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Hire Dr. Mike B.

United Kingdom

USD 50 /hr

Global Product Manager and molecular biologist with 18+years of academic research and 56 peer reviewed publications

Profile Summary

Global product manager with Bio-Rad responsible for strategic portfolio development and marketing strategy for flow cytometry. Project management from initiation to launch of novel reagents including NDA, MTA and supply agreement negotiations. On site testing and data analysis, pricing and stocking and post launch marketing strategy. Creation and development of omni-channel marketing content including emailers, banners, social media, printed collateral, webinars, and website articles. 18+ years of academic research experience in molecular biology and in vivo models in the area of immunology and gene therapy. Experienced in most molecular biology techniques including cloning, tissue culture, iPS generation, virus production, PCR, western blot, immunofluorescence, histology, flow cytometry, and confocal microscopy. Multiple collaborations leading to 56 peer reviewed publications. ASPeL project licence and personal licence holder.

Subject Matter Expertise

• ★ Molecular Biology
• ☆ Cytometry
• ☆ Gene Therapy
• ☆ Sales & Marketing

Services

• Writing
• Research

Writing Technical Writing

Research Systematic Literature Review

Work Experience

University College London

- Present

Global Product Manager

Bio-Rad

July 2015 - December 2019

Senior Research Associate

University College London

January 2006 - July 2015

Research Associate

University College London

January 1996 - December 2005

Education

PhD

University College London

1998 - 2006

BSc (Hons) Immunology

University of Edinburgh

1992 - 1996

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Shangaris P, Loukogeorgakis SP, Subramaniam S, Flouri C, Jackson LH, Wang W, Blundell MP, Liu S, Eaton S, Bakhamis N, et al.(2019). Publisher Correction: In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques . Scientific reports.

Shangaris P, Loukogeorgakis SP, Subramaniam S, Flouri C, Jackson LH, Wang W, Blundell MP, Liu S, Eaton S, Bakhamis N, et al.(2019). In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques . Scientific reports.

Abdul-Razak HH, Rocca CJ, Howe SJ, Alonso-Ferrero ME, Wang J, Gabriel R, Bartholomae CC, Gan CHV, Garín MI, Roberts A, et al.(2018). Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency . Scientific reports.

Shangaris P, Loukogeorgakis SP, Blundell MP, Petra E, Shaw SW, Ramachandra DL, Maghsoudlou P, Urbani L, Thrasher AJ, De Coppi P, et al.(2018). Long-Term Hematopoietic Engraftment of Congenic Amniotic Fluid Stem Cells After in Utero Intraperitoneal Transplantation to Immune Competent Mice . Stem cells and development.

Ghosh S, Carmo M, Calero-Garcia M, Ricciardelli I, Bustamante Ogando JC, Blundell MP, Schambach A, Ashton-Rickardt PG, Booth C, Ehl S, et al.(2018). T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations . The Journal of allergy and clinical immunology.

Domogala A, Blundell M, Thrasher A, Lowdell MW, Madrigal JA, Saudemont A(2017). Natural killer cells differentiated in vitro from cord blood CD34+ cells are more advantageous for use as an immunotherapy than peripheral blood and cord blood natural killer cells . Cytotherapy.

Standing AS, Malinova D, Hong Y, Record J, Moulding D, Blundell MP, Nowak K, Jones H, Omoyinmi E, Gilmour KC, et al.(2016). Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actin-regulatory gene WDR1 . The Journal of experimental medicine.

Pedroza-Pacheco I, Shah D, Domogala A, Luevano M, Blundell M, Jackson N, Thrasher A, Madrigal A, Saudemont A(2016). Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation . Scientific reports.

Malinova D, Fritzsche M, Nowosad CR, Armer H, Munro PM, Blundell MP, Charras G, Tolar P, Bouma G, Thrasher AJ(2015). WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts . Journal of leukocyte biology.

Escobedo-Cousin M, Jackson N, Laza-Briviesca R, Ariza-McNaughton L, Luevano M, Derniame S, Querol S, Blundell M, Thrasher A, Soria B, et al.(2015). Natural Killer Cells Improve Hematopoietic Stem Cell Engraftment by Increasing Stem Cell Clonogenicity In Vitro and in a Humanized Mouse Model . PloS one.

