Profile Details

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Hire Dr. Murugappan S.

United States

USD 60 /hr

Biophysicist/Biochemist expertise in assay development for small/large molecule based early drug discovery research

Profile Summary

Biochemist/Biophysicist with 12+ years of experience in expression, purification, and biophysical/biochemical characterization of soluble and membrane proteins. Expertise in protein-protein/peptide, protein-small molecule, peptide/protein-lipid, and protein-nucleic acid interactions progressing the early drug discovery research. Core competencies include: ● Demonstrated success in leading protein sciences group and designing/executing biochemical/biophysical assays for multiple programs ● Experience managing CRO resources (FFS & FTE model) for protein science and structural biology work. ● Experience leading biochemistry/biophysics group in a fast-paced environment ● Conscientious team player and collaborator with exemplary observational, analytical, and communication skills

Subject Matter Expertise

• ★ Biochemistry
• ★ Biophysics
• ★ Antibody Engineering
• ☆ Molecular Modeling
• ☆ Separation & Purification
• ☆ Biochemical Assays
• ☆ Structural Biology
• ☆ Lipidomics
• ☆ Recombinant Protein Expression
• ☆ Protein/Enzyme Engineering
• ☆ Drug Design
• ☆ Rare Diseases
• ☆ Cancer Research

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, Newswriting

Research Market Research, User Research, Feasibility Study, Fact Checking, Gap Analysis, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis

Product Development Formulation, Product Validation

Work Experience

Senior Scientist

Kymera Therapeutics

May 2022 - Present

Scientist II

Syros Pharmaceuticals Inc

July 2020 - Present

Senior Scientist

Syros Pharmaceuticals

February 2022 - April 2022

Broad Institute

March 2017 - June 2020

Education

University of Connecticut

September 2009 - February 2017

Certifications

• INTRODUCTION TO MOLECULAR MODELING IN DRUG DISCOVERY

  Schrodinger

  December 2019 - Present

• Light Scattering University

  Wyatt Technology Corporation

  December 2018 - Present

Publications

JOURNAL ARTICLE

Wayne Mitchell, Emily A. Ng, Jeffrey D. Tamucci, Kevin J. Boyd, Murugappan Sathappa, Adrian Coscia, Meixia Pan, Xianlin Han, Nicholas A. Eddy, Eric R. May, et al.(2020). The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action . Journal of Biological Chemistry. 295. (21). p. 7452--7469. Elsevier {BV}