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Hire Dr. Yosif E.

Japan

USD 85 /hr

Medical doctor and strong research professional with a PhD focused on Tumor Immunology and Cell Therapy

Profile Summary

After completing medical university, I moved to Japan to further my education and pursue doctoral studies in Tumor Immunology and Cell therapy. I received PhD at Hyogo College of Medicine where I was awarded PhD student of the year in 2018. . In 2018 my paper IL‐18 Primes Murine NK cells for Poliferation by Promoting Protein Synthesis, Survival, and Autophagy (DOI:10.1002/JLB.1HI1017-396RR) was accepted in Journal of Leukocyte Biology and it was highlighted in the section Frontline Science of the journal. In this paper we clarified some of the mechanisms by which IL-18 transduces its signals and processes that occur in the NK cells after stimulation with IL-18 and IL-2. In order to deepen my knowledge in the field of immunology and my technical skills I got a position as Postdoctoral Research Fellow at the National Center of Neurology and Psychiatry, Department of Immunology. My work now is focused on neuroimmunology, specifically- multiple sclerosis (MS) and autoimmunity. Main purpose of my project is to phenotype and describe the regulation of self reactive T cells in MS, both in human and in mice MS model- experimental autoimmune encephalomyelitis (EAE). In this project I use different gene modified mice and apply various techniques for analysis including single-channel microarrays (whole genome analysis), FACS analysis and rtPCR. I am enthusiastic about furthering field knowledge, advancement of scientific discoveries, and publishing professional papers.

Subject Matter Expertise

• ★ Biology/Life Sciences
• ★ Cancer Research
• ☆ Neuroscience
• ☆ Cytometry
• ☆ Multiple Sclerosis
• ☆ Medical Sciences

Services

• Writing
• Research
• Product Development

Writing Technical Writing

Research Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Product Development Formulation

Work Experience

PostDoc

National Center of Neurology and Psychiatry

September 2018 - Present

PostDoc

Hyogo College of Medicine

April 2018 - Present

Education

PhD

Hyogo College of Medicine

April 2013 - August 2018

MD

Medical University of Sofia

September 2005 - December 2012

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2020). IL-12 regulates the expansion, phenotype, and function of murine NK cells activated by IL-15 and IL-18 . Cancer Immunology, Immunotherapy.

(2019). Interleukin-18-deficient mice develop hippocampal abnormalities related to possible depressive-like behaviors . Neuroscience.

(2019). Upregulation of Natural Killer Cells Proliferation by Cytokine Stimulation . Monoclonal antibodies in immunodiagnosis and immunotherapy.

(2018). Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia . Journal of translational medicine.

(2018). Frontline Science: IL-18 primes murine NK cells for proliferation by promoting protein synthesis, survival, and autophagy . Journal of Leukocyte Biology. 104. (2). p. 253--264. Wiley

(2018). Frontline Science: IL-18 primes murine NK cells for proliferation by promoting protein synthesis, survival, and autophagy . Journal of Leukocyte Biology. Wiley-Blackwell

(2018). Physiological and molecular effects of interleukin-18 administration on the mouse kidney . Journal of Translational Medicine. 16. (1). p. 51.

(2017). Interleukin-18 and testosterone levels in men with metabolic syndrome . The Aging Male. p. 1--8. Informa {UK} Limited

(2017). Molecular analysis of the mouse brain exposed to chronic mild stress: The influence of hepatocyte nuclear factor 4α on physiological homeostasis . Molecular Medicine Reports. 16. (1). p. 301--309. Spandidos Publications

(2017). Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes . Endocrine Connections. p. EC--17--0273. {BioScientifica}

(2016). Dysfunction of mitochondria and deformed gap junctions in the heart of IL-18-deficient mice . American Journal of Physiology-Heart and Circulatory Physiology. 311. (2). p. H313--H325. American Physiological Society

(2016). Interleukin-18–deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis . Translational Research. 173. p. 101--114.e7. Elsevier {BV}

(2016). Augmentation of immune checkpoint cancer immunotherapy with IL18 . Clinical Cancer Research. 22. (12). p. 2969-2980.