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★★★★★
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USD 50 /hr
Hire Dr. Paul V.
Belgium
USD 50 /hr

consult and advice on different aspects of lipids/related compounds (isolation, analysis, biochemistry, metabolism)

Profile Summary
Subject Matter Expertise
Services
Writing Technical Writing, General Proofreading & Editing
Research Scientific and Technical Research, Systematic Literature Review
Consulting Healthcare Consulting, Scientific and Technical Consulting
Work Experience

Consultant

--

January 2022 - Present

Professor

KULeuven (University of Leuven, Belgium)

September 1994 - December 2020

AssociateProfessor

KULeuven (University of Leuven, Belgium)

October 1992 - September 1994

Lector

KULeuven (University of Leuven, Belgium)

October 1991 - September 1992

First assistant

KULeuven (University of Leuven, Belgium)

October 1988 - September 1991

PostdoctoralResearcher

Duke University Medical Center

June 1986 - August 1988

Education

PhD Biomedical Sciences

KULeuven

April 1981 - May 1986

Master Science

KULeuven

September 1977 - July 1979

Bachelor Biology

KULeuven

September 1975 - July 1977

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Paul P. Van Veldhoven (2024). A Stable and Sensitive TLC-Spray for Thiols, Disulfides and Thioesters . Chromatographia.
Cláudio F. Costa, Celien Lismont, Serhii Chornyi, Janet Koster, Hongli Li, Mohamed A.F. Hussein, Paul P. Van Veldhoven, Hans R. Waterham, Marc Fransen (2024). The solute carrier SLC25A17 sustains peroxisomal redox homeostasis in diverse mammalian cell lines . Free Radical Biology and Medicine.
Daniëlle Swinkels, Sai Kocherlakota, Yannick Das, Adriaan D. Dane, Eric J. M. Wever, Frédéric M. Vaz, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes (2023). DHA Shortage Causes the Early Degeneration of Photoreceptors and RPE in Mice With Peroxisomal β-Oxidation Deficiency . Investigative Opthalmology & Visual Science.
Paul Van Veldhoven, Sai Kocherlakota, Yannick Das, Danielle Swinkels, Maarten Vanmunster, Manon Callens, Stefan Vinckier, Frederic Vaz, Debasish Sinha, Marc Fransen, et al. (2023). The murine retinal pigment epithelium requires peroxisomal β-oxidation to maintain lysosomal function and prevent dedifferentiation . Proceedings of the National Academy of Sciences.
Paul Van Veldhoven, Franziska Paul, Calista Ng, Umar Mohamad Sahari, Shahriar Nafissi, Yalda Nilipoor, Alireza Tavasoli, Carine Bonnard, Pui Mun Wong, nasrinsadat Nabavizadeh, et al. (2022). RABENOSYN separation-of-function mutations uncouple endosomal recycling from lysosomal degradation, causing a distinct Mendelian disorder . Human Molecular Genetics.
Celien Lismont, Iulia Revenco, Hongli Li, Cláudio F. Costa, Lisa Lenaerts, Mohamed A. F. Hussein, Jonas De Bie, Bernard Knoops, Paul P. Van Veldhoven, Rita Derua, et al. (2022). Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells . Frontiers in Cell and Developmental Biology.
Chloë Goossens, Ruben Weckx, Sarah Derde, Sarah Vander Perre, Inge Derese, Paul P. Van Veldhoven, Bart Ghesquière, Greet Van den Berghe, Lies Langouche (2021). Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate . Critical Care.
David L. Ebenezer, Ramaswamy Ramchandran, Panfeng Fu, Lizar A. Mangio, Vidyani Suryadevara, Alison W. Ha, Evgeny Berdyshev, Paul P. Van Veldhoven, Stephen J. Kron, Fabian Schumacher, et al. (2021). Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells . Cell Biochemistry and Biophysics.
Yannick Das, Daniëlle Swinkels, Sai Kocherlakota, Stefan Vinckier, Frédéric M. Vaz, Eric Wever, Antoine H. C. van Kampen, Bokkyoo Jun, Khanh V. Do, Lieve Moons, et al. (2021). Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis in the Retina and Causes Visual Dysfunction in Mice . Frontiers in Cell and Developmental Biology.
(2020). Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid . Frontiers in cell and developmental biology.
(2019). Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex . Current biology : CB.
Ivana Geric, Sandra Schoors, Christel Claes, Pierre Gressens, Claudia Verderio, Catherine M. Verfaillie, Paul P. Van Veldhoven, Peter Carmeliet, Myriam Baes (2019). Metabolic Reprogramming during Microglia Activation . Immunometabolism.
Goossens, C., Weckx, R., Derde, S., Dufour, T., Vander Perre, S., Pauwels, L., Thiessen, S.E., Van Veldhoven, P.P., Van Den Berghe, G., Langouche, L.(2019). Adipose tissue protects against sepsis-induced muscle weakness in mice: From lipolysis to ketones . Critical Care. 23. (1).
Das, Y., Roose, N., De Groef, L., Fransen, M., Moons, L., Van Veldhoven, P.P., Baes, M.(2019). Differential distribution of peroxisomal proteins points to specific roles of peroxisomes in the murine retina . Molecular and Cellular Biochemistry. 456. (1-2). p. 53-62.
Lismont, C., Koster, J., Provost, S., Baes, M., Van Veldhoven, P.P., Waterham, H.R., Fransen, M.(2019). Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting . Biochimica et Biophysica Acta - Biomembranes.
Baboota, R.K., Shinde, A.B., Lemaire, K., Fransen, M., Vinckier, S., Van Veldhoven, P.P., Schuit, F., Baes, M.(2019). Functional peroxisomes are required for β-cell integrity in mice . Molecular Metabolism. 22. p. 71-83.
Lismont, C., Nordgren, M., Brees, C., Knoops, B., Van Veldhoven, P.P., Fransen, M.(2019). Peroxisomes as modulators of cellular protein thiol oxidation: A new model system . Antioxidants and Redox Signaling. 30. (1). p. 22-29.
Malheiro, A.R., Correia, B., Ferreira da Silva, T., Bessa-Neto, D., Van Veldhoven, P.P., Brites, P.(2019). Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment . Brain Pathology.
Geric, I., Tyurina, Y.Y., Krysko, O., Krysko, D.V., De Schryver, E., Kagan, V.E., Van Veldhoven, P.P., Baes, M., Verheijden, S.(2018). Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency . Immunology. 153. (3). p. 342-356.
Shinde, A.B., Baboota, R.K., Denis, S., Loizides-Mangold, U., Peeters, A., Espeel, M., Malheiro, A.R., Riezman, H., Vinckier, S., Vaz, F.M., et al.(2018). Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites . Mitochondrion. 39. p. 51-59.
Karnati, S., Oruqaj, G., Janga, H., Tumpara, S., Colasante, C., Van Veldhoven, P.P., Braverman, N., Pilatz, A., Mariani, T.J., Baumgart-Vogt, E.(2018). PPARα-mediated peroxisome induction compensates PPARγ-deficiency in bronchiolar club cells . PLoS ONE. 13. (9).
Karnati, S., Garikapati, V., Liebisch, G., Van Veldhoven, P.P., Spengler, B., Schmitz, G., Baumgart-Vogt, E.(2018). Quantitative lipidomic analysis of mouse lung during postnatal development by electrospray ionization tandem mass spectrometry . PLoS ONE. 13. (9).
Lyman, K.A., Han, Y., Heuermann, R.J., Cheng, X., Kurz, J.E., Lyman, R.E., Van Veldhoven, P.P., Chetkovich, D.M.(2017). Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels . Journal of Biological Chemistry. 292. (43). p. 17718-17730.
Muthuramu, I., Amin, R., Postnov, A., Mishra, M., Aboumsallem, J.P., Dresselaers, T., Himmelreich, U., Van Veldhoven, P.P., Gheysens, O., Jacobs, F., et al.(2017). Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice . Molecular Therapy. 25. (11). p. 2513-2525.
Muthuramu, I., Amin, R., Postnov, A., Mishra, M., Jacobs, F., Gheysens, O., Van Veldhoven, P.P., De Geest, B.(2017). Coconut oil aggravates pressure overload-induced cardiomyopathy without inducing obesity, systemic insulin resistance, or cardiac steatosis . International Journal of Molecular Sciences. 18. (7).
Morvay, P.L., Baes, M., Van Veldhoven, P.P.(2017). Differential activities of peroxisomes along the mouse intestinal epithelium . Cell Biochemistry and Function. 35. (3). p. 144-155.
Alecu, I., Tedeschi, A., Behler, N., Wunderling, K., Lamberz, C., Lauterbach, M.A.R., Gaebler, A., Ernst, D., Van Veldhoven, P.P., Al-Amoudi, A., et al.(2017). Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction . Journal of Lipid Research. 58. (1). p. 42-59.
Jenkins, B.J., Seyssel, K., Chiu, S., Pan, P.-H., Lin, S.-Y., Stanley, E., Ament, Z., West, J.A., Summerhill, K., Griffin, J.L., et al.(2017). Odd Chain Fatty Acids; New Insights of the Relationship between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance . Scientific Reports. 7.
Jenkins, B., De Schryver, E., Van Veldhoven, P.P., Koulman, A.(2017). Peroxisomal 2-hydroxyacyl-coa lyase is involved in endogenous biosynthesis of heptadecanoic acid . Molecules. 22. (10).
Prasad, R., Hadjidemetriou, I., Maharaj, A., Meimaridou, E., Buonocore, F., Saleem, M., Hurcombe, J., Bierzynska, A., Barbagelata, E., Bergadá, I., et al.(2017). Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome . Journal of Clinical Investigation. 127. (3). p. 942-953.
