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Hire Dr. Maroun B.

Switzerland

USD 100 /hr

Geneticist and bioinformatician with 13+ years of experience leveraging AI for drug discovery and translational medicine

Profile Summary

A multidisciplinary researcher with over 13 years of experience at the intersection of biology, computation, and translational medicine. I specialize in generating and deciphering complex multi-omics data to address challenges in immunity, metabolism, and aging. As a senior scientific program manager at EPFL, I helped lead a team of over 30 scientists, directing bioinformatics efforts and managing cross-functional collaborations with industry leaders like Janssen Pharmaceuticals to identify novel disease interception targets. I have played a significant role in securing over $10M in research funding from public and private entities. Currently, I am focused on leveraging AI to accelerate biomedical research and drug development. My recent work involves developing novel transformer architectures and agentic AI systems for cancer biomarker discovery and clinical genetics, utilizing agentic frameworks and various LLM-based solutions. I have a proven track record of mentoring over 20 scientists, establishing robust data strategies, and effectively communicating scientific findings to diverse audiences.

Subject Matter Expertise

• ☆ Computational Biology
• ☆ Biostatistics
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ Omics
• ☆ Genomics
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ Next Generation Sequencing (NGS)
• ☆ ATAC-Seq
• ☆ DNA Sequencing
• ☆ Gene Expression Analysis
• ☆ Genome Sequencing
• ☆ RNA Sequencing
• ☆ ChIP-Seq
• ☆ Data Analysis
• ☆ Predictive Modeling & Analytics
• ☆ Data Processing
• ☆ Data Exploration
• ☆ Cluster Analysis
• ☆ Data Visualization
• ☆ Data Management
• ☆ Data Manipulation
• ☆ Machine Learning
• ☆ Data Mining
• ☆ Artificial Intelligence
• ☆ Statistics
• ☆ Multivariate Analysis
• ☆ Correlation Analysis
• ☆ Study Design
• ☆ Health Data Analysis
• ☆ Bioinformatics
• ☆ Gene & Protein Expression Analysis
• ☆ Systems Biology
• ☆ Knowledge Management
• ☆ Information & Knowledge Management
• ☆ Data Storage
• ☆ SQL
• ☆ Excel
• ☆ R
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Phenotypic Assays
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Feasibility Studies
• ☆ Literature Search
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Grant Writing

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing, General Proofreading & Editing

Research Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Digital Strategy Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Algorithm Design-ML, Big Data Analytics, Text Mining & Analytics, Data Mining, Data Cleaning, Data Processing, Data Insights

Work Experience

Visiting Researcher

Idiap Research Institute

November 2024 - Present

Staff scientist / Senior Scientific Program Manager

École Polytechnique Fédérale de Lausanne

September 2019 - December 2023

Postdoctoral researcher

École Polytechnique Fédérale de Lausanne Institut de Bioingénierie

October 2016 - August 2019

Education

PhD (Global Health Institute and Institute of Bioengineering)

Ecole Polytechnique Federale de Lausanne Lemaitre Lab

May 2012 - September 2016

Certifications

• RESAL Module 1: Introductory Course in Laboratory Animal Science

  Federation of European Laboratory Animal Science Associations (FELASA B)

  January 2017 - December 2023

Publications

JOURNAL ARTICLE

Bou Sleiman, Maroun, Gao, Arwen W., Alam, Gaby El, Zhu, Yunyun, Li, Weisha, Sulc, Jonathan, Li, Xiaoxu, Katsyuba, Elena, Li, Terytty Y., Overmyer, Katherine A., et al.(2024). High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan . Cell Reports. 43. (10).

Bou Sleiman, Maroun, Li, Xiaoxu, Morel, Jean-David, Sulc, Jonathan, Masi, Alessia De, Lalou, Amélia, Benegiamo, Giorgia, Poisson, Johanne, Liu, Yasmine, Alvensleben, Giacomo V. G. Von, et al.(2024). Systems genetics of metabolic health in the BXD mouse genetic reference population . Cell Systems. 15. (6). p. 497--509.e3.

Bou Sleiman, Maroun, Choi, Sungwoo, Kang, Ju-Gyeong, Tran, Yen T. H., Jeong, Sun-Hye, Park, Kun-Young, Shin, Hyemi, Kim, Young Hoon, Park, Myungsun, Nahmgoong, Hahn, et al.(2024). Hippo–YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass . Nature Metabolism. 6. (5). p. 847--860.

