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Biomedical Scientist | Life Sciences Advisor | Expert in Gene & RNA therapeutics & Drug Delivery
Profile Summary
Subject Matter Expertise
Services
Writing
Medical Writing,
Non-Medical Regulatory Writing,
Technical Writing
Research
Market Research,
Technology Scouting,
Fact Checking,
Gray Literature Search,
Scientific and Technical Research,
Systematic Literature Review,
Secondary Data Collection
Consulting
Healthcare Consulting,
Scientific and Technical Consulting
Product Development
Formulation,
Product Evaluation,
Concept Development
Work Experience
Junior Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde
January 2019 - Present 
Post-doctoral fellow
INEB
January 2012 - December 2018
Education
PhD (Laboratory Medicine)
Karolinska Institutet
March 2005 - August 2011
BSc (Biochemistry)
Universidade de Coimbra
September 1999 - September 2004
Certifications
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Product Management and Business Development
Invictus Sciences
https://www.icloud.com/iclouddrive/0efYIGRVPMgD6OdP1L5txkPig#Pedro_Moreno_ADVPMDB_CertifMarch 2024 - Present
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Clinical Investigator (Level 1)
Nova Medical School - Faculty of Medical Sciences - University of Lisbon
https://www.icloud.com/iclouddrive/0d662mRDl7qsAWgKmxJiy8ihg#Pedro_Moreno_CLICcertificateJuly 2023 - Present
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Drug Development Product Management Specialization (by University of California San Diego)
coursera
https://www.coursera.org/account/accomplishments/specialization/certificate/GSRXYLKHCZ3PJanuary 2023 - Present
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Financing Biotech Innovation
Technical University of Munich by edX online
https://courses.edx.org/certificates/c40d3ee26dec435aa3d4077c76d556bbSeptember 2022 - Present
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The science and business of biotechnology
MITx by EdX
https://courses.edx.org/certificates/7287e735f61944b6b76dc26e9e4f9c13July 2022 - Present
Publications
JOURNAL ARTICLE
Pedro M. D. Moreno, João Cortinhas, Ana S. Martins, Ana P. Pêgo (2022). Engineering a Novel Self-Assembled Multi-siRNA Nanocaged Architecture with Controlled Enzyme-Mediated siRNA Release . ACS Applied Materials & Interfaces.
Moreno, P.M.D., Ferreira, A.R., Salvador, D., Rodrigues, M.T., Torrado, M., Carvalho, E.D., Tedebark, U., Sousa, M.M., Amaral, I.F., Wengel, J., et al.(2018). Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury . Molecular Therapy - Nucleic Acids. 11. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 393-406.
Leiro, V., Garcia, J.P., Moreno, P.M.D., Spencer, A.P., Fernandez-Villamarin, M., Riguera, R., Fernandez-Megia, E., Paula Pêgo, A.(2017). Biodegradable PEG-dendritic block copolymers: Synthesis and biofunctionality assessment as vectors of siRNA . Journal of Materials Chemistry B. 5. (25). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4901-4917.
Zaghloul, E.M., Gissberg, O., Moreno, P.M.D., Siggens, L., Hallbrink, M., Jørgensen, A.S., Ekwall, K., Zain, R., Wengel, J., Lundin, K.E., et al.(2017). CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression . Nucleic Acids Research. 45. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5153-5169.
Honcharenko, M., Bestas, B., Jezowska, M., Wojtczak, B.A., Moreno, P.M.D., Romanowska, J., Bächle, S.M., Darzynkiewicz, E., Jemielity, J., Smith, C.I.E., et al.(2016). Synthetic m<inf>3</inf>G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a nuclear import signal . RSC Advances. 6. (56). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 51367-51373.
Kralovicova, J., Moreno, P.M.D., Cross, N.C.P., Pêgo, A.P., Vorechovsky, I.(2016). Antisense Oligonucleotides Modulating Activation of a Nonsense-Mediated RNA Decay Switch Exon in the ATM Gene . Nucleic Acid Therapeutics. 26. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 392-400.
Moreno, P.M.D., Santos, J.C., Gomes, C.P., Varela-Moreira, A., Costa, A., Leiro, V., Mansur, H., Peîgo, A.P.(2016). Delivery of Splice Switching Oligonucleotides by Amphiphilic Chitosan-Based Nanoparticles . Molecular Pharmaceutics. 13. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 344-356.
Gomes, C.P., Varela-Moreira, A., Leiro, V., Lopes, C.D.F., Moreno, P.M.D., Gomez-Lazaro, M., Pêgo, A.P.(2016). A high-throughput bioimaging study to assess the impact of chitosan-based nanoparticle degradation on DNA delivery performance . Acta Biomaterialia. 46. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 129-140.