Mezzar, S., De Schryver, E., Asselberghs, S., Meyhi, E., Morvay, P.L., Baes, M., Van Veldhoven, P.P.(2017). Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1862. (9). p. 972-990.
Baes, M., Van Veldhoven, P.P.(2016). Hepatic dysfunction in peroxisomal disorders . Biochimica et Biophysica Acta - Molecular Cell Research. 1863. (5). p. 956-970.
Haberkant, P., Stein, F., Höglinger, D., Gerl, M.J., Brügger, B., Van Veldhoven, P.P., Krijgsveld, J., Gavin, A.-C., Schultz, C.(2016). Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions . ACS Chemical Biology. 11. (1). p. 222-230.
Wouters, M.M., Balemans, D., Van Wanrooy, S., Dooley, J., Cibert-Goton, V., Alpizar, Y.A., Valdez-Morales, E.E., Nasser, Y., Van Veldhoven, P.P., Vanbrabant, W., et al.(2016). Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients with Irritable Bowel Syndrome . Gastroenterology. 150. (4). p. 875-887.e9.
Schoors, S., Bruning, U., Missiaen, R., Queiroz, K.C.S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A.R., Christen, S., Goveia, J., et al.(2015). Fatty acid carbon is essential for dNTP synthesis in endothelial cells . Nature. 520. (7546). p. 192-197.
Wang, X., Gao, M., Schouteden, S., Roebroek, A., Eggermont, K., Van Veldhoven, P.P., Liu, G., Peters, T., Scharffetter-Kochanek, K., Verfaillie, C.M., et al.(2015). Hematopoietic stem/progenitor cells directly contribute to arteriosclerotic progression via integrin β<inf>2</inf> . Stem Cells. 33. (4). p. 1230-1240.
Kariminejad, A., Nafissi, S., Nilipoor, Y., Tavasoli, A., Van Veldhoven, P.P., Bonnard, C., Ng, Y.T., Majoie, C.B., Reversade, B., Hennekam, R.C.(2015). Intellectual disability, muscle weakness and characteristic face in three siblings: A newly described recessive syndrome mapping to 3p24.3-p25.3 . American Journal of Medical Genetics, Part A. 167. (11). p. 2508-2515.
Schulz, J.G., Laranjeira, A., Van Huffel, L., G&#228;rtner, A., Vilain, S., Bastianen, J., Van Veldhoven, P.P., Dotti, C.G.(2015). Glial β-Oxidation regulates drosophila energy metabolism . Scientific Reports. 5.
Peeters, A., Shinde, A.B., Dirkx, R., Smet, J., De Bock, K., Espeel, M., Vanhorebeek, I., Vanlander, A., Van Coster, R., Carmeliet, P., et al.(2015). Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation . Biochimica et Biophysica Acta - Molecular Cell Research. 1853. (2). p. 285-298.
Lismont, C., Nordgren, M., Van Veldhoven, P.P., Fransen, M.(2015). Redox interplay between mitochondria and peroxisomes . Frontiers in Cell and Developmental Biology. 3. (MAY).
Crick, P.J., Beckers, L., Baes, M., Van Veldhoven, P.P., Wang, Y., Griffiths, W.J.(2015). The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid . Steroids. 99. (PB). p. 172-177.
Verbeek, J., Lannoo, M., Pirinen, E., Ryu, D., Spincemaille, P., Elst, I.V., Windmolders, P., Thevissen, K., Cammue, B.P.A., Van Pelt, J., et al.(2015). Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis . Gut. 64. (4). p. 673-683.
Ihlefeld, K., Vienken, H., Claas, R.F., Blankenbach, K., Rudowski, A., Ter Braak, M., Koch, A., Van Veldhoven, P.P., Pfeilschifter, J., Zu Heringdorf, D.M.(2015). Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts . Journal of Lipid Research. 56. (1). p. 60-69.
Nicola&#239;, J., De Bruyn, T., Van Veldhoven, P.P., Keemink, J., Augustijns, P., Annaert, P.(2015). Verapamil hepatic clearance in four preclinical rat models: Towards activity-based scaling . Biopharmaceutics and Drug Disposition. 36. (7). p. 462-480.
Schoors, S., Bruning, U., Missiaen, R., Queiroz, K.C.S., Borgers, G., Elia, I., Zecchin, A., Cantelmo, A.R., Christen, S., Goveia, J., et al.(2015). Erratum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells (Nature (2015) 520 (192-197) DOI:10.1038/nature14362) . Nature. 526. (7571). p. 144.
Nordgren, M., Francisco, T., Lismont, C., Hennebel, L., Brees, C., Wang, B., van Veldhoven, P.P., Azevedo, J.E., Fransen, M.(2015). Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts . Autophagy. 11. (8). p. 1326-1340.
Tillander, V., Nordstr&#246;m, E.A., Reilly, J., Strozyk, M., Van Veldhoven, P.P., Hunt, M.C., Alexson, S.E.H.(2014). Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria . Cellular and Molecular Life Sciences. 71. (5). p. 933-948.
Verheijden, S., Beckers, L., De Munter, S., Van Veldhoven, P.P., Baes, M.(2014). Central nervous system pathology in MFP2 deficiency: Insights from general and conditional knockout mouse models . Biochimie. 98. (1). p. 119-126.
Apanasets, O., Grou, C.P., Van Veldhoven, P.P., Brees, C., Wang, B., Nordgren, M., Dodt, G., Azevedo, J.E., Fransen, M.(2014). PEX5, the Shuttling Import Receptor for Peroxisomal Matrix Proteins, Is a Redox-Sensitive Protein . Traffic. 15. (1). p. 94-103.
Arroyo, A.I., Camoletto, P.G., Morando, L., Sassoe-Pognetto, M., Giustetto, M., Van Veldhoven, P.P., Schuchman, E.H., Ledesma, M.D.(2014). Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model . EMBO Molecular Medicine. 6. (3). p. 398-413.
Mezzar, S., De Schryver, E., Van Veldhoven, P.P.(2014). RP-HPLC-fluorescence analysis of aliphatic aldehydes: Application to aldehyde-generating enzymes HACL1 and SGPL1 . Journal of Lipid Research. 55. (3). p. 573-582.
Gao, M., Zhao, D., Schouteden, S., Sorci-Thomas, M.G., Van Veldhoven, P.P., Eggermont, K., Liu, G., Verfaillie, C.M., Feng, Y.(2014). Regulation of high-density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression . Arteriosclerosis, Thrombosis, and Vascular Biology. 34. (9). p. 1900-1909.
Van der Eecken, V., Clippe, A., Dekoninck, S., Goemaere, J., Walbrecq, G., Van Veldhoven, P.P., Knoops, B.(2013). Abolition of peroxiredoxin-5 mitochondrial targeting during canid evolution . PloS one. 8. (9).
Bot, M., Van Veldhoven, P.P., de Jager, S.C.A., Johnson, J., Nijstad, N., Van Santbrink, P.J., Westra, M.M., Van Der Hoeven, G., Gijbels, M.J., M&#252;ller-Tidow, C., et al.(2013). Hematopoietic Sphingosine 1-Phosphate Lyase Deficiency Decreases Atherosclerotic Lesion Development in LDL-Receptor Deficient Mice . PLoS ONE. 8. (5).
Verheijden, S., Bottelbergs, A., Krysko, O., Krysko, D.V., Beckers, L., De Munter, S., Van Veldhoven, P.P., Wyns, S., Kulik, W., Nave, K.-A., et al.(2013). Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation . Neurobiology of Disease. 58. p. 258-269.
Wang, B., Van Veldhoven, P.P., Brees, C., Rubio, N., Nordgren, M., Apanasets, O., Kunze, M., Baes, M., Agostinis, P., Fransen, M.(2013). Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells . Free Radical Biology and Medicine. 65. p. 882-894.
Van Veldhoven, P.P., Baes, M.(2013). Peroxisome deficient invertebrate and vertebrate animal models . Frontiers in Physiology. 4 NOV.
De Bock, K., Georgiadou, M., Schoors, S., Kuchnio, A., Wong, B.W., Cantelmo, A.R., Quaegebeur, A., Ghesqui&#232;re, B., Cauwenberghs, S., Eelen, G., et al.(2013). Role of PFKFB3-driven glycolysis in vessel sprouting . Cell. 154. (3). p. 651-663.
Reina, E., Camacho, L., Casas, J., Van Veldhoven, P.P., Fabrias, G.(2012). Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry . Chemistry and Physics of Lipids. 165. (2). p. 225-231.
Feng, Y., Schouteden, S., Geenens, R., van Duppen, V., Herijgers, P., Holvoet, P., van Veldhoven, P.P., Verfaillie, C.M.(2012). Hematopoietic Stem/Progenitor Cell Proliferation and Differentiation Is Differentially Regulated by High-Density and Low-Density Lipoproteins in Mice . PLoS ONE. 7. (11).
Nesic, I., Guix, F.X., Vennekens, K., Michaki, V., Van Veldhoven, P.P., Feiguin, F., De Strooper, B., Dotti, C.G., Wahle, T.(2012). Alterations in phosphatidylethanolamine levels affect the generation of Aβ . Aging Cell. 11. (1). p. 63-72.
Baes, M., Van Veldhoven, P.P.(2012). Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies . Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822. (9). p. 1489-1500.
Bottelbergs, A., Verheijden, S., Van Veldhoven, P.P., Just, W., Devos, R., Baes, M.(2012). Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system . Journal of Neuroinflammation. 9.
Martens, K., Bottelbergs, A., Peeters, A., Jacobs, F., Espeel, M., Carmeliet, P., Van Veldhoven, P.P., Baes, M.(2012). Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone . Molecular Genetics and Metabolism. 107. (4). p. 735-747.
Nordgren, M., Wang, B., Apanasets, O., Brees, C., Van Veldhoven, P.P., Fransen, M.(2012). Potential limitations in the use of KillerRed for fluorescence microscopy . Journal of Microscopy. 245. (3). p. 229-235.
Peeters, A., Fraisl, P., Van Den Berg, S., Van Themaat, E.V.L., Van Kampen, A., Rider, M.H., Takemori, H., Van Dijk, K.W., Van Veldhoven, P.P., Carmeliet, P., et al.(2011). Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression . Journal of Biological Chemistry. 286. (49). p. 42162-42179.
