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USD 25 /hr
Hire Dr. Toufic A.
Ireland
USD 25 /hr
Pharmacovigilance. Medical devices (ISO 13485, design control 820.30). Process analytical technology. Sensors. Proteins. Antibiotics. Reviews. Proposals. SOPs. R&D.
Profile Summary
Subject Matter Expertise
Services
Writing
Clinical Trial Documentation,
Technical Writing,
Copywriting,
Newswriting
Research
Market Research,
User Research,
Meta-Research,
Feasibility Study,
Fact Checking,
Gap Analysis,
Gray Literature Search,
Systematic Literature Review,
Secondary Data Collection
Consulting
Digital Strategy Consulting,
Scientific and Technical Consulting,
Regulatory Consulting
Data & AI
Predictive Modeling,
Statistical Analysis,
Algorithm Design-Non ML,
Data Visualization,
Big Data Analytics,
Data Processing,
Data Insights
Product Development
Formulation,
Stability/Shelf Life Testing,
Product Evaluation,
Material Sourcing,
Product Validation,
Manufacturing,
Concept Development,
Prototyping
Work Experience
Researcher/ Pharmacovigilance
IQVIA
March 2021 - Present
R&D - consulting, contracting, freelance
Kappa Crystals Ltd - Ireland
January 2019 - Present
Medical device coordinator R&D
Mylan/Viatris
March 2020 - January 2021
Technology Innovation - Chemical engineering, drug discovery and drug manufacturing
Science Foundation Ireland
January 2017 - February 2019
R&D engineer
Dairy Processing Technology Centre - Ireland
January 2016 - December 2016
R&D scientist/engineer
Innopharma Technology - EU FP7 projects - Ireland/EU
January 2014 - December 2015
Postdoc - scientist
Washington University School of Medicine - NIH USA
May 2013 - December 2013
PhD fellow - Biochemistry, crystallography, proteins
Trinity College Dublin - Ireland
December 2008 - May 2013
Intern - Research and development - Genomics, Radioactive assays, Proteins and DNA
CNRS and Paris-Orsay (IBBMC labs) - France
February 2008 - July 2008
Intern - Bioinformatics, nuclear receptors, cloning strategies
CNRS and Strasbourg Univ. (IGBMC labs)
April 2007 - June 2007
Education
Ph.D. (School of Medicine and School of Biochemistry and Immunology)
Trinity College Dublin
December 2008 - May 2013 
MSc/Eng Structure-function of Biomolecules (Pharmacy)
Ecole Polytechnique
2007 - 2008
BSc/Maitrise in Molecular biology and Genetics
University of Poitiers
2007 - 2007
Certifications
- Certification details not provided.
Publications
JOURNAL ARTICLE
Luke Kiernan, Ian Jones, Lauri Kurki, Patrick J. Cullen, Toufic El Arnaout(2020). Adaptive Background Correction of Crystal Image Datasets: Towards Automated Process Control . Sensing and Imaging. 21. (1). Springer Science and Business Media {LLC}
Chen B, Tian EK, He B, Tian L, Han R, Wang S, Xiang Q, Zhang S, El Arnaout T, Cheng W(2020). Overview of lethal human coronaviruses . Signal transduction and targeted therapy.
Markiewicz-Keszycka M, Becker D, Cama-Moncunill X, Casado-Gavalda MP, Cullen PJ, El Arnaout T, O'Donnell C, Sullivan C, Zhao M(2019). Rapid analysis of magnesium in infant formula powder using laser-induced breakdown spectroscopy . International dairy journal.
(2019). Targeting Lipoprotein Biogenesis: Considerations towards Antimicrobials . Trends in Biochemical Sciences (CELL).
Wei Cheng, Declan A. Doyle, Toufic El Arnaout(2018). The N-acyltransferase Lnt: Structure-function insights from recent simultaneous studies . International Journal of Biological Macromolecules. 117. p. 870--877. Elsevier {BV}
Cheng W, Doyle DA, El Arnaout T(2018). The N-acyltransferase Lnt: Structure-function insights from recent simultaneous studies . International journal of biological macromolecules.
