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Hire Dr. Manasmita D.

India

USD 30 /hr

A Biomedical Professional and Musician | Expert in Formulation Chemistry, Nanomedicine, Drug Delivery & Biomedical Imaging

Profile Summary

I am an experienced biomedical researcher, who aspires to apply her cross-disciplinary skill sets for developing potential solutions to human health issues. Originally trained as a synthetic organic chemist, I have spent more than 8 years in the field of cancer nanomedicine. My past research primarily focused on the formulation, characterization and PK/PD evaluation of a variety of novel drug delivery systems based on biopolymers, lipids, carbon nanotubes and magnetic nanoparticles. In 2013, I joined Biomedical Research Imaging Center at UNC to gain specialized training in small animal imaging. In 2014, I received NIH-sponsored Multimodal Neuroimaging Training Program (MNTP) award by University of Pittsburgh. I spent 6 week at CMU and UPMC learning various neuroimaging modalities including fMRI, DTI, MEG, EEG, PET and optical imaging. During this time, I also mastered various pharmacokinetic modeling techniques to interpret clinical PET data from glioma patients. Initially, my research at UNC focused on dissecting the neuronal and glial components of BOLD-fMRI signal using optogenetic and chemogenetic fMRI. Later, I combined chemogenetics with pharmacological fMRI and 18F-FDG PET to decipher the functional projections of genetically distinct subpopulations of central norepinephrine neurons regulating complex behavioral and physiological processes in vivo. My research on chemogenetic fMRI has brought me Cross Disciplinary Fellowship award from Human Frontier Science Program and Summa Cum Laude Merit Award from ISMRM. I have also integrated my formulation skills with current imaging experience to build a dedicated Contrast agent and molecular MRI core facility at CAMRI that provides cost-effective solutions and consultancy to preclinical researchers worldwide using nanoparticles for several diagnostic applications including CBV-fMRI, micro-MR angiography, magnetomotive ultrasound imaging and in vitro cell labeling. I am still continuing research along this line while exploring opportunities for an independent career where I want to combine my cross-disciplinary skill-sets to develop a unique research track focused on molecular theranostics. Apart from Science, I also hold a B.Mus-diploma in Indian Classical Music. Currently, I am trying to use my expertise in Indian Classical Music and Neuroscience to solve various social, cognitive and behavioral issues while creating public awareness on the healing power of Indian Classical Music.

Subject Matter Expertise

• ★ Molecular Imaging
• ★ Nanobiotechnology
• ★ Formulation
• ☆ Nanotechnology
• ☆ Biomaterials
• ☆ Organic Chemistry
• ☆ Biochemistry
• ☆ Neurochemistry
• ☆ Neuropharmacology
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Medical Imaging/Radiology
• ☆ Magnetic Resonance Imaging (MRI)
• ☆ Ultrasound
• ☆ Diagnostic Radiology
• ☆ Cancer Research

Services

• Writing
• Research
• Consulting
• Product Development

Writing Technical Writing, Copywriting, Newswriting

Research Market Research, Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Product Development Formulation, Stability/Shelf Life Testing

Work Experience

Scientific and Non Scientific writer

Kolabtree-freelancing

January 2020 - Present

Director, Contrast Agent and Molecular MRI, Center for Animal MRI

University of North Carolina - Chapel Hill

July 2015 - December 2020

Post Doctoral Research Associate, Biomedical Research Imaging Center and Dept. of Neurology

university of north carolina at chapel hill

July 2013 - July 2018

Summer student, Multimodal Neuroimaging Training Program

University of Pittsburgh Medical Center and Carneigie Melon University

June 2014 - July 2014

Research Scientist (Project), Center for Pharmaceutical Nanotechnology, Dept. of Pharmaceutics

National Institute of Pharmaceutical Education and Research (NIPER Mohali, India)

February 2010 - July 2013

Research Fellow and Teaching Assistant in Chemistry (Organic Chemistry)