Lewis, A.S., Vaidya, S.P., Blaiss, C.A., Liu, Z., Stoub, T.R., Brager, D.H., Chen, X., Bender, R.A., Estep, C.M., Popov, A.B., et al.(2011). Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal I<inf>h</inf> localization and function and promotes antidepressant behavior in mice . Journal of Neuroscience. 31. (20). p. 7424-7440.
Vaisy, M., Szlufcik, K., De Bock, K., Eijnde, B.O., Van Proeyen, K., Verbeke, K., Van Veldhoven, P., Hespel, P.(2011). Exercise-induced, but not creatine-induced, decrease in intramyocellular lipid content improves insulin sensitivity in rats . Journal of Nutritional Biochemistry. 22. (12). p. 1178-1185.
Peeters, A., Swinnen, J.V., Van Veldhoven, P.P., Baes, M.(2011). Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis . Biochimie. 93. (10). p. 1828-1838.
Ivashchenko, O., Van Veldhoven, P.P., Brees, C., Ho, Y.-S., Terlecky, S.R., Fransen, M.(2011). Intraperoxisomal redox balance in mammalian cells: Oxidative stress and interorganellar cross-talk . Molecular Biology of the Cell. 22. (9). p. 1440-1451.
Van der Eecken, V., Clippe, A., Van Veldhoven, P.P., Knoops, B.(2011). Mitochondrial targeting of peroxiredoxin 5 is preserved from annelids to mammals but is absent in pig Sus scrofa domesticus . Mitochondrion. 11. (6). p. 973-981.
He, M., Pei, Z., Mohsen, A.-W., Watkins, P., Murdoch, G., Van Veldhoven, P.P., Ensenauer, R., Vockley, J.(2011). Identification and characterization of new long chain Acyl-CoA dehydrogenases . Molecular Genetics and Metabolism. 102. (4). p. 418-429.
Sodero, A.O., Trov&#242;, L., Iannilli, F., Van Veldhoven, P., Dotti, C.G., Martin, M.G.(2011). Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: Relevance for neuronal survival under stress and in aging . Journal of Neurochemistry. 116. (5). p. 747-755.
Fraccascia, P., Casteels, M., De Schryver, E., Van Veldhoven, P.P.(2011). Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase . Biochimica et Biophysica Acta - Proteins and Proteomics. 1814. (10). p. 1226-1233.
Trov&#242;, L., Van Veldhoven, P.P., Mart&#237;n, M.G., Dotti, C.G.(2011). Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis . Journal of Cell Science. 124. (8). p. 1308-1315.
Vandecaetsbeek, I., Christensen, S.B., Liu, H., Van Veldhoven, P.P., Waelkens, E., Eggermont, J., Raeymaekers, L., M&#248;ller, J.V., Nissen, P., Wuytack, F., et al.(2011). Thapsigargin affinity purification of intracellular P<inf>2A</inf>-type Ca<sup>2+</sup> ATPases . Biochimica et Biophysica Acta - Molecular Cell Research. 1813. (5). p. 1118-1127.
Van Veldhoven, P.P.(2010). Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism . Journal of Lipid Research. 51. (10). p. 2863-2895.
Krysko, O., Bottelbergs, A., Veldhoven, P.V., Baes, M.(2010). Combined deficiency of peroxisomal β-oxidation and ether lipid synthesis in mice causes only minor cortical neuronal migration defects but severe hypotonia . Molecular Genetics and Metabolism. 100. (1). p. 71-76.
Rysman, E., Brusselmans, K., Scheys, K., Timmermans, L., Derua, R., Munck, S., Van Veldhoven, P.P., Waltregny, D., Dani&#235;ls, V.W., Machiels, J., et al.(2010). De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation . Cancer Research. 70. (20). p. 8117-8126.
Claas, R.F., ter Braak, M., Hegen, B., Hardel, V., Angioni, C., Schmidt, H., Jakobs, K.H., Van Veldhoven, P.P., Heringdorf, D.M.z.(2010). Enhanced Ca<sup>2+</sup> storage in sphingosine-1-phosphate lyase-deficient fibroblasts . Cellular Signalling. 22. (3). p. 476-483.
Extier, A., Langelier, B., Perruchot, M.-H., Guesnet, P., Van Veldhoven, P.P., Lavialle, M., Alessandri, J.-M.(2010). Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion . Journal of Nutritional Biochemistry. 21. (3). p. 180-187.
Kashiwayama, Y., Tomohiro, T., Narita, K., Suzumura, M., Glumoff, T., Hiltunen, J.K., Van Veldhoven, P.P., Hatanaka, Y., Imanaka, T.(2010). Identification of a substrate-binding site in a peroxisomal β-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative . Journal of Biological Chemistry. 285. (34). p. 26315-26325.
Van Proeyen, K., Szlufcik, K., Nielens, H., Pelgrim, K., Deldicque, L., Hesselink, M., Van Veldhoven, P.P., Hespel, P.(2010). Training in the fasted state improves glucose tolerance during fat-rich diet . Journal of Physiology. 588. (21). p. 4289-4302.
Weber, C., Krueger, A., M&#252;nk, A., Bode, C., Van Veldhoven, P.P., Gr&#228;ler, M.H.(2009). Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice . Journal of Immunology. 183. (7). p. 4292-4301.
Coli&#233;, S., Van Veldhoven, P.P., Kedjouar, B., Bedia, C., Albinet, V., Sorli, S.-C., Garcia, V., Djavaheri-Mergny, M., Bauvy, C., Codogno, P., et al.(2009). Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation . Cancer Research. 69. (24). p. 9346-9353.
Huybrechts, S.J., Van Veldhoven, P.P., Hoffman, I., Zeevaert, R., De Vos, R., Demaerel, P., Brams, M., Jaeken, J., Fransen, M., Cassiman, D.(2009). Identification of a novel PEX14 mutation in Zellweger syndrome . BMJ Case Reports.
Huybrechts, S.J., Van Veldhoven, P.P., Brees, C., Mannaerts, G.P., Los, G.V., Fransen, M.(2009). Peroxisome dynamics in cultured mammalian cells . Traffic. 10. (11). p. 1722-1733.
Anthonio, E.A., Brees, C., Baumgart-Vogt, E., Hongu, T., Huybrechts, S.J., Van Dijck, P., Mannaerts, G.P., Kanaho, Y., Van Veldhoven, P.P., Fransen, M.(2009). Small G proteins in peroxisome biogenesis: The potential involvement of ADP-ribosylation factor 6 . BMC Cell Biology. 10.
Hagen, N., Van Veldhoven, P.P., Proia, R.L., Park, H., Merrill Jr., A.H., Van Echten-Deckert, G.(2009). Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons . Journal of Biological Chemistry. 284. (17). p. 11346-11353.
Hellemans, K.H., Hannaert, J.-C., Denys, B., Steffensen, K.R., Raemdonck, C., Martens, G.A., Van Veldhoven, P.P., Gustafsson, J.-A., Pipeleers, D.(2009). Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARα-dependent stearoyl-coenzyme a desaturase . PLoS ONE. 4. (9).
Camoletto, P.G., Vara, H., Morando, L., Connell, E., Marletto, F.P., Giustetto, M., Sasso&#232;-Pognetto, M., Van Veldhoven, P.P., Ledesma, M.D.(2009). Synaptic vesicle docking: Sphingosine regulates syntaxin1 interaction with Munc18 . PLoS ONE. 4. (4).
Bedia, C., Camacho, L., Casas, J., Abad, J.L., Delgado, A., Van Veldhoven, P.P., Fabri&#224;s, G.(2009). Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity . ChemBioChem. 10. (5). p. 820-822.
Hulshagen, L., Krysko, O., Bottelbergs, A., Huyghe, S., Klein, R., Van Veldhoven, P.P., De Deyn, P.P., D&#39;Hooge, R., Hartmann, D., Baes, M.(2008). Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration . Journal of Neuroscience. 28. (15). p. 4015-4027.
Galvan, C., Camoletto, P.G., Cristofani, F., Van Veldhoven, P.P., Ledesma, M.D.(2008). Anomalous surface distribution of glycosyl phosphatidyl inositol-anchored proteins in neurons lacking acid sphingomyelinase . Molecular Biology of the Cell. 19. (2). p. 509-522.
Fransen, M., Amery, L., Hartig, A., Brees, C., Rabijns, A., Mannaerts, G.P., Van Veldhoven, P.P.(2008). Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b . Biochimica et Biophysica Acta - Molecular Cell Research. 1783. (5). p. 864-873.
Aragon&#233;s, J., Schneider, M., Van Geyte, K., Fraisl, P., Dresselaers, T., Mazzone, M., Dirkx, R., Zacchigna, S., Lemieux, H., Jeoung, N.H., et al.(2008). Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism . Nature Genetics. 40. (2). p. 170-180.
Martens, K., Ver Loren van Themaat, E., van Batenburg, M.F., Hein&#228;niemi, M., Huyghe, S., Van Hummelen, P., Carlberg, C., Van Veldhoven, P.P., Van Kampen, A., Baes, M.(2008). Coordinate induction of PPARα and SREBP2 in multifunctional protein 2 deficient mice . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1781. (11-12). p. 694-702.
Nguyen, S.D., Baes, M., Van Veldhoven, P.P.(2008). Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1781. (8). p. 400-405.
Huybrechts, S.J., Van Veldhoven, P.P., Hoffman, I., Zeevaert, R., De Vos, R., Demaerel, P., Brams, M., Jaeken, J., Fransen, M., Cassiman, D.(2008). Identification of a novel PEX14 mutation in Zellweger syndrome . Journal of Medical Genetics. 45. (6). p. 376-383.
Graf, C., Zemann, B., Rovina, P., Urtz, N., Schanzer, A., Reuschel, R., Mechtcheriakova, D., M&#252;ller, M., Fischer, E., Reichel, C., et al.(2008). Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice . Journal of Immunology. 180. (5). p. 3457-3466.
Peest, U., Sensken, S.-C., Andr&#233;ani, P., H&#228;nel, P., Van Veldhoven, P.P., Gr&#228;ler, M.H.(2008). S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake . Journal of Cellular Biochemistry. 104. (3). p. 756-772.
