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Hire Dr. Indu J.

Malaysia

USD 50 /hr

Freelancer with 20 + years of experience in biodiversity, nutrition and health. Scientific writer

Profile Summary

I have over 30 years of research experience in biodiversity, sustainable agriculture, biotechnology, and nutrition. My main interest lies in the value-adding biodiversity through frontier sciences such as Metabolomics and Nutrigenomics. I have since set an herbal in-situ conservatory, developed herbal products and fruit extracts with validated anti-diabetic, anti-atherosclerotic, anti-cholesterol, and anti-viral activities, filed four patents, licensed its technologies, and managed to register five trade secrets. In my research, I use multidisciplinary approaches (transcriptomics, metabolomics, chemoinformatics, pharmacokinetics, and in-vivo animal models) to gain a more holistic approach and better understand how dietary compounds alter our metabolism and affect various cellular pathways through gene regulation. To date, I am also actively involved in the following activities: • Editing and copywriting, including writing white documents on a wide variety of topics, involving nutrition, biodiversity, sustainable agriculture, biotechnology, and pharmaceutical sciences • Assessing biodiversity and promoting sustainable agriculture • Formulating herbal, nutraceutical, and personal care products • Securing and implementing high-impact projects to meet the needs and the challenges of the agriculture, food, and wellness industry.

Subject Matter Expertise

• ★ Nutrition Science
• ☆ Natural Product Chemistry
• ☆ Molecular Biology
• ☆ Metabolomics
• ☆ Food Science

Services

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing

Research Fact Checking, Gap Analysis, Gray Literature Search, Systematic Literature Review

Consulting Scientific and Technical Consulting

Product Development Formulation, Product Validation

Work Experience

Research Specialist (Metabolomics and Nutrigenomics)

Malaysian Agricultural Reserach and Development Institute (MARDI)

April 1986 - Present

Education

PhD (Molecular Biology and Biochemistry)

University of Glasgow, UK

December 2002 - December 2005

MSc (Plant Science)

University of California, Riverside

March 1991 - February 1993

BSc (Botany)

University Malaya

August 1981 - August 1985

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

In vivo toxicity and antioxidant of pressurize hot water Phyllanthus tenellus Roxb. extracts @article{2021, doi = {10.1186/s12906-021-03260-y}, url = {https://doi.org/10.1186%2Fs12906-021-03260-y}, year = 2021, month = {mar}, publisher = {Springer Science and Business Media {LLC}}, volume = {21}, number = {1}, author = {Swee Keong Yeap and Chean Yeah Yong and Umar Faruq and Hui Kian Ong and Zahiah binti Mohamed Amin and Wan Yong Ho and Shaiful Sharifudin and Indu Bala Jaganath}, title = {In vivo toxicity and antioxidant of pressurize hot water Phyllanthus tenellus Roxb. extracts}} . BMC Complementary Medicine and Therapies.

PEG-b-PLGA Nanoparticles Loaded with Geraniin from Phyllanthus Watsonii Extract as a Phytochemical Delivery Model @article{2020, doi = {10.3390/app10144891}, url = {https://doi.org/10.3390%2Fapp10144891}, year = 2020, month = {jul}, publisher = {{MDPI} {AG}}, volume = {10}, number = {14}, pages = {4891}, author = {Kogilavanee Devasvaran and Sreegayathri Jairaman and Nur Azirah Yahaya and Indu Bala S. Jaganath and Yit Lung Khung and Vuanghao Lim and Siti Hawa Ngalim}, title = {{PEG}-b-{PLGA} Nanoparticles Loaded with Geraniin from Phyllanthus Watsonii Extract as a Phytochemical Delivery Model}} . Applied Sciences.

Pressurized hot water extraction of hydrosable tannins from Phyllanthus tenellus Roxb. @article{2019, doi = {10.1186/s13065-019-0653-0}, url = {https://doi.org/10.1186%2Fs13065-019-0653-0}, year = 2019, month = {dec}, publisher = {Springer Science and Business Media {LLC}}, volume = {13}, number = {1}, author = {Noor Hidayah Mohd Jusoh and Atiqah Subki and Swee Keong Yeap and Ken Choy Yap and Indu Bala Jaganath}, title = {Pressurized hot water extraction of hydrosable tannins from Phyllanthus tenellus Roxb.}} . BMC Chemistry.