Maroun Bou Sleiman, Anna Park, Kwang-eun Kim, Isaac Park, Sang Heon Lee, Kun-Young Park, Minkyo Jung, Xiaoxu Li, Su Jeong Lee, Dae-Soo Kim, et al. (2023). Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice . Nature Communications.

Bou Sleiman, Maroun, Park, Anna, Kim, Kwang-eun, Park, Isaac, Lee, Sang Heon, Park, Kun-Young, Jung, Minkyo, Li, Xiaoxu, Lee, Su Jeong, Kim, Dae-Soo, et al.(2023). Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice . Nature Communications. 14. (1). p. 3746.

Bou Sleiman, Maroun, Li, Xiaoxu, Morel, Jean-David, Benegiamo, Giorgia, Poisson, Johanne, Bachmann, Bachmann, Rapin, Alexis, Willams, Evan, Perino, Alessia, Schoonjans, Kristina, et al.(2023). Genetic and dietary modulators of the inflammatory response in the gastro-intestinal tract of the BXD mouse genetic reference population . eLife. 12.

Bou Sleiman, Maroun, Morel, Jean-David, Li, Terytty Yang, Alvensleben, Giacomo von, Bachmann, Alexis M., Hofer, Dina, Broeckx, Ellen, Ma, Jing Ying, Carreira, Vinicius, Chen, Tao, et al.(2023). Mitochondrial and NAD$^\textrm+$ metabolism predict recovery from acute kidney injury in a diverse mouse population . JCI Insight. 8. (3).

Bou Sleiman, Maroun, Benegiamo, Giorgia, von Alvensleben, Giacomo V.G., Rodríguez-López, Sandra, Goeminne, Ludger J.E., Bachmann, Alexis M., Morel, Jean-David, Broeckx, Ellen, Ma, Jing Ying, Carreira, Vinicius, et al.(2023). The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression . Journal of Experimental Medicine. 220. (4). p. e20221738.

Bou Sleiman, Maroun, Liu, Yasmine, Scantlebery, Angelique M. L., Strotjohann, Keno, Rodriguez-Lopez, Sandra, Li, Xiaoxu, Homicsko, Krisztian, Smith, Karen, Ciavarri, Jeffrey, Houtkooper, Riekelt H., et al.(2023). INHIBITING SARM1 IS MORE EFFICACIOUS THAN NICOTINAMIDE RIBOSIDE SUPPLEMENTATION FOR THE TREATMENT OF A MOUSE MODEL WITH NAFLD/NASH. Hepatology.

Bou Sleiman, Maroun, Benegiamo, Giorgia, Wohlwend, Martin, Rodríguez-López, Sandra, Goeminne, Ludger J. E., Laurila, Pirkka-Pekka, Klevjer, Marie, Salonen, Minna K., Lahti, Jari, Jha, Pooja, et al.(2022). COX7A2L genetic variants determine cardiorespiratory fitness in mice and human . Nature Metabolism. 4. (10). p. 1336--1351.

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Science.

Bou Sleiman, Maroun, Roy, Suheeta, Gao, Arwen W., Sadler, Marie C., von Alvensleben, Giacomo V. G., Li, Hao, Sen, Saunak, Harrison, David E., Nelson, James F., Strong, Randy, et al.(2022). Sex- and age-dependent genetics of longevity in a heterogeneous mouse population . Science. 377. (6614). p. eabo3191.

Bou Sleiman, Maroun, Li, Hao, Perino, Alessia, Huang, Qingyao, Von Alvensleben, Giacomo V. G., Banaei-Esfahani, Amir, Velazquez-Villegas, Laura A., Gariani, Karim, Korbelius, Melanie, Imbach, J&#233;romine, et al.(2022). Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis . Cell Metabolism.

Bou Sleiman, Maroun, Bachmann, Alexis Maximilien, Morel, Jean-David, El Alam, Gaby, Rodr&#237;guez-L&#243;pez, Sandra, Imamura de lima, Tanes, Goeminne, Ludger J. E., Benegiamo, Giorgia, Loric, Sylvain, Conti, Marc, et al.(2022). Genetic background and sex control the outcome of high-fat diet feeding in mice . iScience. 25. (6). p. 104468.

