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★★★★★
☆☆☆☆☆
USD 10 /hr
Hire Dr. Thokhir Basha S.
India
USD 10 /hr

11+ Years in Biotech, Statistics, Bioinformatics & Data Analytics | Skilled in Python, R, SQL, ADMET NGS Docking PowerBI

Profile Summary
Subject Matter Expertise
Services
Writing Non-Medical Regulatory Writing, Technical Writing, Creative Writing, Newswriting, General Proofreading & Editing
Research Market Research, User Research, Gray Literature Search, Scientific and Technical Research, Secondary Data Collection
Consulting Go-to-Market Strategy Consulting, Healthcare Consulting, Scientific and Technical Consulting
Data & AI Predictive Modeling, Statistical Analysis, Image Processing, Image Analysis, Algorithm Design-ML, Data Visualization, Text Mining & Analytics, Data Mining, Data Cleaning, Data Processing
Product Development Formulation, Recipe Development, Stability/Shelf Life Testing, Product Validation, Concept Development, Packaging Design
Work Experience

Researcher, Research Associate

SRKR Engineering College

November 2020 - Present

Junior Research Scientist

Eesavyasa Technologies Pvt.Ltd

November 2017 - April 2019

Project Assistant II

Indian Institute of Chemical Technology

December 2006 - March 2012

Education

Ph.D (Medicinal chemistry and pharmacology & IPS (Institute of pharmaceutical sciences))

Indian Institute of Chemical Technology and King's college London

September 2012 - July 2019

Ph. D

Indian Institute of Chemical Technology

September 2012 - October 2016

M.Sc (Master of Science)

Bharathidasan University

March 2004 - April 2006

Certifications
  • Data Science for Biologists Hands-on Internship

    BioTecNika

    March 2025 - Present

  • Drug Discovery & Development

    Decode LIFE (UDYAM-HR-xxxxxxx)

    November 2023 - Present

  • Life Member of Scholars Academic & Scientific Society

    Scholars Academic & Scientific Society
    http://www.sassociety.com

    July 2023 - Present

  • Python for Biologists

    The Institute of Biotechnological Research (UDYAM-GJ-xxxxxxxxxx)

    June 2023 - Present

  • Cancer Genomics with NGS

    Decode LIFE (UDYAM-HR-xxxxxxx)