Standing A, Malinova D, Record J, Moulding D, Blundell M, Nowak K, Jones H, Omoyinmi E, Nanthapisal S, Gomes SM, et al.(2015). Severe autoinflammatory disease caused by mutation in a gene controlling actin cytoskeletal dynamics and cure with allogeneic haematopoetic stem cell transplantation . Pediatric rheumatology online journal.

Shaw SW, Blundell MP, Pipino C, Shangaris P, Maghsoudlou P, Ramachandra DL, Georgiades F, Boyd M, Thrasher AJ, Porada CD, et al.(2015). Sheep CD34+ amniotic fluid cells have hematopoietic potential and engraft after autologous in utero transplantation . Stem cells (Dayton, Ohio).

Carmo M, Risma KA, Arumugam P, Tiwari S, Hontz AE, Montiel-Equihua CA, Alonso-Ferrero ME, Blundell MP, Schambach A, Baum C, et al.(2014). Perforin gene transfer into hematopoietic stem cells improves immune dysregulation in murine models of perforin deficiency . Molecular therapy : the journal of the American Society of Gene Therapy.

Ricciardelli I, Blundell MP, Brewin J, Thrasher A, Pule M, Amrolia PJ(2014). Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells . Blood.

Pipino C, Mukherjee S, David AL, Blundell MP, Shaw SW, Sung P, Shangaris P, Waters JJ, Ellershaw D, Cavazzana M, et al.(2014). Trisomy 21 mid-trimester amniotic fluid induced pluripotent stem cells maintain genetic signatures during reprogramming: implications for disease modeling and cryobanking . Cellular reprogramming.

Griera M, Martin-Villar E, Banon-Rodríguez I, Blundell MP, Jones GE, Anton IM, Thrasher AJ, Rodriguez-Puyol M, Calle Y(2014). Integrin linked kinase (ILK) regulates podosome maturation and stability in dendritic cells . The international journal of biochemistry & cell biology.

Luevano M, Domogala A, Blundell M, Jackson N, Pedroza-Pacheco I, Derniame S, Escobedo-Cousin M, Querol S, Thrasher A, Madrigal A, et al.(2014). Frozen cord blood hematopoietic stem cells differentiate into higher numbers of functional natural killer cells in vitro than mobilized hematopoietic stem cells or freshly isolated cord blood hematopoietic stem cells . PloS one.

Carbonaro DA, Zhang L, Jin X, Montiel-Equihua C, Geiger S, Carmo M, Cooper A, Fairbanks L, Kaufman ML, Sebire NJ, et al.(2013). Preclinical demonstration of lentiviral vector-mediated correction of immunological and metabolic abnormalities in models of adenosine deaminase deficiency . Molecular therapy : the journal of the American Society of Gene Therapy.

Charrier S, Blundell M, Cédrone G, Louache F, Vainchenker W, Thrasher AJ, Galy A(2013). Wiskott-Aldrich syndrome protein-deficient hematopoietic cells can be efficiently mobilized by granulocyte colony-stimulating factor . Haematologica.

Schachtner H, Calaminus SD, Sinclair A, Monypenny J, Blundell MP, Leon C, Holyoake TL, Thrasher AJ, Michie AM, Vukovic M, et al.(2013). Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane . Blood.

Furmanski AL, O'Shaughnessy RF, Saldana JI, Blundell MP, Thrasher AJ, Sebire NJ, Davies EG, Crompton T(2013). T-cell reconstitution after thymus xenotransplantation induces hair depigmentation and loss . The Journal of investigative dermatology.

Rivat C, Booth C, Alonso-Ferrero M, Blundell M, Sebire NJ, Thrasher AJ, Gaspar HB(2012). SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease . Blood.

Moschidou D, Mukherjee S, Blundell MP, Jones GN, Atala AJ, Thrasher AJ, Fisk NM, De Coppi P, Guillot PV(2012). Human mid-trimester amniotic fluid stem cells cultured under embryonic stem cell conditions with valproic acid acquire pluripotent characteristics . Stem cells and development.