Bou Sleiman, Maroun, Gao, Arwen W., El Alam, Gaby, Lalou, Am&#233;lia, Li, Terytty Yang, Molenaars, Marte, Zhu, Yunyun, Overmyer, Katherine A., Shishkova, Evgenia, Hof, Kevin, et al.(2022). Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains . iScience. 25. (2). p. 103734.

Bou Sleiman, Maroun, Porcu, Eleonora, Sadler, Marie C., Lepik, Kaido, Auwerx, Chiara, Wood, Andrew R., Weihs, Antoine, Ribeiro, Diogo M., Bandinelli, Stefania, Tanaka, Toshiko, et al.(2021). Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome . Nature Communications. 12. (1). p. 5647.

Bou Sleiman, Maroun, Roy, Suheeta, Jha, Pooja, Ingels, Jesse F., Chapman, Casey J., McCarty, Melinda S., Ziebarth, Jesse D., Hook, Michael, Sun, Anna, Zhao, Wenyuan, et al.(2021). Gene-by-environment modulation of lifespan and weight gain in the murine BXD family . Nature Metabolism. 3. (9). p. 1217--1227.

Terytty Yang Li and Maroun Bou Sleiman and Hao Li and Arwen W. Gao and Adrienne Mottis and Alexis Maximilien Bachmann and Gaby El Alam and Xiaoxu Li and Ludger J. E. Goeminne and Kristina Schoonjans and Johan Auwerx(2021). The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress . Nature Aging. 1. (2). p. 165--178. Springer Science and Business Media {LLC}

Maroun Bou Sleiman and Michael Vincent Frochaux and Tommaso Andreani and Dani Osman and Roderic Guigo and Bart Deplancke(2020). Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes . Genome Biology. 21. (1). Springer Science and Business Media {LLC}

Michael V. Frochaux and Maroun Bou Sleiman and Vincent Gardeux and Riccardo Dainese and Brian Hollis and Maria Litovchenko and Virginie S. Braman and Tommaso Andreani and Dani Osman and Bart Deplancke(2020). cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel . Genome Biology. 21. (1). Springer Science and Business Media {LLC}

Maroun Bou Sleiman, Giovanni Sorrentino, Alessia Perino, Ece Yildiz, Gaby El Alam, Antimo Gioiello, Roberto Pellicciari, Kristina Schoonjans(2020). Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration . Gastroenterology. 159. (3). p. 956--968.e8. Elsevier {BV}

Maroun Bou Sleiman, Pooja Jha, Riekelt Houtkooper, Robert W. Williams, Xu Wang, Johan Auwerx(2020). The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators . Cell Reports. 32. (13). p. 108203. Elsevier {BV}

Bou Sleiman, Maroun, Sorrentino, Giovanni, Perino, Alessia, Yildiz, Ece, El Alam, Gaby, Gioiello, Antimo, Pellicciari, Roberto, Schoonjans, Kristina(2020). Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration . Gastroenterology. 159. (3). p. 956--968.e8.

Bou Sleiman, Maroun, Jha, Pooja, Houtkooper, Riekelt, Williams, Robert W., Wang, Xu, Auwerx, Johan(2020). The Gene-Regulatory Footprint of Aging Highlights Conserved Central Regulators . Cell Reports. 32. (13).

Bou Sleiman, Maroun, Frochaux, Michael V., Gardeux, Vincent, Dainese, Riccardo, Hollis, Brian, Litovchenko, Maria, Braman, Virginie S., Andreani, Tommaso, Osman, Dani, Deplancke, Bart(2020). cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel . Genome Biology. 21. (1). p. 6.

Bou Sleiman, Maroun, Frochaux, Michael Vincent, Andreani, Tommaso, Osman, Dani, Guigo, Roderic, Deplancke, Bart(2020). Enteric infection induces Lark-mediated intron retention at the 5′ end of Drosophila genes . Genome Biology. 21. (1). p. 4.