    March 2024 - April 2024

Publications
JOURNAL ARTICLE
Shaikh Faazil, M. Shaheer Malik, Saleh A. Ahmed, Qazi Mohammad Sajid Jamal, Shaikh Thoukhir Basha, Munirah M. Al-Rooqi, Rami J. Obaid, Jihan Qurban, Iqbal N Shaikh, Basim H. Asghar, et al. (2023). New quinoline-thiolactone conjugates as potential antitubercular and antibacterial agents . Journal of Molecular Structure.
M. Shaheer Malik, Syed Farooq Adil, Ziad Moussa, Hatem M. Altass, Ismail I. Althagafi, Moataz Morad, Mohammad Azam Ansari, Qazi Mohammad Sajid Jamal, Rami J. Obaid, Abdulrahman A. Al-Warthan, et al. (2021). Rational Design and Synthesis of Naphthalene Diimide Linked Bis-Naphthalimides as DNA Interactive Agents . Frontiers in Chemistry.
Malik, M.S., Farooq Adil, S., Moussa, Z., Altass, H.M., Althagafi, I.I., Morad, M., Ansari, M.A., Sajid Jamal, Q.M., Obaid, R.J., Al-Warthan, A.A., et al.(2021). Rational Design and Synthesis of Naphthalene Diimide Linked Bis-Naphthalimides as DNA Interactive Agents . Frontiers in Chemistry. 9.
Thoukhir B. Shaik, M. Shaheer Malik, Sunitha R. Routhu, Zaki S. Seddigi, Ismail I. Althagafi, Ahmed Kamal (2020). Evaluation of Anticancer and Anti-Mitotic Properties of Quinazoline and Quinazolino-Benzothiadiazine Derivatives . Anti-Cancer Agents in Medicinal Chemistry.
Thoukhir B. Shaik, M. Shaheer Malik, Sunitha R. Routhu, Zaki S. Seddigi, Ismail I. Althagafi, Ahmed Kamal(2020). Evaluation of Anticancer and Anti-Mitotic Properties of Quinazoline and Quinazolino-Benzothiadiazine Derivatives . Anti-Cancer Agents in Medicinal Chemistry. 20. (5). p. 599--611. Bentham Science Publishers Ltd.
Shaik, T.B., Malik, M.S., Routhu, S.R., Seddigi, Z.S., Althagafi, I.I., Kamal, A.(2020). Evaluation of anticancer and anti-mitotic properties of quinazoline and quinazolino-benzothiadiazine derivatives . Anti-Cancer Agents in Medicinal Chemistry. 20. (5). p. 599-611.
Mahesh R, Nayak VL, Babu KS, Riyaz S, Shaik TB, Kumar GB, Mallipeddi PL, Reddy CR, Shekar KC, Jose J, et al. (2017). Design, Synthesis, and in vitro and in vivo Evaluations of (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors . ChemMedChem.
Mahesh R, Nayak VL, Babu KS, Riyaz S, Shaik TB, Kumar GB, Mallipeddi PL, Reddy CR, Shekar KC, Jose J, et al.(2017). Design, Synthesis, and in vitro and in vivo Evaluations of (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors . ChemMedChem.
A.V. Subba Rao, Konderu Swapna, Siddiq Pasha Shaik, V. Lakshma Nayak, T. Srinivasa Reddy, Satish Sunkari, Thokhir Basha Shaik, Chandrakant Bagul, Ahmed Kamal (2017). Synthesis and biological evaluation of cis -restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers . Bioorganic & Medicinal Chemistry.
Subba Rao, A.V., Swapna, K., Shaik, S.P., Lakshma Nayak, V., Srinivasa Reddy, T., Sunkari, S., Shaik, T.B., Bagul, C., Kamal, A.(2017). Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers . Bioorganic and Medicinal Chemistry. 25. (3). p. 977-999.
Shaik, T.B., Hussaini, S.M.A., Nayak, V.L., Sucharitha, M.L., Malik, M.S., Kamal, A.(2017). Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents . Bioorganic and Medicinal Chemistry Letters. 27. (11). p. 2549-2558.
Mahesh, R., Nayak, V.L., Babu, K.S., Riyaz, S., Shaik, T.B., Kumar, G.B., Mallipeddi, P.L., Reddy, C.R., Shekar, K.C., Jose, J., et al.(2017). Design, Synthesis, and in vitro and in vivo Evaluations of (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors . ChemMedChem. 12. (9). p. 678-700.
Sultana, F., Shaik, S.P., Nayak, V.L., Hussaini, S.M.A., Marumudi, K., Sridevi, B., Shaik, T.B., Bhattacharjee, D., Alarifi, A., Kamal, A.(2017). Design, Synthesis and Biological Evaluation of 2-Anilinopyridyl-Linked Oxindole Conjugates as Potent Tubulin Polymerisation Inhibitors . ChemistrySelect. 2. (31). p. 9901-9910.
Subba Rao AV, Swapna K, Shaik SP, Lakshma Nayak V, Srinivasa Reddy T, Sunkari S, Shaik TB, Bagul C, Kamal A (2016). Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers . Bioorganic & medicinal chemistry.
