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Hire Dr. Sourav B.

United States

Profile Summary

I obtained my Ph.D. degree from MRC laboratory, Dundee, UK with Prof. Dario Alessi. My thesis work was focused on LKB1 tumor suppressor activated NUAK1 kinase pathway in normal and various cancer cells. NUAK1 was reported to be an essential anti-apoptotic factor in Myc driven tumorigenesis and hence in collaboration with Dr. Nathanael Gray, Harvard Medical School, I developed highly specific NUAK1 inhibitors that target NUAK1 in various Myc overexpressing cancer cells. The inhibitors were extremely specific to NUAK1 and only inhibited NUAK1 within a range of 140 kinases tested including the close isoform NUAK2. Furthermore, I elucidated the role of NUAK1 as an essential kinase regulating the progression of the G2/M stage of the cell cycle and NUAK1 inhibition led to a cell cycle arrest and apoptotic cell death in various cancer cells. I have extensive expertise in various techniques in biochemistry and cancer biology including cell migration, invasion, proliferation and a strong background of pharmacological techniques like drug screening, in vitro and in vivo IC50 measurements of drugs on various cancer cells. During my PhD training, I developed avid interest in understanding how cancers progress and metastasize, and how we can intervene this process and save patients by targeting the abnormal signal transduction in cancer cells. This interest remains unchanged in my current post-doctoral research in Prof. Dixon’s laboratory, UCSD.

Subject Matter Expertise

• ☆ Biochemistry
• ☆ Kinases
• ☆ Cell Signaling Pathways
• ☆ Protein/Enzyme Engineering
• ☆ Oncology
• ☆ Cancer Research

Services

• Consulting
• Product Development

Work Experience

Academic

University of Dundee

March 2020 - Present

Post-doctoral scholar

University of California San Diego

July 2014 - Present

Education

PhD Life Sciences (MRC)

MRC Protein Phosphorylation Unit

October 2009 - November 2013

M.Res. Biomedical Sciences (Biomedical Sciences)

University of Glasgow

September 2008 - December 2009

B.Tech Biotechnology (Biotechnology)

Yashwantrao Chavan Maharashtra Open University

June 2004 - June 2008

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Sourav Banerjee, Tiantian Wei, Jue Wang, Jenna J. Lee, Haydee L. Gutierrez, Owen Chapman, Sandra E. Wiley, Joshua E. Mayfield, Vasudha Tandon, Edwin F. Juarez, et al.(2019). Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression . Proceedings of the National Academy of Sciences. 116. (49). p. 24881--24891. National Academy of Sciences

Sourav Banerjee, Tiantian Wei, Jue Wang, Jenna J. Lee, Haydee L. Gutierrez, Owen Chapman, Sandra E. Wiley, Joshua E. Mayfield, Vasudha Tandon, Edwin F. Juarez, et al.(2019). Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression . Proceedings of the National Academy of Sciences. 116. (49). p. 24881--24891. Proceedings of the National Academy of Sciences

Sourav Banerjee, Yimin Qiu, Erik Poppleton, Arya Mekkat, Hongtao Yu, Sandra E. Wiley, Jack E. Dixon, David L. Kaplan, Yu Shan Lin, Barbara Brodsky(2018). Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide . Biophysical Journal. 115. (12). p. 2327--2335. Biophysical Society

Sourav Banerjee, Chenggong Ji, Joshua E. Mayfield, Apollina Goel, Junyu Xiao, Jack E. Dixon, Xing Guo(2018). Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2 . Proceedings of the National Academy of Sciences. 115. (32). p. 8155--8160. National Academy of Sciences

Sourav Banerjee, Chenggong Ji, Joshua E. Mayfield, Apollina Goel, Junyu Xiao, Jack E. Dixon, Xing Guo(2018). Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2 . Proceedings of the National Academy of Sciences. 115. (32). p. 8155--8160. Proceedings of the National Academy of Sciences

(2018). Enzymatic Phosphorylation of Ser in a Type I Collagen Peptide . Biophysical Journal.

Sourav Banerjee, Jelena Todoric, Laura Antonucci, Giuseppe Di Caro, Ning Li, Xuefeng Wu, Nikki K. Lytle, Debanjan Dhar, Johan B. Fagman, Cecille D. Browne, et al.(2017). Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas . Cancer Cell. 32. (6). p. 824--839.e8. Elsevier

(2017). Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas .

Todoric, J., Antonucci, L., Di Caro, G., Li, N., Wu, X., Lytle, N.K., Dhar, D., Banerjee, S., Fagman, J.B., Browne, C.D., et al.(2017). Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas . Cancer Cell. 32. (6). p. 824-839.e8.

Sourav Banerjee, Xing Guo, Xiaorong Wang, Zhiping Wang, Jing Yang, Lan Huang, Jack E. Dixon(2016). Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis . Nature Cell Biology. 18. (2). p. 202--212. Nature Publishing Group

Guo, X., Wang, X., Wang, Z., Banerjee, S., Yang, J., Huang, L., Dixon, J.E.(2016). Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis . Nature Cell Biology. 18. (2). p. 202-212.

Sourav Banerjee, Giorgio Cozza, Mauro Salvi, Elena Tibaldi, Vincent S. Tagliabracci, Jack E. Dixon, Lorenzo A. Pinna(2015). A new role for sphingosine: Up-regulation of Fam20C . Biochimica et Biophysica Acta. Proteins and Proteomics. 1854. (10). p. 1718--1726. Elsevier

Cozza, G., Salvi, M., Banerjee, S., Tibaldi, E., Tagliabracci, V.S., Dixon, J.E., Pinna, L.A.(2015). A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins . Biochimica et Biophysica Acta - Proteins and Proteomics. 1854. (10). p. 1718-1726.

Sourav Banerjee, Anna Zagorska, Maria Deak, David G. Campbell, Alan Prescott, Dario Alessi(2014). Interplay between Polo kinase . Biochemical Journal. 461. (2). p. 233--245. Portland Press

Sourav Banerjee, Sara J Buhrlage, Hai-Tsang Huang, Xianming Deng, Wenjun Zhou, Jinhua Wang, Ryan Traynor, Alan Prescott, Dario Alessi, Nathanael S. Gray(2014). Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases . Biochemical Journal. 457. (1). p. 215--225. Portland Press

Banerjee, S., Buhrlage, S.J., Huang, H.-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A.R., Alessi, D.R., Gray, N.S.(2014). Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases . Biochemical Journal. 457. (1). p. 215-225.

Banerjee, S., Zagórska, A., Deak, M., Campbell, D.G., Prescott, A.R., Alessi, D.R.(2014). Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1β^MYPT1 phosphatase complex and the SC^βTrCP E3 ubiquitin ligase . Biochemical Journal. 461. (2). p. 233-245.

Sourav Banerjee, Anna Zagorska, Maria Deak, David G. Campbell, Mariko Hirano, Shinichi Aizawa, Alan Prescott, Dario Alessi(2010). New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion . Science Signaling. 3. (115). p. --. American Association for the Advancement of Science

Zagórska, A., Deak, M., Campbell, D.G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A.R., Alessi, D.R.(2010). New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion . Science Signaling. 3. (115).