Moschidou D, Mukherjee S, Blundell MP, Drews K, Jones GN, Abdulrazzak H, Nowakowska B, Phoolchund A, Lay K, Ramasamy TS, et al.(2012). Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach . Molecular therapy : the journal of the American Society of Gene Therapy.

Kallinikou K, Anjos-Afonso F, Blundell MP, Ings SJ, Watts MJ, Thrasher AJ, Linch DC, Bonnet D, Yong KL(2012). Engraftment defect of cytokine-cultured adult human mobilized CD34(+) cells is related to reduced adhesion to bone marrow niche elements . British journal of haematology.

Montiel-Equihua CA, Zhang L, Knight S, Saadeh H, Scholz S, Carmo M, Alonso-Ferrero ME, Blundell MP, Monkeviciute A, Schulz R, et al.(2012). The β-globin locus control region in combination with the EF1α short promoter allows enhanced lentiviral vector-mediated erythroid gene expression with conserved multilineage activity . Molecular therapy : the journal of the American Society of Gene Therapy.

Macpherson L, Monypenny J, Blundell MP, Cory GO, Tomé-García J, Thrasher AJ, Jones GE, Calle Y(2011). Tyrosine phosphorylation of WASP promotes calpain-mediated podosome disassembly . Haematologica.

Huston MW, van Til NP, Visser TP, Arshad S, Brugman MH, Cattoglio C, Nowrouzi A, Li Y, Schambach A, Schmidt M, et al.(2011). Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning . Molecular therapy : the journal of the American Society of Gene Therapy.

Bouma G, Mendoza-Naranjo A, Blundell MP, de Falco E, Parsley KL, Burns SO, Thrasher AJ(2011). Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming . Blood.

Mandegar MA, Moralli D, Khoja S, Cowley S, Chan DY, Yusuf M, Mukherjee S, Blundell MP, Volpi EV, Thrasher AJ, et al.(2011). Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells . Human molecular genetics.

Mukherjee S, Santilli G, Blundell MP, Navarro S, Bueren JA, Thrasher AJ(2011). Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells . PloS one.

Almarza E, Zhang F, Santilli G, Blundell MP, Howe SJ, Thornhill SI, Bueren JA, Thrasher AJ(2011). Correction of SCID-X1 using an enhancerless Vav promoter . Human gene therapy.

Santilli G, Almarza E, Brendel C, Choi U, Beilin C, Blundell MP, Haria S, Parsley KL, Kinnon C, Malech HL, et al.(2010). Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells . Molecular therapy : the journal of the American Society of Gene Therapy.

Kane NM, Nowrouzi A, Mukherjee S, Blundell MP, Greig JA, Lee WK, Houslay MD, Milligan G, Mountford JC, von Kalle C, et al.(2010). Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors . Molecular therapy : the journal of the American Society of Gene Therapy.

Zhang F, Frost AR, Blundell MP, Bales O, Antoniou MN, Thrasher AJ(2010). A ubiquitous chromatin opening element (UCOE) confers resistance to DNA methylation-mediated silencing of lentiviral vectors . Molecular therapy : the journal of the American Society of Gene Therapy.

Blundell MP, Worth A, Bouma G, Thrasher AJ(2010). The Wiskott-Aldrich syndrome: The actin cytoskeleton and immune cell function . Disease markers.

Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, et al.(2009). Phosphorylation of WASp is a key regulator of activity and stability in vivo . Proceedings of the National Academy of Sciences of the United States of America.

Karwacz K, Mukherjee S, Apolonia L, Blundell MP, Bouma G, Escors D, Collins MK, Thrasher AJ(2009). Nonintegrating lentivector vaccines stimulate prolonged T-cell and antibody responses and are effective in tumor therapy . Journal of virology.

Boxall SA, Cook GP, Pearce D, Bonnet D, El-Sherbiny YM, Blundell MP, Howe SJ, Leek JP, Markham AF, de Wynter EA(2008). Haematopoietic repopulating activity in human cord blood CD133+ quiescent cells . Bone marrow transplantation.

Blundell MP, Bouma G, Calle Y, Jones GE, Kinnon C, Thrasher AJ(2008). Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy . Molecular therapy : the journal of the American Society of Gene Therapy.

