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Hire Dr. Samik C.

United States

Cancer Researcher with 10+ years of experience and with a flair to solve problems.

Profile Summary

I am a cancer research scientist with a strong background in molecular biology and a flair to solve problems. I am looking forward to pursuing a career in research and development where I can make a positive contribution to the world by applying my scientific knowledge and skillset. ⚫ RESEARCHER I have 10+ years of experience in the field of cancer research both in vitro and in vivo systems which resulted in 23 peer-reviewed scientific publications in reputed journals and cited >700 times. Designed and executed experiments for analyzing and characterization of a wide range of cancer cell signaling. Helped to secure more than $600,000 in research grants from NIH and Indian agencies. ⚫ COLLABORATOR A cross-functional collaborator who has successfully managed multiple national and international collaborations with academicians, clinicians, and biotech/pharma experts which led to 6 peer-reviewed publications. ⚫ LEADER AND MENTOR Instructed, supervised, and mentored multiple MS and summer students, post-docs, and junior research fellows on standard laboratory procedures and motivated them to learn and perform at their best, which led to faster completion of projects. As a board member of the Boston Children’s Hospital postdoc association, organized several career development, mentoring, and social events for other postdocs. Helped in organization >6 national and international symposiums. ⚫ PROJECT MANAGER Effectively managed and coordinated with supervisors and collaborators for the perfect and timely execution of projects. Assured consistent protocol reproducibility without exceeding the predefined laboratory budget. Successfully negotiated with different biochemical and biotechnology companies to bargain the best deals of different consumables and reagents. ⚫ REVIEWER AND SCIENTIFIC WRITER Acted as an ad-hoc reviewer for 10> peer-reviewed journals. Reviewed 50+ manuscripts and book chapters. Served as a judge for the American Society for Biochemistry and Molecular Biology (ASBMB) Northeast Regional Meeting for two consecutive years. Please feel free to connect with me on LinkedIn or samik8981@gmail.com.

Subject Matter Expertise

• ★ Cell Signaling Pathways
• ★ Cancer Research

Services

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing, Copywriting, Newswriting

Research Market Research, User Research, Feasibility Study, Fact Checking, Gap Analysis, Gray Literature Search, Systematic Literature Review

Consulting Scientific and Technical Consulting

Product Development Formulation, Product Evaluation

Work Experience

Postdoctoral research fellow

Boston Children's Hospital

December 2015 - Present

https://connects.catalyst.harvard.edu/Profiles/display/Person/144933

Harvard Medical School

December 2015 - Present

Postdoctoral Scientist

MRC Toxicology Unit

February 2015 - October 2015

Ph.D research fellow/ Graduate research assistant

Bose Institute - Centenary Campus

January 2008 - January 2015

Education

Ph.D (Biochemistry)

University of Calcutta Department of Biochemistry

January 2008 - January 2015

Certifications

• Scientists Teaching Science

  Boston Children's Hospital

  July 2020 - Present

• Commercializing Technology: New Venture Creation for Life Scientists

  Boston Children's Hospital

  July 2018 - Present

• LEAD (Leadership Exploration and Development) Program

  Boston Children's Hospital

  April 2018 - Present

• Python for Life Scientists

  Boston Children's Hospital

  April 2018 - Present

• Analyzing and Communicating Biomedical Research II: Statistics and Probability for Life Scientists

  Boston Children's Hospital

  October 2017 - Present

Publications

JOURNAL ARTICLE

Samik Chakraborty and Murugabaskar Balan and Akash Sabarwal and Toni K. Choueiri and Soumitro Pal(2021). Metabolic reprogramming in renal cancer: Events of a metabolic disease . Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1876. (1). p. 188559. Elsevier {BV}

Samik Chakraborty, Yasaman Hamedani, Kalpana Ghoshal, Akash Sabarwal, Soumitro Pal, Sankha Bhowmick, Murugabaskar Balan(2020). Novel Honokiol-eluting PLGA-based scaffold effectively restricts the growth of renal cancer cells . PLOS ONE. 15. (12). p. e0243837. Public Library of Science ({PLoS})

Akash Sabarwal and Samik Chakraborty and Simran Mahanta and Selina Banerjee and Murugabaskar Balan and Soumitro Pal(2020). A Novel Combination Treatment with Honokiol and Rapamycin Effectively Restricts c-Met-Induced Growth of Renal Cancer Cells, and also Inhibits the Expression of Tumor Cell PD-L1 Involved in Immune Escape . Cancers. 12. (7). p. 1782. {MDPI} {AG}

Murugabaskar Balan and Samik Chakraborty and Soumitro Pal(2019). Signaling Molecules in Posttransplantation Cancer . Clinics in Laboratory Medicine. 39. (1). p. 171--183. Elsevier {BV}

Samik Chakraborty and Murugabaskar Balan and Evelyn Flynn and David Zurakowski and Toni K. Choueiri and Soumitro Pal(2019). Activation of c-Met in cancer cells mediates growth-promoting signals against oxidative stress through Nrf2-HO-1 . Oncogenesis. 8. (2). Springer Science and Business Media {LLC}

(2017). Honokiol inhibits c-Met-HO-1 tumor-promoting pathway and its cross-talk with calcineurin inhibitor-mediated renal cancer growth . Scientific Reports.

(2017). PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2 . Free radical biology & medicine.

et al.(2016). Non-migratory tumorigenic intrinsic cancer stem cells ensure breast cancer metastasis by generation of CXCR4(+) migrating cancer stem cells . Oncogene.

(2016). Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer . Scientific Reports.

et al.(2014). Nuclear matrix protein SMAR1 represses c-Fos-mediated HPV18 E6 transcription through alteration of chromatin histone deacetylation . The Journal of biological chemistry.

et al.(2014). Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation: dual role of scaffold/matrix attachment region-binding protein 1 (SMAR1) in breast cancer cells . The Journal of biological chemistry.

et al.(2014). Contribution of the ROS-p53 feedback loop in thuja-induced apoptosis of mammary epithelial carcinoma cells . Oncology reports.

(2014). Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells . FEBS letters.

et al.(2014). Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis . PloS one.

et al.(2014). ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors . Cell death & disease.

et al.(2014). Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop . Stem cell research & therapy.

et al.(2013). Targeting RET to induce medullary thyroid cancer cell apoptosis: an antagonistic interplay between PI3K/Akt and p38MAPK/caspase-8 pathways . Apoptosis : an international journal on programmed cell death.

et al.(2012). Nifetepimine, a dihydropyrimidone, ensures CD4+ T cell survival in a tumor microenvironment by maneuvering sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) . The Journal of biological chemistry.

et al.(2012). Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells . Oncogene.

(2012). Operation 'p53 Hunt' to combat cancer: theaflavins in action . Frontiers in bioscience (Scholar edition).

(2010). Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk . FEBS letters.

CONFERENCE POSTER

Samik Chakraborty and Murugabaskar Balan and Soumitro Pal(2019). Abstract 1039: c-Met activation promotes epithelial-to-mesenchymal transition (EMT) in renal cancer cells through the upregulation of the chemokine receptor CXCR7 . Tumor Biology. American Association for Cancer Research