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☆☆☆☆☆

Hire Dr. Simone C.

Germany

USD 50 /hr

Expert in RNA-LNPs for pulmonary delivery, gene editing, nebulization, formulation design, and scientific writing

Profile Summary

I am a Pharmacist with a PhD in Biotechnology, specializing in drug delivery systems. During my PhD, I worked on the synthesis and functionalization of inhalable nanoparticles for in vitro evaluation in tuberculosis treatment, and as a Postdoc, my research focuses on RNA-based lipid nanoparticles for pulmonary delivery. One of my main projects involves developing CRISPR/Cas9 lipid nanoparticles for gene editing in lung cancer. Additionally, I work on refining analytical techniques for accurate characterization of mRNA-lipid nanoparticles and am involved in projects investigating the nebulization properties of siRNA and mRNA-LNPs, as well as studying the influence of lipid composition on the fate of siRNA-LNPs. I bring extensive expertise in formulation design, characterization, optimization, in vitro assessments, and pulmonary administration in preclinical models. My contributions to the field include publications in nanomedicine, drug delivery, and biointerfaces, as well as involvement in patent applications. I have strong experience writing scientific papers, grants, book chapters, and reviewing for international journals. Furthermore, I excel in mentoring students, designing projects, and providing constructive feedback on their reports, theses, and presentations. My skills in scientific writing and presenting complex ideas clearly make me a strong candidate for freelance scientific work.

Subject Matter Expertise

• ★ Drug Formulation
• ★ Gene Therapy
• ★ Drug Delivery Technologies
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Drug Development
• ☆ Bioanalytical Testing
• ☆ Drug Stability Testing
• ☆ Preclinical Research
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Drug Efficacy Testing
• ☆ Liposomes
• ☆ Pharmaceutical Technology
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ Literature Search
• ☆ Gap Analysis
• ☆ Presentation Design
• ☆ Animation & Illustration
• ☆ Scientific Animation & Illustration
• ☆ Medical Illustration
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Instructional Materials
• ☆ Release Notes
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing
• ☆ Language Translation
• ☆ Grant Writing
• ☆ Formulation
• ☆ Pharmaceutical Formulation

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Copywriting, Creative Writing

Research Gap Analysis, Scientific and Technical Research

Consulting Scientific and Technical Consulting

Data & AI Data Visualization

Product Development Formulation, Manufacturing

Work Experience

Postdoctoral Researcher

Ludwig-Maximilians Univerisity Munich

July 2024 - Present

Postdoctoral Fellow (Alexander von Humboldt Foundation)

Ludwig-Maximilians Univerisity Munich

October 2021 - June 2024

Postdoctoral Researcher

Federal University of Ouro Preto (UFOP, Brazil)

May 2020 - September 2021

Assistant professor of Pharmaceutical Technology (temporary)

Federal University of Ouro Preto (UFOP, Brazil)

July 2014 - January 2015

Education

PhD in Biotechnology

Federal University of Ouro Preto

May 2014 - February 2019

Masters in Pharmaceutical Sciences

Federal University of Ouro Preto

March 2011 - July 2013

Pharmacist

Federal University of Ouro Preto

August 2005 - January 2010

Certifications

• Advanced training in legal regulations of laboratory animal work

  Ludwig-Maximilians University of Munich

  December 2022 - Present

• Reading Comprehension - German

  Carl Duisberg Centren

  June 2022 - Present

• Reading Comprehension - French

  Alliance française

  September 2013 - Present

• Written English

  AI School

  January 2010 - Present

Publications

JOURNAL ARTICLE

Marta Cabibbo, Cinzia Scialabba, Emanuela F. Craparo, Simone P. Carneiro, Olivia M. Merkel, Gennara Cavallaro (2024). Diving into RNAi Therapy: An Inhalable Formulation Based on Lipid–Polymer Hybrid Systems for Pulmonary Delivery of siRNA . Biomacromolecules.

Simone Carneiro, Kai Berkenfeld, Carolina Corzo, Flavia Laffleur, Sharareh Salar-Behzadi, Benjamin Winkeljann, Golbarg Esfahani (2024). Formulation strategies, preparation methods, and devices for pulmonary delivery of biologics . European Journal of Pharmaceutics and Biopharmaceutics.

Charmante Registre, Luciana Miranda Silva, Farah Registre, Rodrigo Dian de Oliveira Aguiar Soares, Karina Taciana Santos Rubio, Simone Pinto Carneiro, Orlando David Henrique dos Santos (2024). Targeting Leishmania Promastigotes and Amastigotes Forms through Amino Acids and Peptides: A Promising Therapeutic Strategy . ACS Infectious Diseases.

