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Hire Susmita G.

United States

USD 100 /hr

Cancer Biologist with 10+ years of research experience | Scientific Writer | Research Consultant | Guest Reviewer (MDPI)

Profile Summary

Dear future collaborators, I am an enthusiastic researcher with professional expertise in the field of Cancer Therapeutics, Cancer Immunology and Inflammation Biology. I received my Ph.D. from India. My Ph.D. work was focused on isolation and characterization of an active compound having anti-arthritic properties from Bungarus fasciatus venom. I obtained my first postdoctoral training from Ben-Gurion University of the Negev, Israel. There I established a novel tumor explant culture system for predicting patient specific drug responses. Thereafter, I joined MD Anderson Cancer Center, USA for my second postdoctoral training. I started investigating potential drug combinations that can be translated from bench to bedside in patients with KRAS mutated colorectal cancer using high-throughput drug screens. Presently, I am a Research Investigator in MD Anderson Cancer Center, USA and I am involved in (1) reprogramming of induced pluripotent stem cells (iPSCs) and in vitro differentiation to NK cells and (2) improvement of NK cell anti-tumor activity in AML patients. I have presented my scientific work in several international conferences including AACR annual meeting 2022 and 2023. My academic training and research experience to-date have provided me an in-depth knowledge of translational cancer research; scientific data analysis; writing scientific articles, fellowships and grants. I am honored to serve as a Guest Reviewer for MDPI journals. I have peer-reviewed several research articles for International Journal of Molecular Sciences, Cancers (Basel) and Journal of Clinical Medicine where I have given valuable input to improve the overall quality of the article. I am thrilled to collaborate with you in your next project. With Regards, Susmita Ghosh, Ph.D.

Subject Matter Expertise

• ☆ Zoology
• ☆ Venom
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Apoptosis
• ☆ Molecular Biology
• ☆ Gene Expression Analysis
• ☆ Kinases
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cytochemistry
• ☆ Cell Signaling Pathways
• ☆ Stem Cell Research
• ☆ Histology
• ☆ Microscopy
• ☆ Fluorescence Microscopy
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ 3D Cell Culture
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Drug Development
• ☆ In vivo Preclinical Toxicology
• ☆ Colorectal Cancer
• ☆ Pulmonology/Respiratory Disease
• ☆ Lung Cancer
• ☆ Cancer Research

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Analysis, Data Visualization

Work Experience

Research Investigator

The University of Texas MD Anderson Cancer Center

October 2023 - Present

Postdoctoral fellow

The University of Texas MD Anderson Cancer Center

November 2020 - October 2023

Research Fellow

Ben-Gurion University (Beer Sheva, Israel)

March 2018 - April 2019

Education

Ph.D. in Science (Zoology)

University of Calcutta - Rajabazar Science College Campus

2013 - 2018

M.Sc. (Zoology)

Presidency University

2010 - 2012

B.Sc. (Honors) (Zoology)

South Calcutta Girls' College

2007 - 2010

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Susmita Ghosh, Fan Fan, Reid T. Powell, Jason Roszik, Yong Sung Park, Clifford Stephan, Manu Sebastian, Lin Tan, Alexey V. Sorokin, Philip L. Lorenzi, et al. (2023). Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer . Molecular Cancer Therapeutics.

Susmita Ghosh, Fan Fan, Reid Powell, Jason Roszik, Yongsun Park, Mary Sobieski, Alexey Sorokin, Clifford Stephan, Scott Kopetz, Lee M. Ellis, et al.(2023). Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo . PLOS ONE. 18. (3). p. e0281063. Public Library of Science ({PLoS})

Fan, F., Ghosh, S., Powell, R., Roszik, J., Park, Y., Sobieski, M., Sorokin, A., Stephan, C., Kopetz, S., Ellis, L.M., et al.(2023). Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo . PLoS ONE. 18. (3 March).

Ghosh, S., Fan, F., Powell, R.T., Roszik, J., Park, Y.S., Stephan, C., Sebastian, M., Tan, L., Sorokin, A.V., Lorenzi, P.L., et al.(2023). Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer . Molecular Cancer Therapeutics. 22. (8). p. 962-975.

Susmita Ghosh (2022). Cytospin-A Regulates Colorectal Cancer Cell Division and Migration by Modulating Stability of Microtubules and Actin Filaments . Cancers.

Ghosh, Susmita, Fan, Fan, Roszik, Jason, Xia, Ling, Wang, Rui, Ye, Xiangcang, Hawke, David, Ellis, Lee M., Bhattacharya, Rajat (2022). Cytospin-A Regulates Colorectal Cancer Cell Division and Migration by Modulating Stability of Microtubules and Actin Filaments . Cancers.

Fan, F., Roszik, J., Xia, L., Ghosh, S., Wang, R., Ye, X., Hawke, D., Ellis, L.M., Bhattacharya, R.(2022). Cytospin-A Regulates Colorectal Cancer Cell Division and Migration by Modulating Stability of Microtubules and Actin Filaments . Cancers. 14. (8).

Susmita Ghosh (2021). Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity . Scientific reports.

Ghosh, Susmita, Ottolenghi, Aner, Bolel, Priyanka, Sarkar, Rhitajit, Greenshpan, Yariv, Iraqi, Muhammed, Bhattacharya, Baisali, Taylor, Zoe, V, Kundu, Kiran, Radinsky, Olga, et al. (2021). Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity . Scientific Reports.

