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Profile Details
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USD 100 /hr
Hire Dr. Manlio V.
United Kingdom
USD 100 /hr

High profile scientist, expert in metabolism, epigenetics and aging. I am devoted to help you grow and gain visibility.

Profile Summary
Subject Matter Expertise
Writing Clinical Trial Documentation, Technical Writing, Copywriting, Newswriting
Research Feasibility Study, Gray Literature Search, Systematic Literature Review
Consulting Scientific and Technical Consulting
Data & AI Statistical Analysis
Product Development Formulation
Work Experience


Liverpool John Moores University

November 2022 - Present

Principal Investigator

International Clinical Research Center (FNUSA-ICRC)

March 2016 - December 2022


European Molecular Biology Laboratory

June 2005 - September 2008

PhD in Internal Medicine

University of Geneva

January 2001 - December 2004


University of Catania, Catania, Italy

September 1994 - July 1999

  • Certification details not provided.
Manlio Vinciguerra, Jan Frohlich (2020). Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe? . GeroScience.
Manlio Vinciguerra, Andrea Maugeri, Ota Hlinomaz, Antonella Agodi, Martina Barchitta, Sarka Kunzova, Hana Bauerova, Ondrej Sochor, Jose R. Medina-Inojosa, Francisco Lopez-Jimenez, et al. (2020). Is Drinking Alcohol Really Linked to Cardiovascular Health? Evidence from the Kardiovize 2030 Project . Nutrients.
Manlio Vinciguerra, Andrea Maugeri, Ota Hlinomaz, Antonella Agodi, Martina Barchitta, Sarka Kunzova, Hana Bauerova, Ondrej Sochor, Jose Medina-Inojosa, Francisco Lopez-Jimenez, et al. (2020). Is Drinking Alcohol Really Linked to Cardiovascular Health? Evidence from the Kardiovize 2030 Project . Nutrients.
Manlio Vinciguerra, Gianluigi Mazzoccoli, Annalucia Carbone, Angela Relógio(2020). The Circadian Clock, the Immune System, and Viral Infections: The Intricate Relationship Between Biological Time and Host-Virus Interaction . Pathogens. 9. (2). p. 83. {MDPI} {AG}
Manlio Vinciguerra, Andrea Maugeri (2020). The Effects of Meal Timing and Frequency, Caloric Restriction, and Fasting on Cardiovascular Health: an Overview . Journal of Lipid and Atherosclerosis.
Manlio Vinciguerra, Kristina Kovacovicova(2019). Isolation of senescent cells by iodixanol ({OptiPrep}) density gradient-based separation . Cell Proliferation. Wiley
Manlio Vinciguerra, Gianluigi Mazzoccoli, Ali Keshavarzian(2019). Hedgehog signaling keeps liver clock in check . Journal of Hepatology. 70. (6). p. 1054--1056. Elsevier {BV}
Manlio Vinciguerra, Julie Bienertova-Vasku, Marek Buzga, Francesc Villaroya (2018). Adipokines as Biomarkers in Health and Disease . Disease Markers.
Manlio Vinciguerra, Oriana Lo Re, Julien Douet, Marcus Buschbeck, Caterina Fusilli, Valerio Pazienza, Concetta Panebianco, Carlo Castruccio Castracani, Tommaso Mazza, Giovanni Li Volti(2018). Histone variant {macroH}2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells . Epigenetics. 13. (8). p. 829--845. Informa {UK} Limited
Manlio Vinciguerra, Andrea Maugeri, Maria Grazia Mazzone, Francesco Giuliano, Guido Basile, Martina Barchitta, Antonella Agodi (2018). Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy . Oxidative Medicine and Cellular Longevity.
Manlio Vinciguerra, Oriana Lo Re, Concetta Panebianco, Stefania Porto, Carlo Cervi, Francesca Rappa, Stefano Di Biase, Michele Caraglia, Valerio Pazienza(2017). Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells . Journal of Cellular Physiology. 233. (2). p. 1202--1212. Wiley
Di Biase, S. and Shim, H.S. and Kim, K.H. and Vinciguerra, M. and Rappa, F. and Wei, M. and Brandhorst, S. and Cappello, F. and Mirzaei, H. and Lee, C. and Longo, V.D.(2017). Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy . PLoS Biology. 15. (3).
Di Biase, S., Shim, H.S., Kim, K.H., Vinciguerra, M., Rappa, F., Wei, M., Brandhorst, S., Cappello, F., Mirzaei, H., Lee, C., et al.(2017). Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy . PLoS Biology. 15. (3).