Fernanda B Perasoli, Luan S B Silva, Bruna I C Figueiredo, Isabelle C Pinto, Lorrane J F Amaro, Juliana C S Almeida Bastos, Simone P Carneiro, Vânia P R Araújo, Felipe R G Beato, Ana P M Barboza, et al. (2024). Poly(methylmethacrylate-co-dimethyl acrylamide)–silver nanocomposite prevents biofilm formation in medical devices . Nanomedicine.

Simone Carneiro, Natascha Hartl, David C. Jürgens, Ann-Christine König, Ximian Xiao, Runhui Liu, Stefanie M. Hauck, Olivia Merkel(2023). Protein corona investigations of polyplexes with varying hydrophobicity – From method development to in vitro studies . International Journal of Pharmaceutics. 643. p. 123257. Elsevier {BV}

Simone P. Carneiro, Antonietta Greco, Enrica Chiesa, IDA GENTA, Olivia Merkel(2023). Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases . Expert Opinion on Drug Delivery. p. 1--17. Informa {UK} Limited

Charmante Registre, Rodrigo D. O. A. Soares, Karina T. S. Rubio, Orlando D. H. Santos, Simone P. Carneiro (2023). A Systematic Review of Drug-Carrying Nanosystems Used in the Treatment of Leishmaniasis . ACS Infectious Diseases.

Perasoli, F., Silva, L., Figueiredo, B., Bastos, J., Carneiro, S., Sampaio, J., Araújo, V., Beato, F.R., Araújo, F., Barboza, A.P., et al.(2023). Mechanisms Related to Inhibition of Fungal Biofilm Formation on Medical Device Coated with Poly(Methylmethacrylate-co-Dimethylacrylamide) . Biointerface Research in Applied Chemistry. 13. (4).

Yao Jin, Friederike Adams, Anny Nguyen, Sebastian Sturm, Simone Carnerio, Knut Müller-Caspary, Olivia Merkel (2023). Synthesis and application of spermine-based amphiphilic poly(β-amino ester)s for siRNA delivery . Nanoscale Advances.

Perasoli, F., Silva, L., Figueiredo, B., Bastos, J., Carneiro, S., Sampaio, J., Araújo, V., Beato, F.R., Araújo, F., Barboza, A.P., et al.(2023). Mechanisms Related to Inhibition of Fungal Biofilm Formation on Medical Device Coated with Poly(Methylmethacrylate-co-Dimethylacrylamide) . Biointerface Research in Applied Chemistry. 13. (4).

Registre, C., Soares, R.D.O.A., Rubio, K.T.S., Santos, O.D.H., Carneiro, S.P.(2023). A Systematic Review of Drug-Carrying Nanosystems Used in the Treatment of Leishmaniasis . ACS Infectious Diseases. 9. (3). p. 423-449.

Registre, C., Soares, R.D.O.A., Rubio, K.T.S., Santos, O.D.H., Carneiro, S.P.(2023). A Systematic Review of Drug-Carrying Nanosystems Used in the Treatment of Leishmaniasis . ACS Infectious Diseases. 9. (3). p. 423-449.

Carneiro, S.P., Greco, A., Chiesa, E., Genta, I., Merkel, O.M.(2023). Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases . Expert Opinion on Drug Delivery.

Carneiro, S.P., Greco, A., Chiesa, E., Genta, I., Merkel, O.M.(2023). Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases . Expert Opinion on Drug Delivery.

Mechanisms Related to Inhibition of Fungal Biofilm Formation on Medical Device Coated with Poly(Methylmethacrylate-co-Dimethylacrylamide) @article{2022, doi = {10.33263/briac134.332}, url = {https://doi.org/10.33263%2Fbriac134.332}, year = 2022, month = {sep}, publisher = {{AMG} Transcend Association}, volume = {13}, number = {4}, pages = {332}, title = {Mechanisms Related to Inhibition of Fungal Biofilm Formation on Medical Device Coated with Poly(Methylmethacrylate-co-Dimethylacrylamide)}, journal = {Biointerface Research in Applied Chemistry}} . Biointerface Research in Applied Chemistry.

Curso de Verão em Biotecnologia: um relato da experiência na Universidade Federal de Ouro Preto <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Revista Brasileira de Ensino Superior.

(2019). Pyrazinoic acid-Poly(malic acid) biodegradable nanoconjugate for efficient intracellular delivery . Precision Nanomedicine.

