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Hire Yasmim G.

Brazil

USD 30 /hr

Chemist with 7+ years of experience in medical research

Profile Summary

I have dedicated my research endeavors to the comprehensive exploration of diverse scientific domains. Initially, my focus centered on the synthesis, characterization, and evaluation of ruthenium(II) complexes, specifically delving into their leishmanicidal and antitumoral properties. My foray extended into the intricate realm of nanosystems, where I briefly contributed to the development of cintillator-based formulations functionalized with ruthenium-nitrosyl complexes. This work aimed at enhancing conventional radiotherapy through the innovative application of X-ray-induced Photodynamic Therapy. As a Ph.D. student, my pursuits have evolved towards the cutting-edge field of nanomedicine. I have experience in the development of nanocarriers for gene and drug co-delivery, design of experiment (DoE), physicochemical characterization and in vitro biological evaluation.

Subject Matter Expertise

• ★ Nanotechnology
• ★ Multivariate Analysis
• ★ Cell Culture
• ☆ Dewatering & Drying Technology
• ☆ Materials Science & Engineering
• ☆ Nanotechnology & Nanomaterials
• ☆ Inorganic Chemistry
• ☆ Physical Chemistry
• ☆ Biopolymers
• ☆ Polymer Chemistry
• ☆ Analytical Chemistry
• ☆ Mass Spectrometry
• ☆ Liquid Chromatography/HPLC
• ☆ Thermal Analysis
• ☆ Particle Size Distribution
• ☆ Structural Chemistry
• ☆ Microencapsulation
• ☆ Supramolecular Chemistry
• ☆ Flow Chemistry
• ☆ Biochemistry
• ☆ Apoptosis
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Data Collection
• ☆ Statistics
• ☆ Applied Chemistry
• ☆ Cytometry
• ☆ Medical Sciences

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Copywriting, Creative Writing, General Proofreading & Editing

Research Gap Analysis, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Predictive Modeling

Product Development Formulation, Stability/Shelf Life Testing

Work Experience

PhD Student and Researcher, Department of Pharmaceutical Science

University of Sao Paulo

May 2021 - Present

MSc research student, Chemistry Institute

Federal University of Uberlandia (Brazil)

February 2018 - August 2020

Intern

Adfert Aditivos Indústria e Comércio LTDA

March 2017 - July 2017

Education

PhD student (School of Pharmaceutical Sciences in Ribeirão Preto)

University of São Paulo

April 2021 - March 2026

MSc in Chemistry (Instituto de Química)

Universidade Federal de Uberlândia

March 2018 - August 2020

BSc in Industrial Chemistry (Instituto de Química)

Universidade Federal de Uberlândia

May 2013 - August 2017

Certifications

• MSc in Chemistry

  Federal University of Uberlândia

  August 2020 - Present

• BSc in Industrial Chemistry

  Federal University of Uberlândia

  August 2017 - Present

Publications

JOURNAL ARTICLE

Yasmim G. Gonçalves, Marcelo Kravicz, Taís N.C. Massaro, Jennyfer A. Aldana-Mejía, Jairo K. Bastos, Maria Vitória B. L. Bentley, Priscyla D. Marcato (2024). Rational design of solid lipid-polymer hybrid nanoparticles: An innovative glycoalkaloids-carrier with potential for topical melanoma treatment . Colloids and Surfaces B: Biointerfaces.

Yasmim G. Gonçalves, Amanda B. Becceneri, Angelica E. Graminha, Victor M. Miranda, Rafaella R. Rios, Francisco Rinaldi-Neto, Mônica S. Costa, Ana C. R. Gonçalves, Victor M. Deflon, Kelly A. G. Yoneyama, et al. (2023). New ruthenium(ii) complexes with cyclic thio- and semicarbazone: evaluation of cytotoxicity and effects on cell migration and apoptosis of lung cancer cells . Dalton Transactions.

(2020). Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity . Scientific Reports.