Toscano MG, Frecha C, Benabdellah K, Cobo M, Blundell M, Thrasher AJ, García-Olivares E, Molina IJ, Martin F(2008). Hematopoietic-specific lentiviral vectors circumvent cellular toxicity due to ectopic expression of Wiskott-Aldrich syndrome protein . Human gene therapy.

Laurie KL, Blundell MP, Baxendale HE, Howe SJ, Sinclair J, Qasim W, Brunsberg U, Thrasher AJ, Holmdahl R, Gustafsson K(2007). Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector . Gene therapy.

Moulding DA, Blundell MP, Spiller DG, White MR, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff PJ, Kinnon C, et al.(2007). Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia . The Journal of experimental medicine.

Apolonia L, Waddington SN, Fernandes C, Ward NJ, Bouma G, Blundell MP, Thrasher AJ, Collins MK, Philpott NJ(2007). Stable gene transfer to muscle using non-integrating lentiviral vectors . Molecular therapy : the journal of the American Society of Gene Therapy.

Charrier S, Dupré L, Scaramuzza S, Jeanson-Leh L, Blundell MP, Danos O, Cattaneo F, Aiuti A, Eckenberg R, Thrasher AJ, et al.(2006). Lentiviral vectors targeting WASp expression to hematopoietic cells, efficiently transduce and correct cells from WAS patients . Gene therapy.

Ancliff PJ, Blundell MP, Cory GO, Calle Y, Worth A, Kempski H, Burns S, Jones GE, Sinclair J, Kinnon C, et al.(2006). Two novel activating mutations in the Wiskott-Aldrich syndrome protein result in congenital neutropenia . Blood.

Sabri S, Foudi A, Boukour S, Franc B, Charrier S, Jandrot-Perrus M, Farndale RW, Jalil A, Blundell MP, Cramer EM, et al.(2006). Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment . Blood.

Nabarro S, Himoudi N, Papanastasiou A, Gilmour K, Gibson S, Sebire N, Thrasher A, Blundell MP, Hubank M, Canderan G, et al.(2005). Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein . The Journal of experimental medicine.

Martín F, Toscano MG, Blundell M, Frecha C, Srivastava GK, Santamaría M, Thrasher AJ, Molina IJ(2005). Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences . Gene therapy.

de Noronha S, Hardy S, Sinclair J, Blundell MP, Strid J, Schulz O, Zwirner J, Jones GE, Katz DR, Kinnon C, et al.(2004). Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein . Blood.

Calle Y, Jones GE, Jagger C, Fuller K, Blundell MP, Chow J, Chambers T, Thrasher AJ(2004). WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption . Blood.

Ahmed F, Ings SJ, Pizzey AR, Blundell MP, Thrasher AJ, Ye HT, Fahey A, Linch DC, Yong KL(2003). Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model . Blood.

Jones GE, Zicha D, Dunn GA, Blundell M, Thrasher A(2002). Restoration of podosomes and chemotaxis in Wiskott-Aldrich syndrome macrophages following induced expression of WASp . The international journal of biochemistry & cell biology.

Burns S, Thrasher AJ, Blundell MP, Machesky L, Jones GE(2001). Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation . Blood.

Leverrier Y, Lorenzi R, Blundell MP, Brickell P, Kinnon C, Ridley AJ, Thrasher AJ(2001). Cutting edge: the Wiskott-Aldrich syndrome protein is required for efficient phagocytosis of apoptotic cells . Journal of immunology (Baltimore, Md. : 1950).

Demaison C, Brouns G, Blundell MP, Goldman JP, Levinsky RJ, Grez M, Kinnon C, Thrasher AJ(2000). A defined window for efficient gene marking of severe combined immunodeficient-repopulating cells using a gibbon ape leukemia virus-pseudotyped retroviral vector . Human gene therapy.

Blundell MP, Demaison C, Brouns G, Goldman JP, Gaspar HB, Kinnon C, Thrasher AJ, Lazzari L, Sirchia G(1999). Quality of repopulation in nonobese diabetic severe combined immunodeficient mice engrafted with expanded cord blood CD34+ cells . Blood.

Goldman JP, Blundell MP, Lopes L, Kinnon C, Di Santo JP, Thrasher AJ(1998). Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain . British journal of haematology.