Oaxaca-Castillo, D., Andreoletti, P., Vluggens, A., Yu, S., van Veldhoven, P.P., Reddy, J.K., Cherkaoui-Malki, M.(2007). Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single gene . Biochemical and Biophysical Research Communications. 360. (2). p. 314-319.
Van Overloop, H., Van Veldhoven, P.P.(2007). Ceramide-dependent release of ceramide kinase from cultured cells . Biochemical and Biophysical Research Communications. 364. (1). p. 169-174.
Van Overloop, H., Denizot, Y., Baes, M., Van Veldhoven, P.P.(2007). On the presence of C<inf>2</inf>-ceramide in mammalian tissues: Possible relationship to etherphospholipids and phosphorylation by ceramide kinase . Biological Chemistry. 388. (3). p. 315-324.
Min, J., Mesika, A., Sivaguru, M., Van Veldhoven, P.P., Alexander, H., Futerman, A.H., Alexander, S.(2007). (Dihydro)ceramide synthase 1-regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1 . Molecular Cancer Research. 5. (8). p. 801-812.
Hellemans, K., Kerckhofs, K., Hannaert, J.-C., Martens, G., Van Veldhoven, P., Pipeleers, D.(2007). Peroxisome proliferator-activated receptor α-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity . FEBS Journal. 274. (23). p. 6094-6105.
Fraccascia, P., Sniekers, M., Casteels, M., Van Veldhoven, P.P.(2007). Presence of thiamine pyrophosphate in mammalian peroxisomes . BMC Biochemistry. 8.
Brusselmans, K., Timmermans, L., Van De Sande, T., Van Veldhoven, P.P., Guan, G., Shechter, I., Claessens, F., Verhoeven, G., Swinnen, J.V.(2007). Squalene synthase, a determinant of raft-associated cholesterol and modulator of cancer cell proliferation . Journal of Biological Chemistry. 282. (26). p. 18777-18785.
Casteels, M., Sniekers, M., Fraccascia, P., Mannaerts, G.P., Van Veldhoven, P.P.(2007). The role of 2-hydroxyacyl-CoA lyase, a thiamin pyrophosphate-dependent enzyme, in the peroxisomal metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight-chain fatty acids . Biochemical Society Transactions. 35. (5). p. 876-880.
Dirkx, R., Meyhi, E., Asselberghs, S., Reddy, J., Baes, M., Van Veldhoven, P.P.(2007). β-Oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts . Biochemical and Biophysical Research Communications. 357. (3). p. 718-723.
Vastiau, I.M.K., Anthonio, E.A., Brams, M., Brees, C., Young, S.G., Van De Velde, S., Wanders, R.J.A., Mannaerts, G.P., Baes, M., Van Veldhoven, P.P., et al.(2006). Farnesylation of Pex19p is not essential for peroxisome biogenesis in yeast and mammalian cells . Cellular and Molecular Life Sciences. 63. (14). p. 1686-1699.
Van Overloop, H., Gijsbers, S., Van Veldhoven, P.P.(2006). Further characterization of mammalian ceramide kinase: Substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies . Journal of Lipid Research. 47. (2). p. 268-283.
Baes, M., Van Veldhoven, P.P.(2006). Generalised and conditional inactivation of Pex genes in mice . Biochimica et Biophysica Acta - Molecular Cell Research. 1763. (12). p. 1785-1793.
Huyghe, S., Schmalbruch, H., Hulshagen, L., Van Veldhoven, P., Baes, M., Hartmann, D.(2006). Peroxisomal multifunctional protein-2 deficiency causes motor deficits and glial lesions in the adult central nervous system . American Journal of Pathology. 168. (4). p. 1321-1334.
Huyghe, S., Schmalbruch, H., De Gendt, K., Verhoeven, G., Guillou, F., Van Veldhoven, P.P., Baes, M.(2006). Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in sertoli cells and male fertility in mice . Endocrinology. 147. (5). p. 2228-2236.
Huyghe, S., Mannaerts, G.P., Baes, M., Van Veldhoven, P.P.(2006). Peroxisomal multifunctional protein-2: The enzyme, the patients and the knockout mouse model . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1761. (9). p. 973-994.
Sniekers, M., Foulon, V., Mannaerts, G.P., Van Maldergem, L., Mandel, H., Gelb, B.D., Casteels, M., Van Veldhoven, P.P.(2006). Thiamine pyrophosphate: An essential cofactor for the α-oxidation in mammals - Implications for thiamine deficiencies? . Cellular and Molecular Life Sciences. 63. (13). p. 1553-1563.
Fransen, M., Vastiau, I., Brees, C., Brys, V., Mannaerts, G.P., Van Veldhoven, P.P.(2005). Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis . Journal of Molecular Biology. 346. (5). p. 1275-1286.
Dirkx, R., Vanhorebeek, I., Martens, K., Schad, A., Grabenbauer, M., Fahimi, D., Declercq, P., Van Veldhoven, P.P., Baes, M.(2005). Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities . Hepatology. 41. (4). p. 868-878.
Foulon, V., Sniekers, M., Huysmans, E., Asselberghs, S., Mahieu, V., Mannaerts, G.P., Van Veldhoven, P.P., Casteels, M.(2005). Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: A revised pathway for the α-oxidation of straight chain fatty acids . Journal of Biological Chemistry. 280. (11). p. 9802-9812.
Ferdinandusse, S., Denis, S., Overmars, H., Van Eeckhoudt, L., Van Veldhoven, P.P., Duran, M., Wanders, R.J.A., Baes, M.(2005). Developmental changes of bile acid composition and conjugation in L- and D-bifunctional protein single and double knockout mice . Journal of Biological Chemistry. 280. (19). p. 18658-18666.
Van Overloop, H., Van Der Hoeven, G., Van Veldhoven, P.P.(2005). N-Acyl migration in ceramides . Journal of Lipid Research. 46. (4). p. 812-816.
Min, J., Van Veldhoven, P.P., Zhang, L., Hanigan, M.H., Alexander, H., Alexander, S.(2005). Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner . Molecular Cancer Research. 3. (5). p. 287-296.
Hanley, P.J., Dr&#246;se, S., Brandt, U., Lareau, R.A., Banerjee, A.L., Srivastava, D.K., Banaszak, L.J., Barycki, J.J., Van Veldhoven, P.P., Daut, J.(2005). 5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for β-oxidation of fatty acids . Journal of Physiology. 562. (2). p. 307-318.
Pettus, B.J., Baes, M., Busman, M., Hannun, Y.A., Van Veldhoven, P.P.(2004). Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders . Rapid Communications in Mass Spectrometry. 18. (14). p. 1569-1574.
Genter, M.B., Van Veldhoven, P.P., Jegga, A.G., Sakthivel, B., Kong, S., Stanley, K., Witte, D.P., Ebert, C.L., Aronow, B.J.(2004). Microarray-based discovery of highly expressed olfactory mucosal genes: Potential roles in the various functions of the olfactory system . Physiological Genomics. 16. p. 67-81.
Fransen, M., Vastiau, I., Brees, C., Brys, V., Mannaerts, G.P., Van Veldhoven, P.P.(2004). Potential Role for Pex19p in Assembly of PTS-Receptor Docking Complexes . Journal of Biological Chemistry. 279. (13). p. 12615-12624.
Sakai, Y., Takahashi, H., Wakasa, Y., Kotani, T., Yurimoto, H., Miyachi, N., Van Veldhoven, P.P., Kato, N.(2004). Role of α-methylacyl coenzyme A racemase in the degradation of methyl-branched alkanes by Mycobacterium sp. strain P101 . Journal of Bacteriology. 186. (21). p. 7214-7220.
Casteels, M., Foulon, V., Mannaerts, G.P., Van Veldhoven, P.P.(2003). Alpha-oxidation of 3-methyl-substituted fatty acids and its thiamine dependence . European Journal of Biochemistry. 270. (8). p. 1619-1627.
Swinnen, J.V., Van Veldhoven, P.P., Timmermans, L., De Schrijver, E., Brusselmans, K., Vanderhoydonc, F., Van De Sande, T., Heemers, H., Heyns, W., Verhoeven, G.(2003). Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains . Biochemical and Biophysical Research Communications. 302. (4). p. 898-903.
Foulon, V., Asselberghs, S., Geens, W., Mannaerts, G.P., Casteels, M., Van Veldhoven, P.P.(2003). Further studies on the substrate spectrum of phytanoyl-CoA hydroxylase: Implications for Refsum disease? . Journal of Lipid Research. 44. (12). p. 2349-2355.
Janssen, A., Gressens, P., Grabenbauer, M., Baumgart, E., Schad, A., Vanhorebeek, I., Brouwers, A., Declercq, P.E., Fahimi, D., Evrard, P., et al.(2003). Neuronal Migration Depends on Intact Peroxisomal Function in Brain and in Extraneuronal Tissues . Journal of Neuroscience. 23. (30). p. 9732-9741.
Jia, Y., Qi, C., Zhang, Z., Hashimoto, T., Rao, M.S., Huyghe, S., Suzuki, Y., Van Veldhoven, P.P., Baes, M., Reddy, J.K.(2003). Overexpression of Peroxisome Proliferator-activated Receptor-α (PPARα)-regulated Genes in Liver in the Absence of Peroxisome Proliferation in Mice Deficient in both L- and D-Forms of Enoyl-CoA Hydratase/Dehydrogenase Enzymes of Peroxisomal β-Oxidation System . Journal of Biological Chemistry. 278. (47). p. 47232-47239.
Beil, M., Micoulet, A., Von Wichert, G., Paschke, S., Walther, P., Omary, M.B., Van Veldhoven, P.P., Gern, U., Wolff-Hieber, E., Eggermann, J., et al.(2003). Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells . Nature Cell Biology. 5. (9). p. 803-811.
Gijsbers, S., Asselberghs, S., Herdewijn, P., Van Veldhoven, P.P.(2002). 1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1580. (1). p. 1-8.
Fransen, M., Brees, C., Ghys, K., Amery, L., Mannaerts, G.P., Ladant, D., Van Veldhoven, P.P.(2002). Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay . Molecular &amp; cellular proteomics : MCP. 1. (3). p. 243-252.
Compernolle, V., Brusselmans, K., Acker, T., Hoet, P., Tjwa, M., Beck, H., Plaisance, S., Dor, Y., Keshet, E., Lupu, F., et al.(2002). Erratum: Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice (Nature Medicine (2002) 8 (702-710)) . Nature Medicine. 8. (11). p. 1329.
Ghys, K., Fransen, M., Mannaerts, G.P., Van Veldhoven, P.P.(2002). Functional studies on human Pex7p: Subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins . Biochemical Journal. 365. (1). p. 41-50.
Compernolle, V., Brusselmans, K., Acker, T., Hoet, P., Tjwa, M., Beck, H., Plaisance, S., Dor, Y., Keshet, E., Lupu, F., et al.(2002). Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice . Nature Medicine. 8. (7). p. 702-710.
Luo, Y.-S., Nicaud, J.-M., Van Veldhoven, P.P., Chardot, T.(2002). The acyl-CoA oxidases from the yeast Yarrowia lipolytica: Characterization of Aox2p . Archives of Biochemistry and Biophysics. 407. (1). p. 32-38.
Baes, M., Gressens, P., Huyghe, S., De Nys, K., Qi, C., Jia, Y., Mannaerts, G.P., Evrard, P., Van Veldhoven, P.P., Declercq, P.E., et al.(2002). The neuronal migration defect in mice with Zellweger syndrome (Pex5 knockout) is not caused by the inactivity of peroxisomal β-oxidation . Journal of Neuropathology and Experimental Neurology. 61. (4). p. 368-374.
Quarck, R., De Geest, B., Stengel, D., Mertens, A., Lox, M., Theilmeier, G., Michiels, C., Raes, M., Bult, H., Collen, D., et al.(2001). Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice . Circulation. 103. (20). p. 2495-2500.
De Nys, K., Meyhi, E., Mannaerts, G.P., Fransen, M., Van Veldhoven, P.P.(2001). Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1533. (1). p. 66-72.
Van Veldhoven, P.P., Meyhi, E., Squires, R.H., Fransen, M., Fournier, B., Brys, V., Bennett, M.J., Mannaerts, G.P.(2001). Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: Possible link between racemase deficiency and malabsorption and vitamin K deficiency . European Journal of Clinical Investigation. 31. (8). p. 714-722.
Van Veldhoven, P.P., Casteels, M., Mannaerts, G.P., Baes, M.(2001). Further insights into peroxisomal lipid breakdown via α- and β-oxidation . Biochemical Society Transactions. 29. (2). p. 292-298.
Fransen, M., Wylin, T., Brees, C., Mannaerts, G.P., Van Veldhoven, P.P.(2001). Human Pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences . Molecular and Cellular Biology. 21. (13). p. 4413-4424.
Amery, L., Sano, H., Mannaerts, G.P., Snider, J., Van Looy, J., Fransen, M., Van Veldhoven, P.P.(2001). Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals . Biochemical Journal. 357. (3). p. 635-646.
Amery, L., Mannaerts, G.P., Subramani, S., Van Veldhoven, P.P., Fransen, M.(2001). Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology . Combinatorial Chemistry and High Throughput Screening. 4. (7). p. 545-552.
Van Houte, H., De Hoffmann, E., Van Veldhoven, P.P., Mannaerts, G.P., Carchon, H., Baes, M.I., Declercq, P.E.(2001). Oxidative catabolism of α-tocopherol in rat liver microsomes . Lipids. 36. (4). p. 367-372.
Huyghe, S., Casteels, M., Janssen, A., Meulders, L., Mannaerts, G.P., Declercq, P.E., Van Veldhoven, P.P., Baes, M.(2001). Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse . Biochemical Journal. 353. (3). p. 673-680.
Kinard, F., Jaworski, K., Sergent-Engelen, T., Goldstein, D., Van Veldhoven, P.P., Holvoet, P., Trouet, A., Schneider, Y.-J., Remacle, C.(2001). Smooth muscle cells influence monocyte response to LDL as well as their adhesion and transmigration in a coculture model of the arterial wall . Journal of Vascular Research. 38. (5). p. 479-491.
Gijsbers, S., Van Der Hoeven, G., Van Veldhoven, P.P.(2001). Subcellular study of sphingoid base phosphorylation in rat tissues: Evidence for multiple sphingosine kinases . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1532. (1-2). p. 37-50.
Van Veldhoven, P.P., Mannaerts, G.P., Declercq, P., Baes, M.(2000). Do sphingoid bases interact with the peroxisome proliferator activated receptor α (PPAR-α)? . Cellular Signalling. 12. (7). p. 475-479.
Janssen, A., Baes, M., Gressens, P., Mannaerts, G.P., Declercq, P., Van Veldhoven, P.P.(2000). Docosahexaenoic acid deficit is not a major pathogenic factor in peroxisome-deficient mice . Laboratory Investigation. 80. (1). p. 31-35.
Causeret, C., Geeraert, L., Van der Hoeven, G., Mannaerts, G.P., Van Veldhoven, P.P.(2000). Further characterization of rat dihydroceramide desaturase: Tissue distribution, subcellular localization, and substrate specificity . Lipids. 35. (10). p. 1117-1125.
Theilmeier, G., De Geest, B., Van Veldhoven, P.P., Stengel, D., Michiels, C., Lox, M., Landeloos, M., Chapman, M.J., Ninio, E., Collen, D., et al.(2000). HDL-associated PAF-AH reduces endothelial adhesiveness in apoE(-/-) mice . FASEB Journal. 14. (13). p. 2032-2039.
Van Veldhoven, P.P., Gijsbers, S., Mannaerts, G.P., Vermeesch, J.R., Brys, V.(2000). Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22 . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1487. (2-3). p. 128-134.
Antonenkov, V.D., Croes, K., Waelkens, E., Van Veldhoven, P.P., Mannaerts, G.P.(2000). Identification, purification and characterization of an acetoacetyl-CoA thiolase from rat liver peroxisomes . European Journal of Biochemistry. 267. (10). p. 2981-2990.
Baes, M., Huyghe, S., Carmeliet, P., Declercq, P.E., Collen, D., Mannaerts, G.P., Van Veldhoven, P.P.(2000). Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids . Journal of Biological Chemistry. 275. (21). p. 16329-16336.
Antonenkov, V.D., Van Veldhoven, P.P., Mannaerts, G.P.(2000). Isolation and subunit composition of native sterol carrier protein 2/3-oxoacyl-coenzyme A thiolase from normal rat liver peroxisomes . Protein Expression and Purification. 18. (3). p. 249-256.
Amery, L., Fransen, M., De Nys, K., Mannaerts, G.P., Van Veldhoven, P.P.(2000). Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans . Journal of Lipid Research. 41. (11). p. 1752-1759.
Gressens, P., Baes, M., Leroux, P., Lombet, A., Van Veldhoven, P., Janssen, A., Vamecq, J., Marret, S., Evrard, P.(2000). Neuronal migration disorder in Zellweger mice is secondary to glutamate receptor dysfunction . Annals of Neurology. 48. (3). p. 336-343.
Mannaerts, G.P., Van Veldhoven, P.P., Casteels, M.(2000). Peroxisomal Lipid Degradation via β- and α-oxidation in Mammals . Cell Biochemistry and Biophysics. 32. p. 73-87.
Croes, K., Foulon, V., Casteels, M., Van Veldhoven, P.P., Mannaerts, G.P.(2000). Phytanoyl-CoA hydroxylase: Recognition of 3-methyl-branched acyl-CoAs and requirement for GTP or ATP and Mg<sup>2+</sup> in addition to its known hydroxylation cofactors . Journal of Lipid Research. 41. (4). p. 629-636.
Yamashita, H., Avraham, S., Jiang, S., London, R., Van Veldhoven, P.P., Subramani, S., Rogers, R.A., Avraham, H.(1999). Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro . Journal of Biological Chemistry. 274. (42). p. 29897-29904.
Antonenkov, V.D., Van Veldhoven, P.P., Waelkens, E., Mannaerts, G.P.(1999). Comparison of the stability and substrate specificity of purified peroxisomal 3-oxoacyl-CoA thiolases A and B from rat liver . Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1437. (2). p. 136-141.
Fransen, M., Van Veldhoven, P.P., Subramani, S.(1999). Identification of peroxisomal proteins by using M13 phage protein VI phage display: Molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase . Biochemical Journal. 340. (2). p. 561-568.
Vleurick, L., K&#252;hn, E.R., Decuypere, E., Van Veldhoven, P.P.(1999). Isolation of plasma membranes and golgi apparatus from a single chicken liver homogenate. Journal of Cellular Biochemistry. 72. (3). p. 349-355.
Gijsbers, S., Mannaerts, G.P., Himpens, B., Van Veldhoven, P.P.(1999). N-Acetyl-sphingenine-1-phosphate is a potent calcium mobilizing agent . FEBS Letters. 453. (3). p. 269-272.
M&#246;ller, G., L&#252;ders, J., Markus, M., Husen, B., Van Veldhoven, P.P., Adamski, J.(1999). Peroxisome targeting of porcine 17β-hydroxysteroid dehydrogenase type IV/D-specific multifunctional protein 2 is mediated by its C-terminal tripeptide AKI. Journal of Cellular Biochemistry. 73. (1). p. 70-78.
Foulon, V., Antonenkov, V.D., Croes, K., Waelkens, E., Mannaerts, G.P., Van Veldhoven, P.P., Casteels, M.(1999). Purification, molecular cloning, and expression of 2-hydroxyphytanoyl- CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during α-oxidation of 3-methyl- branched fatty acids . Proceedings of the National Academy of Sciences of the United States of America. 96. (18). p. 10039-10044.
Gijsbers, S., Causeret, C., Van Der Hoeven, G., Van Veldhoven, P.P.(1999). Sphingosine kinase: Assay conditions, tissue distribution in rat, and subcellular localization in rat kidney and liver . Lipids. 34. (6 SUPPL.).