Pindjakova, J., Sartini, C., Re, O.L., Rappa, F., Coupe, B., Lelouvier, B., Pazienza, V., Vinciguerra, M.(2017). Gut dysbiosis and adaptive immune response in diet-induced obesity vs. Systemic inflammation . Frontiers in Microbiology. 8. (JUN).
Volti, G.L., Avola, R., Vinciguerra, M.(2017). Commentary: Fasting-mimicking diet reduces HO-1 to promote T cell-mediated tumor cytotoxicity . Frontiers in Oncology. 7. (JUN).
Soeda, J., Cordero, P., Li, J., Mouralidarane, A., Asilmaz, E., Ray, S., Nguyen, V., Carter, R., Novelli, M., Vinciguerra, M., et al.(2017). Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity . International Journal of Food Sciences and Nutrition. 68. (4). p. 455-466.
Morgan, M.L., Sigala, B., Soeda, J., Cordero, P., Nguyen, V., Mckee, C., Mouraliderane, A., Vinciguerra, M., Oben, J.A.(2016). Acetylcholine induces fibrogenic effects via M2/M3 acetylcholine receptors in non-alcoholic steatohepatitis and in primary human hepatic stellate cells . Journal of Gastroenterology and Hepatology (Australia). 31. (2). p. 475-483.
Re, O.L., Vinciguerra, M.(2016). Macrohistone H2A1 takes the center stage in cancer research as a regulator of stemness . Translational Cancer Research. 5. p. S747-S750.
Mazzoccoli, G., Laukkanen, M.O., Vinciguerra, M., Colangelo, T., Colantuoni, V.(2016). A Timeless Link Between Circadian Patterns and Disease . Trends in Molecular Medicine. 22. (1). p. 68-81.
Mazzoccoli, G., Miele, L., Oben, J., Grieco, A., Vinciguerra, M.(2016). Biology, Epidemiology, Clinical aspects of hepatocellular Carcinoma and the role of Sorafenib . Current Drug Targets. 17. (7). p. 783-799.
Borghesan, M., Fusilli, C., Rappa, F., Panebianco, C., Rizzo, G., Oben, J.A., Mazzoccoli, G., Faulkes, C., Pata, I., Agodi, A., et al.(2016). DNA Hypomethylation and histone variant macroH2A1 synergistically attenuate chemotherapy-induced senescence to promote hepatocellular carcinoma progression . Cancer Research. 76. (3). p. 594-606.
Panebianco, C., Oben, J.A., Vinciguerra, M., Pazienza, V.(2016). Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings . Clinical and Experimental Medicine. p. 1-12.
Mazzoccoli, G., Rubino, R., Tiberio, C., Giuliani, F., Vinciguerra, M., Oben, J., De Cata, A., Tarquini, R., De Cosmo, S., Liu, S., et al.(2016). Clock gene expression in human and mouse hepatic models shows similar periodicity but different dynamics of variation . Chronobiology International. 33. (2). p. 181-190.
Soeda, J., Mouralidarane, A., Cordero, P., Li, J., Nguyen, V., Carter, R., Kapur, S.R., Pombo, J., Poston, L., Taylor, P.D., et al.(2016). Maternal obesity alters endoplasmic reticulum homeostasis in offspring pancreas . Journal of Physiology and Biochemistry. 72. (2). p. 281-291.
Jueliger, S., Lyons, J., Cannito, S., Pata, I., Pata, P., Shkolnaya, M., Lo Re, O., Peyrou, M., Villarroya, F., Pazienza, V., et al.(2016). Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma . Epigenetics. 11. (10). p. 709-720.
Pazienza, V., Panebianco, C., Rappa, F., Memoli, D., Borghesan, M., Cannito, S., Oji, A., Mazza, G., Tamburrino, D., Fusai, G., et al.(2016). Histone macroH2A1.2 promotes metabolic health and leanness by inhibiting adipogenesis . Epigenetics and Chromatin. 9. (1). p. 1-19.
Burhan, I., Furini, G., Lortat-Jacob, H., Atobatele, A.G., Scarpellini, A., Schroeder, N., Atkinson, J., Maamra, M., Nutter, F.H., Watson, P., et al.(2016). Interplay between transglutaminases and heparan sulphate in progressive renal scarring . Scientific Reports. 6.
Balasus, D., Way, M., Fusilli, C., Mazza, T., Morgan, M.Y., Cervello, M., Giannitrapani, L., Soresi, M., Agliastro, R., Vinciguerra, M., et al.(2016). The association of variants in PNPLA3 and GRP78 and the risk of developing hepatocellular carcinoma in an Italian population . Oncotarget. 7. (52). p. 86791-86802.
Mazzoccoli, G., Colangelo, T., Panza, A., Rubino, R., De Cata, A., Tiberio, C., Valvano, M.R., Pazienza, V., Merla, G., Augello, B., et al.(2016). Deregulated expression of cryptochrome genes in human colorectal cancer . Molecular Cancer. 15. (1).
