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Hire Xiang X.

United States

Toxicology, Gastroenterology, Cancer Biology and Biochemistry

Profile Summary

Subject Matter Expertise

Services

Writing

Writing Clinical Trial Documentation, Technical Writing

Work Experience

Assistant Professor

University of New Mexico

January 2018 - Present

Research Investigator

University of Michigan

July 2015 - January 2018

Education

Shanghai Institute of Materia Medica Chinese Academy of Sciences

September 2005 - June 2010

Certifications

Certification details not provided.

Publications

JOURNAL ARTICLE

Xiang Xue, Wenxiao Zheng, Zhenrong Ma, Xi Sun, Yehong Huang, Bin Lu, Xiaogang Chen, Xuexian Yang, Xiang Wu(2020). Exposure time determines the protective effect of Trichinella spiralis on experimental colitis . Microbial Pathogenesis. 147. p. 104263. Elsevier {BV}

(2020). Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19 . Aging.

(2020). Death from Covid-19 of 23 Health Care Workers in China . The New England journal of medicine.

Xiang Xue, Daniel M. Falcon(2019). The Role of Immune Cells and Cytokines in Intestinal Wound Healing . International Journal of Molecular Sciences. 20. (23). p. 6097. {MDPI} {AG}

Xiang Xue, Daniel Falcon (2019). The Role of Immune Cells and Cytokines in Intestinal Wound Healing . International Journal of Molecular Sciences.

Xiang Xue, Sadeesh K. Ramakrishnan, Huabing Zhang, Xiaoya Ma, Inkyung Jung, Andrew J. Schwartz, Daniel Triner, Samantha N. Devenport, Nupur K. Das, Melody Y. Zeng, et al.(2019). Intestinal non-canonical {NF}$\upkappa$B signaling shapes the local and systemic immune response . Nature Communications. 10. (1). Springer Science and Business Media {LLC}

Xiang Xue, Hyeoncheol Kim, Kunlun Yin, Daniel M. Falcon(2019). The interaction of Hemin and Sestrin2 modulates oxidative stress and colon tumor growth . Toxicology and Applied Pharmacology. 374. p. 77--85. Elsevier {BV}

Xiang Xue, Min-Jung Park, Sapna Iyer, Juliana Bragazzi Cunha, Shufang Gu, David Moons, Steven W. Pipe, John A. Williams, Diane M. Simeone, Yatrik M. Shah, et al.(2018). {HIF}1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas . Gastroenterology. 154. (6). p. 1630--1634.e3. Elsevier {BV}

Xiang Xue, Cen Xie, Tomoki Yagai, Yuhong Luo, Xianyi Liang, Tao Chen, Qiong Wang, Dongxue Sun, Jie Zhao, Sadeesh K Ramakrishnan, et al.(2017). Activation of intestinal hypoxia-inducible factor 2$\upalpha$ during obesity contributes to hepatic steatosis . Nature Medicine. Springer Nature

Xue, Xiang, Triner, Daniel, Schwartz, Andrew J., Jung, Inkyung, Colacino, Justin A., Shah, Yatrik M.(2017). Epithelial Hypoxia- Inducible Factor 2 alpha Facilitates the Progression of Colon Tumors through Recruiting Neutrophils . Molecular and Cellular Biology. 37. (5).

Xue, Xiang, Ma, Xiaoya, Zhang, Huabing, Shah, Yatrik M(2017). Hypoxia-inducible factor 2alpha (HIF-2alpha) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity . The Journal of biological chemistry.

Xue, Xiang, Ji, Tuo, Takabayashi, Hidehiko, Mao, Maria, Han, Xu, Brazil, Jennifer C., Eaton, Kathryn A., Shah, Yatrik M., Todisco, Andrea(2017). Regulation and function of bone morphogenetic protein signaling in colonic injury and inflammation . American Journal of Physiology-Gastrointestinal and Liver Physiology. 312. (1). p. G24-G33.