In vitro characterization and in vivo toxicity, antioxidant and immunomodulatory effect of fermented foods; Xeniji™ @article{2017, doi = {10.1186/s12906-017-1845-6}, url = {https://doi.org/10.1186%2Fs12906-017-1845-6}, year = 2017, month = {jun}, publisher = {Springer Science and Business Media {LLC}}, volume = {17}, number = {1}, author = {Noraisyah Zulkawi and Kam Heng Ng and Rizi Zamberi and Swee Keong Yeap and Dilan Satharasinghe and Indu Bala Jaganath and Anisah Binti Jamaluddin and Sheau Wei Tan and Wan Yong Ho and Noorjahan Banu Alitheen and Kamariah Long}, title = {In vitro characterization and in vivo toxicity, antioxidant and immunomodulatory effect of fermented foods$\mathsemicolon$ Xeniji{\texttrademark}}} . BMC Complementary and Alternative Medicine.

Computational Analysis of Gynura bicolor Bioactive Compounds as Dipeptidyl Peptidase-IV Inhibitor @article{2017, doi = {10.1155/2017/5124165}, url = {https://doi.org/10.1155%2F2017%2F5124165}, year = 2017, month = {aug}, publisher = {Hindawi Limited}, volume = {2017}, pages = {1--16}, author = {Lina Rozano and Muhammad Redha Abdullah Zawawi and Muhamad Aizuddin Ahmad and Indu Bala Jaganath}, title = {Computational Analysis of Gynura bicolor Bioactive Compounds as Dipeptidyl Peptidase-{IV} Inhibitor}} . Advances in Bioinformatics.

Draft Genome Sequence of Blood Disease Bacterium A2 HR-MARDI, a Pathogen Causing Banana Bacterial Wilt @article{2017, doi = {10.1128/genomea.00408-17}, url = {https://doi.org/10.1128%2Fgenomea.00408-17}, year = 2017, month = {jun}, publisher = {American Society for Microbiology}, volume = {5}, number = {22}, author = {Rafidah Badrun and Norliza Abu Bakar and Rozeita Laboh and Rohaiza Redzuan and Indu Bala Jaganath}, title = {Draft Genome Sequence of Blood Disease Bacterium A2 {HR}-{MARDI}, a Pathogen Causing Banana Bacterial Wilt}} . Genome Announcements.

Chlorogenic acids and the acyl-quinic acids: discovery, biosynthesis, bioavailability and bioactivity @article{2017, doi = {10.1039/c7np00030h}, url = {https://doi.org/10.1039%2Fc7np00030h}, year = 2017, publisher = {Royal Society of Chemistry ({RSC})}, volume = {34}, number = {12}, pages = {1391--1421}, author = {Michael~N. Clifford and Indu B. Jaganath and Iziar A. Ludwig and Alan Crozier}, title = {Chlorogenic acids and the acyl-quinic acids: discovery, biosynthesis, bioavailability and bioactivity}} . Natural Product Reports.

The in vivo hepato-recovery effects of the polyphenol-rich fermented food Xeniji™ on ethanol-induced liver damage @article{2017, doi = {10.1039/c7ra04616b}, url = {https://doi.org/10.1039%2Fc7ra04616b}, year = 2017, publisher = {Royal Society of Chemistry ({RSC})}, volume = {7}, number = {61}, pages = {38287--38299}, author = {Noraisyah Zulkawi and Kam Heng Ng and Rizi Zamberi and Swee Keong Yeap and Indu Bala Jaganath and Dilan Satharasinghe and Chean Yeah Yong and Anisah Binti Jamaluddin and Sheau Wei Tan and Wan Yong Ho and Noorjahan Banu Alitheen and Kamariah Long}, title = {The in vivo hepato-recovery effects of the polyphenol-rich fermented food Xeniji{\texttrademark} on ethanol-induced liver damage}} . RSC Advances.

Yeap, S.K., Beh, B.K., Ho, W.Y., Mohd Yusof, H., Mohamad, N.E., Ali, N.M., Jaganath, I.B., Alitheen, N.B., Koh, S.P., Long, K.(2015). In vivo antioxidant and hypolipidemic effects of fermented mung bean on hypercholesterolemic mice . Evidence-based Complementary and Alternative Medicine. 2015.

Rozano, L., Zawawi, M.R.A., Ahmad, M.A., Jaganath, I.B.(2015). Comparative docking study of ‘dukung anak’ phytonutrient compounds with anti-cholesterol properties . Jurnal Teknologi. 77. (31). p. 37-43.

Tang, Y.-Q., Jaganath, I.B., Manikam, R., Sekaran, S.D.(2015). Phyllanthus spp. Exerts Anti-Angiogenic and Anti-Metastatic Effects Through Inhibition on Matrix Metalloproteinase Enzymes . Nutrition and Cancer. 67. (5). p. 783-795.

Tang, Y.-Q., Jaganath, I.B., Manikam, R., Sekaran, S.D.(2014). Inhibition of MAPKs, Myc/Max, NFκB, and hypoxia pathways by phyllanthus prevents proliferation, metastasis and angiogenesis in human melanoma (MeWo) cancer cell line . International Journal of Medical Sciences. 11. (6). p. 564-577.