Ottolenghi, A., Bolel, P., Sarkar, R., Greenshpan, Y., Iraqi, M., Ghosh, S., Bhattacharya, B., Taylor, Z.V., Kundu, K., Radinsky, O., et al.(2021). Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity . Scientific Reports. 11. (1).

Ghosh, Susmita, Fan, Fan, Ellis, Lee, Bhattacharya, Rajat (2021). Effects of chemotherapy on activation of the STING signaling pathway and enhancing immunotherapy responses in colorectal cancer . Cancer Research.

Susmita Ghosh (2019). Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA . Cancer immunology research.

Susmita Ghosh (2019). Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy . Frontiers in oncology.

Ghosh, Susmita, Prasad, Manu, Kundu, Kiran, Cohen, Limor, Yegodayev, Ksenia M., Zorea, Jonathan, Joshua, Ben-Zion, Lasry, Batel, Dimitstein, Orr, Bahat-Dinur, Anat, et al. (2019). Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy . Frontiers in Oncology.

Ghosh, S., Prasad, M., Kundu, K., Cohen, L., Yegodayev, K.M., Zorea, J., Joshua, B.-Z., Lasry, B., Dimitstein, O., Bahat-Dinur, A., et al.(2019). Tumor tissue explant culture of patient-derived xenograft as potential prioritization tool for targeted therapy . Frontiers in Oncology. 9. (JAN).

Ghosh, Susmita, Kundu, Kiran, Sarkar, Rhitajit, Edri, Avishay, Brusilovsky, Michael, Gershoni-Yahalom, Orly, Yossef, Rami, Shemesh, Avishai, Soria, Jean-Charles, Lazar, Vladimir, et al. (2019). Inhibition of the NKp44-PCNA Immune Checkpoint Using a mAb to PCNA . Cancer Immunology Research.

Kundu, K., Ghosh, S., Sarkar, R., Edri, A., Brusilovsky, M., Gershoni-Yahalom, O., Yossef, R., Shemesh, A., Soria, J.-C., Lazar, V., et al.(2019). Inhibition of the NKp44-PCNA immune checkpoint using a MAb to PCNA . Cancer Immunology Research. 7. (7). p. 1120-1134.

Susmita Ghosh (2018). IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer . Cell death & disease.

Susmita Ghosh (2018). NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death . Frontiers in immunology.

Ghosh, Susmita, Shemesh, Avishai, Kundu, Kiran, Peleg, Refael, Yossef, Rami, Kaplanov, Irena, Khrapunsky, Yana, Gershoni-Yahalom, Orly, Rabinski, Tatiana, Cerwenka, Adelheid, et al. (2018). NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death . Frontiers in Immunology.

Shemesh, A., Kundu, K., Peleg, R., Yossef, R., Kaplanov, I., Ghosh, S., Khrapunsky, Y., Gershoni-Yahalom, O., Rabinski, T., Cerwenka, A., et al.(2018). NKp44-derived peptide binds proliferating cell nuclear antigen and mediates tumor cell death . Frontiers in Immunology. 9. (MAY).

Ghosh, S., Elkabets, M., Kundu, K., Roisman, L., Levitas, D., Porgador, A., Peled, N. (2018). Ex Vivo 2(star)2(star)2 Tumor Tissue Explant Culture for Precision Medicine in Immunotherapy and TKI progressors in Lung Cancer . Journal of Thoracic Oncology.

Ghosh, Susmita, Zorea, Jonatan, Prasad, Manu, Cohen, Limor, Li, Nan, Schefzik, Roman, Rotblat, Barak, Brors, Benedikt, Elkabets, Moshe (2018). IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in <i>PIK3CA</i>-driven ovarian cancer . Cell Death and Disease.

Zorea, J., Prasad, M., Cohen, L., Li, N., Schefzik, R., Ghosh, S., Rotblat, B., Brors, B., Elkabets, M.(2018). IGF1R upregulation confers resistance to isoform-specific inhibitors of PI3K in PIK3CA-driven ovarian cancer . Cell Death and Disease. 9. (10).

Susmita Ghosh (2016). Anti-osteoarthritic activity of Bungarus fasciatus venom fraction BF-F47 involving molecular markers in the rats . Toxicon : official journal of the International Society on Toxinology.

Ghosh, Susmita, Gomes, Antony, Ghosh, Sourav, SahaA, Ialyani, Saha, Partha Pratim, Dasgupta, Subir Chandra, Gomes, Aparna (2016). Anti-osteoarthritic activity of Bungarus fasciatus venom fraction BF-F47 involving molecular markers in the rats . Toxicon.

Gomes, A., Ghosh, S., Ghosh, S., Saha, K., Saha, P.P., Dasgupta, S.C., Gomes, A.(2016). Anti-osteoarthritic activity of Bungarus fasciatus venom fraction BF-F47 involving molecular markers in the rats . Toxicon. 118. p. 43-46.

Ghosh, S., Saha, P.P., Dasgupta, S.C., Gomes, A.(2016). Antinociceptive, anti-inflammatory and antiarthritic activities of Bungarus fasciatus venom in experimental animal models . Indian Journal of Experimental Biology. 54. (9). p. 569-576.

Abstract 1056: Determining efficacy of combining the MEK inhibitor trametinib with vincristine identified by unbiased high throughput screening in RAS-mutated colorectal cancer cells .

Abstract 1285: Chemotherapy induces PD-L1 overexpression in CRC through NF-κBp65 .