Hao Li and Daria Rukina and Fabrice P.A. David and Terytty Yang Li and Chang-Myung Oh and Arwen W. Gao and Elena Katsyuba and Maroun Bou Sleiman and Andrea Komljenovic and Qingyao Huang and Robert W. Williams and Marc Robinson-Rechavi and Kristina Schoonjans and Stephan Morgenthaler and Johan Auwerx(2019). Identifying gene function and module connections by the integration of multispecies expression compendia . Genome Research. 29. (12). p. 2034--2045. Cold Spring Harbor Laboratory

Bou Sleiman, Maroun, Li, Hao, Rukina, Daria, David, Fabrice P. A., Li, Terytty Yang, Oh, Chang-Myung, Gao, Arwen W., Katsyuba, Elena, Komljenovic, Andrea, Huang, Qingyao, et al.(2019). Identifying gene function and module connections by the integration of multispecies expression compendia . Genome Research.

Dali Ma and Maroun Bou-Sleiman and Pauline Joncour and Claire-Emmanuelle Indelicato and Michael Frochaux and Virginie Braman and Maria Litovchenko and Gilles Storelli and Bart Deplancke and Fran{\c{c}}ois Leulier(2019). Commensal Gut Bacteria Buffer the Impact of Host Genetic Variants on Drosophila Developmental Traits under Nutritional Stress . iScience. 19. p. 436--447. Elsevier {BV}

Bou Sleiman, Maroun, Ma, Dali, Joncour, Pauline, Indelicato, Claire-Emmanuelle, Frochaux, Michael, Braman, Virginie, Litovchenko, Maria, Storelli, Gilles, Deplancke, Bart, Leulier, Fran&#231;ois(2019). Commensal Gut Bacteria Buffer the Impact of Host Genetic Variants on Drosophila Developmental Traits under Nutritional Stress . iScience. 19. p. 436--447.

Maria Cristina Letizia and Matteo Cornaglia and Raphaël Trouillon and Vincenzo Sorrentino and Laurent Mouchiroud and Maroun S. Bou Sleiman and Johan Auwerx and Martin A. M. Gijs(2018). Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution . Microsystems & Nanoengineering. 4. (1). Springer Science and Business Media {LLC}

Michael Hook and Suheeta Roy and Evan G. Williams and Maroun Bou Sleiman and Khyobeni Mozhui and James F. Nelson and Lu Lu and Johan Auwerx and Robert W. Williams(2018). Genetic cartography of longevity in humans and mice: Current landscape and horizons . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864. (9). p. 2718--2732. Elsevier {BV}

Bou Sleiman, Maroun, Hook, Michael, Roy, Suheeta, Williams, Evan G., Mozhui, Khyobeni, Nelson, James F., Lu, Lu, Auwerx, Johan, Williams, Robert W.(2018). Genetic cartography of longevity in humans and mice: Current landscape and horizons . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.

Pooja Jha and Molly T. McDevitt and Emina Halilbasic and Evan G. Williams and Pedro M. Quiros and Karim Gariani and Maroun B. Sleiman and Rahul Gupta and Arne Ulbrich and Adam Jochem and Joshua J. Coon and Michael Trauner and David J. Pagliarini and Johan Auwerx(2018). Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes . Cell Systems. 6. (6). p. 709--721.e6. Elsevier {BV}

Bou Sleiman, Maroun, Jha, Pooja, McDevitt, Molly T., Halilbasic, Emina, Williams, Evan G., Quiros, Pedro M., Gariani, Karim, Gupta, Rahul, Ulbrich, Arne, Jochem, Adam, et al.(2018). Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes . Cell Systems. 6. (6). p. 709--721.e6.

Pooja Jha and Molly T. McDevitt and Rahul Gupta and Pedro M. Quiros and Evan G. Williams and Karim Gariani and Maroun B. Sleiman and Leo Diserens and Adam Jochem and Arne Ulbrich and Joshua J. Coon and Johan Auwerx and David J. Pagliarini(2018). Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species . Cell Systems. 6. (6). p. 722--733.e6. Elsevier {BV}

Bou Sleiman, Maroun, Jha, Pooja, McDevitt, Molly T., Gupta, Rahul, Quiros, Pedro M., Williams, Evan G., Gariani, Karim, Diserens, Leo, Jochem, Adam, Ulbrich, Arne, et al.(2018). Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species . Cell Systems. 6. (6). p. 722--733.e6.

Bou Sleiman, Maroun, Letizia, Maria Cristina, Cornaglia, Matteo, Trouillon, Rapha&#235;l, Sorrentino, Vincenzo, Mouchiroud, Laurent, Auwerx, Johan, Gijs, Martin A. M.(2018). Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution . Microsystems & Nanoengineering. 4. (1). p. 6.

