Profile Details

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USD 55 /hr

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☆☆☆☆☆

Hire Dr. Shuo L.

United States

USD 55 /hr

Scientist with 10+ years experience in CRISPR design/editing, cell biology, neurobiology, imaging and academic writing

Profile Summary

I am a dedicated scientist with extensive experience in advanced cell engineering and genome editing, having worked in CRISPR-based biotech companies for the past two and a half years. My work has focused on editing established cell lines derived from a wide range of tissues, including the brain, muscle, skin, lung, heart, liver, stomach, pancreas, intestine, and blood. In addition, my technical expertise includes confocal imaging and neuronal morphology analysis, as well as identifying developmental and disease-related signaling pathways through genetic analysis. I have a strong foundation in molecular biology techniques, encompassing DNA, RNA, and protein analysis, and am proficient in bacteria and cell culture methods. I completed my Ph.D. in Neuroscience, and my postdoctoral training focused on neural development and neuroregeneration. I am dedicated to improving human health, and my research involves identifying molecular mechanisms underlying neurodegenerative and autoimmune disorders. I have led 4 different neuroscience projects since graduate school, and I independently discovered cellular functions for a conserved autoimmune risk gene and identified key genes required for the efficient generation of neurons from non-neuronal cells. I authored and co-authored 13 publications in leading journals such as Curr Biol, J Cell Biol, Development, and PNAS. My strong will to learn, passion for discovery, and ability to work well in a team drive my continuous pursuit of excellence in science and innovation.

Subject Matter Expertise

• ★ Study Design
• ★ Cell Culture
• ★ Gene Editing/CRISPR
• ☆ Developmental Biology
• ☆ Embryology
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Biochemical Assays
• ☆ Apoptosis
• ☆ Enzyme Activity Assays
• ☆ Binding Assays
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ DNA Sequencing
• ☆ Genome Sequencing
• ☆ Microinjection
• ☆ Mutagenesis
• ☆ Plasmid DNA
• ☆ Kinases
• ☆ Cell Biology
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Stem Cell Research
• ☆ Neuroscience
• ☆ Cognitive Neuroscience
• ☆ Neuroanatomy
• ☆ Developmental Neuroscience
• ☆ Molecular Neuroscience
• ☆ Neurobiology
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Cell Line Engineering
• ☆ Biomolecular Engineering
• ☆ Genetic Engineering
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Technical & Scientific Writing
• ☆ Science Communication

Services

• Writing
• Research
• Consulting

Writing Technical Writing, Newswriting, Audio Transcription, General Proofreading & Editing, Translation

Research Feasibility Study, Technology Scouting, Fact Checking, Gray Literature Search, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Work Experience

Scientists

EditCo

April 2024 - Present

Scientists

Synthego Corporation

July 2022 - March 2024

Associate Specialist III

UCSF Cardiovascular Research Institute

September 2017 - September 2021

Education

PhD

Washington University in St. Louis

August 2003 - August 2009

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Shuo Luo, Xin Wang, Meirong Bai, Wei Jiang, Zhe Zhang, Yifan Chen, Dengke K. Ma(2021). The conserved autoimmune-disease risk gene TMEM39A regulates lysosome dynamics . Proceedings of the National Academy of Sciences. 118. (6). Proceedings of the National Academy of Sciences

Shuo Luo, Zhe Zhang, Andrew D. Chisholm, Guilherme Oliveira Barbosa, Meirong Bai, Thomas B. Kornberg, Dengke K. Ma(2021). The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response . PLOS Genetics. 17. (2). p. e1009317. Public Library of Science ({PLoS})

(2020). Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking . Science advances.

(2019). VHL-1 inactivation and mitochondrial antioxidants rescue C. elegans dopaminergic neurodegeneration . Protein & cell.

(2018). A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans . eLife.

(2017). The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage . Current biology : CB.

(2014). The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans . Development (Cambridge, England).

(2010). HID-1, a new component of the peptidergic signaling pathway . Genetics.

(2008). Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans . Proceedings of the National Academy of Sciences of the United States of America.

(2006). Regulators of kinesin involved in polarized trafficking and axon outgrowth . Journal of biology.

(2006). Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans . Molecular biology of the cell.

(2006). Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay . Nature protocols.

(2005). {alpha}-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner . The Journal of cell biology.