Toufic El Arnaout, P. J. Cullen(2017). Non-invasive 3D and 360° optical imaging of micro-particles . Scientific Reports. 7. (1). Springer Nature
Toufic El Arnaout, Lauri Kurki, Tapio Vaarala, Kai Ojala, P.J. Cullen, Carl Sullivan(2016). Crystallization monitoring using simultaneous bright field and PlasDIC imaging . Chemical Engineering Journal. 300. p. 64--74. Elsevier {BV}
(2016). Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin. Science.
Vogeley L, El Arnaout T, Bailey J, Stansfeld PJ, Boland C, Caffrey M(2016). Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin . Science (New York, N.Y.).
(2016). A novel backlight fiber optical probe and image algorithms for real time size-shape analysis during crystallization. Chemical Engineering Science.
(2016). Crystallization monitoring using simultaneous Bright Field and PlasDIC imaging. Chemical Engineering Journal.
Pabari RM, Togashi D, Cama-Moncunill R, El Arnaout T, Rifai H, Cruise P, Cullen PJ, Sullivan C(2015). Multipoint near-infrared spectrometry for real-time monitoring of protein conformational stability in powdered infant formula . International journal of food sciences and nutrition.
(2015). Multipoint NIR spectrometry for real-time monitoring of protein conformational stability in powdered infant formula . Int. Jr. of Food Sci. and Nut.
Tan J, Rouse SL, Li D, Pye VE, Vogeley L, Brinth AR, El Arnaout T, Whitney JC, Howell PL, Sansom MS, et al.(2014). A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa . Acta crystallographica. Section D, Biological crystallography.
Serre M, El Arnaout T, Brooks M, Durand D, Lisboa J, Lazar N, Raynal B, van Tilbeurgh H, Quevillon-Cheruel S(2014). Correction: The Carboxy-Terminal αN Helix of the Archaeal XerA Tyrosine Recombinase Is a Molecular Switch to Control Site-Specific Recombination . PloS one.
(2014). A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa. Acta. D.
Serre MC, El Arnaout T, Brooks MA, Durand D, Lisboa J, Lazar N, Raynal B, van Tilbeurgh H, Quevillon-Cheruel S(2013). The carboxy-terminal αN helix of the archaeal XerA tyrosine recombinase is a molecular switch to control site-specific recombination . PloS one.
(2013). The carboxy-terminal αN helix of the archaeal XerA Tyrosine recombinase is a molecular switch of recombination. Plos One.
PATENT
ONLINE RESOURCE
(2016). The crystal structure of a membrane peptidase bound to antibiotic (PDB: 5DIR). Protein Data Bank.
(2014). In meso structure of alginate transporter, AlgE, from Pseudomoas aeruginosa, PAO1. Crystal form 3 . RCSB Protein Data Bank.
(2014). In meso structure of alginate transporter, AlgE, from Pseudomonas aeruginosa, PAO1 . RCSB Protein Data Bank.
(2014). In meso structure of alginate transporter, AlgE, from Pseudomoas aeruginosa, PAO1, crystal form 2 . RCSB Protein Data Bank.
(2012). The structure of a dimeric recombinase (PDB 4A8E). Protein Data Bank.
CONFERENCE PAPER
(2015). Novel Multipoint NIRS: Overcoming the limitation of sample heterogeneity in static and motion conditions. ICEF12.
(2015). Moisture content determination of powdered infant formula utilising a novel Multiprobe Spectroscopy system. ICEF12.
(2015). Developing a new PAT Device and Algorithms for the In situ Imaging of Crystallization. IFPAC (pharmacy).
(2015). Multipoint NIR Spectroscopy for Moisture Content Determination of Powered Formula in Static and Dynamic Conditions. IFPAC (pharmacy).
(2015). Towards greater crystallization process control using novel optical engineering techniques and algorithms. EuPAT (pharmacy).
DISSERTATION THESIS
(2013). Structure-function studies of the prolipoprotein signal peptidase, LspA. Trinity College Dublin.
(2008). Structural & Biochemical approaches on DNA binding proteins. University Paris XI.
(2007). Cloning strategies and nuclear receptor studies. University of Strasbourg.
CONFERENCE POSTER
(2011). Cloning, expression and purification of a prolipoprotein signal peptidase. TCD SFI visitors’ day.
(2010). Applying a GFP fusion-based expression system for crystallization and structural studies. ICCBM13.
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