Croes, K., Casteels, M., Dieuaide-Noubhani, M., Mannaerts, G.P., Van Veldhoven, P.P.(1999). Stereochemistry of the α-oxidation of 3-methyl-branched fatty acids in rat liver . Journal of Lipid Research. 40. (4). p. 601-609.
Antonenkov, V.D., Van Veldhoven, P.P., Mannaerts, G.P.(1999). The commonly used Mg<sup>2+</sup>-enolate assay can lead to underestimation of thiolase activity . Analytical Biochemistry. 267. (2). p. 418-420.
Antonenkov, V.D., Van Veldhoven, P.P., Mannaerts, G.P.(1999). The growing family of peroxisomal thiolases . Lipids. 34. (6 SUPPL.).
Croes, K., Van Veldhoven, P.P., Mannaerts, G.P., Casteels, M.(1999). α-Oxidation of 3-methyl-branched fatty acids: A revised pathway confined to peroxisomes . Lipids. 34. (6 SUPPL.).
Amery, L., Brees, C., Baes, M., Setoyama, C., Miura, R., Mannaerts, G.P., Van Veldhoven, P.P.(1998). C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal . Biochemical Journal. 336. (2). p. 367-371.
Caira, F., Cl&#233;mencet, M.-C., Cherkaoui-Malki, M., Dieuaide-Noubhani, M., Pacot, C., Van Veldhoven, P.P., Latruffe, N.(1998). Differential regulation by a peroxisome proliferator of the different multifunctional proteins in guinea pig: cDNA cloning of the guinea pig D-specific multifunctional protein 2 . Biochemical Journal. 330. (3). p. 1361-1368.
Van Veldhoven, P.P., Meyhi, E., Mannaerts, G.P.(1998). Enzymatic quantitation of cholesterol esters in lipid extracts . Analytical Biochemistry. 258. (1). p. 152-155.
Battaile, K.P., McBurney, M., Van Veldhoven, P.P., Vockley, J.(1998). Human long chain, very long chain and medium chain acyl-CoA dehydrogenases are specific for the S-enantiomer of 2-methylpentadecanoyl-CoA . Biochimica et Biophysica Acta - Lipids and Lipid Metabolism. 1390. (3). p. 333-338.
Wylin, T., Baes, M., Brees, C., Mannaerts, G.P., Fransen, M., Van Veldhoven, P.P.(1998). Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii . European Journal of Biochemistry. 258. (2). p. 332-338.
Stier, H., Fahimi, H.D., Van Veldhoven, P.P., Mannaerts, G.P., V&#246;lkl, A., Baumgart, E.(1998). Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): Possible involvement of the peroxisome proliferator-activated receptor α (PPARα) . Differentiation. 64. (1). p. 55-66.
Esquenet, M., Swinnen, J.V., Van Veldhoven, P.P., Denef, C., Heyns, W., Verhoeven, G.(1998). Retinoids stimulate lipid synthesis and accumulation in LNCaP prostatic adenocarcinoma cells . Molecular and Cellular Endocrinology. 136. (1). p. 37-46.
Van Veldhoven, P.P.(1998). New insights in peroxisomal beta-oxidation. Implications for human peroxisomal disorders . Verhandelingen - Koninklijke Academie voor Geneeskunde van België. 60. (3). p. 195-214.
Lametschwandtner, G., Brocard, C., Fransen, M., Van Veldhoven, P., Berger, J., Hartig, A.(1998). The difference in recognition of terminal tripeptides as peroxisomal targeting signal I between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it . Journal of Biological Chemistry. 273. (50). p. 33635-33643.
Van Veldhoven, P.P., Croes, K., Casteels, M., Mannaerts, G.P.(1997). 2-Methylacyl racemase: A coupled assay based on the use of pristanoyl-CoA oxidase/peroxidase and reinvestigation of its subcellular distribution in rat and human liver . Biochimica et Biophysica Acta - Lipids and Lipid Metabolism. 1347. (1). p. 62-68.
Moghrabi, N.N., Naylor, S.L., Van Veldhoven, P.P., Baumgart, E., Dawson, D.B., Bennett, M.J.(1997). Assignment of the human peroxisomal branched-chain Acyl-CoA oxidase gene to chromosome 3p21.1-p14.2 by rodent/human somatic cell hybridization . Biochemical and Biophysical Research Communications. 231. (3). p. 767-769.
Baes, M., Gressens, P., Baumgart, E., Carmeliet, P., Casteels, M., Fransen, M., Evrard, P., Fahimi, D., Declercq, P.E., Collen, D., et al.(1997). A mouse model for Zellweger syndrome . Nature Genetics. 17. (1). p. 49-57.
Geeraert, L., Mannaerts, G.P., Van Veldhoven, P.P.(1997). Conversion of dihydroceramide into ceramide: Involvement of a desaturase . Biochemical Journal. 327. (1). p. 125-132.
Dieuaide-Noubhani, M., Novikov, D., Baumgart, E., Vanhooren, J.C.T., Fransen, M., Goethals, M., Vandekerckhove, J., Van Veldhoven, P.P., Mannaerts, G.P.(1997). Erratum: Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C<inf>27</inf>bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins (FEBS, Volume 240, No.3) . European Journal of Biochemistry. 243. (1-2). p. 537.
Fransen, M., Brees, C., Van Veldhoven, P.P., Mannaerts, G.P.(1997). Erratum: The visualization of peroxisomal proteins containing a C- terminal targeting sequence on western blot by using the biotinylated PTS1- recepter (Analytical Biochemistry (1996) 242:1 (26-30)) . Analytical Biochemistry. 246. (2). p. 270-271.
Vanhooren, J.C.T., Marynen, P., Mannaerts, G.P., Van Veldhoven, P.P.(1997). Evidence for the existence of a pristanoyl-CoA oxidase gene in man . Biochemical Journal. 325. (3). p. 593-599.
Dieuaide-Noubhani, M., Asselberghs, S., Mannaerts, G.P., Van Veldhoven, P.P.(1997). Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal β-oxidation of pristanic acid . Biochemical Journal. 325. (2). p. 367-373.
Croes, K., Casteels, M., Asselberghs, S., Herdewijn, P., Mannaerts, G.P., Van Veldhoven, P.P.(1997). Formation of a 2-methyl-branched fatty aldehyde during peroxisomal α-oxidation . FEBS Letters. 412. (3). p. 643-645.
Dieuaide-Noubhani, M., Novikov, D., Vandekerckhove, J., Van Veldhoven, P.P., Mannaerts, G.P.(1997). Identification and characterization of the 2-enoyl-CoA hydratases involved in peroxisomal β-oxidation in rat liver . Biochemical Journal. 321. (1). p. 253-259.
Van Veldhoven, P.P., Swinnen, J.V., Esquenet, M., Verhoeven, G.(1997). Lipase-based quantitation of triacylglycerols in cellular lipid extracts: Requirement for presence of detergent and prior separation by thin- layer chromatography . Lipids. 32. (12). p. 1297-1300.
Van Houte, H.A., Van Veldhoven, P.P., Mannaerts, G.P., Baes, M.I., Declercq, P.E.(1997). Metabolism of dolichol, dolichoic acid and nordolichoic acid in cultured cells . Biochimica et Biophysica Acta - Lipids and Lipid Metabolism. 1347. (1). p. 93-100.
Croes, K., Van Veldhoven, P.P., Mannaerts, G.P., Casteels, M.(1997). Production of formyl-CoA during peroxisomal α-oxidation of 3-methyl-branched fatty acids . FEBS Letters. 407. (2). p. 197-200.
Antonenkov, V.D., Van Veldhoven, P.P., Waelkens, E., Mannaerts, G.P.(1997). Substrate specificities of 3-oxoacyl-CoA thiolase a and sterol carrier protein 2/3-oxoacyl-coa thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates . Journal of Biological Chemistry. 272. (41). p. 26023-26031.
Novikov, D., Dieuaide-Noubhani, M., Vermeesch, J.R., Fournier, B., Mannaerts, G.P., Van Veldhoven, P.P.(1997). The human peroxisomal multifunctional protein involved in bile acid synthesis: Activity measurement, deficiency in Zellweger syndrome and chromosome mapping . Biochimica et Biophysica Acta - Molecular Basis of Disease. 1360. (3). p. 229-240.
Distel, B., Erdmann, R., Gould, S.J., Blobel, G., Crane, D.I., Cregg, J.M., Dodt, G., Fujiki, Y., Goodman, J.M., Just, W.W., et al.(1996). A unified nomenclature for peroxisome biogenesis factors . Journal of Cell Biology. 135. (1). p. 1-3.
Swinnen, J.V., Van Veldhoven, P.P., Esquenet, M., Heyns, W., Verhoeven, G.(1996). Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP . Endocrinology. 137. (10). p. 4468-4474.
Willard, J., Vicanek, C., Battaile, K.P., Van Veldhoven, P.P., Fauq, A.H., Rozen, R., Vockley, J.(1996). Cloning of a cDNA for short/branched chain acyl-coenzyme A dehydrogenase from rat and characterization of its tissue expression and substrate specificity . Archives of Biochemistry and Biophysics. 331. (1). p. 127-133.
Dieuaide-Noubhani, M., Novikov, D., Baumgart, E., Vanhooren, J.C.T., Fransen, M., Goethals, M., Vandekerckhove, J., Van Veldhoven, P.P., Mannaerts, G.P.(1996). Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C<inf>27</inf> bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins . European Journal of Biochemistry. 240. (3). p. 660-666.
Van Veldhoven, P.P., Baumgart, E., Mannaerts, G.P.(1996). Iodixanol (optiprep), an improved density gradient medium for the iso-osmotic isolation of rat liver peroxisomes . Analytical Biochemistry. 237. (1). p. 17-23.
Baumgart, E., Vanhooren, J.C.T., Fransen, M., Marynen, P., Puype, M., Vandekerckhove, J., Leunissen, J.A.M., Fahimi, H.D., Mannaerts, G.P., Van Veldhoven, P.P.(1996). Molecular characterization of the human peroxisomal branchedchain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome . Proceedings of the National Academy of Sciences of the United States of America. 93. (24). p. 13748-13753.