Hao Li and Xu Wang and Daria Rukina and Qingyao Huang and Tao Lin and Vincenzo Sorrentino and Hongbo Zhang and Maroun Bou Sleiman and Danny Arends and Aaron McDaid and Peiling Luan and Naveed Ziari and Laura A. Vel{\'{a}}zquez-Villegas and Karim Gariani and Zoltan Kutalik and Kristina Schoonjans and Richard A. Radcliffe and Pjotr Prins and Stephan Morgenthaler and Robert W. Williams and Johan Auwerx(2018). An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function . Cell Systems. 6. (1). p. 90--102.e4. Elsevier {BV}

Bou Sleiman, Maroun, Li, Hao, Wang, Xu, Rukina, Daria, Huang, Qingyao, Lin, Tao, Sorrentino, Vincenzo, Zhang, Hongbo, Arends, Danny, McDaid, Aaron, et al.(2018). An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function . Cell Systems. 6. (1). p. 90--102.e4.

Olli Matilainen and Maroun S. Bou Sleiman and Pedro M. Quiros and Susana M. D. A. Garcia and Johan Auwerx(2017). The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress . Nature Communications. 8. (1). Springer Science and Business Media {LLC}

Maroun S. Bou Sleiman and Dani Osman and Andreas Massouras and Ary A. Hoffmann and Bruno Lemaitre and Bart Deplancke(2015). Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence . Nature Communications. 6. (1). Springer Science and Business Media {LLC}

Bou Sleiman, Maroun, Bou Sleiman, Maria, Abbas, Ossama, Btadini, Waed, Najjar, Tracy, Tofaili, Mona, Chedraoui, Adele, Khalil, Samar, Kibbi, Abdul Ghani, Kurban, Mazen(2015). Novel mutation in LIPH in a Lebanese patient with autosomal recessive woolly hair/hypotrichosis . The Journal of Dermatology. 42. (8). p. 822--824.

Bou Sleiman, Maroun, Osman, Dani, Massouras, Andreas, Hoffmann, Ary A., Lemaitre, Bruno, Deplancke, Bart(2015). Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence . Nat Commun. 6.

Claudine Neyen and Olivier Binggeli and Pietro Roversi and Lise Bertin and Maroun Bou Sleiman and Bruno Lemaitre(2015). The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects . Developmental & Comparative Immunology. 50. (2). p. 166--174. Elsevier {BV}

Bou Sleiman, Maroun, Neyen, Claudine, Binggeli, Olivier, Roversi, Pietro, Bertin, Lise, Lemaitre, Bruno(2014). The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects1 . Developmental & Comparative Immunology. 50. (2). p. 166--174.

Wen-bin~Alfred Chng and Maroun~S.~Bou Sleiman and Fanny Schüpfer and Bruno Lemaitre(2014). Transforming Growth Factor β/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression . Cell Reports. 9. (1). p. 336--348. Elsevier {BV}

Bou Sleiman, Maroun, Chng, Wen-bin Alfred, Sch&#252;pfer, Fanny, Lemaitre, Bruno(2014). Transforming Growth Factor β/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression . Cell Reports. 9. (1). p. 336--348.

Bou Sleiman, Maroun, Possik, Elite J., Ghattas, Ingrid R., Smith, Colin A.(2013). Randomized codon mutagenesis reveals that the HIV Rev arginine-rich motif is robust to substitutions and that double substitution of two critical residues alters specificity . Journal of Molecular Recognition. 26. (6). p. 286--296.

OTHER

Maroun Bou Sleiman, Arwen W. Gao, Gaby El Alam, Am&#233;lia Lalou, Terytty Yang Li, Marte Molenaars, Yunyun Zhu, Katherine A. Overmyer, Evgenia Shishkova, Kevin Hof, et al.(2021). Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains . Cold Spring Harbor Laboratory

Maroun Bou Sleiman, Suheeta Roy, Pooja Jha, Evan G. Williams, Jesse F. Ingels, Casey J. Chapman, Melinda S. McCarty, Michael Hook, Anna Sun, Wenyuan Zhao, et al.(2019). Gene-by-environmental modulation of longevity and weight gain in the murine BXD family . Cold Spring Harbor Laboratory