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USD 125 /hr
Hire Dr. Tyler G.
United States
USD 125 /hr
Delivering the Impossible, Chemist, Formulations, Non-Viral Vectors, Gene Therapy Scientist and Engineer
Profile Summary
Subject Matter Expertise
Services
Research
Fact Checking,
Gray Literature Search,
Systematic Literature Review,
Secondary Data Collection
Product Development
Formulation
Work Experience
Scientist
Precision Biosciences
May 2017 - Present
Education
University of North Carolina at Chapel Hill
- Present 
PhD, Molecular Pharmaceutics and Engineering
University of North Carolina Chapel Hill
August 2013 - May 2017
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Das, M., Shen, L., Liu, Q., Goodwin, T.J., Huang, L.(2019). Nanoparticle Delivery of RIG-I Agonist Enables Effective and Safe Adjuvant Therapy in Pancreatic Cancer . Molecular Therapy. 27. (3). p. 507-517.
Shen, L., Li, J., Liu, Q., Song, W., Zhang, X., Tiruthani, K., Hu, H., Das, M., Goodwin, T.J., Liu, R., et al.(2018). Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers . ACS Nano.
Zhou, J., Liu, M., Sun, H., Feng, Y., Xu, L., Chan, A.W.H., Tong, J.H., Wong, J., Chong, C.C.N., Lai, P.B.S., et al.(2018). Hepatoma-intrinsic CCRK inhibition diminishes myeloid-derived suppressor cell immunosuppression and enhances immune-checkpoint blockade efficacy . Gut. 67. (5). p. 931-944.
Song, W., Shen, L., Wang, Y., Liu, Q., Goodwin, T.J., Li, J., Dorosheva, O., Liu, T., Liu, R., Huang, L.(2018). Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap . Nature Communications. 9. (1).
Buchanan, M.K., Needham, C.N., Neill, N.E., White, M.C., Kelly, C.B., Mastro-Kishton, K., Chauvigne-Hines, L.M., Goodwin, T.J., McIver, A.L., Bartolotti, L.J., et al.(2017). Glycoconjugated site-selective DNA-methylating agent targeting glucose transporters on glioma cells . Biochemistry. 56. (2). p. 421-440.
Goodwin, T.J., Huang, L.(2017). Investigation of phosphorylated adjuvants co-encapsulated with a model cancer peptide antigen for the treatment of colorectal cancer and liver metastasis . Vaccine. 35. (19). p. 2550-2557.
Goodwin, T.J., Shen, L., Hu, M., Li, J., Feng, R., Dorosheva, O., Liu, R., Huang, L.(2017). Liver specific gene immunotherapies resolve immune suppressive ectopic lymphoid structures of liver metastases and prolong survival . Biomaterials. 141. p. 260-271.
Hu, K., Miao, L., Goodwin, T.J., Li, J., Liu, Q., Huang, L.(2017). Quercetin Remodels the Tumor Microenvironment to Improve the Permeation, Retention, and Antitumor Effects of Nanoparticles . ACS Nano. 11. (5). p. 4916-4925.
Miao, L., Li, J., Liu, Q., Feng, R., Das, M., Lin, C.M., Goodwin, T.J., Dorosheva, O., Liu, R., Huang, L.(2017). Transient and Local Expression of Chemokine and Immune Checkpoint Traps to Treat Pancreatic Cancer . ACS Nano. 11. (9). p. 8690-8706.
Luo, C., Sun, J., Sun, B., Liu, D., Miao, L., Goodwin, T.J., Huang, L., He, Z.(2016). Facile Fabrication of Tumor Redox-Sensitive Nanoassemblies of Small-Molecule Oleate Prodrug as Potent Chemotherapeutic Nanomedicine . Small. 12. (46). p. 6353-6362.
Goodwin, T.J., Zhou, Y., Musetti, S.N., Liu, R., Huang, L.(2016). Local and transient gene expression primes the liver to resist cancer metastasis . Science Translational Medicine. 8. (364).
Goodwin, T.J., Huang, L.(2016). On the article “Findings questioning the involvement of Sigma-1 receptor in the uptake of anisamide-decorated particles” [J. Control. Release 224 (2016) 229–238]: Letter to the Editor 1 (September 14, 2016) . Journal of Controlled Release. 243. p. 382-385.
BOOK CHAPTER
Goodwin, T., Huang, L.(2014). Nonviral vectors. we have come a long way . Advances in Genetics. 88. p. 1-12.
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