Baumgart, E., Vanhooren, J.C.T., Fransen, M., Van Leuven, F., Fahimi, H.D., Van Veldhoven, P.P., Mannaerts, G.P.(1996). Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase . Biochemical Journal. 320. (1). p. 115-121.
Van Veldhoven, P.P., Croes, K., Asselberghs, S., Herdewijn, P., Mannaerts, G.P.(1996). Peroxisomal β-oxidation of 2-methyl-branched acyl-CoA esters: Stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase . FEBS Letters. 388. (1). p. 80-84.
Van Veldhoven, P.P., Asselberghs, S., Eyssen, H.J., Mannaerts, G.P.(1996). Stabilisation and partial purification of triton X-100 solubilised trihydroxycoprostanoyl-Coa synthetase from rat liver . Biochemistry and Molecular Biology International. 40. (3). p. 447-457.
Vanhooren, J.C.T., Fransen, M., De B&#233;thune, B., Baumgart, E., Baes, M., Torrekens, S., Van Leuven, F., Mannaerts, G.P., Van Veldhoven, P.P.(1996). Rat pristanoyl-CoA oxidase - cDNA cloning and recognition of its C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor . European Journal of Biochemistry. 239. (2). p. 302-309.
Van Houte, H.A., Busson, R.H., Parmentier, G.G., Eyssen, H.J., Van Veldhoven, P.P., Mannaerts, G.P., Baes, M.I., Declercq, P.E.(1996). Synthesis of [1-<sup>14</sup>C] nordolichoic acid . Chemistry and Physics of Lipids. 82. (1). p. 79-83.
Fransen, M., Brees, C., Van Veldhoven, P.P., Mannaerts, G.P.(1996). The visualization of peroxisomal proteins containing a C-terminal targeting sequence on western blot by using the biotinylated PTS1-receptor . Analytical Biochemistry. 242. (1). p. 26-30.
Croes, K., Casteels, M., De Hoffmann, E., Mannaerts, G.P., Van Veldhoven, P.P.(1996). α-Oxidatian of 3-methyl-substituted fatty acids in rat liver. Production of formic acid instead of CO<inf>2</inf>, cofactor requirements, subcellular localization and formation of a 2-hydroxy-3-methylacyl-CoA intermediate . European Journal of Biochemistry. 240. (3). p. 674-683.
Van Veldhoven, P.P.(1995). Activity measurements of acyl-CoA oxidases in human liver . Journal of Inherited Metabolic Disease. 18. (1 Supplement). p. 125-134.
Van Veldhoven, P.P., Bishop, W.R., Yurivich, D.A., Bell, R.M.(1995). Ceramide quantitation: Evaluation of a mixed micellar assay using E. coli diacylglycerol kinase . Biochemistry and Molecular Biology International. 36. (1). p. 21-30.
Croes, K., Casteels, M., van Veldhoven, P.P., P. Mannaerts, G.(1995). Evidence for the importance of iron in the a-oxidation of 3-methyl-substituted fatty acids in the intact cell . Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1255. (1). p. 63-67.
Fransen, M., Brees, C., Baumgart, E., Vanhooren, J.C.T., Baes, M., Mannaerts, G.P., Van Veldhoven, P.P.(1995). Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor . Journal of Biological Chemistry. 270. (13). p. 7731-7736.
De Ceuster, P., Mannaerts, G.P., Van Veldhoven, P.P.(1995). Identification and subcellular localization of sphinganine-phosphatases in rat liver . Biochemical Journal. 311. (1). p. 139-146.
Marynen, P., Fransen, M., Raeymaekers, P., Mannaerts, G.P., Van Veldhoven, P.P.(1995). The gene for the peroxisomal targeting signal import receptor (PXR1) is located on human chromosome 12p13, flanked by TPI1 and D12S1089 . Genomics. 30. (2). p. 366-368.
Vanhooren, J.C.T., Asselberghs, S., Eyssen, H.J., Mannaerts, G.P., Van Veldhoven, P.P.(1994). Activation of 3-methyl-branched fatty acids in rat liver . International Journal of Biochemistry. 26. (9). p. 1095-1101.
Casteels, M., Croes, K., Van Veldhoven, P.P., Mannaerts, G.P.(1994). Aminotriazole is a potent inhibitor of α-oxidation of 3-methyl-substituted fatty acids in rat liver . Biochemical Pharmacology. 48. (10). p. 1973-1975.
Van Veldhoven, P.P., Mannaerts, G.P.(1994). Assembly of the peroxisomal membrane . Sub-cellular biochemistry. 22. p. 231-261.
Huang, S., Van Veldhoven, P.P., Asselberghs, S., Eyssen, H.J., de Hoffmann, E., Mannaerts, G.P.(1994). Comparison of fatty acid α-oxidation by rat hepatocytes and by liver microsomes fortified with NADPH, Fe<sup>3+</sup> and phosphate . Lipids. 29. (10). p. 671-678.
Van Veldhoven, P.P., De Ceuster, P., Rozenberg, R., Mannaerts, G.P., de Hoffmann, E.(1994). On the presence of phosphorylated sphingoid bases in rat tissues A mass-spectrometric approach . FEBS Letters. 350. (1). p. 91-95.
VAN VELDHOVEN, P.P., VAN ROMPUY, P., FRANSEN, M., DE B&#201;THUNE, B., MANNAERTS, G.P.(1994). Large‐scale purification and further characterization of rat pristanoyl‐CoA oxidase . European Journal of Biochemistry. 222. (3). p. 795-801.
Novikov, D.K., Vanhove, G.F., Carchon, H., Asselberghs, S., Eyssen, H.J., Van Veldhoven, P.P., Mannaerts, G.P.(1994). Peroxisomal β-oxidation. Purification of four novel 3-hydroxyacyl-CoA dehydrogenases from rat liver peroxisomes . Journal of Biological Chemistry. 269. (43). p. 27125-27135.
Van Veldhoven, P.P., Van Rompuy, P., Vanhooren, C.T., Mannaerts, G.P.(1994). Purification and further characterization of peroxisomal trihydroxycoprostanoyl-CoA oxidase from rat liver . Biochemical Journal. 304. (1). p. 195-200.
Van Veldhoven, P.P., Mannaerts, G.P.(1994). Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: Evidence for the existence of a sphingosine phosphatase . Biochemical Journal. 299. (3). p. 597-601.
Van Houte, H.A., Busson, R.H., Parmentier, G.G., Declercq, P.E., van Veldhoven, P.P., Mannaerts, G.P., Eyssen, H.J.(1994). Synthesis of [1-<sup>14</sup>C] dolichoic acid . Chemistry and Physics of Lipids. 72. (1). p. 103-107.
Fransen, M., Brees, C.A.E., de B&#233;thune, B., Van Veldhoven, P.P., Mannerts, G.P.(1994). The 80 kDa cytosolic protein that binds the C-terminal part of rat acyl-CoA oxidase is not a peroxisomal import receptor but a prolyl-endopeptidase . BBA - General Subjects. 1201. (2). p. 157-164.
Van Veldhoven, P.P., Huang, S., Eyssen, H.J., Mannaerts, G.P.(1993). The deficient degradation of synthetic 2- and 3-methyl-branched fatty acids in fibroblasts from patients with peroxisomal disorders . Journal of Inherited Metabolic Disease. 16. (2). p. 381-391.
Vanhove, G., Veldhoven, P.P.V., Eyssen, H.J., Mannaerts, G.P.(1993). Mitochondrial short-chain acyl-CoA dehydrogenase of human liver and kidney can function as an oxidase . Biochemical Journal. 292. (1). p. 23-30.
Mannaerts, G.P., Van Veldhoven, P.P.(1993). Metabolic pathways in mammalian peroxisomes . Biochimie. 75. (3-4). p. 147-158.
van Veldhoven, P.P., Mannaerts, G.P.(1993). Sphingosine-phosphate lyase . Advances in lipid research. 26. p. 69-98.
Mannaerts, G.P., Van Veldhoven, P.P.(1993). Peroxisomal beta-oxidation,Peroxysomale beta-oxydatie . Verhandelingen - Koninklijke Academie voor Geneeskunde van België. 55. (1). p. 45-78.
Vanhove, G.F., Van Veldhoven, P.P., Fransen, M., Denis, S., Eyssen, H.J., Wanders, R.J.A., Mannaerts, G.P.(1993). The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney . Journal of Biological Chemistry. 268. (14). p. 10335-10344.
Mannaerts, G.P., Van Veldhoven, P.P.(1992). Role of peroxisomes in mammalian metabolism . Cell Biochemistry and Function. 10. (3). p. 141-151.
Van Veldhoven, P.P., Vanhove, G., Assselberghs, S., Eyssen, H.J., Mannaerts, G.P.(1992). Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: Palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase . Journal of Biological Chemistry. 267. (28). p. 20065-20074.
Huang, S., Van Veldhoven, P.P., Vanhoutte, F., Parmentier, G., Eyssen, H.J., Mannaerts, G.P.(1992). α-Oxidation of 3-methyl-substituted fatty acids in rat liver . Archives of Biochemistry and Biophysics. 296. (1). p. 214-223.
Van Veldhoven, P.P., Matthews, T.J., Bolognesi, D.P., Bell, R.M.(1992). Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells . Biochemical and Biophysical Research Communications. 187. (1). p. 209-216.
Verheyden, K., Fransen, M., Van Veldhoven, P.P., Mannaerts, G.P.(1992). Presence of small GTP-binding proteins in the peroxisomal membrane . BBA - Biomembranes. 1109. (1). p. 48-54.
Van Veldhoven, P.P., Vanhove, G., Vanhoutte, F., Dacremont, G., Parmentier, G., Eyssen, H.J., Mannaerts, G.P.(1991). Identification and purification of a peroxisomal branched chain fatty acyl-CoA oxidase . Journal of Biological Chemistry. 266. (36). p. 24676-24683.
Vanhove, G., Van Veldhoven, P.P., Vanhoutte, F., Parmentier, G., Eyssen, H.J., Mannaerts, G.P.(1991). Mitochondrial and peroxisomal β oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver . Journal of Biological Chemistry. 266. (36). p. 24670-24675.
Borchardt, R.A., Bishop, W.R., Bocckino, S.B., Loomis, C.R., Roben, D.M., Ramer, J.K., Van Veldhoven, P.P., Bell, R.M.(1991). Quantification of diradylglycerols: a reply . Biochemical Journal. 280.
Van Veldhoven, P.P., Mannaerts, G.P.(1991). Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver . Journal of Biological Chemistry. 266. (19). p. 12502-12507.
Van Veldhoven, P.P., Brees, C., Mannaerts, G.P.(1991). d-Aspartate oxidase, a peroxisomal enzyme in liver of rat and man . BBA - General Subjects. 1073. (1). p. 203-208.
Mannaerts, G.P., Van Veldhoven, P.P.(1990). The peroxisome: Functional properties in health and disease . Biochemical Society Transactions. 18. (1). p. 87-89.
Casteels, M., Schepers, L., Van Veldhoven, P.P., Eyssen, H.J., Mannaerts, G.P.(1990). Separate peroxisomal oxidases for fatty acyl-CoAs and trihydroxycoprostanoyl-CoA in human liver . Journal of Lipid Research. 31. (10). p. 1865-1872.
Schepers, L., Van Veldhoven, P.P., Casteelst, M., Eyssen, H.J., Mannaerts, G.P.(1990). Presence of three Acyl-CoA oxidases in rat liver peroxisomes: An inducible fatty acyl-coa oxidase, a noninducible fatty acyl-coa oxidase, and a noninducible trihydroxycoprostanoyl-Coa oxidase . Journal of Biological Chemistry. 265. (9). p. 5242-5246.
Casteels, M., Schepers, L., Van Veldhoven, P.P., Mannaerts, G.P.(1990). Separate peroxisomal acyl-CoA oxidases for fatty acids and trihydroxycoprostanic acid in human liver . Biochemical Society Transactions. 18. (5). p. 1003-1004.
Van Veldhoven, P.P., Foglesong, R.J., Bell, R.M.(1989). A facile enzymatic synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate . Journal of Lipid Research. 30. (4). p. 611-616.
Schepers, L., Van Veldhoven, P.P., Eyssen, H.J., Mannaerts, G.P.(1989). Separate peroxisomal oxidases for long-chain acyl-CoA and trihydroxycoprostanoyl-CoA . Biochemical Society Transactions. 17. (6). p. 1076.
Van Veldhoven, P.P., Bishop, W.R., Bell, R.M.(1989). Enzymatic quantification of sphingosine in the picomole range in cultured cells . Analytical Biochemistry. 183. (1). p. 177-189.
Lemmens, M., Verheyden, K., Van Veldhoven, P., Vereecke, J., Mannaerts, G.P., Carmeliet, E.(1989). Single-channel analysis of a large conductance channel in peroxisomes from rat liver . BBA - Biomembranes. 984. (3). p. 351-359.
Van Veldhoven, P.P., Bell, R.M.(1988). Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells . Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 959. (2). p. 185-196.
Mannaerts, G.P., Van Veldhoven, P.P.(1988). Influence of drugs on liver mitochondria and peroxisomes . Archives of Toxicology. 62. (SUPPL. 12). p. 225-232.
Suyatna, F.D., van Veldhoven, P.P., Borgers, M., Mannaerts, G.P.(1988). Phospholipid composition and amphiphile content of isolated sarcolemma from normal and autolytic rat myocardium . Journal of Molecular and Cellular Cardiology. 20. (1). p. 47-62.
Schepers, L., Casteels, M., Vamecq, J., Parmentier, G., Van Veldhoven, P.P., Mannaerts, G.P.(1988). β-Oxidation of the carboxyl side chain of prostaglandin E<inf>2</inf> in rat liver peroxisomes and mitochondria . Journal of Biological Chemistry. 263. (6). p. 2724-2731.
Van Veldhoven, P.P., Just, W.W., Mannaerts, G.P.(1987). Permeability of the peroxisomal membrane to cofactors of beta-oxidation. Evidence for the presence of a pore-forming protein . Journal of Biological Chemistry. 262. (9). p. 4310-4318.
Van Veldhoven, P.P., Mannaerts, G.P.(1987). Inorganic and organic phosphate measurements in the nanomolar range . Analytical Biochemistry. 161. (1). p. 45-48.
Van Veldhoven, P.P., Mannaerts, G.P.(1986). Coenzyme a in purified peroxisomes is not freely soluble in the matrix but firmly bound to a matrix protein . Biochemical and Biophysical Research Communications. 139. (3). p. 1195-1201.
Van Veldhoven, P., Mannaerts, G.P.(1985). Comparison of the activities of some peroxisomal and extraperoxisomal lipid-metabolizing enzymes in liver and extrahepatic tissues of the rat . Biochemical Journal. 227. (3). p. 737-741.
Van Veldhoven, P., Declercq, P.E., Debeer, L.J., Mannaerts, G.P.(1984). Effects of benfluorex and fenofibrate treatment on mitochondrial and peroxisomal marker enzymes in rat liver . Biochemical Pharmacology. 33. (7). p. 1153-1155.
Declercq, P.E., Haagsman, H.P., van Veldhoven, P., Debeer, L.J., Van Golde, L.M., Mannaerts, G.P.(1984). Rat liver dihydroxyacetone-phosphate acyltransferase and their contribution to glycerolipid synthesis . Journal of Biological Chemistry. 259. (14). p. 9064-9075.
Van Veldhoven, P., Debeer, L.J., Mannaerts, G.P.(1983). Water- and solute-accessible spaces of purified peroxisomes. Evidence that peroxisomes are permeable to NAD+ . The Biochemical journal. 210. (3). p. 685-693.
Mannaerts, G.P., Van Veldhoven, P., Van Broekhoven, A., Vandebroek, G., Debeer, L.J.(1982). Evidence that peroxisomal acyl-CoA synthetase is located at the cytoplasmic side of the peroxisomal membrane . The Biochemical journal. 204. (1). p. 17-23.
Van Veldhoven, P., Debeer, L.J., Mannaerts, G.P.(1982). Water and solute-accessible spaces of hepatic peroxisomes purified from clofibrate-treated rats . Biology of the Cell. 45. (2).
Ververken, D., Van Veldhoven, P., Proost, C., Carton, H., De Wulf, H.(1982). On the Role of Calcium Ions in the Regulation of Glycogenolysis in Mouse Brain Cortical Slices . Journal of Neurochemistry. 38. (5). p. 1286-1295.
Van Veldhoven, P., Carton, H.(1982). Enkephalinase a activity in different regions of brain and spinal cord of normal and chronic arthritic rats . FEBS Letters. 138. (1). p. 76-78.
BOOK CHAPTER
Sai Kocherlakota, Dani&#235;lle Swinkels, Paul P. Van Veldhoven, Myriam Baes (2023). Mouse Models to Study Peroxisomal Functions and Disorders: Overview, Caveats, and Recommendations . Methods in Molecular Biology.
Baes, M., Verheijden, S., Van Veldhoven, P.P.(2014). Mouse models with peroxisome biogenesis defects . Molecular Machines Involved in Peroxisome Biogenesis and Maintenance. p. 17-36.
BOOK
Fransen, M., Nordgren, M., Wang, B., Apanasets, O., Van Veldhoven, P.P.(2013). Aging, age-related diseases and peroxisomes . Subcellular Biochemistry. 69. p. 45-65.
Baes, M., Van Veldhoven, P.P.(2003). Lessons from knockout mice. I: Phenotypes of mice with peroxisome biogenesis disorders . Advances in Experimental Medicine and Biology. 544. p. 113-122.
Foulon, V., Casteels, M., Mannaerts, G.P., Gelb, B.D., Van Veldhoven, P.P.(2003). Thiamine pyrophosphate: An essential cofactor in the mammalian metabolism of 3-methyl-branched fatty acids - Implications for thiamine deficiencies? . Advances in Experimental Medicine and Biology. 544. p. 305-306.
Van Veldhoven, P.P., Mannaerts, G.P., Casteels, M., Croes, K.(2000). Hepatic α-oxidation of phytanic acid: A revised pathway . Advances in Experimental Medicine and Biology. 466. p. 273-281.
Van Veldhoven, P.P., Mannaerts, G.P.(2000). Role and organization of peroxisomal β-oxidation . Advances in Experimental Medicine and Biology. 466. p. 261-272.
Van Veldhoven, P.P.(2000). Sphingosine-1-phosphate lyase . Methods in Enzymology. 311. p. 244-254.
Vleurick, L., Van Veldhoven, P., Decuypere, E., K&#252;hn, E.R.(1998). Intracellular growth hormone receptors in chicken liver . Annals of the New York Academy of Sciences. 839. p. 538-540.
Mannaerts, G.P., Van Veldhoven, P.P.(1996). Functions and organization of peroxisomal β-oxidation . Annals of the New York Academy of Sciences. 804. p. 99-115.
Fransen, M., Marynen, P., Baumgart, E., Vanhooren, J.C.T., Mannaerts, G.P., Van Veldhoven, P.P.(1996). Further characterization of the human peroxisomal C-terminal targeting signal protein import receptor . Annals of the New York Academy of Sciences. 804. p. 672-673.
Vanhooren, J.C.T., Baumgart, E., Fransen, M., Mannaerts, G.P., Van Veldhoven, P.P.(1996). Mammalian Peroxisomal Acyl-CoA Oxidases: I. Molecular Characterization of Rat Pristanoyl-CoA Oxidase . Annals of the New York Academy of Sciences. 804. p. 674-675.
Baumgart, E., Vanhooren, J.C.T., Fransen, M., Van Veldhoven, P.P., Mannaerts, G.P.(1996). Mammalian Peroxisomal Acyl-CoA Oxidases: II. Molecular Characterization of Rat Trihydroxycoprostanoyl-CoA Oxidase . Annals of the New York Academy of Sciences. 804. p. 676-677.
Baumgart, E., Vanhooren, J.C.T., Fransen, M., Mannaerts, G.P., Van Veldhoven, P.P.(1996). Mammalian Peroxisomal Acyl-CoA Oxidases: III. Molecular Characterization of Human Branched Chain Fatty Acyl-CoA Oxidase . Annals of the New York Academy of Sciences. 804. p. 678-679.
Dieuaide, M., Novikov, D.K., Carchon, H., Van Veldhoven, P.P., Mannaerts, G.P.(1996). Substrate stereospecificities of rat liver peroxisomal 3-hydroxyacyl-CoA dehydrogenases . Annals of the New York Academy of Sciences. 804. p. 680-681.
Croes, K., Casteels, M., Van Veldhoven, P.P., Mannaerts, G.P.(1996). α-Oxidation in intact and permeabilized rat hepatocytes . Annals of the New York Academy of Sciences. 804. p. 682-683.