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USD 25 /hr

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Hire Dr. Yun L.

United States

USD 25 /hr

Experienced DMPK & Clinical pharmacology expert in different modalities with IND and BLA/MAA experiences

Profile Summary

Experience serving in the capacity of a DMPK/Clinical pharmacology expert on drug discovery and development programs in the pharmaceutical/biotechnology industry and corresponding experience in designing and executing nonclinical ADME/PK/PD/DDI strategies and studies in various therapeutic areas. Hands on experience with R, Phoenix, Julia, NONMEM

Subject Matter Expertise

• ★ Preclinical ADME/PK/PD
• ★ Investigational New Drug (IND) Application Consulting
• ★ Vaccine Development
• ☆ Drug Development
• ☆ Drug-Drug Interactions
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Pharmaceutical Regulatory Affairs
• ☆ Drug Efficacy Testing
• ☆ Bioavailability
• ☆ Clinical Trials
• ☆ Clinical Trial Design
• ☆ Oncology
• ☆ Radiation Therapy
• ☆ Chemotherapy
• ☆ Pediatric Oncology
• ☆ Hematology
• ☆ Infectious Disease
• ☆ Viral Diseases
• ☆ Respiratory Syncytial Virus (RSV)
• ☆ Epstein-Barr Virus (EBV)
• ☆ Ebola
• ☆ Chikungunya
• ☆ Regulatory Affairs
• ☆ Immunotherapy
• ☆ Gene Therapy
• ☆ Hemophilia
• ☆ Drug Delivery Technologies
• ☆ Liposomes
• ☆ Pharmaceutical Technology

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Non-Medical Regulatory Writing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Predictive Modeling

Product Development Formulation

Work Experience

Sr. Scientist

Moderna Inc

March 2023 - Present

Project Lead

Moderna Therapeutics (United States)

March 2023 - Present

Research Scientist

Roche

November 2020 - March 2023

Research Scientist

Spark Therapeutics Inc

November 2020 - March 2023

Graduate Student/Research Assistant

University of North Carolina at Chapel Hill

September 2016 - October 2020

Education

PhD (Molecular Pharmaceutics and Pharmacoengineering)

University of North Carolina at Chapel Hill

September 2016 - August 2020

PhD

University of North Carolina at Chapel Hill

August 2016 - August 2020

PharmD (Doctor of Pharmacy)

Shenyang Pharmaceutical University - China

August 2011 - July 2016

Certifications

• Principles of Clinical Pharmacology

  NIH

  September 2021 - Present

Publications

JOURNAL ARTICLE

Jianfeng Guo and Zhuo Yu and Dandan Sun and Yifang Zou and Yun Liu and Leaf Huang(2021). Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma . Molecular Cancer. 20. (1). Springer Science and Business Media {LLC}

Xuefei Zhou and Yun Liu and Mengying Hu and Menglin Wang and Xiangrui Liu and Leaf Huang(2021). Relaxin gene delivery modulates macrophages to resolve cancer fibrosis and synergizes with immune checkpoint blockade therapy . Science Advances. 7. (8). American Association for the Advancement of Science ({AAAS})

Nasha Qiu and Yun Liu and Qi Liu and Yanzuo Chen and Limei Shen and Mengying Hu and Xuefei Zhou and Youqing Shen and Jianqing Gao and Leaf Huang(2021). Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy . Biomaterials. 269. p. 120604. Elsevier {BV}

Yun Liu and Karthik Tiruthani and Menglin Wang and Xuefei Zhou and Nasha Qiu and Yang Xiong and Chad V. Pecot and Rihe Liu and Leaf Huang(2021). Tumor-targeted gene therapy with lipid nanoparticles inhibits tumor-associated adipocytes and remodels the immunosuppressive tumor microenvironment in triple-negative breast cancer . Nanoscale Horizons. 6. (4). p. 319--329. Royal Society of Chemistry ({RSC})

Manisit Das and Xuefei Zhou and Yun Liu and Anirban Das and Benjamin G. Vincent and Jingjing Li and Rihe Liu and Leaf Huang(2020). Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth . Translational Oncology. 13. (12). p. 100856. Elsevier {BV}

Yun Liu and Nasha Qiu and Limei Shen and Qi Liu and Jing Zhang and Yung-Yi Cheng and Kuo-Hsiung Lee and Leaf Huang(2020). Nanocarrier-mediated immunogenic chemotherapy for triple negative breast cancer . Journal of Controlled Release. 323. p. 431--441. Elsevier {BV}

Yun Liu and Jianfeng Guo and Leaf Huang(2020). Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies . Theranostics. 10. (7). p. 3099--3117. Ivyspring International Publisher

Jing Zhang and Limei Shen and Xiang Li and Wantong Song and Yun Liu and Leaf Huang(2019). Nanoformulated Codelivery of Quercetin and Alantolactone Promotes an Antitumor Response through Synergistic Immunogenic Cell Death for Microsatellite-Stable Colorectal Cancer . ACS Nano. 13. (11). p. 12511--12524. American Chemical Society ({ACS})

Yanzuo Chen and Wantong Song and Limei shen and Nasha Qiu and Mengying Hu and Yun Liu and Qi Liu and Leaf Huang(2019). Vasodilator Hydralazine Promotes Nanoparticle Penetration in Advanced Desmoplastic Tumors . ACS Nano. American Chemical Society ({ACS})

Qi Liu and Manisit Das and Yun Liu and Leaf Huang(2018). Targeted drug delivery to melanoma . Advanced Drug Delivery Reviews. 127. p. 208--221. Elsevier {BV}

Qi Liu and Hongda Zhu and Yun Liu and Sara Musetti and Leaf Huang(2018). BRAF peptide vaccine facilitates therapy of murine BRAF-mutant melanoma . Cancer Immunology, Immunotherapy. 67. (2). p. 299--310. Springer Science and Business Media {LLC}

Lin Hou and Qi Liu and Limei Shen and Yun Liu and Xueqiong Zhang and Fengqian Chen and Leaf Huang(2018). Nano-delivery of fraxinellone remodels tumor microenvironment and facilitates therapeutic vaccination in desmoplastic melanoma . Theranostics. 8. (14). p. 3781--3796. Ivyspring International Publisher