Organometallic Complex Strongly Impairs Chikungunya Virus Entry to the Host Cells @ARTICLE{10.3389/fmicb.2020.608924, AUTHOR= {Oliveira, Débora Moraes de and Santos, Igor de Andrade and Martins, Daniel Oliveira Silva and Gonçalves, Yasmim Garcia and Cardoso-Sousa, Léia and Sabino-Silva, Robinson and Von Poelhsitz, Gustavo and Franca, Eduardo de Faria and Nicolau-Junior, Nilson and Pacca, Carolina Colombelli and Merits, Andres and Harris, Mark and Jardim, Ana Carolina Gomes}, TITLE= {Organometallic Complex Strongly Impairs Chikungunya Virus Entry to the Host Cells}, JOURNAL= {Frontiers in Microbiology}, VOLUME= {11}, PAGES= {3204}, YEAR= {2020}, URL= {https://www.frontiersin.org/article/10.3389/fmicb.2020.608924}, DOI= {10.3389/fmicb.2020.608924}, ISSN= {1664-302X}, ABSTRACT= {Chikungunya fever is a disease caused by the Chikungunya virus (CHIKV) that is transmitted by the bite of the female of Aedes sp. mosquito. The symptoms include fever, muscle aches, skin rash, and severe joint pains. The disease may develop into a chronic condition and joint pain for months or years. Currently, there is no effective antiviral treatment against CHIKV infection. Treatments based on natural compounds have been widely studied, as many drugs were produced by using natural molecules and their derivatives. Alpha-phellandrene (α-Phe) is a naturally occurring organic compound that is a ligand for ruthenium, forming the organometallic complex [Ru₂Cl₄(p-cymene)₂] (RcP). Organometallic complexes have shown promising as candidate molecules to a new generation of compounds that presented relevant biological properties, however, there is a lack of knowledge concerning the anti-CHIKV activity of these complexes. The present work evaluated the effects of the RcP and its precursors, the hydrate ruthenium(III) chloride salt (RuCl₃⋅xH₂O) (Ru) and α-Phe, on CHIKV infection in vitro. To this, BHK-21 cells were infected with CHIKV-nanoluciferase (CHIKV-nanoluc), a viral construct harboring the nanoluciferase reporter gene, at the presence or absence of the compounds for 16 h. Cytotoxicity and impact on infectivity were analyzed. The results demonstrated that RcP exhibited a strong therapeutic potential judged by the selective index > 40. Antiviral effects of RcP on different stages of the CHIKV replicative cycle were investigated; the results showed that it affected early stages of virus infection reducing virus replication by 77% at non-cytotoxic concentrations. Further assays demonstrated the virucidal activity of the compound that completely blocked virus infectivity. In silico molecular docking calculations suggested different binding interactions between aromatic rings of RcP and the loop of amino acids of the E2 envelope CHIKV glycoprotein mainly through hydrophobic interactions. Additionally, infrared spectroscopy spectral analysis indicated interactions of RcP with CHIKV glycoproteins. These data suggest that RcP may act on CHIKV particles, disrupting virus entry to the host cells. Therefore, RcP may represent a strong candidate for the development of anti-CHIKV drugs.}} . Frontiers in Microbiology.

Costa, M.S., Gonçalves, Y.G., Teixeira, S.C., Nunes, D.C.D.O., Lopes, D.S., da Silva, C.V., da Silva, M.S., Borges, B.C., Silva, M.J.B., Rodrigues, R.S., et al.(2019). Increased ROS generation causes apoptosis-like death: Mechanistic insights into the anti-Leishmania activity of a potent ruthenium(II) complex . Journal of Inorganic Biochemistry. 195. p. 1-12.

Costa, M.S., Gonçalves, Y.G., Nunes, D.C.O., Napolitano, D.R., Maia, P.I.S., Rodrigues, R.S., Rodrigues, V.M., Von Poelhsitz, G., Yoneyama, K.A.G.(2017). Anti-Leishmania activity of new ruthenium(II) complexes: Effect on parasite-host interaction . Journal of Inorganic Biochemistry. 175. p. 225-231.

DISSERTATION THESIS

GONÇALVES, Yasmim Garcia. Efeito citotóxico contra células de câncer de pulmão de novos complexos de rutênio(II) contendo ligantes bifosfínicos, tiossemicarbazonas e semicarbazonas. 2020. 114 f. Dissertação (Mestrado em Química) - Universidade Federal de Uberlândia, Uberlândia, 2020. Disponível em: http://doi.org/10.14393/ufu.di.2020.635 .