Mazzoccoli, G., Tarquini, R., Valoriani, A., Oben, J., Vinciguerra, M., Marra, F.(2016). Management strategies for hepatocellular carcinoma: old certainties and new realities . Clinical and Experimental Medicine. 16. (3). p. 243-256.
Sanjabi, B., Dashty, M., Özcan, B., Akbarkhanzadeh, V., Rahimi, M., Vinciguerra, M., Van Rooij, F., Al-Lahham, S., Sheedfar, F., Van Kooten, T.G., et al.(2015). Lipid droplets hypertrophy: A crucial determining factor in insulin regulation by adipocytes . Scientific Reports. 5.
Rahimi, M., Ng, E.-P., Bakhtiari, K., Vinciguerra, M., Ahmad, H.A., Awala, H., Mintova, S., Daghighi, M., Bakhshandeh Rostami, F., De Vries, M., et al.(2015). Zeolite Nanoparticles for Selective Sorption of Plasma Proteins . Scientific Reports. 5.
Sheedfar, F., Vermeer, M., Pazienza, V., Villarroya, J., Rappa, F., Cappello, F., Mazzoccoli, G., Villarroya, F., Van Der Molen, H., Hofker, M.H., et al.(2015). Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high-fat diet . International Journal of Obesity. 39. (2). p. 331-338.
Agodi, A., Barchitta, M., Quattrocchi, A., Maugeri, A., Canto, C., Marchese, A.E., Vinciguerra, M.(2015). Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population . Genes and Nutrition. 10. (5).
D'Aronzo, M., Vinciguerra, M., Mazza, T., Panebianco, C., Saracino, C., Pereira, S.P., Graziano, P., Pazienza, V.(2015). Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models . Oncotarget. 6. (21). p. 18545-18557.
Mazza, T., Fusilli, C., Saracino, C., Mazzoccoli, G., Tavano, F., Vinciguerra, M., Pazienza, V.(2015). Functional impact of autophagy-related genes on the homeostasis and dynamics of pancreatic cancer cell lines . IEEE/ACM Transactions on Computational Biology and Bioinformatics. 12. (3). p. 667-678.
Agodi, A., Barchitta, M., Quattrocchi, A., Maugeri, A., Vinciguerra, M.(2015). DAPK1 promoter methylation and cervical cancer risk: A systematic review and a meta-analysis . PLoS ONE. 10. (8).
McKee, C., Sigala, B., Soeda, J., Mouralidarane, A., Morgan, M., Mazzoccoli, G., Rappa, F., Cappello, F., Cabibi, D., Pazienza, V., et al.(2015). Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis . Scientific Reports. 5.
Tavano, F., Pazienza, V., Fontana, A., Burbaci, F.P., Panebianco, C., Saracino, C., Lombardi, L., De Bonis, A., Di Mola, F.F., Di Sebastiano, P., et al.(2015). SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: Effect of starvation . Chronobiology International. 32. (4). p. 497-512.
Vinciguerra, M.(2015). Nitric oxide as a protector from nonalcoholic fatty liver disease . Hepatology. 61. (6). p. 2115-2116.
Brandhorst, S., Choi, I.Y., Wei, M., Cheng, C.W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L.P., Park, R., Vinciguerra, M., et al.(2015). A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan . Cell Metabolism. 22. (1). p. 86-99.
Longo, V.D., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H.M., Caruso, C., Curiel, T.J., De Cabo, R., Franceschi, C., Gems, D., et al.(2015). Interventions to slow aging in humans: Are we ready? . Aging Cell. 14. (4). p. 497-510.
Demolli, S., Doebele, C., Doddaballapur, A., Lang, V., Fisslthaler, B., Chavakis, E., Vinciguerra, M., Sciacca, S., Henschler, R., Hecker, M., et al.(2015). MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2 . Journal of Molecular and Cellular Cardiology. 88. p. 111-119.
Mouralidarane, A., Soeda, J., Sugden, D., Bocianowska, A., Carter, R., Ray, S., Saraswati, R., Cordero, P., Novelli, M., Fusai, G., et al.(2015). Maternal obesity programs offspring non-alcoholic fatty liver disease through disruption of 24-h rhythms in mice . International Journal of Obesity. 39. (9). p. 1339-1348.
Rahimi, M., Vinciguerra, M., Daghighi, M., özcan, B., Akbarkhanzadeh, V., Sheedfar, F., Amini, M., Mazza, T., Pazienza, V., Motazacker, M.M., et al.(2015). Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans . Oncotarget. 6. (30). p. 29818-29832.