Cardona, M.E., Simonson, O.E., Oprea, I.I., Moreno, P.M.D., Silva-Lara, M.F., Mohamed, A.J., Christensson, B., Gahrton, G., Dilber, M.S., Smith, C.I.E., et al.(2016). A murine model of acute myeloid leukemia with Evi1 overexpression and autocrine stimulation by an intracellular form of GM-CSF in DA-3 cells . Leukemia and Lymphoma. 57. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 183-192.
Geny, S., Moreno, P.M.D., Krzywkowski, T., Gissberg, O., Andersen, N.K., Isse, A.J., El-Madani, A.M., Lou, C., Pabon, Y.V., Anderson, B.A., et al.(2016). Next-generation bis-locked nucleic acids with stacking linker and 2′-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes . Nucleic Acids Research. 44. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2007-2019.
Santos, J.C.C., Moreno, P.M.D., Mansur, A.A.P., Leiro, V., Mansur, H.S., Pêgo, A.P.(2015). Functionalized chitosan derivatives as nonviral vectors: Physicochemical properties of acylated N,N,N-trimethyl chitosan/oligonucleotide nanopolyplexes . Soft Matter. 11. (41). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 8113-8125.
Rocha, C.S.J., Wiklander, O.P.B., Larsson, L., Moreno, P.M.D., Parini, P., Lundin, K.E., Smith, C.I.E.(2015). RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form . Journal of Molecular and Cellular Cardiology. 82. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 186-193.
Milton, S., Honcharenko, D., Rocha, C.S.J., Moreno, P.M.D., Edvard Smith, C.I., Strömberg, R.(2015). Nuclease resistant oligonucleotides with cell penetrating properties . Chemical Communications. 51. (19). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4044-4047.
Oprea, I.I., Viola, J.R., Moreno, P.M.D., Simonson, O.E., Rodin, S., Teller, N., Tryggvason, K., Lundin, K.E., Girnita, L., Edvard Smith, C.I.(2014). Repeatable, inducible micro-RNA-based technology tightly controls liver transgene expression . Molecular Therapy - Nucleic Acids. 3.
Bestas, B., McClorey, G., Tedebark, U., Moreno, P.M.D., Roberts, T.C., Hammond, S.M., Smith, C.I.E., Wood, M.J.A., Andaloussi, S.E.(2014). Design and application of bispecific splice-switching oligonucleotides . Nucleic Acid Therapeutics. 24. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 13-24.
Bestas, B., Moreno, P.M.D., Blomberg, K.E.M., Mohammad, D.K., Saleh, A.F., Sutlu, T., Nordin, J.Z., Guterstam, P., Gustafsson, M.O., Kharazi, S., et al.(2014). Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model . Journal of Clinical Investigation. 124. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4067-4081.
Moreno, P.M.D., P�go, A.P.(2014). Therapeutic antisense oligonucleotides against cancer: Hurdling to the clinic . Frontiers in Chemistry. 2. (OCT).
Gomes, C.P., Ferreira Lopes, C.D., Duarte Moreno, P.M., Varela-Moreira, A., Alonso, M.J., Pêgo, A.P.(2014). Translating chitosan to clinical delivery of nucleic acid-based drugs . MRS Bulletin. 39. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 60-70.
Moreno, P.M.D., Geny, S., Pabon, Y.V., Bergquist, H., Zaghloul, E.M., Rocha, C.S.J., Oprea, I.I., Bestas, B., Andaloussi, S.E., Jørgensen, P.T., et al.(2013). Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA . Nucleic Acids Research. 41. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3257-3273.
Honcharenko, M., Zytek, M., Bestas, B., Moreno, P., Jemielity, J., Darzynkiewicz, E., Smith, C.I.E., Strömberg, R.(2013). Synthesis and evaluation of stability of m<inf>3</inf>G-CAP analogues in serum-supplemented medium and cytosolic extract . Bioorganic and Medicinal Chemistry. 21. (24). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7921-7928.
Zaghloul, E.M., Madsen, A.S., Moreno, P.M.D., Oprea, I.I., El-Andaloussi, S., Bestas, B., Gupta, P., Pedersen, E.B., Lundin, K.E., Wengel, J., et al.(2011). Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA . Nucleic Acids Research. 39. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1142-1154.
Ezzat, K., El Andaloussi, S., Zaghloul, E.M., Lehto, T., Lindberg, S., Moreno, P.M.D., Viola, J.R., Magdy, T., Abdo, R., Guterstam, P., et al.(2011). PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation . Nucleic Acids Research. 39. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5284-5298.