Indian Institute of Technology, Kharagpur

October 2005 - January 2010

Education

PhD

Indian Institute of Technology, Kharagpur

October 2005 - February 2011

MSc (Chemistry)

Indian Institute of Technology

July 2003 - July 2005

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Esteban A. Oyarzabal and Li-Ming Hsu and Manasmita Das and Tzu-Hao Harry Chao and Jingheng Zhou and Sheng Song and Weiting Zhang and Kathleen G. Smith and Natale R. Sciolino and Irina Y. Evsyukova and Hong Yuan and Sung-Ho Lee and Guohong Cui and Patricia Jensen and Yen-Yu Ian Shih(2022). Chemogenetic stimulation of tonic locus coeruleus activity strengthens the default mode network . Science Advances. 8. (17). American Association for the Advancement of Science ({AAAS})

Das M, Oyarzabal EA, Chen L, Lee SH, Shah N, Gerlach G, Zhang W, Chao TH, Berge NVD, Liu C, et al.(2021). One-pot synthesis of carboxymethyl-dextran coated iron oxide nanoparticles (CION) for preclinical fMRI and MRA applications . NeuroImage.

Harwinder Singh and Sreejesh Sreedharan and Esteban Oyarzabal and Tufan Singha Mahapatra and Nicola Green and Yen-Yu Ian Shih and Manasmita Das and Jim. A. Thomas and Sumit Kumar Pramanik and Amitava Das(2020). Mitochondriotropic lanthanide nanorods: implications for multimodal imaging . Chemical Communications. 56. (57). p. 7945--7948. Royal Society of Chemistry ({RSC})

Yu-Wei Chen and Manasmita Das and Esteban A. Oyarzabal and Qing Cheng and Nicholas W. Plummer and Kathleen G. Smith and Grace K. Jones and Daniel Malawsky and Jerrel L. Yakel and Yen-Yu Ian Shih and Patricia Jensen(2019). A subset of noradrenergic (NE) neurons defined by developmental expression of Hoxb1 have a distinct role in attenuating the behavioral response to acute stress . Molecular Psychiatry. 24. (5). p. 625--625. Springer Science and Business Media {LLC}

Chen, Yu-Wei and Das, Manasmita and Oyarzabal, Esteban A and Cheng, Qing and Plummer, Nicholas W and Smith, Kathleen G and Jones, Grace K and Malawsky, Daniel and Yakel, Jerrel L and Shih, Yen-Yu Ian and others(2019). Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses. Molecular psychiatry. 24. (5). p. 710. Nature Publishing Group

Decot, Heather K and Namboodiri, Vijay MK and Gao, Wei and McHenry, Jenna A and Jennings, Joshua H and Lee, Sung-Ho and Kantak, Pranish A and Kao, Yu-Chieh Jill and Das, Manasmita and Witten, Ilana B and others(2017). Coordination of brain-wide activity dynamics by dopaminergic neurons. Neuropsychopharmacology. 42. (3). p. 615. Nature Publishing Group

Jain, Sanyog and Jain, Roopal and Das, Manasmita and Agrawal, Ashish K and Thanki, Kaushik and Kushwah, Varun(2014). Combinatorial bio-conjugation of gemcitabine and curcumin enables dual drug delivery with synergistic anticancer efficacy and reduced toxicity. RSC Advances. 4. (55). p. 29193--29201. Royal Society of Chemistry

Das, Manasmita and Jain, Roopal and Agrawal, Ashish Kumar and Thanki, Kaushik and Jain, Sanyog(2014). Macromolecular bipill of gemcitabine and methotrexate facilitates tumor-specific dual drug therapy with higher benefit-to-risk ratio. Bioconjugate chemistry. 25. (3). p. 501--509. ACS Publications

Das, Manasmita(2014). Does the targeted delivery of theranostic carbon nanotubes have potential as a valid anticancer strategy?. Therapeutic delivery. 5. (1). p. 1--5. Future Science Ltd London, UK