Yeap, S.K., Beh, B.K., Kong, J., Ho, W.Y., Mohd Yusof, H., Mohamad, N.E., Hussin, A.B., Jaganath, I.B., Alitheen, N.B., Jamaluddin, A., et al.(2014). In vivo hypocholesterolemic effect of MARDI fermented red yeast rice water extract in high cholesterol diet fed mice . Evidence-based Complementary and Alternative Medicine. 2014.

Lee, S.H., Jaganath, I.B., Manikam, R., Sekaran, S.D.(2013). Inhibition of Raf-MEK-ERK and Hypoxia pathways by Phyllanthus prevents metastasis in human lung (A549) cancer cell line . BMC Complementary and Alternative Medicine. 13.

Lee, S.H., Tang, Y.Q., Jaganath, I.B., Sekaran, S.D., Devi, S.(2013). Phyllanthus, a broad spectrum anti-cancer agent: Properties and mechanisms of activities . Journal of the University of Malaya Medical Centre. 16. (SPECIAL).

Lee, S.H., Tang, Y.Q., Rathkrishnan, A., Wang, S.M., Ong, K.C., Manikam, R., Payne, B.J., Jaganath, I.B., Sekaran, S.D.(2013). Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2 . BMC Complementary and Alternative Medicine. 13.

Tan, W.C., Jaganath, I.B., Manikam, R., Sekaran, S.D.(2013). Evaluation of antiviral activities of four local Malaysian phyllanthus species against herpes simplex viruses and possible antiviral target . International Journal of Medical Sciences. 10. (13). p. 1817-1829.

Chua, L.S., Yap, K.C., Jaganath, I.B.(2013). Comparison of total phenolic content, scavenging activity and HPLC-ESI-MS/MS profiles of both young and mature leaves and stems of andrographis paniculata . Natural Product Communications. 8. (12). p. 1725-1729.

Tang, Y.-Q., Jaganath, I., Manikam, R., Sekaran, S.D.(2013). Phyllanthus suppresses prostate cancer cell, PC-3, proliferation and induces apoptosis through multiple signalling pathways (MAPKs, PI3K/Akt, NF B, and Hypoxia) . Evidence-based Complementary and Alternative Medicine. 2013.

Lee, S.H., Jaganath, I.B., Wang, S.M., Sekaran, S.D.(2011). Antimetastatic effects of phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines . PLoS ONE. 6. (6).

Amin, N.M., Bunawan, H., Redzuan, R.A., Jaganath, I.B.S.(2011). Erwinia mallotivora sp., a new pathogen of papaya (Carica papaya) in peninsular Malaysia . International Journal of Molecular Sciences. 12. (1). p. 39-45.

Tang, Y.-Q., Jaganath, I.B., Sekaran, S.D.(2010). Phyllanthus spp. induces selective growth inhibition of PC-3 and mewo human cancer cells through modulation of cell cycle and induction of apoptosis . PLoS ONE. 5. (9). p. 1-11.

Crozier, A., Jaganath, I.B., Clifford, M.N.(2009). Dietary phenolics: Chemistry, bioavailability and effects on health . Natural Product Reports. 26. (8). p. 1001-1043.

Jaganath, I.B., Mullen, W., Lean, M.E.J., Edwards, C.A., Crozier, A.(2009). In vitro catabolism of rutin by human fecal bacteria and the antioxidant capacity of its catabolites . Free Radical Biology and Medicine. 47. (8). p. 1180-1189.

Jaganath, I.B., Mullen, W., Edwards, C.A., Crozier, A.(2006). The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man . Free Radical Research. 40. (10). p. 1035-1046.

https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-021-03260-y .

In vivo toxicity and antioxidant of pressurize hot water Phyllanthus tenellus Roxb. extracts.

BOOK

Jaganath, I.B., Crozier, A.(2011). Flavonoid Biosynthesis . Plant Metabolism and Biotechnology. p. 293-320.

Jaganath, I.B., Crozier, A.(2009). Dietary Flavonoids and Phenolic Compounds . Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology. p. 1-49.

Jaganath, I.B., Crozier, A.(2008). Overview of health-promoting compounds in fruit and vegetables . Improving the Health-Promoting Properties of Fruit and Vegetable Products. p. 3-37.

Crozier, A., Yokota, T., Jaganath, I.B., Marks, S., Saltmarsh, M., Clifford, M.N.(2007). Secondary Metabolites in Fruits, Vegetables, Beverages and Other Plant-based Dietary Components . Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet. p. 208-302.

Crozier, A., Jaganath, I.B., Clifford, M.N.(2007). Phenols, Polyphenols and Tannins: An Overview . Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet. p. 1-24.