Podrini, C., Koffas, A., Choksh, S., Vinciguerra, M., Lelliott, C.J., White, J.K., Adissu, H.A., Williams, R., Greco, A.(2015). MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis . FASEB Journal. 29. (5). p. 1676-1687.
Mazzoccoli, G., Dagostino, M.P., Vinciguerra, M., Ciccone, F., Paroni, G., Seripa, D., Addante, F., Montella, R.C., De Cosmo, S., Sera, F., et al.(2014). An association study between epicardial fat thickness and cognitive impairment in the elderly . American Journal of Physiology - Heart and Circulatory Physiology. 307. (9). p. H1269-H1276.
Borghesan, M., Mazzoccoli, G., Sheedfar, F., Oben, J., Pazienza, V., Vinciguerra, M.(2014). Histone variants and lipid metabolism . Biochemical Society Transactions. 42. (5). p. 1409-1413.
Mazzoccoli, G., Vinciguerra, M., Papa, G., Piepoli, A.(2014). Circadian clock circuitry in colorectal cancer . World Journal of Gastroenterology. 20. (15). p. 4197-4207.
Barchitta, M., Quattrocchi, A., Maugeri, A., Vinciguerra, M., Agodi, A.(2014). LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: A systematic review and meta-analysis . PLoS ONE. 9. (10).
Vinciguerra, M.(2014). Normalization of a NAFLD gene expression signature . Hepatology. 60. (4). p. 1445-1445.
Tavano, F., Fontana, A., Pellegrini, F., Burbaci, F.P., Rappa, F., Cappello, F., Copetti, M., Maiello, E., Lombardi, L., Graziano, P., et al.(2014). Modeling interactions between Human Equilibrative Nucleoside Transporter-1 and other factors involved in the response to gemcitabine treatment to predict clinical outcomes in pancreatic ductal adenocarcinoma patients . Journal of Translational Medicine. 12. (1).
Mazzoccoli, G., Longhitano, C., Vinciguerra, M.(2014). Cardio-hepatic metabolic derangements and valproic acid . Current Clinical Pharmacology. 9. (2). p. 165-170.
Pazienza, V., Pomara, C., Cappello, F., Calogero, R., Carrara, M., Mazzoccoli, G., Vinciguerra, M.(2014). The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling . American Journal of Physiology - Heart and Circulatory Physiology. 307. (7). p. H939-H944.
Carter, R., Mouralidarane, A., Soeda, J., Ray, S., Pombo, J., Saraswati, R., Novelli, M., Fusai, G., Rappa, F., Saracino, C., et al.(2014). Non-alcoholic fatty pancreas disease pathogenesis: A role for developmental programming and altered circadian rhythms . PLoS ONE. 9. (3).
de Matthaeis, A., Greco, A., Dagostino, M.P., Paroni, G., Fontana, A., Vinciguerra, M., Mazzoccoli, G., Seripa, D., Vendemiale, G.(2014). Effects of hypercapnia on peripheral vascular reactivity in elderly patients with acute exacerbation of chronic obstructive pulmonary disease . Clinical Interventions in Aging. 9. p. 871-878.
Planavila, A., Villarroya, F., Vinciguerra, M.(2014). Nutrilent sgnaling and cardiovascular aging . Heart and Metabolism. (63). p. 4-7.
Sheedfar, F., Sung, M.M.Y., Aparicio-Vergara, M., Kloosterhuis, N.J., Miquilena-Colina, M.E., Vargas-Castrillón, J., Febbraio, M., Jacobs, R.L., de Bruin, A., Vinciguerra, M., et al.(2014). Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease . Aging. 6. (4). p. 281-295.
Rizzo, M., Montalto, G., Vinciguerra, M.(2014). Exploring lipid-related treatment options for the treatment of NASH . Current Vascular Pharmacology. 12. (5). p. 741-744.
Pazienza, V., Borghesan, M., Mazza, T., Sheedfar, F., Panebianco, C., Williams, R., Mazzoccoli, G., Andriulli, A., Nakanishi, T., Vinciguerra, M.(2014). SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation . Aging. 6. (1). p. 35-47.
Mazzoccoli, G., Tevy, M.F., Borghesan, M., Vergini, M.R.D., Vinciguerra, M.(2014). Caloric restriction and aging stem cells: The stick and the carrot? . Experimental Gerontology. 50. (1). p. 137-148.
Vinciguerra, M., Tevy, M.F., Mazzoccoli, G.(2014). A ticking clock links metabolic pathways and organ systems function in health and disease . Clinical and experimental medicine. 14. (2). p. 133-140.
Mazzoccoli, G., De Cata, A., Piepoli, A., Vinciguerra, M.(2014). The circadian clock and the hypoxic response pathway in kidney cancer . Tumor Biology. 35. (1). p. 1-7.
Panza, A., Votino, C., Gentile, A., Valvano, M.R., Colangelo, T., Pancione, M., Micale, L., Merla, G., Andriulli, A., Sabatino, L., et al.(2014). Peroxisome proliferator-activated receptor γ-mediated induction of microRNA-145 opposes tumor phenotype in colorectal cancer . Biochimica et Biophysica Acta - Molecular Cell Research. 1843. (6). p. 1225-1236.
Mazzoccoli, G., Vinciguerra, M., Oben, J., Tarquini, R., De Cosmo, S.(2014). Non-alcoholic fatty liver disease: The role of nuclear receptors and circadian rhythmicity . Liver International. 34. (8). p. 1133-1152.
Sciacca, S., Pilato, M., Mazzoccoli, G., Pazienza, V., Vinciguerra, M.(2013). Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease . Heart and Vessels. 28. (2). p. 268-275.
Mazzoccoli, G., Tomanin, R., Mazza, T., D'Avanzo, F., Salvalaio, M., Rigon, L., Zanetti, A., Pazienza, V., Francavilla, M., Giuliani, F., et al.(2013). Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment . BMC Medical Genomics. 6. (1).
Planavila, A., Redondo, I., Hondares, E., Vinciguerra, M., Munts, C., Iglesias, R., Gabrielli, L.A., Sitges, M., Giralt, M., Van Bilsen, M., et al.(2013). Fibroblast growth factor 21 protects against cardiac hypertrophy in mice . Nature Communications. 4.
Rappa, F., Greco, A., Podrini, C., Cappello, F., Foti, M., Bourgoin, L., Peyrou, M., Marino, A., Scibetta, N., Williams, R., et al.(2013). Immunopositivity for Histone MacroH2A1 Isoforms Marks Steatosis-Associated Hepatocellular Carcinoma . PLoS ONE. 8. (1).
Benegiamo, G., Mazzoccoli, G., Cappello, F., Rappa, F., Scibetta, N., Oben, J., Greco, A., Williams, R., Andriulli, A., Vinciguerra, M., et al.(2013). Mutual Antagonism between Circadian Protein Period 2 and Hepatitis C Virus Replication in Hepatocytes . PLoS ONE. 8. (4).
Rappa, F., Greco, A., Podrini, C., Cappello, F., Foti, M., Bourgoin, L., Peyrou, M., Marino, A., Scibetta, N., Williams, R., et al.(2013). Correction: Immunopositivity for histone MacroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma (PLoS ONE) . PLoS ONE. 8. (3).
Vinciguerra, M.(2013). Targeting chromatin remodelers to treat hepatocellular carcinoma . Hepatology. 57. (3).
Tevy, M.F., Giebultowicz, J., Pincus, Z., Mazzoccoli, G., Vinciguerra, M.(2013). Aging signaling pathways and circadian clock-dependent metabolic derangements . Trends in Endocrinology and Metabolism. 24. (5). p. 229-237.
Anderson, G., Beischlag, T.V., Vinciguerra, M., Mazzoccoli, G.(2013). The circadian clock circuitry and the AHR signaling pathway in physiology and pathology . Biochemical Pharmacology. 85. (10). p. 1405-1416.
Vinciguerra, M.(2013). Paracrine mechanisms, signaling and epigenetics in repairing damaged tissue . Recent Patents on Regenerative Medicine. 3. (1). p. 1-4.
Vinciguerra, M., Borghesan, M., Pazienza, V., Piepoli, A., Palmieri, O., Tarquini, R., Tevy, M.F., De Cata, A., Mazzoccoli, G.(2013). The transcriptional regulators, the immune system and the the circadian clock . Journal of biological regulators and homeostatic agents. 27. (1). p. 9-22.
Benegiamo, G., Vinciguerra, M., Guarnieri, V., Niro, G., Andriulli, A., Pazienza, V.(2013). Hepatitis delta virus induces specific DNA methylation processes in Huh-7 liver cancer cells . FEBS Letters. 587. (9). p. 1424-1428.
Panza, A., Pazienza, V., Ripoli, M., Benegiamo, G., Gentile, A., Valvano, M.R., Augello, B., Merla, G., Prattichizzo, C., Tavano, F., et al.(2013). Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer . Biochimica et Biophysica Acta - Molecular Cell Research. 1833. (8). p. 1853-1865.
Vinciguerra, M.(2013). Old age and steatohepatitis: A dangerous liaison? . Hepatology. 58. (2). p. 830-831.
Bonny, O., Vinciguerra, M., Gumz, M.L., Mazzoccoli, G.(2013). Molecular bases of circadian rhythmicity in renal physiology and pathology . Nephrology Dialysis Transplantation. 28. (10). p. 2421-2431.
Pazienza, V., Niro, G.A., Fontana, R., Vinciguerra, M., Andriulli, A.(2013). Advance in molecular diagnostic tools for hepatitis B virus detection . Clinical Chemistry and Laboratory Medicine. 51. (9). p. 1707-1717.