Xiang Xue, Kyriaki Bakirtzi, Ivy Ka Man Law, Dimitrios Iliopoulos, Yatrik M. Shah, Charalabos Pothoulakis(2016). Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1$\upalpha${\textendash}{miR}-210 Signaling . The Journal of Immunology. 196. (10). p. 4311--4321. The American Association of Immunologists

Ro SH, Xue X, Ramakrishnan SK, Cho CS, Namkoong S, Jang I, Semple IA, Ho A, Park HW, Shah YM, Lee JH, eLife, 2016, vol. 5 .

Xue, Xiang, Jungles, Kylie, Onder, Gunseli, Samhoun, Jalal, Gyorffy, Balazs, Hardiman, Karin M.(2016). HIF-3 alpha 1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling . Oncotarget. 7. (10). p. 11567-11579.

Xue, Xiang, Bakirtzi, Kyriaki, Law, Ivy Ka Man, Iliopoulos, Dimitrios, Shah, Yatrik M., Pothoulakis, Charalabos(2016). Neurotensin Promotes the Development of Colitis and Intestinal Angiogenesis via Hif-1 alpha-miR-210 Signaling . Journal of Immunology. 196. (10). p. 4311-4321.

Ro, Seung-Hyun, Xuel, Xiang, Ramakrishnan, Sadeesh K., Cho, Chun-Seok, Namkoong, Sim, Jang, Insook, Semple, Ian A., Ho, Allison, Park, Hwan-Woo, Shah, Yatrik M., et al.(2016). Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis . Elife. 5.

Mori H, Yao Y, Learman BS, Kurozumi K, Ishida J, Ramakrishnan SK, Overmyer KA, Xue X, Cawthorn WP, Reid MA, Taylor M, Ning X, Shah YM, MacDougald OA, Scientific reports, 2016, vol. 6, pp. 21520 .

Xue, Xiang, Ramakrishnan, Sadeesh K., Weisz, Kevin, Triner, Daniel, Xie, Liwei, Attili, Durga, Pant, Asha, Gyorffy, Balazs, Zhan, Mingkun, Carter-Su, Christin, et al.(2016). Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis . Cell Metabolism. 24. (3). p. 447-461.

Xue, Xiang, Sherman, Matthew A, Suresh, Madathilparambil V, Dolgachev, Vladislav A, McCandless, Lane K, Ziru, Li, Machado-Aranda, David, Shah, Yatrik M, Raghavendran, Krishnan(2016). Molecular Characterization of Hypoxic Alveolar Epithelial Cells After Lung Contusion Indicates an Important Role for HIF-1alpha . Annals of surgery.

Xue, Xiang, Mori, Hiroyuki, Yao, Yao, Learman, Brian S., Kurozumi, Kazuhiko, Ishida, Joji, Ramakrishnan, Sadeesh K., Overmyer, Katherine A., Cawthorn, William P., Reid, Michael A., et al.(2016). Induction of WNT11 by hypoxia and hypoxia-inducible factor-1 alpha regulates cell proliferation, migration and invasion . Scientific Reports. 6.

Fu Y, Zheng X, Bao L, Xu K, Cheng X, Sun M, Xue X, Chen H, Yang T, Zhang M, Scandinavian journal of clinical and laboratory investigation, 2015, vol. 75, no. 4, pp. 319-326 .

Fu Y, Zheng X, Bao L, Xu K, Cheng X, Sun M, Xue X, Chen H, Yang T, Zhang M(2015). Assessment of physiological factors for the establishment of serum insulin reference intervals in healthy Chinese Han adults: A community-based large cross-sectional study .

Manna, S.K., Tanaka, N., Krausz, K.W., Haznadar, M., Xue, X., Matsubara, T., Bowman, E.D., Fearon, E.R., Harris, C.C., Shah, Y.M., et al.(2014). Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans . Gastroenterology. 146. (5). p. 1313-1324.

Xue, X., Ramakrishnan, S.K., Shah, Y.M.(2014). Activation of HIF-1α does not increase intestinal tumorigenesis . American Journal of Physiology - Gastrointestinal and Liver Physiology. 307. (2).

