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Hire Dr. Miguel C.

United Kingdom

USD 100 /hr

Drug Discovery & TPD Expert | Oncology, Target Validation & Translational R&D Consultant

Profile Summary

I am a biologist and drug discovery leader with over 20 years of experience in oncology and targeted protein degradation (TPD). Most recently, I served as Associate Director of Drug Discovery at PhoreMost, where I led cross-functional programmes integrating assay biology, protein sciences, and computational chemistry to advance novel oncology degraders from target validation through preclinical development. I specialise in: • Target identification & validation (oncology, immunology, TPD) • Chemical biology & assay design (AlphaLISA, FP, SPR, cell-based readouts) • Omics data interpretation (RNAseq, proteomics) • Programme & portfolio management, CRO coordination, and translational strategy I offer freelance support in scientific consulting, literature analysis, target feasibility assessment, experimental design, and scientific writing or review for grant applications, investor decks, or publications.

Subject Matter Expertise

• ★ Biochemical Assays
• ★ Drug Target Identification
• ★ Scientific Proofreading & Editing
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Structural Biology
• ☆ Apoptosis
• ☆ Enzyme Activity Assays
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Genetics
• ☆ Microarrays
• ☆ Omics
• ☆ Transcriptomics
• ☆ Proteomics
• ☆ Chromatin
• ☆ Epigenetics
• ☆ PCR
• ☆ Molecular Cloning
• ☆ Next Generation Sequencing (NGS)
• ☆ DNA Sequencing
• ☆ Protein Sequencing
• ☆ Gene Expression Analysis
• ☆ Mutagenesis
• ☆ Exome Sequencing
• ☆ Recombinant DNA
• ☆ RNA Synthesis
• ☆ RNA Sequencing
• ☆ Plasmid DNA
• ☆ DNA Damage & Repair
• ☆ ChIP-Seq
• ☆ Kinases
• ☆ Cell Biology
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Biophysics
• ☆ Biotechnology & Bioengineering
• ☆ Recombinant Protein Expression
• ☆ Microscopy
• ☆ Light Microscopy
• ☆ Fluorescence Microscopy
• ☆ Biomarker Discovery
• ☆ Cell Culture
• ☆ Primary Cells
• ☆ Cell Banking
• ☆ Cell Line Engineering
• ☆ Large Scale Cell Culture
• ☆ Biomolecular Engineering
• ☆ Genetic Engineering
• ☆ Gene Editing/CRISPR
• ☆ Protein/Enzyme Engineering
• ☆ Blotting
• ☆ Immunohistochemistry
• ☆ Cytometry
• ☆ Cell Aging
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Phenotypic Assays
• ☆ High Content Screening/Imaging
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Technical & Scientific Writing
• ☆ Journal Selection
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ White Papers
• ☆ Textbook Content Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Systematic Literature Review
• ☆ Project Management
• ☆ Risk Management

Services

• Writing
• Research
• Consulting

Writing Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Work Experience

Associate Director

PhoreMost Ltd

June 2022 - July 2025

Education

PhD

UNIVERSITY OF CAMBRIDGE

October 2006 - April 2010

Certifications

• Leadership Programme

  Babraham Research Campus & Focal Point

  April 2025 - Present

• Project Leadership and Managing Meetings

  Michael Heath Consulting

  January 2022 - Present

• Managing Mental Health in Workplace

  MIND / MHFA

  January 2021 - Present

• Introduction to Project Management

  RiverRhee Consulting

  January 2018 - Present

Publications

JOURNAL ARTICLE

Miguel Coelho, Amy Emery, Bryn S. Hardwick, Alex T. Crooks, Nadia Milech, Paul M. Watt, Chandan Mithra, Vikrant Kumar, Saranya Giridharan, Gayathri Sadasivam, et al. (2021). Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library . Cell Chemical Biology.

Coelho MB, Ascher DB, Gooding C, Lang E, Maude H, Turner D, Llorian M, Pires DE, Attig J, Smith CW(2016). Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins . Biochemical Society transactions.

Coelho MB, Attig J, Ule J, Smith CW(2016). Matrin3: connecting gene expression with the nuclear matrix . Wiley interdisciplinary reviews. RNA.

Coelho MB, Attig J, Bellora N, König J, Hallegger M, Kayikci M, Eyras E, Ule J, Smith CW(2015). Nuclear matrix protein Matrin3 regulates alternative splicing and forms overlapping regulatory networks with PTB . The EMBO journal.

Coelho MB, Smith CW(2014). Regulation of alternative pre-mRNA splicing . Methods in molecular biology (Clifton, N.J.).

Gooding C, Edge C, Lorenz M, Coelho MB, Winters M, Kaminski CF, Cherny D, Eperon IC, Smith CW(2013). MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3 . Nucleic acids research.

Miguel Coelho, Panagiota Kafasla, Ian Mickleburgh, Miriam Llorian, Clare Gooding, Dmitry Cherny, Amar Joshi, Olga Kotik-Kogan, Stephen Curry, Ian C. Eperon, et al. (2012). Defining the roles and interactions of PTB . Biochemical Society Transactions.

Joshi A, Coelho MB, Kotik-Kogan O, Simpson PJ, Matthews SJ, Smith CW, Curry S(2011). Crystallographic analysis of polypyrimidine tract-binding protein-Raver1 interactions involved in regulation of alternative splicing . Structure (London, England : 1993).

Cherny D, Gooding C, Eperon GE, Coelho MB, Bagshaw CR, Smith CW, Eperon IC(2010). Stoichiometry of a regulatory splicing complex revealed by single-molecule analyses . The EMBO journal.

Pacheco TR, Coelho MB, Desterro JM, Mollet I, Carmo-Fonseca M(2006). In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site . Molecular and cellular biology.

OTHER

Rajgor D, Gooding C, Hayward R, Coelho MB, Smith CW, Shanahan CM(2018). Lamin A/C controls nuclear matrin-3 levels and localization, but not alternative splicing of cassette exons .

EDITED BOOK

Miguel B. Coelho, Miguel B. Coelho (2012). Alternative pre‐mRNA Splicing .

Miguel B. Coelho, Miguel B. Coelho, Christopher W. J. Smith (2012). Alternative Splice Site Selection . Alternative pre‐mRNA Splicing.