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Hire Taufeeque A.

United States

USD 75 /hr

Expert Cancer Research Scientist | Drug Development & ROS-Activated Prodrug Specialist

Profile Summary

Ph.D. biochemist and Principal Investigator with 5+ years of hands-on research experience in cancer therapeutics and translational medicine. Expertise centers on developing novel, tumor-selective therapies, particularly ROS-activated prodrugs (e.g., phenylboronic acid nitrogen mustards) for cancers like triple-negative breast cancer (TNBC). Proven track record in designing and executing in vitro and in vivo studies (cell culture, xenograft models, flow cytometry, Western blot, PCR, ELISA) to evaluate drug safety, efficacy, and mechanism of action. Successfully filed patents, secured NIH/commercialization grants, and published in peer-reviewed journals (e.g., ACS Pharmacology & Translational Science, Cancers). As founder/CEO of SynXT Therapeutics, I bring experience in project leadership, commercialization strategy, and interdisciplinary collaboration. Available for freelance projects in medical/scientific writing, data analysis, experimental design, grant writing, and consulting on cancer research, drug development, and molecular biology.

Subject Matter Expertise

• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Apoptosis
• ☆ Oxidative Stress & Mitochondrial Function
• ☆ Antioxidants
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ Microarrays
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Gene Expression Analysis
• ☆ Recombinant DNA
• ☆ DNA Damage & Repair
• ☆ Biomarker Discovery
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Pharmacology
• ☆ In vivo Preclinical Toxicology
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Carcinogenesis

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Medical Writing

Research User Research, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Data Visualization, Data Cleaning, Data Processing, Data Insights

Work Experience

CEO

SynXT Therapeutics Inc.,

January 2024 - Present

Graduate Research & Teaching Assistant

University of Wisconsin-Milwaukee

January 2019 - August 2024

Manufacturing Engineer

GE Healthcare

November 2016 - December 2018

Education

PhD. Chemistry (Chemistry and Biochemistry)

University of Wisconsin–Milwaukee

January 2019 - August 2024

B. Sc. Biomolecular Engineering (Biomolecular Engineering)

Milwaukee School of Engineering

November 2011 - May 2015

Certifications

• Six Sigma Green Belt Certification

  Milwaukee School of Engineering

  May 2015 - Present

Publications

JOURNAL ARTICLE

Taufeeque Ali, Eron Saxon, Xiaohua Peng (2024). Hydrogen peroxide responsive theranostics for cancer-selective activation of DNA alkylators and real-time fluorescence monitoring in living cells . European Journal of Medicinal Chemistry.

Taufeeque Ali, Daniel Li, Thilini Nimasha Fernando Ponnamperumage, Alexis Kimberly Peterson, Jatin Pandey, Kulsum Fatima, John Brzezinski, Julia Anna Rose Jakusz, Hanlun Gao, Gilbert Edward Koelsch, et al. (2024). Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment . Cancers.

Ali, T., Li, D., Ponnamperumage, T.N.F., Peterson, A.K., Pandey, J., Fatima, K., Brzezinski, J., Jakusz, J.A.R., Gao, H., Koelsch, G.E., et al.(2024). Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment . Cancers. 16. (12).

Saxon, E., Ali, T., Peng, X.(2024). Hydrogen peroxide responsive theranostics for cancer-selective activation of DNA alkylators and real-time fluorescence monitoring in living cells . European Journal of Medicinal Chemistry. 276.

Taufeeque Ali, Qi Zhang, Zechao Lin, Xiaohua Peng (2023). Development of 4,4′-dibromobinaphthalene analogues with potent photo-inducible DNA cross-linking capability and cytotoxicity towards breast MDA-MB 468 cancer cells . Bioorganic Chemistry.

Zhang, Q., Ali, T., Lin, Z., Peng, X.(2023). Development of 4,4′-dibromobinaphthalene analogues with potent photo-inducible DNA cross-linking capability and cytotoxicity towards breast MDA-MB 468 cancer cells . Bioorganic Chemistry. 140.

Taufeeque Ali, Heli Fan, Muhammad Asad Uz Zaman, Wenbing Chen, Anahit Campbell, Qi Zhang, Nurul Islam Setu, Eron Saxon, Nicolas M. Zahn, Anna M. Benko, et al. (2021). Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer . ACS Pharmacology & Translational Science.

Fan, H., Zaman, M.A.U., Chen, W., Ali, T., Campbell, A., Zhang, Q., Setu, N.I., Saxon, E., Zahn, N.M., Benko, A.M., et al.(2021). Assessment of Phenylboronic Acid Nitrogen Mustards as Potent and Selective Drug Candidates for Triple-Negative Breast Cancer . ACS Pharmacology and Translational Science. 4. (2). p. 687-702.

PREPRINT

Taufeeque Ali, Daniel Li, Thilini Nimasha Fernando Ponnamperumage, Alexis Kimberly Peterson, Jatin Pandey, Kulsum Fatima, John Brzezinski, Julia Anna Rose Jakusz, Hanlun Gao, Gilbert Edward Koelsch, et al. (2024). Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment .

Taufeeque Ali, Qi Zhang, Zechao Lin, Xiaohua Peng (2023). Development of 4,4’-Dibromobinaphthalene Analogues with Potent Photo-Inducible DNA Cross-Linking Capability and Cytotoxicity Towards Cancer Cells .

OTHER

Zhang, Q., Ali, T., Lin, Z., Peng, X.(2023). Development of 4,4’-Dibromobinaphthalene Analogues with Potent Photo-Inducible DNA Cross-Linking Capability and Cytotoxicity Towards Cancer Cells . SSRN.