Simone Pinto Carneiro, Karen Vitor Carvalho, Rodrigo Dian de Oliveira Aguiar Soares, Cl&#225;udia Martins Carneiro, Milton H&#233;rcules Guerra de Andrade, Rafael Silva Duarte, Orlando David Henrique dos Santos(2019). Functionalized rifampicin-loaded nanostructured lipid carriers enhance macrophages uptake and antimycobacterial activity . Colloids and Surfaces B: Biointerfaces. 175. p. 306--313. Elsevier {BV}

(2019). Seasonality study of essential oil from leaves of Cymbopogon densiflorus and nanoemulsion development with antioxidant activity . Flavour and Fragrance Journal.

Seibert, J.B., Rodrigues, I.V., Carneiro, S.P., Amparo, T.R., Lanza, J.S., Fr&#233;zard, F.J.G., de Souza, G.H.B., Santos, O.D.H.D.(2019). Seasonality study of essential oil from leaves of Cymbopogon densiflorus and nanoemulsion development with antioxidant activity . Flavour and Fragrance Journal. 34. (1). p. 5-14.

Carneiro, S.P., Carvalho, K.V., de Oliveira Aguiar Soares, R.D., Carneiro, C.M., de Andrade, M.H.G., Duarte, R.S., dos Santos, O.D.H.(2019). Functionalized rifampicin-loaded nanostructured lipid carriers enhance macrophages uptake and antimycobacterial activity . Colloids and Surfaces B: Biointerfaces. 175. p. 306-313.

Carneiro, S.P., Carvalho, K.V., de Oliveira Aguiar Soares, R.D., Carneiro, C.M., de Andrade, M.H.G., Duarte, R.S., dos Santos, O.D.H.(2019). Functionalized rifampicin-loaded nanostructured lipid carriers enhance macrophages uptake and antimycobacterial activity . Colloids and Surfaces B: Biointerfaces. 175. p. 306-313.

Seibert, J.B., Rodrigues, I.V., Carneiro, S.P., Amparo, T.R., Lanza, J.S., Fr&#233;zard, F.J.G., de Souza, G.H.B., Santos, O.D.H.D.(2019). Seasonality study of essential oil from leaves of Cymbopogon densiflorus and nanoemulsion development with antioxidant activity . Flavour and Fragrance Journal. 34. (1). p. 5-14.

(2015). Feasability of a new process to produce fast disintegrating pellets as novel multiparticulate dosage form for pediatric use . International Journal of Pharmaceutics.

(2015). Evaluation of short cycles of ultrasound application in nanoemulsions to obtain nanocapsules . Ultrasonics Sonochemistry.

Carneiro, S.P., Cruz, R.M., Dos Santos, O.D.H.(2015). Evaluation of short cycles of ultrasound application in nanoemulsions to obtain nanocapsules . Ultrasonics Sonochemistry. 27. p. 536-542.

Carneiro, S.P., Cruz, R.M., Dos Santos, O.D.H.(2015). Evaluation of short cycles of ultrasound application in nanoemulsions to obtain nanocapsules . Ultrasonics Sonochemistry. 27. p. 536-542.

Hoang Thi, T.H., Lhafidi, S., Carneiro, S.P., Flament, M.-P.(2015). Feasability of a new process to produce fast disintegrating pellets as novel multiparticulate dosage form for pediatric use . International Journal of Pharmaceutics. 496. (2). p. 842-849.

Hoang Thi, T.H., Lhafidi, S., Carneiro, S.P., Flament, M.-P.(2015). Feasability of a new process to produce fast disintegrating pellets as novel multiparticulate dosage form for pediatric use . International Journal of Pharmaceutics. 496. (2). p. 842-849.

(2014). Preparation and in vitro Evaluation of α and &#946; -Amyrins Loaded Nanoemulsions . Current Pharmaceutical Biotechnology.

Rodrigues, I.V., Seibert, J.B., Carneiro, S.P., De Souza, G.H.B., Dos Santos, O.D.H., Lopes, N.P.(2013). Preparation and in vitro evaluation of α and β -amyrins loaded nanoemulsions . Current Pharmaceutical Biotechnology. 14. (15). p. 1235-1241.

Rodrigues, I.V., Seibert, J.B., Carneiro, S.P., De Souza, G.H.B., Dos Santos, O.D.H., Lopes, N.P.(2013). Preparation and in vitro evaluation of α and β -amyrins loaded nanoemulsions . Current Pharmaceutical Biotechnology. 14. (15). p. 1235-1241.