis, Image Processing, Image Analysis, Algorithm Design-Non ML, Algorithm Design-ML, Data Visualization, Big Data Analytics, Text Mining & Analytics, Data Mining, Data Cleaning, Data Processing, Data Insights

Product Development Formulation, Recipe Development, Product Evaluation, Product Validation, Manufacturing, Quality Assurance & Control (QA/QC), Product Compliance , Concept Development, Prototyping

Work Experience

PhD Candidate and Research Fellow

Mayo Clinic

August 2020 - Present

Clinical Research Coordinator

Mayo Clinic

January 2020 - August 2020

Research Technologist

Mayo Clinic

October 2014 - January 2020

Special Project Associate

Mayo Clinic

July 2012 - October 2014

Biology and Chemistry Teacher

Beaconhouse School System

August 2011 - May 2012

QA/QC Chemist

Xenon Pharamaceutical Pvt. Ltd.

July 2008 - September 2008

Education

PhD. (Biochemistry and Molecular Biology)

Mayo Clinic in Florida

August 2020 - Present

MPhil (Biotechnology)

Forman Christian College

October 2009 - November 2011

BSc Hon (Chemistry )

Forman Christian College

September 2005 - June 2009

Certifications

• Ingenuity Pathway Analysis

  Qaigen

  March 2024 - Present

• Certified Clinical Research Coordinator

  CITI Program

  March 2020 - Present

• RCR For Research Administrators

  CITI Program

  March 2020 - Present

• Bronze Quality Essentials Certification

  Mayo Clinic

  May 2019 - Present

• GCP for Clinical Trials with Investigational Drugs and Medical Devices (U.S. FDA Focus) - GCP

  Citi Protam

  July 2019 - July 2022

Publications

JOURNAL ARTICLE

Sharoon Akhtar, Joshua W. Ogony, Laura M. Pacheco-Spann, Amanda Arnold, Jennifer V. Cabezas, Nicole Cruz-Reyes, Camila Pacheco Erak, Pria J. Westerman, Savanna A. Touré, Stacey J. Winham, et al. (2025). A STAT1-GBP1 axis modulates epithelial proliferation in postpartum breast tissue by repressing CDKI expression . Breast Cancer Research.

(2020). Novel tumor-targeted liposomes comprised of an MDM2 antagonist plus proteasome inhibitor display anti-tumor activity in a xenograft model of bortezomib-resistant Waldenstrom macroglobulinemia . Leukemia & Lymphoma.

(2019). Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia . Clinical Cancer Research.

(2018). Comparative Analysis on the Anti-Tumor Activity of Venetoclax and Obinutuzumab (VO) Versus Venetoclax and Rituximab (VR) in Primary CLL Cells, Ex Vivo . Blood.

(2018). Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells . British Journal of Haematology.

(2017). Waldenstrom macroglobulinemia cells devoid of BTKC481S or CXCR4WHIM-like mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment . Blood Cancer Journal.

(2016). Drug Resistance Alters CD38 Expression and in Vitro Response to Daratumumab in Waldenstrom Macroglobulinemia Cells . Blood.

(2016). Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells . Blood Cancer Journal.

(2016). The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells . Scientific Reports.

(2015). Induction of Resistance to Proteasome Inhibition Preferentially Switches Survival Dependence from Bcl-2 to XIAP in Preclinical Models of Waldenstrom Macroglobulinemia: Pre-Clinical Rationale for Early Clinical Sequencing of ABT199 . Blood.

(2015). Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells . British Journal of Haematology.

(2015). Immunophenotyping of Waldenströms Macroglobulinemia Cell Lines Reveals Distinct Patterns of Surface Antigen Expression: Potential Biological and Therapeutic Implications . PLOS ONE.

(2014). Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia . Blood Cancer Journal.

(2014). AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia . British Journal of Haematology.

(2012). In vitro dephytinization and bioavailability of essential minerals in several wheat varieties . Journal of Cereal Science.