Xie, L., Xue, X., Taylor, M., Ramakrishnan, S.K., Nagaoka, K., Hao, C., Gonzalez, F.J., Shah, Y.M.(2014). Hypoxia-inducible factor/MAZ-dependent induction of caveolin-1 regulates colon permeability through suppression of occludin, leading to hypoxia-induced inflammation . Molecular and Cellular Biology. 34. (16). p. 3013-3023.

Xue, X., Shah, Y.M.(2013). Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer . Carcinogenesis. 34. (1). p. 163-169.

Wu, X., Xue, X., Tang, J., Cheng, X., Tian, W., Jiang, R., Zang, R.(2013). Evaluation of risk factors for venous thromboembolism in Chinese women with epithelial ovarian cancer . International Journal of Gynecological Cancer. 23. (1). p. 65-72.

Xue, X., Shah, Y.M.(2013). In vitro organoid culture of primary mouse colon tumors . Journal of visualized experiments : JoVE. (75).

Xue, X., Shah, Y.M.(2013). Intestinal iron homeostasis and colon tumorigenesis . Nutrients. 5. (7). p. 2333-2351.

Xue, X., Ramakrishnan, S., Anderson, E., Taylor, M., Zimmermann, E.M., Spence, J.R., Huang, S., Greenson, J.K., Shah, Y.M.(2013). Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice . Gastroenterology. 145. (4). p. 831-841.

Xue, X., Shah, Y. M.(2013). Hypoxia-Inducible Factor-2 alpha Promotes Intestinal Inflammation Through Induction of Epithelial TNF-alpha . Faseb Journal. 27.

Xue, X., Shah, Y.M.(2013). Hypoxia-inducible factor-2α is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer . Carcinogenesis. 34. (1). p. 163-169.

Xue, X., Shah, Y.M.(2013). Intestinal iron homeostasis and colon tumorigenesis . Nutrients. 5. (7). p. 2333-2351.

Anderson, E.R., Taylor, M., Xue, X., Ramakrishnan, S.K., Martin, A., Xie, L., Bredell, B.X., Gardenghi, S., Rivella, S., Shah, Y.M.(2013). Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia . Proceedings of the National Academy of Sciences of the United States of America. 110. (50).

Shah, Y., Xue, X.(2012). Hypoxia-inducible factor-2 alpha regulates intestinal inflammation and colon cancer . Faseb Journal. 26. p. 1.

Anderson, E.R., Taylor, M., Xue, X., Martin, A., Moons, D.S., Bishr Omary, M., Shah, Y.M.(2012). The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression . Molecular and Cellular Biology. 32. (19). p. 4068-4077.

Xue, X., Taylor, M., Anderson, E., Hao, C., Qu, A., Greenson, J.K., Zimmermann, E.M., Gonzalez, F.J., Shah, Y.M.(2012). Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis . Cancer Research. 72. (9). p. 2285-2293.

Xue, Xiang, Liu, Xia, Gong, Likun, Qi, Xinming, Wu, Yuanfeng, Xing, Guozhen, Luan, Yang, Xiao, Ying, Wu, Xiongfei, Li, Yan, et al.(2012). 1 H NMR-based metabolomic analysis of triptolide-induced toxicity in liver-specific cytochrome P450 reductase knockout mice . Metabolomics. 8. (5). p. 907--918.

Xue X, Gong LK, Maeda K, Luan Y, Qi XM, Sugiyama Y, Ren J, Molecular pharmaceutics, 2011, vol. 8, no. 6, pp. 2183-2192 .

Chen M, Gong L, Qi X, Xing G, Luan Y, Wu Y, Xiao Y, Yao J, Li Y, Xue X, Pan G, Ren J, Toxicological sciences : an official journal of the Society of Toxicology, 2011, vol. 122, no. 2, pp. 288-296 .

Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, Chen M, Gu J, Ren J, Toxicology letters, 2011, vol. 205, no. 1, pp. 47-54 .