Mazza, T., Castellana, S., Andriulli, A., Auffray, C., Vinciguerra, M., Pazienza, V.(2013). Affinity analysis of differentially expressed genes in hepatocytes expressing HCV core genotype 1b or 3a . BioSystems. 114. (1). p. 64-68.
Sheedfar, F., Biase, S.D., Koonen, D., Vinciguerra, M.(2013). Liver diseases and aging: Friends or foes? . Aging Cell. 12. (6). p. 950-954.
Vinciguerra, M., Mazzoccoli, G., Piccoli, C., Tataranni, T., Andriulli, A., Pazienza, V.(2013). Exploitation of host clock gene machinery by hepatitis viruses B and C . World Journal of Gastroenterology. 19. (47). p. 8902-8909.
Sigala, B., McKee, C., Soeda, J., Pazienza, V., Morgan, M., Lin, C.-I., Selden, C., Vander Borght, S., Mazzoccoli, G., Roskams, T., et al.(2013). Sympathetic Nervous System Catecholamines and Neuropeptide Y Neurotransmitters Are Upregulated in Human NAFLD and Modulate the Fibrogenic Function of Hepatic Stellate Cells . PLoS ONE. 8. (9).
Podrini, C., Borghesan, M., Greco, A., Pazienza, V., Mazzoccoli, G., Vinciguerra, M.(2013). Redox homeostasis and epigenetics in non-alcoholic fatty liver disease (NAFLD) . Current Pharmaceutical Design. 19. (15). p. 2737-2746.
Pazienza, V., Piepoli, A., Panza, A., Valvano, M.R., Benegiamo, G., Vinciguerra, M., Andriulli, A., Mazzoccoli, G.(2012). SIRT1 and the clock gene machinery in colorectal cancer . Cancer Investigation. 30. (2). p. 98-105.
Vinciguerra, M., Santini, M.P., Martinez, C., Pazienza, V., Claycomb, W.C., Giuliani, A., Rosenthal, N.(2012). mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart . Aging Cell. 11. (1). p. 139-149.
Manlio Vinciguerra, Valerio Pazienza, Francesca Tavano, Giorgia Benegiamo, Francesca Paola Burbaci, Massimiliano Copetti, Fabio Francesco di Mola, Angelo Andriulli, Pierluigi di Sebastiano(2012). Correlations among {PPAR}, {DNMT}1, and {DNMT}3B Expression Levels and Pancreatic Cancer . {PPAR} Research. 2012. p. 1--7. Hindawi Publishing Corporation
Pazienza, V., Vinciguerra, M., Mazzoccoli, G.(2012). PPARs signaling and cancer in the gastrointestinal system . PPAR Research.
Pazienza, V., Tavano, F., Benegiamo, G., Vinciguerra, M., Burbaci, F.P., Copetti, M., Di Mola, F.F., Andriulli, A., Di Sebastiano, P.(2012). Correlations among PPARγ, DNMT1, and DNMT3B expression levels and pancreatic cancer . PPAR Research.
Mazzoccoli, G., Cai, Y., Liu, S., Francavilla, M., Giuliani, F., Piepoli, A., Pazienza, V., Vinciguerra, M., Yamamoto, T., Takumi, T.(2012). REV-ERBα and the clock gene machinery in mouse peripheral tissues: A possible role as a synchronizing hinge . Journal of Biological Regulators and Homeostatic Agents. 26. (2). p. 265-276.
Mazzoccoli, G., Francavilla, M., Giuliani, F., Aucella, F., Vinciguerra, M., Pazienza, V., Piepoli, A., Benegiamo, G., Liu, S., Cai, Y.(2012). Clock gene expression in mouse kidney and testis: Analysis of periodical and dynamical patterns . Journal of Biological Regulators and Homeostatic Agents. 26. (2). p. 303-311.
Bolasco, G., Calogero, R., Carrara, M., Al Banchaabouchi, M., Bilbao, D., Mazzoccoli, G., Vinciguerra, M.(2012). Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice . Aging. 4. (6). p. 402-416.
Deblon, N., Bourgoin, L., Veyrat-Durebex, C., Peyrou, M., Vinciguerra, M., Caillon, A., Maeder, C., Fournier, M., Montet, X., Rohner-Jeanrenaud, F., et al.(2012). Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats . British Journal of Pharmacology. 165. (7). p. 2325-2340.
Mazzoccoli, G., Sothern, R.B., Francavilla, M., Giuliani, F., Carughi, S., Muscarella, L.A., Fazio, V.M., Parrella, P., Vinciguerra, M., Tarquini, R.(2012). Hormone and cytokine circadian alteration in non-small cell lung cancer patients . International Journal of Immunopathology and Pharmacology. 25. (3). p. 691-702.
Mazzoccoli, G., Pazienza, V., Panza, A., Valvano, M.R., Benegiamo, G., Vinciguerra, M., Andriulli, A., Piepoli, A.(2012). ARNTL2 and SERPINE1: Potential biomarkers for tumor aggressiveness in colorectal cancer . Journal of Cancer Research and Clinical Oncology. 138. (3). p. 501-511.
Fontana, L., Vinciguerra, M., Longo, V.D.(2012). Growth factors, nutrient signaling, and cardiovascular aging . Circulation Research. 110. (8). p. 1139-1150.
Planavila, A., Dominguez, E., Navarro, M., Vinciguerra, M., Iglesias, R., Giralt, M., Lope-Piedrafita, S., Ruberte, J., Villarroya, F.(2012). Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart . Journal of Molecular and Cellular Cardiology. 53. (4). p. 521-531.
Mazzoccoli, G., Pazienza, V., Vinciguerra, M.(2012). Clock genes and clock-controlled genes in the regulation of metabolic rhythms . Chronobiology International. 29. (3). p. 227-251.
Benegiamo, G., Vinciguerra, M., Mazzoccoli, G., Piepoli, A., Andriulli, A., Pazienza, V.(2012). DNA methyltransferases 1 and 3b expression in Huh-7 cells expressing HCV core protein of different genotypes . Digestive Diseases and Sciences. 57. (6). p. 1598-1603.
Tonkin, J., Villarroya, F., Puri, P.L., Vinciguerra, M.(2012). SIRT1 signaling as potential modulator of skeletal muscle diseases . Current Opinion in Pharmacology. 12. (3). p. 372-376.
Mazzoccoli, G., Francavilla, M., Pazienza, V., Benegiamo, G., Piepoli, A., Vinciguerra, M., Giuliani, F., Yamamoto, T., Takumi, T.(2012). Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach . Chronobiology International. 29. (10). p. 1300-1311.
Ripoli, M., Barbano, R., Balsamo, T., Piccoli, C., Brunetti, V., Coco, M., Mazzoccoli, G., Vinciguerra, M., Pazienza, V.(2011). Hypermethylated levels of E-cadherin promoter in Huh-7 cells expressing the HCV core protein . Virus Research. 160. (1-2). p. 74-81.
Clément, S., Peyrou, M., Sanchez-Pareja, A., Bourgoin, L., Ramadori, P., Suter, D., Vinciguerra, M., Guilloux, K., Pascarella, S., Rubbia-Brandt, L., et al.(2011). Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets . Hepatology. 54. (1). p. 38-49.
Mazzoccoli, G., Sothern, R.B., Greco, A., Pazienza, V., Vinciguerra, M., Liu, S., Cai, Y.(2011). Time-related dynamics of variation in core clock gene expression levels in tissues relevant to the immune system . International Journal of Immunopathology and Pharmacology. 24. (4). p. 869-879.
Boon, R.A., Seeger, T., Heydt, S., Fischer, A., Hergenreider, E., Horrevoets, A.J.G., Vinciguerra, M., Rosenthal, N., Sciacca, S., Pilato, M., et al.(2011). MicroRNA-29 in aortic dilation: Implications for aneurysm formation . Circulation Research. 109. (10). p. 1115-1119.
Vinciguerra, M., Santini, M.P., Claycomb, W.C., Ladurner, A.G., Rosenthal, N.(2010). Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity . Aging. 2. (1). p. 43-62.
Vinciguerra, M., Hede, M., Rosenthal, N.(2010). To the editor . Journal of Applied Physiology. 108. (6). p. 1829-1830.
Zanchi, A., Maillard, M., Jornayvaz, F.R., Vinciguerra, M., Deleaval, P., Nussberger, J., Burnier, M., Pechere-Bertschi, A.(2010). Effects of the peroxisome proliferator-activated receptor (PPAR)-γ agonist pioglitazone on renal and hormonal responses to salt in diabetic and hypertensive individuals . Diabetologia. 53. (8). p. 1568-1575.
Vinciguerra, M., Fulco, M., Ladurner, A., Sartorelli, V., Rosenthal, N.(2010). SirT1 in muscle physiology and disease: Lessons from mouse models . DMM Disease Models and Mechanisms. 3. (5-6). p. 298-303.
Pazienza, V., Vinciguerra, M., Andriulli, A., Mangia, A.(2010). Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-γ in Huh-7 cells . Journal of General Virology. 91. (7). p. 1678-1686.
Vinciguerra, M., Carrozzino, F., Peyrou, M., Carlone, S., Montesano, R., Benelli, R., Foti, M.(2009). Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN . Journal of Hepatology. 50. (6). p. 1132-1141.
Vinciguerra, M.(2009). Aldosterone, but not increased Na+ influx or NF-kappaB activation, increases kidney-specific WNK1 gene expression in renal collecting duct cells . Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme. 41. (1). p. 67-70.
Veyrat-Durebex, C., Montet, X., Vinciguerra, M., Gjinovci, A., Meda, P., Foti, M., Rohner-Jeanrenaud, F.(2009). The Lou/C rat: A model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue . American Journal of Physiology - Endocrinology and Metabolism. 296. (5).