Hatial, Ishita and Jana, Saibal and Bisai, Shrabani and Das, Manasmita and Ghosh, Ananta Kumar and Anoop, Anakuthil and Basak, Amit(2014). Trienediynes on a 1, 3, 5-trisubstituted benzene template: a new approach for enhancement of reactivity. RSC Advances. 4. (53). p. 28041--28045. Royal Society of Chemistry

Delivery, Intranuclear Drug(2013). Effective in Vivo Cancer Therapy via Estradiol-PEG-Appended Multiwalled Carbon Nanotubes Das, Manasmita; Singh, Raman Preet; Datir, Satyajit R.; Jain, Sanyog. Molecular Pharmaceutics. 10. (9). p. 3404--3416.

Das, Manasmita and Singh, Raman Preet and Datir, Satyajit R and Jain, Sanyog(2013). Intranuclear drug delivery and effective in vivo cancer therapy via Estradiol--PEG-appended multiwalled carbon nanotubes. Molecular pharmaceutics. 10. (9). p. 3404--3416. American Chemical Society

Kumar, Sunil and Das, Manasmita and Singh, Raman Preet and Datir, Satyajit and Chauhan, Dinesh Singh and Jain, Sanyog(2013). Mathematical models for the oxidative functionalization of multiwalled carbon nanotubes. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 419. p. 156--165. Elsevier

Das, Manasmita and Singh, Raman Preet and Datir, Satyajit R and Jain, Sanyog(2013). Surface chemistry dependent “switch” regulates the trafficking and therapeutic performance of drug-loaded carbon nanotubes. Bioconjugate chemistry. 24. (4). p. 626--639. ACS Publications

Das, Manasmita and Datir, Satyajit R and Singh, Raman Preet and Jain, Sanyog(2013). Augmented anticancer activity of a targeted, intracellularly activatable, theranostic nanomedicine based on fluorescent and radiolabeled, methotrexate-folic acid-multiwalled carbon nanotube conjugate. Molecular pharmaceutics. 10. (7). p. 2543--2557. ACS Publications

Jain, Sanyog and Rathi, Vishal V and Jain, Amit K and Das, Manasmita and Godugu, Chandraiah(2012). Folate-decorated PLGA nanoparticles as a rationally designed vehicle for the oral delivery of insulin. Nanomedicine. 7. (9). p. 1311--1337. Future Medicine Ltd London, UK

Singh, Raman Preet and Das, Manasmita and Thakare, Vivek and Jain, Sanyog(2012). Functionalization density dependent toxicity of oxidized multiwalled carbon nanotubes in a murine macrophage cell line. Chemical research in toxicology. 25. (10). p. 2127--2137. ACS Publications

Datir, Satyajit R and Das, Manasmita and Singh, Raman Preet and Jain, Sanyog(2012). Hyaluronate tethered,“smart” multiwalled carbon nanotubes for tumor-targeted delivery of doxorubicin. Bioconjugate chemistry. 23. (11). p. 2201--2213. ACS Publications

Agrawal, Ashish Kumar and Das, Manasmita and Jain, Sanyog(2012). In situ gel systems as ‘smart’carriers for sustained ocular drug delivery. Expert opinion on drug delivery. 9. (4). p. 383--402. Taylor \& Francis

Das, Manasmita and Bandyopadhyay, Debarati and Singh, Raman Preet and Harde, Harshad and Kumar, Sunil and Jain, Sanyog(2012). Orthogonal biofunctionalization of magnetic nanoparticles via “clickable” poly (ethylene glycol) silanes: a “universal ligand” strategy to design stealth and target-specific nanocarriers. Journal of Materials Chemistry. 22. (47). p. 24652--24667. Royal Society of Chemistry

