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Hire Dr. Dhatchana M.

India

USD 30 /hr

Pharmaceutical scientist with interdisciplinary expertise and 20+ years experience in industry and academia

Profile Summary

PhD level Pharmaceutical scientist with 19 plus years of international experience in preclinical research, drug discovery, data analysis, and scientific writing/reviewing. Expertise in the drug discovery and development: Wide work experience in multiple therapeutic areas (e.g., oncology, neurology, diabetes, pain and inflammation). Target identification and validation, assay development and secondary biological testing. Technical abilities: tissue culture, biochemical techniques, enzyme inhibition studies, multiplex PCR, qPCR, advanced nucleic acid amplification techniques, cloning and expression systems, ELISA, assay development and manufacturing. Substantial experience in protein expression and purification in the heterologous host system (Bacterial, Mammalian and Baculoviral/Insect cell system). Gene therapy- in vitro and in vivo gene delivery using cationic polymers and viral vectors. Microarray technology: RNA extraction and quantitation, cDNA synthesis and labelling, hybridization on arrays, scanning of arrays using different software, quantitation and data extraction, data analysis, database search, Northern Blot for validation of microarray results. Affymetrix Gene chip techniques and data analysis.

Subject Matter Expertise

• ★ Biochemistry
• ★ Molecular Biology
• ★ Drug Development
• ☆ Virology
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Microarrays
• ☆ Monoclonal Antibody Production
• ☆ Cell Signaling Pathways
• ☆ Bioinformatics
• ☆ Protein/Enzyme Engineering
• ☆ Drug Design
• ☆ Oncology
• ☆ HIV/AIDS Treatment
• ☆ Gene Therapy
• ☆ Cancer Research
• ☆ Scientific Proofreading & Editing

Services

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing, Copywriting

Research Feasibility Study, Fact Checking, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Product Development Formulation

Work Experience

Senior Consultant

EinNext Biosceinces

April 2020 - Present

Senior Consultant

EinNext Biosciences

April 2020 - Present

Research Scientist

Orchid Chemicals and Pharmaceuticals Limited

January 2008 - December 2020

Senior Research Scientist

Dabur Research Foundation

December 2004 - January 2008

Guest Scientist

Charité Universitätsmedizin Berlin Campus Benjamin Franklin

December 2001 - February 2003

Project assistant

Institute of Genomics and Integrative Biology CSIR

February 2001 - November 2001

Education

Ph.D (Pharmaceutical Science - Biochemistry) (Department of Biochemistry)

University of Madras

August 2011 - December 2019

M.Pharmacy (Department of Pharmacy)

Institute of Technology Banaras Hindu University

July 1998 - March 2000

B.Pharmacy (Department of Pharmaceutical Sciences)

Tamil Nadu Dr MGR Medical University

August 1994 - April 1998

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Jayachandran Karunakaran, Nachiappan Dhatchana Moorthy, Somenath Roy Chowdhury, Saleem Iqbal, Hemanta K. Majumder, Krishnasamy Gunasekaran, Elangovan Vellaichamy, Arasambattu K. Mohanakrishnan(2019). Divergent Synthesis and Evaluation of the in{\hspace{0.25em}}vitro Cytotoxicity Profiles of 3,4-Ethylenedioxythiophenyl-2-propen-1-one Analogues . {ChemMedChem}. Wiley

Nachiappan Dhatchana Moorthy, Siva Ramamoorthy, Bose Muthu Ramalingam, Saleem Iqbal, Arasambattu K Mohanakrishnan, Krishnasamy Gunasekaran, Elangovan Vellaichamy(2018). Novel isothiacalothrixin B analogues exhibit cytotoxic activity on human colon cancer cells in vitro by inducing irreversible {DNA} damage . {PLOS} {ONE}. 13. (9). p. e0202903. Public Library of Science ({PLoS})

{Muthu Ramalingam}, Bose and {Dhatchana Moorthy}, Nachiappan and Chowdhury, Somenath Roy and Mageshwaran, Thiyagarajan and Vellaichamy, Elangovan and Saha, Sourav and Ganesan, Karthikeyan and Rajesh, B. Navin and Iqbal, Saleem and Majumder, Hemanta Kumar and Gunasekaran, Krishnasamy and Siva, Ramamoorthy and Mohanakrishnan, Arasambattu Kannan(2018). Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues . Journal of medicinal chemistry. 61. (3). p. 1285--1315.

Shanmuganathan, T., Parthasarathy, K., Venugopal, M., Arun, Y., Dhatchanamoorthy, N., Prince, A.A.M.(2017). Synthesis, in vitro anti-inflammatory activity and molecular docking studies of novel 4,5-diarylthiophene-2-carboxamide derivatives . Journal of Chemical Sciences. 129. (1). p. 117-130.

Shanmuganathan, T., Venugopal, M., Parthasarathy, K., Dhatchanamoorthy, N., Arun, Y., Prince, A.A.M.(2017). Synthesis of novel bis-allyloxy and hydroxypropoxy derivatives of 4, 5-diaryl thiophene-2-carboxylic acid and their biological evaluation . Journal of Chemical Sciences. 129. (5). p. 623-636.

Ramalingam, B.M., Moorthy, N.D., Vellaichamy, E., Mohanakrishnan, A.K.(2017). Synthesis of Thia-Analogues of Calothrixin B Involving FeCl<inf>3</inf>-Mediated Domino Reaction . Synlett. 28. (1). p. 133-137.

Shanmuganathan, T., Prince, A.A.M., Dhatchanamoorthy, N., Parthasarathy, K., Venugopal, M.(2017). Synthesis, anti-inflammatory activity of picen-13-ylmethylene derivatives . Arkivoc. 2017. (5). p. 67-79.

Karthikeyan, G., Paul-Satyaseela, M., Dhatchana Moorthy, N., Gopalaswamy, R., Narayanan, S.(2014). Functional characterization of Candida albicans Hos2 histone deacetylase . F1000Research. 2.

Panchapakesan, G., Dhayalan, V., Dhatchana Moorthy, N., Saranya, N., Mohanakrishnan, A.K.(2011). Synthesis of 2-substituted 17β-hydroxy/17-methylene estratrienes and their in vitro cytotoxicity in human cancer cell cultures . Steroids. 76. (13). p. 1491-1504.

Chetan, B., Bunha, M., Jagrat, M., Sinha, B.N., Saiko, P., Graser, G., Szekeres, T., Raman, G., Rajendran, P., Moorthy, D., et al.(2010). Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity . Bioorganic and Medicinal Chemistry Letters. 20. (13). p. 3906-3910.

Bhonde, M.R., Hanski, M.-L., Budczies, J., Cao, M., Gillissen, B., Moorthy, D., Simonetta, F., Scher&#252;bl, H., Truss, M., Hagemeier, C., et al.(2006). DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: The lack of this suppression in p53^MUT cells contributes to apoptosis . Journal of Biological Chemistry. 281. (13). p. 8675-8685.

Bhonde, M.R., Hanski, M.-L., Magrini, R., Moorthy, D., M&#252;ller, A., Sausville, E.A., Kohno, K., Wiegand, P., Daniel, P.T., Zeitz, M., et al.(2005). The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x <inf>L</inf> protein . Oncogene. 24. (1). p. 148-156.