Qu, A., Taylor, M., Xue, X., Matsubara, T., Metzger, D., Chambon, P., Gonzalez, F.J., Shah, Y.M.(2011). Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis . Hepatology. 54. (2). p. 472-483.

Anderson, E.R., Xue, X., Shah, Y.M.(2011). Intestinal hypoxia-inducible factor-2α (HIF-2α) is critical for efficient erythropoiesis . Journal of Biological Chemistry. 286. (22). p. 19533-19540.

Qu, A., Taylor, M., Xue, X., Matsubara, T., Metzger, D., Qu, A., Taylor, M., Xue, X., Matsubara, T., Metzger, D., et al.(2011). Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis . Hepatology. 54. (2). p. 472-483.

Xue X, Gong LK, Maeda K, Luan Y, Qi XM, Sugiyama Y, Ren J(2011). Critical role of organic anion transporters 1 and 3 in kidney accumulation and toxicity of aristolochic acid I .

Chen M, Gong L, Qi X, Xing G, Luan Y, Wu Y, Xiao Y, Yao J, Li Y, Xue X, et al.(2011). Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity .

Xue X, Gong L, Qi X, Wu Y, Xing G, Yao J, Luan Y, Xiao Y, Li Y, Wu X, et al.(2011). Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity .

Li Y, Luan Y, Qi X, Li M, Gong L, Xue X, Wu X, Wu Y, Chen M, Xing G, Yao J, Ren J, Toxicological sciences : an official journal of the Society of Toxicology, 2010, vol. 118, no. 2, pp. 435-443 .

Xue, Xiang, Gong, Li-kun, Ren, Jin(2010). Progress of the study of mechanism on drug induced kidney injury . Yao xue xue bao = Acta pharmaceutica Sinica. 45. (10). p. 1199-204.

Li Y, Luan Y, Qi X, Li M, Gong L, Xue X, Wu X, Wu Y, Chen M, Xing G, et al.(2010). Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II .

Xiao Y, Xue X, Wu YF, Xin GZ, Qian Y, Xie TP, Gong LK, Ren J, Acta pharmacologica Sinica, 2009, vol. 30, no. 11, pp. 1559-1565 .

Li Y, Qi XM, Xue X, Wu XF, Wu YF, Chen M, Xing GZ, Luan Y, Ren J, Toxicology letters, 2009, vol. 186, no. 2, pp. 111-114 .

Xiao Y, Xue X, Wu YF, Xin GZ, Qian Y, Xie TP, Gong LK, Ren J(2009). beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism .

Li Y, Qi XM, Xue X, Wu XF, Wu YF, Chen M, Xing GZ, Luan Y, Ren J(2009). The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury .

Xue X, Xiao Y, Zhu H, Wang H, Liu Y, Xie T, Ren J, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, vol. 23, no. 10, pp. 3074-3081 .

Xue X, Xiao Y, Gong L, Guan S, Liu Y, Lu H, Qi X, Zhang Y, Li Y, Wu X, Ren J, Journal of ethnopharmacology, 2008, vol. 119, no. 1, pp. 87-93 .

Zhang Y, Qi X, Gong L, Li Y, Liu L, Xue X, Xiao Y, Wu X, Ren J, Toxicology, 2008, vol. 249, no. 1, pp. 62-68 .

Xiao Y, Ge M, Xue X, Wang C, Wang H, Wu X, Li L, Liu L, Qi X, Zhang Y, Li Y, Luo H, Xie T, Gu J, Ren J, Kidney international, 2008, vol. 73, no. 11, pp. 1231-1239 .

Liu LL, Gong LK, Wang H, Xiao Y, Wu XF, Zhang YH, Xue X, Qi XM, Ren J, Biochemical pharmacology, 2008, vol. 75, no. 4, pp. 914-922 .

Xue X, Xiao Y, Gong L, Guan S, Liu Y, Lu H, Qi X, Zhang Y, Li Y, Wu X, et al.(2008). Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice .

Xiao Y, Ge M, Xue X, Wang C, Wang H, Wu X, Li L, Liu L, Qi X, Zhang Y, et al.(2008). Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity .