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Hire Tahir B.

United Arab Emirates

USD 60 /hr

Computational Virologist | AI-Augmented Genomic Surveillance of RNA Viruses

Profile Summary

I am a computational virologist with a decade of specialized experience in large-scale genomic surveillance, evolutionary dynamics, and immune escape modeling of RNA viruses, particularly SARS-CoV-2, H5N1, and MERS-CoV. My work bridges molecular virology, population genomics, and anticipatory therapeutic design. I have analyzed over 9 million global viral genomes to decode mutation co-occurrence networks, CpG/UpA genomic signatures, codon usage bias, and early-warning signals of monoclonal antibody resistance.

I developed the VIS System—an AI-assisted framework for quantifying immune escape potential in +ssRNA viruses—and recently published a preprint revealing pre-EUA fixation of Pemivibart (VYD2311) escape constellations in SARS-CoV-2 (DOI: 10.20944/preprints202512.2013.v1). I also maintain the Pemivibart Resistance Profiler, a command-line pipeline for real-time detection of resistance signatures in sequencing data.

My research integrates structural protein modeling, evolutionary plausibility scoring, and zoonotic risk assessment to support pandemic preparedness and next-generation mAb design. I hold an M.Sc. in Molecular Biology and contribute data to public repositories under open licenses (CC-BY-4.0). I seek to collaborate with organizations advancing genomic intelligence for global health security.

Subject Matter Expertise

Services

Writing
Research
Consulting
Data & AI
Product Development

Writing Medical Writing

Research Scientific and Technical Research

Consulting Healthcare Consulting, Scientific and Technical Consulting

Data & AI Predictive Modeling, Data Visualization, Big Data Analytics, Data Processing

Product Development Stability/Shelf Life Testing

Work Experience

Consultant Molecular Epidemiology & Genomic Surveillance

GVAtlas Research and Precision Diagnostics Limited United Kingdom

July 2025 - Present

Education

M.Sc. Molecular Biology & Biotechnology

The University of Lahore

July 2008 - August 2010

M.Sc. Molecular Biology (IMBB)

University of Lahore

June 2008 - July 2010

Certifications

DHMS

NCH
https://nchpakistan.gov.pk/doctordetail
January 2025 - Present

Publications

DATA SET

Tahir Bhatti (2025). Temporal Entanglement Points (TEPs) Reveal Population Vulnerability Points in SARS-CoV-2 Lineage Evolution Across the Pandemic Span 2020 - 2025 .

Tahir Bhatti (2025). LP.8.1.1 Emergence in 2025 and Implications for Pemivibart (VYD2311) Therapeutic Efficacy: A Multi-Country Genomic Surveillance Analysis . Zenodo.

Tahir Bhatti (2025). High-Confidence Pemivibart (VYD2311) Escape Haplotypes in U.S. SARS-CoV-2 Sequences, Span 2023 - 2024 .

Tahir Bhatti (2025). Pemivibart Structural Vulnerability Index (PSVI) - Global Spike Escape Haplotype Dataset (n=65,463)Computational surveillance of SARS-CoV-2 escape potential against VYD2311, derived from 65,463 global sequences. Includes residue-level escape flags, PSVI score, and haplotype class. .

Tahir Bhatti (2025). Paxlovid Remains Effective Against Contemporary SARS-CoV-2 Despite Universal Monoclonal Antibody Resistance in a December 2025 Clinical Trial Isolate (SRR29875709) .

Tahir Bhatti (2025). H5N1 Hemagglutinin CpG Depletion in Mammalian Hosts: Evidence of Active Selection for Human-Adaptive Evolution .

Tahir Bhatti (2025). True Signal of Nipah Virus Genomic Diversification: Sampling-Bias-Corrected Mutation Burden Across Endemic Regions (2000 - 2025) . Zenodo.

Tahir Bhatti (2025). Pemivibart Resistance in SARS-CoV-2 is Statistically Unrelated to Ambient Temperature or Air Quality in England (2025) . Zenodo.

Tahir Bhatti (2025). H5N1 with Mammalian-Adaptive Mutations (HA-Q226L, PB2-T271A) in Germany, 2024 - 2025 .

Tahir Bhatti (2025). MERS-CoV Population Vulnerability Meta-Analysis: Host, Geographic, and Temporal Patterns from 1,807 Global Sequences .

Tahir Bhatti (2025). Comparative mosaic trend analysis of coronavirus structural proteins (S, E, M, N) using domain-resolved alignments .

Tahir Bhatti (2025). Emergence of a Predominant S371F-Driven Escape Architecture in SARS-CoV-2 Circulating in December 2025: Genomic Surveillance of Pemivibart (VYD2311) Vulnerability Across 8 Global BioSamples . Zenodo.

Tahir Bhatti (2025). Experimental Validation of Pemivibart (VYD2311) Escape in Four Clinically Flagged SARS-CoV-2 Genomes: Evidence of Functional Resistance Despite Pipeline Classification Artifacts . Zenodo.

Tahir Bhatti (2025). Genomic Surveillance of Pemivibart (VYD2311) Escape-Associated Mutations in SARS-CoV-2: December 2025 BioSamples (n=2) .

Tahir Bhatti (2025). Evidence of a Geographic Epicenter in Pemivibart (VYD2311) Escape: Validation of 817 Natural Isolates Harboring the Complete XFG-Loss Motif (K444T + N460K + F486P) .

Tahir Bhatti (2025). VYD2311+SARS-CoV-2 Co-occurrence Mutation Atlas (2019 - 2025): 3M+ Genomes, 158M Mutations - Full Pandemic Surveillance Dataset . Zenodo.

Tahir Bhatti (2025). Global Trajectories of Therapeutic Monoclonal Antibody Escape in SARS-CoV-2 (2020 - 2026(Projected)): Empirical Evidence of Pemivibart (VYD2311) Obsolescence . Zenodo.

Tahir Bhatti (2025). VP24, VP35, and Glycoprotein Mutation Burden Across 28 Public Zaire ebolavirus Genomes Span=2014 - 2023 .

Tahir Bhatti (2025). Global Time-Resolved Haplotype Dynamics of Pemivibart Escape Mutations: Frequency, Diversity, and Mutational Complexity .

Tahir Bhatti (2025). Prevalent pemivibart escape constellations in global SARS-CoV-2 genomes (R346T, K444T, F456L, F486P) . Zenodo.

Tahir Bhatti (2025). Comprehensive Surveillance of Pemivibart (VYD2311) Escape Mutations in 9,398,268 SARS-CoV-2 Spike Protein Sequences 2020 up to 2025 Q3 .

Tahir Bhatti (2025). Global SARS-CoV-2 Proteome Mutation Burden Atlas Derived From 103 Million Amino Acid Sequences Covering S, N, M, E, ORF1a, ORF1b, ORF3a, ORF6, ORF7a, ORF7b, and ORF8 Proteins Spanning 2020 to Q3-2025 .

Tahir Bhatti (2025). Environmental Gradients and SARS-CoV-2 Mutation Burden: A Genomic Analysis of Air Quality and Temperature Effects . Zenodo.

Tahir Bhatti (2025). VYD2311 (Pemivibart) Escape Co-occurrence Mutations in 42,835 SARS-CoV-2 Genomes from 2025 .

Tahir Bhatti (2025). 2024 SARS-CoV-2 Sequences with Diagnostic Primer/Probe Mismatch Profiles . Zenodo.

Tahir Bhatti (2025). 2025 SARS-CoV-2 Sequences with Diagnostic Primer/Probe Mismatch Profiles (Q1 - Q3) . Zenodo.

Tahir Bhatti (2025). SARS-CoV-2 ORF3a Apoptotic Signal Analysis: n= 9,346,920 genomic sequences span = 2020-2024 . Zenodo.

Tahir Bhatti (2025). VYD2311 Escape Constellation Surveillance in 42,598 SARS-CoV-2 Spike Sequences from 2025 . Zenodo.

Tahir Bhatti (2025). Middle East respiratory syndrome-related coronavirus (MERS-CoV) Amino Acid Sequence Dataset (n = 983,238 Sequences): Raw, Merged, and Compressed FASTA Files with Metadata and QC Summaries . Zenodo.

Tahir Bhatti (2025). A Global Overview of H5N1 Influenza A Virus Protein Distribution and Temporal Trends Using Genomic Metadata and Visualization .

Tahir Bhatti (2025). Curated Protein Metadata and Unique Accessions of MERS-CoV Across Diverse Hosts . Zenodo.

Tahir Bhatti (2025). 34,875 Full-Length MERS-CoV Protein Sequences from Global Isolates (S, M, N, ORF1ab) . Zenodo.

Tahir Bhatti (2025). Conservation of Structural Scaffold Residues in the MERS-CoV Spike Receptor-Binding Domain from Human Lung Isolates . Zenodo.

Tahir Bhatti (2025). MERS-CoV Spike Receptor-Binding Domain Sequences from 182 Human Clinical Isolates with Antibody Escape Hotspot Annotation .

Tahir Bhatti (2025). In vivo evolution of human MERS-CoV reveals dynamic remodeling of the DPP4-binding interface originally defined by Lu et al. (Nature, 2013) . Zenodo.

Tahir Bhatti (2025). Genomic validation of IRF3 antagonism by ORF4a, ORF4b, ORF5, and M in 272 human MERS-CoV isolates . Zenodo.

Tahir Bhatti (2025). Probable Human MHC-I Downregulation Candidate Signals (n=1,237,095) from SARS-CoV-2 ORF8 Variants Observed Across a Subset 1 of 5,000,000 Global Genomes .

Tahir Bhatti (2025). Host-Specific Nucleotide Divergence in MERS-CoV Spike RBD: Primary Hydrogen-Bond and Salt-Bridge Residues in Human vs. Camel Isolates .

Tahir Bhatti (2025). High-Quality SARS-CoV-2 Historical Genomes from China (2020 - 2022): A Curated QC-Passed Dataset (n=157) .

Tahir Bhatti (2025). Analysis of VYD2311-Resistant Residues in SARS-CoV-2 Genome Submissions (Non-INSDC, n = 19,792, 2024 Samples) . Zenodo.

Tahir Bhatti (2025). China SARS-CoV-2 Surveillance Reveals Widespread VYD2311 Escape via S501T . Zenodo.

Tahir Bhatti (2025). Sotrovimab Resistance Genomic Profiling Across 4.68 Million SARS-CoV-2 Genomes . Zenodo.

Tahir Bhatti (2025). Host-Stratified Gene-Level DRACH Motif Atlas of MERS-CoV: Human vs. Non-Human Isolates n=663 . Zenodo.

Tahir Bhatti (2025). Host-Stratified DRACH Motif Atlas of MERS-CoV Comparing Human and Non-Human Genomic Landscapes . Zenodo.

Tahir Bhatti (2025). MERS-CoV Saltation Analysis: Human vs. Non-Human Isolates Relative to Vietnamese Reference (NC_019843.3) . Zenodo.

Tahir Bhatti(2025). DRACHscape: A Genome-Scale Atlas of m6A-Associated DRACH Motifs Across 9.3 Million SARS-CoV-2 Genomes . Mendeley Data

Tahir Bhatti (2025). Curated Spike Protein Sequences from 20 Reference Coronaviruses Across Alpha- and Betacoronavirus Genera . Zenodo.

Tahir Bhatti (2025). Genome-wide analysis of m6A-linked DRACH signatures across 272 human-derived MERS-CoV genomes . Zenodo.

Tahir Bhatti (2025). MERS-CoV Spike Protein S1/S2 Cleavage and Glycosylation Analysis n ~ 399 . Zenodo.

Tahir Bhatti (2025). Genomic Codon Composition and Epidemiological Landscape of H5N9 Influenza A Virus .

Tahir Bhatti (2025). Complete H5N3 Influenza A Virus Genomes: Evolutionary and Host Adaptation Metrics n = 1,613 .

Tahir Bhatti (2025). Complete H5N5 Influenza A Virus Genomes: Codon Adaptation and Metadata .

Tahir Bhatti (2025). Complete Length H5N7 Influenza A Virus Genomes: Host Adaptation and Evolutionary Metrics .

Tahir Bhatti (2025). Complete length H5N6 Influenza A Virus Genomes: Host Adaptation Signatures and Evolutionary Metrics n=6768 .

Tahir Bhatti (2025). H5N1 Influenza A Virus Genomes: Codon Usage, Host Adaptation, and Temporal-Geographic Metadata n=139,000 .

Tahir Bhatti (2025). H5N2 Influenza A Virus Genomes: Codon Bias and Epidemiological Metadata n=12,765 .

Tahir Bhatti (2025). H5N4 Influenza A Virus Genomes: Codon Bias and Metadata .

Tahir Bhatti (2025). H5N8 Influenza A Virus Genomes: Codon Usage Bias and Spatiotemporal Distribution n = 5219 .

Tahir Bhatti (2025). MERS-CoV Spike Gene Evolution through Codon Bias and Nucleotide Composition: Insights from 1,746 Genomes .

Tahir Bhatti (2025). Codon and Composition Bias Define the Contemporary Evolution of H5N1 Influenza A (2025 Global Dataset, n = 11,602) .

Tahir Bhatti (2025). MERS-CoV Pan-Genomic Consensus and Evolutionary Constraint Analysis (n=1,746): Codon Usage, Saltation, and DPP4 Interface Stability . Zenodo.

Tahir Bhatti (2025). Global H5N1 Genomic Insights via Multi-Matrix Analysis of 152,000+ Genomes .

Tahir Bhatti (2025). Large Scale Comparative Genomic Metrics of H5N1 Influenza A and SARS-CoV-2: Codon Usage, Nucleotide Composition, and Mutation Patterns (2024 - 2025) . Zenodo.

Tahir Bhatti (2025). Global H5N1 Mutation Burden: Ranked Trends in Genomic Sequences Span = Q1&2 2025 n=1205 .

Tahir Bhatti (2025). Comprehensive Global Dataset of SARS-CoV-2 Lineages and Spike Mutations for Therapeutic and Vaccine Research (734 Cities, 2019 - 2025 Q1, n=9.4 Million Approx.) .

Tahir Bhatti (2025). SARS-CoV-2 Sequences Temporal Trends Metadata by Country 2019 to 2025 Q1 .

Tahir Bhatti (2025). SARS-CoV-2 S450x S/E, S/M, S/N Residues .

Tahir Bhatti (2025). Global SARS-CoV-2 Genomic Sequences by City (2019 to 2025 Q1): Temporal Trends Across 734 Urban Locations World-Wide .

Tahir Bhatti (2025). Yearly SARS-CoV-2 Sequences Temporal Trends Metadata (2019 to 2025 Q1) Curated TSV Files .

Tahir Bhatti (2025). SARS-CoV-2 RBD/hACE2 Interaction Residues n= ~10 M Span=2020 to Q1 2025 .

Tahir Bhatti(2025). Global SARS-CoV-2 Mutation Constellations V445P + F490S + Q498R + Y505H + T478K subset n=276537 span = 2020 - Q1 2025 . Mendeley Data

Tahir Bhatti (2025). SARS-CoV-2 Spike Residues between 2.0 to 8.0 Angstrom n= ~10M Span=2020 to Q1 2025 . Zenodo.

Tahir Bhatti (2025). Monoclonal Antibody Multi-Target Cocktail Components K417N + G446S + S477N + F486P + N501Y Class III mAb Analysis Sub-Set n=538435 Span=2020 - Q1 2025 . Zenodo.

Tahir Bhatti (2025). SARS-CoV-2 Global 5's Constellation S373P + N440K + D405N + R408S + E484K Sub-Sample n = 227210 Span = 2020 - Q1 2025 . Zenodo.

Bhatti Tahir (2025). SARS-CoV-2 Spike Mutation Frequencies: A High-Resolution Dataset for mAb and Vaccine Design . Zenodo.

Tahir Bhatti (2025). Global Distribution of Probably High-Risk SARS-CoV-2 5-Mutation Constellation (F486P, K444T, N460K, R346T, S371F n=9.2M+ Span 2022-Q12025) . Zenodo.

Tahir Bhatti (2025). Global detection of high risk escape constellation F456L, R346T, K444T, F486P n=1,019,041 span 2020 - Q1 2025 . Zenodo.

Tahir Bhatti (2025). SARS-CoV-2 RBD Mutation Constellations (G339D, S375F, E484A, Q493R, L452R): Insights from Historical Data on Monoclonal Antibody Class 3 Escape Risk Measured from 2021 - 2023 Data . Zenodo.

Tahir Bhatti (2025). SARS-CoV-2 Genomic Assembly Dataset (2022 - Q1 2025): Characterization of the F486P, K444T, N460K, R346T, S371F Mutation Constellation and Its Relevance to Monoclonal Antibody Binding (n=915) .

Tahir Bhatti (2025). Global detection of 915 SARS-CoV-2 genomes encoding a high-risk VYD2311 escape haplotype (F486P+S371F+K444T+N460K+R346T) in 2023 - 2024 surveillance data . Zenodo.

Tahir Bhatti (2025). SARS-CoV-2 S, E, M, N CpG/UpA Analysis Across n = 9,356,279 Unique Genomes from 2020 till early 2025 . Zenodo.

Tahir Bhatti (2025). Codon and Amino Acid Frequencies at 22 Key hACE2 Interface Positions in SARS-CoV-2 Spike (RBD 2020 till early 2025) . Zenodo.

Tahir Bhatti (2025). Triad Under the Spike: A Codon-Level de novo Signature in 9.4M Genomes . Zenodo.

Tahir Bhatti (2025). Codon-Permissive Residues at the hACE2 Interface: Position-Resolved Codon Usage Across 240 Million SARS-CoV-2 Genomes (2020 - 2025) . Zenodo.

Tahir Bhatti (2025). QC Audit of 2.5M SARS-CoV-2 RBD Sequences Reveals Systemic Ambiguity & Outliers . Zenodo.

Tahir Bhatti (2025). Global Haplotype Landscape of SARS-CoV-2 Spike Contact Residues Reveals Dominant Escape Signatures and Systemic Sequencing Ambiguity . Zenodo.

Tahir Bhatti (2025). SARS-CoV-2 RBD Escape Velocity Outpaces mAb Development for 2025 Variants Already Encoded in Global Diversity . Zenodo.

Tahir Bhatti (2025). GC3 Analysis of Global SARS-CoV-2 Genomic Composition Across 35.3 Million Sequences . Zenodo.

Tahir Bhatti (2025). PR2 Analysis of Global SARS-CoV-2 Genomic Composition Across 35.3 Million Sequences . Zenodo.

Tahir Bhatti (2025). Gene-resolved CpG and UpA dinucleotide indices across 4.9 million SARS-CoV-2 genomes . Zenodo.

Bhatti Tahir (2025). CAI in SARS-CoV-2: Host-Adapted Codon Usage at Scale (n = 9,394,000) . Zenodo.

Bhatti Tahir (2025). tAI in SARS-CoV-2: Persistent Selection on Translational Efficiency (n = 9,356,279) . Zenodo.

Bhatti Tahir (2025). SARS-CoV-2 Structural Protein Co-Evolution Network S, E, M, N (n=9.4M) . Zenodo.

Bhatti Tahir (2025). CPB Scores of SARS-CoV-2 Genomes (n = 18,390,482) . Zenodo.

Bhatti Tahir (2025). SARS-CoV-2 Translational Speed Across the Pandemic (n = 9,356,279) . Zenodo.

Bhatti Tahir (2025). SARS-CoV-2 Structural Gene Co-Mutation Atlas: 26 Million Cross-Gene Co-Occurrence Events from Genomic Surveillance . Zenodo.

Bhatti Tahir (2025). Codon Usage Bias in SARS-CoV-2 Spike Gene: A 9-Million-Genome Analysis . Zenodo.

Bhatti Tahir (2025). Co-occurring Mutations in SARS-CoV-2 ORF10 Across 9.3 Million Genomes . Zenodo.

Bhatti Tahir (2025). SARS-CoV-2 Spike Mutation Co-occurrence Network - Segment 2: Genomic Surveillance of Co-evolving Mutations in a Global Dataset . Zenodo.

Bhatti Tahir (2025). Co-occurring Mutations in SARS-CoV-2 ORF10 Across 9.3 Million Genomes . Zenodo.

Bhatti Tahir (2025). SARS-CoV-2 Spike Mutation Co-occurrence Network - Segment 1: Genomic Surveillance of Co-evolving Mutations in a Global Dataset . Zenodo.

Bhatti Tahir (2025). Comprehensive Mutation Profiling of the SARS-CoV-2 Envelope (E) Gene Across 2.8 Million Genomes: A Global Evolutionary Analysis . Zenodo.

Bhatti Tahir (2025). Comprehensive Analysis of SARS-CoV-2 Spike Gene: Mutation Variability, GC/AT Content, and Evolutionary Dynamics Across Randomly Selected 186,457 Genomes . Zenodo.

Tahir Bhatti (2025). Mutation Frequency Profiling and Evolutionary Dynamics of the SARS-CoV-2 Spike Gene Across 2.8 Million Randomly Sampled Genomes .

Bhatti Tahir (2025). Emergence and Rise of E Gene Mutations in SARS-CoV-2: A Longitudinal Study of 9.3 Million Genomes (2020 to 2025) . Zenodo.

Bhatti Tahir (2025). Global Analysis of Co-occurring Mutations in the SARS-CoV-2 Nucleocapsid Gene (n = 4,180,000 Genomes, 2022 - 2025) . Zenodo.

Tahir Bhatti (2025). Global SARS-CoV-2 Nucleocapsid (N) Gene Mutation Dataset: 16.5 Million Records from 4.2 Million Genomes (2022–2025) .

Tahir Bhatti (2025). Spike Mutation Analysis Summary for SARS-CoV-2 Sequences in 2024 (Companion Dataset n > 90,000) .

Bhatti Tahir (2025). GVSTRIP: Implementation Dossier - Confidential Evaluation Copy . Zenodo.

Tahir Bhatti (2025). On a Deterministic Framework for Highly Compressed Reversible Representations of Symbolic Genomic Entities .

Tahir Bhatti (2025). Statistical Analysis of Spike Mutation Co-Occurrence in SARS-CoV-2 (Cramér’s V & Fisher's Test on 79K Genomes) .

Bhatti Tahir (2025). Large Scale Jaccard Similarity Profiling of SARS-CoV-2 Spike Mutation Patterns in 6.8 Million Global Genomes . Zenodo.

Bhatti Tahir (2025). Chi-Square and Mutual Information Profiling of SARS-CoV-2 Spike Mutation Clusters in a Comprehensive Global Dataset . Zenodo.

Tahir Bhatti (2025). Chi-Square Analysis of Spike Protein Mutation Clusters in SARS-CoV-2: A Global Study of 158,342 Historical Genomes from GVATLAS .

Tahir Bhatti (2025). SARS-CoV-2 Isolates from Urine, Placenta, and Nasopharyngeal Samples Reveal No Evidence of Tissue-Specific Mutation Signatures .

Tahir Hussain Bhatti (2025). Synthetic Modeling of Emerging SARS-CoV-2 Recombinant Lineages via Markov Chain Mutation Forecasting .

Tahir Bhatti, Tahir Hussain Bhatti (2025). Limitations of Genomic Surveillance: A Biologically Plausible Synthetic SARS-CoV-2 Spike Variant Escapes Detection by Nextclade .

Tahir Bhatti (2025). Synthetically Engineered SARS-CoV-2 Spike Mutant Designed for Biocompatibility and Drug Resistance . Zenodo.

Tahir Hussain Bhatti (2025). Nucleotide analogue tolerant synthetic RdRp mutant construct for Surveillance and Therapeutic Resistance Monitoring in SARS-CoV-2 .

Bhatti Tahir (2025). Analysis of Spike Protein Mutation Patterns in Publicly Available SARS-CoV-2 Genomic Sequences . Zenodo.

Bhatti Tahir (2025). GVAtlas: Pioneering Genomic Variant Analysis and Visualization for SARS CoV 2 and Beyond . Zenodo.

Bhatti Tahir (2025). Immune Escape Potential of SARS-CoV-2 Spike Mutations L452W, F486P, D614G (Q1 2025) . Zenodo.

Tahir Hussain Bhatti (2025). Spike Protein Mutation Signatures in Circulating SARS-CoV-2 Variants Highlighting Immune Escape Markers and Lineage-Specific Deletion Patterns in Q1 2025 .

Bhatti, T. H. (2025). Tracking Evolution of SARS-CoV-2 NSP7: Mutation Insights from 2,731 Genomes . Zenodo.

Tahir Hussain Bhatti (2025). Mutation Profile Analysis of 3,252 SARS-CoV-2 Genomes from January to Early May 2025: Evidence of High Diversity and Limited Convergent Evolution in NSP7, NSP8, NSP12, and NSP14 .

Bhatti Tahir(2025). Mapping Potential Drug Resistance Mutations in SARS-CoV-2 nsp12 Motifs Q1 2025 . Zenodo

Tahir Hussain Bhatti (2025). Mutation profiling of RdRp Motifs A, C, F, G of SARS-CoV-2 nsp12 - Genomic Surveillance of 3106 Sequences (Jan to Apr 2025) with respect to wild type wuhan-hu-1 .

Tahir Hussain Bhatti(2025). Mutation Profiling and Haplotype Diversity in Conserved Motifs A, C, F, and G of SARS-CoV-2 nsp12: A Genomic Survey Relative to Wuhan-Hu-1 (Jan to Apr 2025, n = 3106) . Zenodo

Tahir Hussain Bhatti (2025). Metadata and Recombinant Candidate Identification in nsp12 Region of 1,407 SARS-CoV-2 Genomes (Early 2025) .

Tahir Hussain Bhatti (2025). Mutation Profiling of SARS-CoV-2 Sample NJ-GBW-GKISBBBF40282/2025 . https://www.ncbi.nlm.nih.gov/.

Tahir Hussain Bhatti, Tahir Hussain Bhatti(2025). Mutation Profiling of SARS-CoV-2 Sample at Multiple Allele Frequency Thresholds . Zenodo

Tahir Hussain Bhatti (2025). Functional and Evolutionary Insights into the Intergenic Deletion n.28271delA in SARS-CoV-2: Implications for Genomic Surveillance and Public Health . https://www.ncbi.nlm.nih.gov.

Tahir Bhatti (2025). Identification of Novel Mutations in SARS-CoV-2 ORF8 Gene: Insights into Potential Functional Implications .

Tahir Bhatti(2025). Genomic Analysis of SARS-CoV-2 GRA Lineage: Identification of Novel Mutation n.28271delA in ORF8 and N Gene . figshare

Tahir Bhatti (2025). Integrated Computational Study of ORF10 Binding Sites: DNA, FMN, and RNA Interaction Predictions .

Tahir Bhatti(2025). Integrated Computational Study of ORF10 Binding Sites: DNA, FMN, and RNA Interaction Predictions . figshare

Tahir Bhatti(2025). Structural Characterization of SARS-CoV-2 ORF10 via AlphaFold2: Binding Pockets and Conserved Functional Motifs . figshare

Tahir Bhatti (2025). Structural and Functional Analysis of SARS-CoV-2 ORF10 Protein Binding Pockets .

Tahir Bhatti(2025). Structural and Functional Analysis of SARS-CoV-2 ORF10 Protein Binding Pockets . figshare

Tahir Bhatti (2025). Structural Characterization of SARS-CoV-2 ORF10 via AlphaFold2: Binding Pockets and Conserved Functional Motifs .

Tahir Bhatti(2025). Novel Insights into the Structural and Functional Analysis of ORF10 Protein Binding Pockets: Identification and Characterization of Two Distinct Druggable Sites . This dataset presents the structural analysis of the ORF10 protein from SARS-CoV-2, including its theoretical model, secondary structure predictions, and visualization outputs. The study was conducted by TahirHB, an independent researcher. For more information about the author, please visit their ORCID profile: https://orcid.org/0009-0003-6042-1616. figshare

Tahir Bhatti (2025). Novel Insights into the Structural and Functional Analysis of ORF10 Protein Binding Pockets: Identification and Characterization of Two Distinct Druggable Sites .

Tahir Bhatti (2025). CpG Signature Profiling and Heatmap Visualization of SARS-CoV Genomes: Tracing the Genomic Divergence From SARS-CoV (2003) to SARS-CoV-2 (2019) .

Tahir Bhatti(2025). CpG Signature Profiling and Heatmap Visualization of SARS-CoV Genomes: Tracing the Genomic Divergence From SARS-CoV (2003) to SARS-CoV-2 (2019) . figshare

Tahir Bhatti (2025). Distinct Evolutionary Trajectory of SARS-CoV-2 Supported by Phylogenetic Analysis of 11 Coronaviruses: A Study of CpG Dynamics, Mutations, and Maximum Likelihood Tree Construction (RAxML) Relative to Wuhan-Hu-1 (NC_045512) .

Tahir Bhatti(2025). Distinct Evolutionary Trajectory of SARS-CoV-2 Supported by Phylogenetic Analysis of 11 Coronaviruses: A Study of CpG Dynamics, Mutations, and Maximum Likelihood Tree Construction (RAxML) Relative to Wuhan-Hu-1 (NC_045512) . figshare

Comparative Genomic Analysis of Coronaviruses Across 2003–2025: Insights into CpG Dynamics and Mutation Profiles Relative to Wuhan-Hu-1 (NC_045512) @misc{https://doi.org/10.6084/m9.figshare.28711058, doi = {10.6084/M9.FIGSHARE.28711058}, url = {https://figshare.com/articles/dataset/Comparative_Genomic_Analysis_of_Coronaviruses_Across_2003_2025_Insights_into_CpG_Dynamics_and_Mutation_Profiles_Relative_to_Wuhan-Hu-1_NC_045512_/28711058}, author = {Bhatti, Tahir}, keywords = {Sequence analysis}, title = {Comparative Genomic Analysis of Coronaviruses Across 2003–2025: Insights into CpG Dynamics and Mutation Profiles Relative to Wuhan-Hu-1 (NC_045512)}, publisher = {figshare}, year = {2025}, copyright = {Creative Commons Attribution 4.0 International}} .

Tahir Bhatti (2025). Comparative Genomic Analysis of Coronaviruses Across 2003–2025: Insights into CpG Dynamics and Mutation Profiles Relative to Wuhan-Hu-1 (NC_045512) .

Tahir Bhatti (2025). CpG Distribution in HKU3-1: A Genomic Perspective on Bat SARS-like Coronavirus (2005) .

Tahir Bhatti(2025). CpG Distribution in HKU3-1: A Genomic Perspective on Bat SARS-like Coronavirus (2005) . figshare

Tahir Bhatti (2025). CpG Analysis of Intergenic Regions in Coronaviruses - Wuhan-Hu-1 .

Tahir Bhatti (2025). CpG Analysis of Intergenic Regions in BetaCoV/Wuhan/IVDC-HB-01/2019 (SARS-CoV-2) .

Tahir Bhatti(2025). CpG Analysis of Intergenic Regions in BetaCoV/Wuhan/IVDC-HB-01/2019 (SARS-CoV-2) . figshare

Tahir Bhatti (2025). CpG Analysis of Intergenic Regions in SARS-CoV (2002-2003, NC_004718.3) .

Tahir Bhatti(2025). CpG Analysis of Intergenic Regions in SARS-CoV (2002-2003, NC_004718.3) . figshare

Tahir Bhatti (2025). Sliding Window CpG Analysis of Civet SARS-CoV (2003-2004, AY304486.1) .

Tahir Bhatti(2025). Analysis of the distribution of CpG sites across the genomes of two Bat SARS-like coronaviruses, ZXC21 and ZC45 (2015-2017), using a sliding window approach . figshare

Tahir Bhatti(2025). Analysis of CpG Distribution in Intergenic Regions of RaTG13 . figshare

Tahir Bhatti (2025). CpG Analysis of Intergenic Regions in BM48-31/BGR/2008 (Bat Coronavirus) .

Tahir Bhatti(2025). CpG Analysis of Intergenic Regions in BM48-31/BGR/2008 (Bat Coronavirus) A SARS-like betacoronavirus found in Bulgarian bats in 2008 . figshare

Tahir Bhatti(2025). Analysis of Intergenic Regions and CpG Distribution in SARS-CoV-2 (Wuhan-Hu-1 Genome) . figshare

Tahir Bhatti (2025). CpG Analysis of Intergenic Regions in BetaCoV/Wuhan/IPBCAMS-WH-01/2019 (SARS-CoV-2) .

Tahir Bhatti (2025). CpG Analysis of Intergenic Regions in Pangolin-CoV (Pangolin Guangdong/2019) .

Tahir Bhatti (2025). Analysis of CpG Distribution in Intergenic Regions of RaTG13 .

Tahir Bhatti(2025). CpG Analysis of Intergenic Regions in Pangolin-CoV (Pangolin Guangdong/2019) . figshare

Tahir Bhatti(2025). This project analyzes the distribution of CpG sites across the genomes of two Bat SARS-like coronaviruses, ZXC21 and ZC45 (2015-2017), using a sliding window approach . figshare

Tahir Hussain Bhatti (2025). Genomic Characterization of a Post-Omicron Recombinant SARS-CoV-2 Strain: Transition from BA.1 to BA.5 Using Public Data (SRR32480181) . Zenodo.

Tahir Bhatti (2025). High-Quality SARS-CoV-2 Historical Genomes from China (2020 - 2022): A Curated QC-Passed Dataset (n=157) . figshare.

Tahir Bhatti (2025). A Global Overview of H5N1 Influenza A Virus Protein Distribution and Temporal Trends Using Genomic Metadata and Visualization . figshare.

Tahir Bhatti (2025). Comparative mosaic trend analysis of coronavirus structural proteins (S, E, M, N) using domain-resolved alignments . figshare.

Tahir Bhatti (2025). Complete H5N3 Influenza A Virus Genomes: Evolutionary and Host Adaptation Metrics n = 1,613 . figshare.

Tahir Bhatti (2025). Codon and Composition Bias Define the Contemporary Evolution of H5N1 Influenza A (2025 Global Dataset, n = 11,602) . figshare.

Tahir Bhatti(2025). Chi-Square and Mutual Information Analysis Reveal Co-Evolving Spike Protein Residue Clusters Associated with ACE2 Binding and Immune Evasion in SARS-CoV-2 . Unpublished

Tahir Bhatti (2025). Codon Usage Bias in MERS-CoV Spike: Global Analysis of 1,746 Genomes Reveals Low-Adaptive Evolutionary Signatures n= 1746 . figshare.

Global Analysis of Co-occurring Mutation Triplets in the SARS-CoV-2 Nucleocapsid Gene (2022–2025) @misc{https://doi.org/10.7910/dvn/uevw2d, doi = {10.7910/DVN/UEVW2D}, url = {https://dataverse.harvard.edu/citation?persistentId=doi:10.7910/DVN/UEVW2D}, author = {Bhatti, Tahir}, keywords = {Medicine, Health and Life Sciences, Other}, title = {Global Analysis of Co-occurring Mutation Triplets in the SARS-CoV-2 Nucleocapsid Gene (2022–2025)}, publisher = {Harvard Dataverse}, year = {2025}} .

Tahir Bhatti (2025). Global SARS-CoV-2 Genomic Sequences by City (2019 to 2025 Q1): Temporal Trends Across 734 Urban Locations World-Wide . figshare.

Tahir Bhatti (2025). Global H5N1 Mutation Burden: Ranked Trends in Genomic Sequences Span = Q1&2 2025 n=1205 . figshare.

Tahir Bhatti (2025). Evidence of a Geographic Epicenter in Pemivibart (VYD2311) Escape: Validation of 817 Natural Isolates Harboring the Complete XFG-Loss Motif (K444T + N460K + F486P) . figshare.

(2025). Functional and Evolutionary Insights into the Intergenic Deletion n.28271delA in SARS-CoV-2.

Tahir Bhatti (2025). Genomic Surveillance of Pemivibart (VYD2311) Escape-Associated Mutations in SARS-CoV-2: December 2025 BioSamples (n=2) . figshare.

Tahir Bhatti (2025). Comprehensive Global Genomic Surveillance of SARS-CoV-2 Structural Gene Mutations (S, E, M, N): High-Resolution Profiling from 2021 to 2024 . Harvard Dataverse.

Tahir Bhatti (2025). Comprehensive Surveillance of Pemivibart (VYD2311) Escape Mutations in 9,398,268 SARS-CoV-2 Spike Protein Sequences 2020 up to 2025 Q3 . figshare.

Tahir Bhatti (2025). Complete length H5N6 Influenza A Virus Genomes: Host Adaptation Signatures and Evolutionary Metrics n=6768 . figshare.

Tahir Bhatti (2025). Complete Length H5N7 Influenza A Virus Genomes: Host Adaptation and Evolutionary Metrics . figshare.

Tahir Bhatti (2025). Complete H5N5 Influenza A Virus Genomes: Codon Adaptation and Metadata . figshare.

Tahir Bhatti(2025). Sliding Window CpG Analysis of Civet SARS-CoV (2003-2004, AY304486.1) . figshare

Tahir Hussain Bhatti (2025). Metadata and Recombinant Candidate Identification in nsp12 Region of 1,407 SARS-CoV-2 Genomes (Early 2025) . figshare.

Tahir Hussain Bhatti (2025). Mutation profiling of RdRp Motifs A, C, F, G of SARS-CoV-2 nsp12 - Genomic Surveillance of 3106 Sequences (Jan to Apr 2025) with respect to wild type wuhan-hu-1 . figshare.

Tahir Hussain Bhatti (2025). Remdesivir Resistance Candidate Genome of SARS-CoV-2 Based on Early 2025 Consensus Sequences . figshare.

Tahir Bhatti (2025). Paxlovid Remains Effective Against Contemporary SARS-CoV-2 Despite Universal Monoclonal Antibody Resistance in a December 2025 Clinical Trial Isolate (SRR29875709) . figshare.

Tahir Bhatti (2025). Probable Human MHC-I Downregulation Candidate Signals (n=1,237,095) from SARS-CoV-2 ORF8 Variants Observed Across a Subset 1 of 5,000,000 Global Genomes . figshare.

Tahir Bhatti (2025). On a Deterministic Framework for Highly Compressed Reversible Representations of Symbolic Genomic Entities . figshare.

Tahir Bhatti (2025). MERS-CoV Spike Receptor-Binding Domain Sequences from 182 Human Clinical Isolates with Antibody Escape Hotspot Annotation . figshare.

Tahir Hussain Bhatti (2025). Metadata and Recombinant Candidate Identification in nsp12 Region of 1,407 SARS-CoV-2 Genomes (Early 2025) . figshare.

Tahir Hussain Bhatti(2025). Metadata and Recombinant Candidate Identification in nsp12 Region of 1,407 SARS-CoV-2 Genomes (Early 2025) . figshare

Tahir Bhatti (2025). Mutation Frequency Profiling and Evolutionary Dynamics of the SARS-CoV-2 Spike Gene Across 2.8 Million Randomly Sampled Genomes . figshare.

Tahir Bhatti (2025). MERS-CoV Population Vulnerability Meta-Analysis: Host, Geographic, and Temporal Patterns from 1,807 Global Sequences . figshare.

Tahir Hussain Bhatti (2025). Limitations of Genomic Surveillance: A Biologically Plausible Synthetic SARS-CoV-2 Spike Variant Escapes Detection by Nextclade . figshare.

Tahir Bhatti (2025). H5N8 Influenza A Virus Genomes: Codon Usage Bias and Spatiotemporal Distribution n = 5219 . figshare.

Tahir Bhatti (2025). H5N4 Influenza A Virus Genomes: Codon Bias and Metadata . figshare.

Tahir Bhatti (2025). Global SARS-CoV-2 IFN-Antagonistic Nucleotide Mutations: ORF6, ORF8, and N Regions (9.36M Genomes) . Harvard Dataverse.

Tahir Bhatti (2025). H5N1 Influenza A Virus Genomes: Codon Usage, Host Adaptation, and Temporal-Geographic Metadata n=139,000 . figshare.

Tahir Bhatti (2025). H5N1 with Mammalian-Adaptive Mutations (HA-Q226L, PB2-T271A) in Germany, 2024 - 2025 . figshare.

Tahir Bhatti (2025). H5N2 Influenza A Virus Genomes: Codon Bias and Epidemiological Metadata n=12,765 . figshare.

Tahir Bhatti (2025). Temporal Entanglement Points (TEPs) Reveal Population Vulnerability Points in SARS-CoV-2 Lineage Evolution Across the Pandemic Span 2020 - 2025 . figshare.

Tahir Hussain Bhatti(2025). Selective Pressure Analysis of SARS-CoV-2 nsp12 Motifs (A, C, F, G) Based on Global Surveillance Samples Collected in Early 2025 N = 1400 . OSF. OSF

Tahir Bhatti (2025). SARS-CoV-2 Spike Gene Mutation Constellations from Global Genomic Surveillance . Harvard Dataverse.

Tahir Bhatti (2025). m5C Motif Atlas of SARS-CoV-2: CG, CCA, and ACW Sites Across 9.36 Million Genomes . Harvard Dataverse.

Tahir Bhatti (2025). VYD2311 (Pemivibart) Escape Co-occurrence Mutations in 42,835 SARS-CoV-2 Genomes from 2025 . figshare.

Tahir Bhatti (2025). VP24, VP35, and Glycoprotein Mutation Burden Across 28 Public Zaire ebolavirus Genomes Span=2014 - 2023 . figshare.

Tahir Bhatti (2025). SARS-CoV-2 Isolates from Urine, Placenta, and Nasopharyngeal Samples Reveal No Evidence of Tissue-Specific Mutation Signatures . figshare.

Tahir Bhatti (2025). SARS-CoV-2 Membrane Gene Mutation Landscape Across 9.3 Million Genomes Over Five Years (2020-2025) . Harvard Dataverse.

Tahir Bhatti (2025). SARS-CoV-2 S450x S/E, S/M, S/N Residues . figshare.

Tahir Bhatti (2025). SARS-CoV-2 Sequences Temporal Trends Metadata by Country 2019 to 2025 Q1 . figshare.

Tahir Bhatti (2025). Statistical Analysis of Spike Mutation Co-Occurrence in SARS-CoV-2 (Cramér’s V & Fisher's Test on 79K Genomes) . figshare.

Tahir Bhatti, Tahir Hussain Bhatti(2025). Statistical Co-Association of SARS-CoV-2 Spike Mutations (Cramér's V Analysis) . Unpublished

Tahir Bhatti (2025). Structural Drift in the SARS-CoV-2 Spike RBD and Furin Cleavage Region . Harvard Dataverse.

Tahir Hussain Bhatti (2025). Synthetic Modeling of Emerging SARS-CoV-2 Recombinant Lineages via Markov Chain Mutation Forecasting . figshare.

Tahir Hussain Bhatti (2025). Spike Protein Mutation Signatures in Circulating SARS-CoV-2 Variants Highlighting Immune Escape Markers and Lineage-Specific Deletion Patterns in Q1 2025 . figshare.

Tahir Bhatti (2025). Chi-Square Analysis of Spike Protein Mutation Clusters in SARS-CoV-2: A Global Study of 158,342 Historical Genomes from GVATLAS . figshare.

Tahir Bhatti (2025). Spike Mutation Analysis Summary for SARS-CoV-2 Sequences in 2024 (Companion Dataset n > 90,000) . figshare.

Tahir Bhatti (2025). Global SARS-CoV-2 Nucleocapsid (N) Gene Mutation Dataset: 16.5 Million Records from 4.2 Million Genomes (2022–2025) . figshare.

Tahir Bhatti (2025). SARS-CoV-2 RBD/hACE2 Interaction Residues n= ~10 M Span=2020 to Q1 2025 . figshare.

Tahir Bhatti (2025). Yearly SARS-CoV-2 Sequences Temporal Trends Metadata (2019 to 2025 Q1) Curated TSV Files . figshare.

Tahir Bhatti (2025). Comprehensive Global Dataset of SARS-CoV-2 Lineages and Spike Mutations for Therapeutic and Vaccine Research (734 Cities, 2019 - 2025 Q1, n=9.4 Million Approx.) . figshare.

Tahir Bhatti (2025). Genomic Codon Composition and Epidemiological Landscape of H5N9 Influenza A Virus . figshare.

Tahir Bhatti (2025). Global Time-Resolved Haplotype Dynamics of Pemivibart Escape Mutations: Frequency, Diversity, and Mutational Complexity . figshare.

Tahir Bhatti (2025). Host-Specific Nucleotide Divergence in MERS-CoV Spike RBD: Primary Hydrogen-Bond and Salt-Bridge Residues in Human vs. Camel Isolates . figshare.

Tahir Bhatti (2025). H5N1 Hemagglutinin CpG Depletion in Mammalian Hosts: Evidence of Active Selection for Human-Adaptive Evolution . figshare.

Tahir Bhatti (2025). High-Confidence Pemivibart (VYD2311) Escape Haplotypes in U.S. SARS-CoV-2 Sequences, Span 2023 - 2024 . figshare.

PREPRINT

Tahir Bhatti (2025). Global Genomic Surveillance Reveals Pre-EUA Fixation of Pemivibart (VYD2311) Escape Constellations in SARS-CoV-2 .

Tahir Hussain Bhatti (2025). Genomic Signatures of Immune Evasion in Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Building Upon the IRF3 Antagonism of the Structural and Accessory Proteins M, ORF4a, ORF4b, and ORF5 .

Tahir Hussain Bhatti (2025). SARS-CoV-2 Escape Haplotypes Show Rising Diversity and Mutational Load in the Context of Monoclonal Antibody Use .

Bhatti, T. (2025). CpG Dinucleotide Dynamics and Future Evolutionary Predictions From Wuhan-Hu-1 to SARS-CoV-2. Unpublished manuscript.

Tahir Bhatti (2025). Global Profiling of m6A-Associated DRACH Motifs in 9.3 Million SARS-CoV-2 Genomes Uncovers Progressive Loss of Host RNA Modification Signatures .

Tahir Bhatti (2025). A Genome-Wide Codon-Permissiveness Framework Uncovers Spike-Centric Escape Hotspots and Distal Epistatic Couplings Across SARS-CoV-2 Structural Proteins .

Tahir Hussain Bhatti (2025). Short Scientific Report: Global Evolutionary and Epidemiological Trends Across H5Nx Influenza A Viruses .

Tahir Bhatti. The Codon-Permissive Epistatic Backbone (CpEB) of SARS-CoV-2: A Genome-Wide Network Driving Variant Success and Enabling Predictive mAb Design. Preprints.org 2025 .

Tahir Bhatti (2025). The Codon-Permissive Epistatic Backbone (CpEB) of SARS-CoV-2: A Genome-Wide Network Driving Variant Success and Enabling Predictive mAb Design .

Bhatti (2025). A High-Resolution Approach to Mapping Spike Protein Evolution for Advancing Antibody Therapy Design .

Tahir Bhatti (2025). Multi-Metric Genomic Profiling of SARS-CoV-2 Spike Mutations (2020 - 2025): Decoding Evolutionary and Lineage Specific Patterns .

Tahir Bhatti (2025). Codon Usage in SARS-CoV-2 Spike: Global Dominance of the Suboptimal TAG Stop Codon and Amino Acid Specific Biases from 9.3 Million Genomes .

Tahir Bhatti (2025). Exceptional Conservation of SARS-CoV-2 ORF10 Across 9.3 Million Genomes Suggests Functional Constraint .

Tahir Hussain Bhatti (2025). Genomic Surveillance Reveals Rising Immune Escape Potential in SARS-CoV-2: A Mutation-Centric Analysis of Spike Evolution in Q1 2025 .

SOFTWARE

Tahir Bhatti (2025). Pemivibart Resistance Profiler: A Codon-Resolved Genomic Surveillance Pipeline for Detecting SARS-CoV-2 Escape Constellations Against the Monoclonal Antibody VYD2311 . Zenodo.

WORKING PAPER

Tahir Bhatti (2025). In Silico Assessment Framework for MERS-CoV Human Adaptation Potential: Structure-Guided Mutagenesis and Binding Affinity Modeling . Zenodo.

The Codon-Permissive Epistatic Backbone (CpEB) of SARS-CoV-2: A Genome-Wide Network Driving Variant Success and Enabling Predictive mAb Design .

Global Genomic Surveillance Reveals Pre-EUA Fixation of Pemivibart (VYD2311) Escape Constellations in SARS-CoV-2 .

A Genome-Wide Codon-Permissiveness Framework Uncovers Spike-Centric Escape Hotspots and Distal Epistatic Couplings Across SARS-CoV-2 Structural Proteins .

Codon Usage in SARS-CoV-2 Spike: Global Dominance of the Suboptimal TAG Stop Codon and Amino Acid Specific Biases from 9.3 Million Genomes .

Multi-Metric Genomic Profiling of SARS-CoV-2 Spike Mutations (2020 - 2025): Decoding Evolutionary and Lineage Specific Patterns .

OTHER

Tahir Bhatti (2025). Structural Validation of Putative DPP4-Contact Residues in MERS-CoV Spike: Residues 511 and 539 Are True Interface Sites, While 499, 534, and 553 Are Immune Escape Signatures . Zenodo.

Tahir Bhatti (2025). Genome-wide mapping of 5-methylcytosine motifs in 272 MERS-CoV genomes . Zenodo.

REPORT

Tahir Bhatti (2025). Development of a Privacy-First, Web-Based Report Generator for Nextclade Outputs .

Tahir Bhatti (2025). Proposal: Functional Mutation Signatures of Neurotropism in Respiratory Pathogens .

REVIEW

Tahir Bhatti(2010). Ataxia Telangiectasia Mutated Serine Threonine Protein Kinase .

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