Profile Details

Create Project

★★★★★

☆☆☆☆☆

USD 20 /hr

★★★★★

☆☆☆☆☆

Hire Dr. Umesh C.

India

USD 20 /hr

Researcher with 10+ years of experience in drug discovery, toxicology, iPSC, oncology, scientific writing etc.

Profile Summary

I am a researcher offering experience in drug discovery, toxicology, predictive toxicity biomarkers, human induced pluripotent stem cells (iPSC), oncology, scientific writing, etc. I am excited to assist you to complete your tasks on time. For the last 3 years, I am volunteering as a Manuscript Reviewer for Elsevier and Portland Press publishers. I recently finished my Postdoc research. I extensively worked on human iPSC and their directed differentiation towards various specific lineages. I was also involved in characterization, batch production, and cryopreservation of human iPSC-derived lineages, Moreover, I have actively involved in the optimization of transfection conditions for efficient CRISPR/Cas9 based gene editing in human iPSC. In addition, I was responsible for writing protocols, SOPs, project reports, etc. During Ph.D. studies, I extensively worked on human iPS and human iPSC-derived cardiomyocytes. We developed a functional assay for predictive toxicity screening and identified early toxicity biomarkers using transcriptomics, microRNA profiling, and metabolomic readouts. I have written and prepared multiple research manuscripts, posters, and project reports. I have 4 years of experience in drug discovery and development company. I have worked on multiple cancer drug discovery projects. I was actively involved in compound library screening, in vitro assay development, toxicity and efficacy studies of hit compounds. I was also involved in writing protocols and project reports. Moreover, I have experience in experimental design, data analysis, and data interpretation. In my research career, I worked on various types of assays, basic molecular biology techniques, instruments, and microscopes. Looking forward to hearing from you.

Subject Matter Expertise

• ★ Stem Cell Research
• ★ Cancer Research
• ★ Manuscript & Journal Article Writing
• ☆ Biology/Life Sciences
• ☆ Biochemical Assays
• ☆ Biomarkers
• ☆ Omics
• ☆ Cell Culture
• ☆ Gene Editing/CRISPR
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Target Identification
• ☆ Hit-to-Lead & Lead Optimization
• ☆ High Content Screening/Imaging
• ☆ Drug Development
• ☆ Preclinical Research
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Oncology
• ☆ Peer Review
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Grant Writing

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Copywriting, Creative Writing, Newswriting, Audio Transcription, General Proofreading & Editing, Translation

Research Meta-Research, Fact Checking, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Image Processing

Work Experience

Reviewer

Elsevier Publishing and Portland Press

July 2017 - Present

Postdoctoral Researcher

University of Helsinki

February 2021 - December 2022

Postdoctoral Researcher

Leiden University Medical Center

April 2018 - March 2020

PhD Research Scholar

University of Cologne

April 2011 - October 2016

Junior Research Scientist

Piramal Life Sciences Ltd

April 2009 - March 2011

Research Associate

Piramal Life Sciences Ltd

March 2007 - March 2009

Project Assistant

National Centre For Cell Science

December 2005 - February 2007

Education

PhD in Cell Biology

University of Cologne

April 2011 - October 2016

MS in Biotechnology

North Maharashtra University

July 2003 - June 2005

BS in Zoology

North Maharashtra University

July 2000 - June 2003

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Umesh Chaudhari, Lotta Pohjolainen, Heikki Ruskoaho, Virpi Talman(2023). Genome-wide profiling of miRNA-gene regulatory networks in mouse postnatal heart development—implications for cardiac regeneration . Frontiers in Cardiovascular Medicine. 10. Frontiers Media {SA}

Rosa A. van Amerongen, Laura T. Morton, Umesh G. Chaudhari, Dennis F.G. Remst, Renate S. Hagedoorn, Cathelijne W. van den Berg, Christian Freund, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk(2023). Human iPSC-derived preclinical models to identify toxicity of tumor-specific T cells with clinical potential . Molecular Therapy - Methods & Clinical Development. 28. p. 249--261. Elsevier {BV}

C.H. Arendzen, U. Chaudhari, S.J. Cramer, C.M.A.H. Freund, C.L. Mummery, A. Ranga, O. Pourquie, H.M.M. Mikkers (2021). Generation of LUMCi041-A-2: Equipping a PAX3 reporter iPSC line with doxycycline inducible H2B-mTurquoise2 for live cell imaging . Stem Cell Research.

(2020). Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells . Cells.

(2018). Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures . Archives of toxicology.

(2018). Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells . Archives of toxicology.

(2017). Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes . Archives of toxicology.

(2017). Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes . Amino acids.

(2016). Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue . Archives of toxicology.

(2016). "Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015 . Archives of toxicology.

(2016). MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes . Archives of toxicology.

(2015). Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment . Archives of toxicology.

(2015). Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems . Toxicology letters.

(2015). Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells . Journal of hepatology.

(2015). Ascorbic Acid-Induced Cardiac Differentiation of Murine Pluripotent Stem Cells: Transcriptional Profiling and Effect of a Small Molecule Synergist of Wnt/β-Catenin Signaling Pathway . Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

(2013). Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals . Stem cells and development.

(2013). Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines . Lung cancer (Amsterdam, Netherlands).

BOOK CHAPTER

Umesh Chaudhari, Vaibhav Shinde, Isaia Sotiriadou, Jürgen Hescheler, Agapios Sachinidis(2014). In Vitro Methods for Cardiotoxicity Testing . Methods in Pharmacology and Toxicology. p. 45--77. Springer New York