Subba Rao AV, Swapna K, Shaik SP, Lakshma Nayak V, Srinivasa Reddy T, Sunkari S, Shaik TB, Bagul C, Kamal A(2016). Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers . Bioorganic & medicinal chemistry.
Hussaini, S.M.A., Yedla, P., Babu, K.S., Shaik, T.B., Chityal, G.K., Kamal, A.(2016). Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives . Chemical Biology and Drug Design. p. 97-109.
Ashraf, M., Shaik, T.B., Malik, M.S., Syed, R., Mallipeddi, P.L., Vardhan, M.V.P.S.V., Kamal, A.(2016). Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability . Bioorganic and Medicinal Chemistry Letters. 26. (18). p. 4527-4535.
Kamal A, Ashraf M, Basha ST, Ali Hussaini SM, Singh S, Vishnuvardhan MV, Kiran B, Sridhar B(2015). Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors . Organic & biomolecular chemistry.
Kamal A, Shaik TB, Malik MS(2015). Embracing synthetic lethality of novel anticancer therapies . Expert opinion on drug discovery.
Kamal, A., Shaik, T.B., Malik, M.S.(2015). Embracing synthetic lethality of novel anticancer therapies . Expert Opinion on Drug Discovery. 10. (10). p. 1119-1132.
Kamal A, Hussaini SM, Nayak VL, Malik MS, Sucharitha ML, Shaik TB, Ashraf M, Bagul C(2014). Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents . Bioorganic & medicinal chemistry.
Kamal A, Balakrishna M, Nayak VL, Shaik TB, Faazil S, Nimbarte VD(2014). Design and synthesis of imidazo[2,1-b]thiazole-chalcone conjugates: microtubule-destabilizing agents . ChemMedChem.
Kamal A, Shaik B, Nayak VL, Nagaraju B, Kapure JS, Shaheer Malik M, Shaik TB, Prasad B(2014). Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers . Bioorganic & medicinal chemistry.
Kamal, A., Balakrishna, M., Nayak, V.L., Shaik, T.B., Faazil, S., Nimbarte, V.D.(2014). Design and synthesis of imidazo[2,1-b]thiazole-chalcone conjugates: Microtubule-destabilizing agents . ChemMedChem. 9. (12). p. 2766-2780.
Kamal, A., Ali Hussaini, S.M., Lakshma Nayak, V., Shaheer Malik, M., Lakshmi Sucharitha, M., Shaik, T.B., Ashraf, M., Bagul, C.(2014). Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents . Bioorganic and Medicinal Chemistry. 22. (24). p. 6755-6767.
Kamal, A., Shaik, B., Nayak, V.L., Nagaraju, B., Kapure, J.S., Shaheer Malik, M., Shaik, T.B., Prasad, B.(2014). Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers . Bioorganic and Medicinal Chemistry. 22. (19). p. 5155-5167.
(2012). Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors . European Journal of Medicinal Chemistry.
(2012). p53–Mdm2 inhibitors: patent review (2009 – 2010) . Expert Opinion on Therapeutic Patents.
Kamal, A., Mallareddy, A., Suresh, P., Shaik, T.B., Lakshma Nayak, V., Kishor, C., Shetti, R.V.C.R.N.C., Sankara Rao, N., Tamboli, J.R., Ramakrishna, S., et al.(2012). Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents . Bioorganic and Medicinal Chemistry. 20. (11). p. 3480-3492.
Kamal, A., Mallareddy, A., Suresh, P., Lakshma Nayak, V., Shetti, R.V.C.R.N.C., Sankara Rao, N., Tamboli, J.R., Shaik, T.B., Vishnuvardhan, M.V.P.S., Ramakrishna, S.(2012). Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents . European Journal of Medicinal Chemistry. 47. (1). p. 530-545.
Kamal, A., Mohammed, A.A., Shaik, T.B.(2012). P53-Mdm2 inhibitors: Patent review (2009-2010) . Expert Opinion on Therapeutic Patents. 22. (2). p. 95-105.
Kamal, A., Srikanth, Y.V.V., Khan, M.N.A., Ashraf, Md., Shaik, T.B., Kalivendi, S.V.(2012). Synthesis, anticancer activity and inhibition of tubulin polymerization of bisindole sulfonates . Letters in Drug Design and Discovery. 9. (3). p. 242-250.
Kamal, A., Kashi Reddy, M., Shaik, T.B., Rajender, Srikanth, Y.V.V., Santhosh Reddy, V., Bharath Kumar, G., Kalivendi, S.V.(2012). Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors . European Journal of Medicinal Chemistry. 50. p. 9-17.
Kamal A, Srikanth YV, Ashraf M, Khan MN, Shaik TB, Kalivendi SV, Suri N, Saxena AK(2011). Synthesis and anticancer activities of new Benzothiadiazinyl Hydrazinecarboxamides and Anilino[1,2,4]triazolo[1,5-b][1,2,4]thiadiazine 5,5-diones. Medicinal chemistry (Shariqah (United Arab Emirates)).