Vinciguerra, M., Sgroi, A., Veyrat-Durebex, C., Rubbia-Brandt, L., Buhler, L.H., Foti, M.(2009). Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog(PTEN) via microRNA-21 up-regulation in hepatocytes . Hepatology. 49. (4). p. 1176-1184.
Leroy, V., De Seigneux, S., Agassiz, V., Hasler, U., Rafestin-Oblin, M.-E., Vinciguerra, M., Martin, P.-Y., Féraille, E.(2009). Aldosterone activates NF-κB in the collecting duct . Journal of the American Society of Nephrology. 20. (1). p. 131-144.
Vinciguerra, M., Veyrat-Durebex, C., Moukil, M.A., Rubbia-Brandt, L., Rohner-Jeanrenaud, F., Foti, M.(2008). PTEN Down-Regulation by Unsaturated Fatty Acids Triggers Hepatic Steatosis via an NF-κBp65/mTOR-Dependent Mechanism . Gastroenterology. 134. (1). p. 268-280.
Cederroth, C.R., Vinciguerra, M., Gjinovci, A., Kühne, F., Klein, M., Cederroth, M., Caille, D., Suter, M., Neumann, D., James, R.W., et al.(2008). Dietary phytoestrogens activate AMP-Activated protein kinase with improvement in lipid and glucose metabolism . Diabetes. 57. (5). p. 1176-1185.
Vinciguerra, M., Foti, M.(2008). PTEN at the crossroad of metabolic diseases and cancer in the liver . Annals of Hepatology. 7. (3). p. 192-199.
De Gottardi, A., Vinciguerra, M., Sgroi, A., Moukil, M., Ravier-Dall'Antonia, F., Pazienza, V., Pugnale, P., Foti, M., Hadengue, A.(2007). Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes . Laboratory Investigation. 87. (8). p. 792-806.
Cederroth, C.R., Vinciguerra, M., Kühne, F., Madani, R., Doerge, D.R., Visser, T.J., Foti, M., Rohner-Jeanrenaud, F., Vassalli, J.-D., Nef, S.(2007). A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice . Environmental Health Perspectives. 115. (10). p. 1467-1473.
Vinciguerra, M., Foti, M.(2006). PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling . Archives of Physiology and Biochemistry. 112. (2). p. 89-104.
Vinciguerra, M., Mordasini, D., Vandewalle, A., Feraille, E.(2005). Hormonal and nonhormonal mechanisms of regulation of the Na,K-pump in collecting duct principal cells . Seminars in Nephrology. 25. (5). p. 312-321.
Hasler, U., Vinciguerra, M., Vandewalle, A., Martin, P.-Y., Féraille, E.(2005). Dual effects of hypertonicity on aquaporin-2 expression in cultured renal collecting duct principal cells . Journal of the American Society of Nephrology. 16. (6). p. 1571-1582.
Vinciguerra, M., Hasler, U., Mordasini, D., Roussel, M., Capovilla, M., Ogier-Denis, E., Vandewalle, A., Martin, P.-Y., Feraille, E.(2005). Cytokines and sodium induce protein kinase A-dependent cell-surface Na,K-ATPase recruitment via dissociation of NF-κB/IκB/protein kinase A catalytic subunit complex in collecting duct principal cells . Journal of the American Society of Nephrology. 16. (9). p. 2576-2585.
Vinciguerra, M., Arnaudeau, S., Mordasini, D., Rousselot, M., Bens, M., Vandewalle, A., Martin, P.-Y., Hasler, U., Feraille, E.(2004). Extracellular hypotonicity increases Na,K-ATPase cell surface expression via enhanced Na<sup>+</sup> influx in cultured renal collecting duct cells . Journal of the American Society of Nephrology. 15. (10). p. 2537-2547.
Vinciguerra, M., Desch&#234;nes, G., Hasler, U., Mordasini, D., Rousselot, M., Doucet, A., Vandewalle, A., Martin, P.-Y., F&#233;raille, E.(2003). Intracellular Na<sup>+</sup> controls cell surface expression of Na,K-ATPase via a cAMP-independent PKA pathway in mammalian kidney collecting duct cells . Molecular Biology of the Cell. 14. (7). p. 2677-2688.
Vinciguerra, M., Musaro, A., Rosenthal, N.(2010). Regulation of muscle atrophy in aging and disease . Advances in Experimental Medicine and Biology. 694. p. 211-233.
F&#233;raille, E., Mordasini, D., Gonin, S., Desch&#234;nes, G., Vinciguerra, M., Doucet, A., Vandewalle, A., Summa, V., Verrey, F., Martin, P.-Y.(2003). Mechanism of control of Na,K-ATPase in principal cells of the mammalian collecting duct . Annals of the New York Academy of Sciences. 986. p. 570-578.