Lehto, T., Simonson, O.E., Mäger, I., Ezzat, K., Sork, H., Copolovici, D.-M., Viola, J.R., Zaghloul, E.M., Lundin, P., Moreno, P.M.D., et al.(2011). A peptide-based vector for efficient gene transfer in vitro and in vivo . Molecular Therapy. 19. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1457-1467.
El Andaloussi, S., Lehto, T., Mäger, I., Rosenthal-Aizman, K., Oprea, I.I., Simonson, O.E., Sork, H., Ezzat, K., Copolovici, D.M., Kurrikoff, K., et al.(2011). Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo . Nucleic Acids Research. 39. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3972-3987.
Lundin, P., Moreno, P.M., Smith, C.E., Andaloussi, S.E.(2011). Circular RNA interference effector molecules (WO10084371) . Expert Opinion on Therapeutic Patents. 21. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 115-119.
Oprea, I.I., Simonson, O.E., Moreno, P.M.D., Viola, J.R., Lundin, K.E., Smith, C.I.E.(2010). Temperature-assisted cyclic hybridization (TACH): An improved method for supercoiled DNA hybridization . Molecular Biotechnology. 45. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 171-179.
Lundin, K.E., Simonson, O.E., Moreno, P.M.D., Zaghloul, E.M., Oprea, I.I., Svahn, M.G., Smith, C.I.E.(2009). Nanotechnology approaches for gene transfer . Genetica. 137. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 47-56.
Moreno, P.M.D., Wenska, M., Lundin, K.E., Wrange, Ö., Strömberg, R., Smith, E.C.I.(2009). A synthetic snRNA m<inf>3</inf>G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids . Nucleic Acids Research. 37. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1925-1935.
Viola, J.R., Leijonmarck, H., Simonson, O.E., Oprea, I.I., Frithiof, R., Purhonen, P., Moreno, P.M.D., Lundin, K.E., Strömberg, R., Smith, C.I.E.(2009). Fatty acid-spermine conjugates as DNA carriers for nonviral in vivo gene delivery . Gene Therapy. 16. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1429-1440.
Smith, C.I., Lundin, K.E., Simonson, O.E., Moreno, P.M., Svahn, M.G., Wenska, M., Strömberg, R.(2008). Building biologically active nucleic acid nanocomplexes . Nucleic acids symposium series (2004). (52). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 27-28.
Lundin, K.E., Hasan, M., Moreno, P.M., Törnquist, E., Oprea, I., Svahn, M.G., Simonson, E.O., Smith, C.I.E.(2005). Increased stability and specificity through combined hybridization of peptide nucleic acid (PNA) and locked nucleic acid (LNA) to supercoiled plasmids for PNA-anchored "Bioplex" formation . Biomolecular Engineering. 22. (5-6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 185-192.
BOOK CHAPTER
(2020). Toward the therapeutic application of small interfering RNA bioconjugates in the central nervous system . Handbook of Innovations in Central Nervous System Regenerative Medicine.
Moreno, P.M.D., Rodrigues, T., Torrado, M., Amaral, I.F., Pêgo, A.P.(2019). Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro and In Vivo Application in the Context of Spinal Cord Injury . Methods in Molecular Biology. 2036. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 205-219.
M.A. Barbosa and I.C. Gonçalves and P.M.D. Moreno and R.M. Gonçalves and S.G. Santos and A.P. Pêgo and I.F. Amaral(2017). 2.13 Chitosan☆ . Comprehensive Biomaterials II. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 279 - 305. Elsevier
Biomaterial-Based Vectors for Targeted Delivery of Nucleic Acids to the Nervous System @inbook {
author = {Pêgo, Ana Paula and Oliveira, Hugo and Moreno, Pedro Miguel},
editor = {Coelho, Jorge},
title = {Biomaterial-Based Vectors for Targeted Delivery of Nucleic Acids to the Nervous System},
pages = {185--224},
publisher = {Springer Netherlands},
year = {2013},
url = {http://dx.doi.org/10.1007/978-94-007-6010-3_7},
doi = {10.1007/978-94-007-6010-3_7}
} . Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment.
P{\^e}go, AnaPaula and Oliveira, Hugo and Moreno, PedroMiguel(2013). Biomaterial-Based Vectors for Targeted Delivery of Nucleic Acids to the Nervous System . Advances in Predictive, Preventive and Personalised Medicine. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 185--224. Springer Netherlands
BOOK
Leiro, V., Moreno, P.M., Sarmento, B., Durão, J., Gales, L., Pêgo, A.P., Barrias, C.C.(2016). Design and preparation of biomimetic and bioinspired materials . Bioinspired Materials for Medical Applications. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-44.
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