Raju BC, Rao RN, Suman P, Yogeeswari P, Sriram D, Shaik TB, Kalivendi SV(2011). Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents . Bioorganic & medicinal chemistry letters.
Kamal, A., Shiva Kumar, M., Ganesh Kumar, C., Shaik, T.B.(2011). Bioconversion of acrylonitrile to acrylic acid by Rhodococcus ruber strain AKSH-84 . Journal of Microbiology and Biotechnology. 21. (1). p. 37-42.
China Raju, B., Nageswara Rao, R., Suman, P., Yogeeswari, P., Sriram, D., Shaik, T.B., Kalivendi, S.V.(2011). Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents . Bioorganic and Medicinal Chemistry Letters. 21. (10). p. 2855-2859.
Jain, N., Yada, D., Shaik, T.B., Vasantha, G., Reddy, P.S., Kalivendi, S.V., Sreedhar, B.(2011). Synthesis and antitumor evaluation of nitrovinyl biphenyls: Anticancer agents based on allocolchicines . ChemMedChem. 6. (5). p. 859-868.
Kamal, A., Suresh, P., Mallareddy, A., Kumar, B.A., Reddy, P.V., Raju, P., Tamboli, J.R., Shaik, T.B., Jain, N., Kalivendi, S.V.(2011). Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents . Bioorganic and Medicinal Chemistry. 19. (7). p. 2349-2358.
Kamal, A., Bharathi, E.V., Reddy, J.S., Ramaiah, M.J., Dastagiri, D., Reddy, M.K., Viswanath, A., Reddy, T.L., Shaik, T.B., Pushpavalli, S.N.C.V.L., et al.(2011). Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents . European Journal of Medicinal Chemistry. 46. (2). p. 691-703.
Kamal, A., Srikanth, Y.V.V., Shaik, T.B., Khan, M.N.A., Ashraf, M., Reddy, M.K., Kumar, K.A., Kalivendi, S.V.(2011). 2-Anilinonicotinyl linked 1,3,4-oxadiazole derivatives: Synthesis, antitumour activity and inhibition of tubulin polymerization . MedChemComm. 2. (9). p. 819-823.
Kamal, A., Srikanth, Y.V.V., Ashraf, Md., Khan, M.N.A., Shaik, T.B., Kalivendi, S.V., Suri, N., Saxena, A.K.(2011). Synthesis and anticancer activities of new benzothiadiazinyl hydrazinecarboxamides and anilino[1,2,4]triazolo[1,5-b][1,2,4]thiadiazine 5,5-diones . Medicinal Chemistry. 7. (3). p. 165-172.
Suresh G, Reddy PP, Babu KS, Shaik TB, Kalivendi SV(2010). Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium . Bioorganic & medicinal chemistry letters.
Kamal A, Srikanth YV, Khan MN, Shaik TB, Ashraf M(2010). Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activity . Bioorganic & medicinal chemistry letters.
Yadav JS, Satyanarayana K, Sreedhar P, Srihari P, Shaik TB, Kalivendi SV(2010). Total synthesis of (+/-)-elegansidiol, (+/-)-farnesiferol B, and (+/-)-farnesiferol D . Bioorganic & medicinal chemistry letters.
Kamal, A., Srikanth, Y.V.V., Khan, M.N.A., Shaik, T.B., Ashraf, M.(2010). Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl <sub>3</sub> and their in vitro evaluation for anticancer activity . Bioorganic and Medicinal Chemistry Letters. 20. (17). p. 5229-5231.
Yadav, J.S., Satyanarayana, K., Sreedhar, P., Srihari, P., Shaik, T.B., Kalivendi, S.V.(2010). Erratum: Total synthesis of (±)-elegansidiol, (±)- farnesiferol B and (±)-farnesiferol D (Bioorganic and Medicinal Chemistry Letters (2010) 20 (3814) DOI: 10.1016/j.bmcl.2010.04.030) . Bioorganic and Medicinal Chemistry Letters. 20. (22). p. 6863.
Yadav, J.S., Satyanarayana, K., Sreedhar, P., Srihari, P., Shaik, T.B., Kalivendi, S.V.(2010). Total synthesis of (±)-elegansidiol, (±)-farnesiferol B, and (±)-farnesiferol D . Bioorganic and Medicinal Chemistry Letters. 20. (12). p. 3814-3817.
Suresh, G., Prabhakar Reddy, P., Suresh Babu, K., Shaik, T.B., Kalivendi, S.V.(2010). Two new cytotoxic labdane diterpenes from the rhizomes of Hedychium coronarium . Bioorganic and Medicinal Chemistry Letters. 20. (24). p. 7544-7548.
Kamal, A., Rajender, Reddy, D.R., Reddy, M.K., Balakishan, G., Shaik, T.B., Chourasia, M., Sastry, G.N.(2009). Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential . Bioorganic and Medicinal Chemistry. 17. (4). p. 1557-1572.
OTHER
Shaik, T.B., Shaheer Malik, M., Seddigi, Z.S., Routhu, S.R., Kamal, A.(2017). Evaluation of anticancer and anti-mitotic properties of quinazoline and quinazolino-benzothiadiazine derivatives . bioRxiv.