Dhak, Prasanta and Dhak, D and Das, M and Subashchandrabose, T and Pramanik, P(2011). A novel synthesis of FeNbO 4 nanorod by hydrothermal process. Journal of Nanoparticle Research. 13. (9). p. 4153--4159. Springer

Jain, Amit K and Swarnakar, Nitin K and Das, Manasmita and Godugu, Chandraiah and Singh, Raman Preet and Rao, Poduri Rama and Jain, Sanyog(2011). Augmented anticancer efficacy of doxorubicin-loaded polymeric nanoparticles after oral administration in a breast cancer induced animal model. Molecular pharmaceutics. 8. (4). p. 1140--1151. ACS Publications

Jain, Sanyog and Das, Manasmita(2011). Conference scene: nanomedicine kindles the development of the ‘elixir of life’. Nanomedicine. 6. (4). p. 599--603. Future Medicine Ltd London, UK

Dhak, Prasanta and Dhak, Debasis and Das, Manasmita and Pramanik, Panchanan(2011). Dielectric and impedance spectroscopy study of Ba 0.8 Bi 2.133 Nb 1.6 Ta 0.4 O 9 ferroelectric ceramics, prepared by chemical route. Journal of Materials Science: Materials in Electronics. 22. (12). p. 1750. Springer US

Jain, Amit K and Das, Manasmita and Swarnakar, Nitin K and Jain, Sanyog(2011). Engineered PLGA nanoparticles: an emerging delivery tool in cancer therapeutics. Critical Reviews™ in Therapeutic Drug Carrier Systems. 28. (1). Begel House Inc.

Swarnakar, Nitin K and Jain, Amit K and Singh, Raman P and Godugu, Chandraiah and Das, Manasmita and Jain, Sanyog(2011). Oral bioavailability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles. Biomaterials. 32. (28). p. 6860--6874. Elsevier

Harde, Harshad and Das, Manasmita and Jain, Sanyog(2011). Solid lipid nanoparticles: an oral bioavailability enhancer vehicle. Expert Opinion on Drug Delivery. 8. (11). p. 1407--1424. Taylor \& Francis

Bhattacharya, Dipsikha and Sahu, Sumanta K and Banerjee, Indranil and Das, Manasmita and Mishra, Debashish and Maiti, Tapas K and Pramanik, Panchanan(2011). Synthesis, characterization, and in vitro biological evaluation of highly stable diversely functionalized superparamagnetic iron oxide nanoparticles. Journal of Nanoparticle Research. 13. (9). p. 4173. Springer Netherlands

Bhattacharya, Dipsikha and Das, Manasmita and Mishra, Debashis and Banerjee, Indranil and Sahu, Sumanta K and Maiti, Tapas K and Pramanik, Panchanan(2011). Folate receptor targeted, carboxymethyl chitosan functionalized iron oxide nanoparticles: a novel ultradispersed nanoconjugates for bimodal imaging. Nanoscale. 3. (4). p. 1653--1662. Royal Society of Chemistry

Jain, Sanyog and Mathur, Rashi and Das, Manasmita and Swarnakar, Nitin K and Mishra, Anil K(2011). Synthesis, pharmacoscintigraphic evaluation and antitumor efficacy of methotrexate-loaded, folate-conjugated, stealth albumin nanoparticles. Nanomedicine. 6. (10). p. 1733--1754. Future Medicine Ltd London, UK

Jain, Sanyog and Thakare, Vivek S and Das, Manasmita and Godugu, Chandraiah and Jain, Amit K and Mathur, Rashi and Chuttani, Krishna and Mishra, Anil K(2011). Toxicity of multiwalled carbon nanotubes with end defects critically depends on their functionalization density. Chemical research in toxicology. 24. (11). p. 2028--2039. ACS Publications

Thakare, Vivek S and Das, Manasmita and Jain, Amit K and Patil, Swapnil and Jain, Sanyog(2010). Carbon nanotubes in cancer theragnosis. Nanomedicine. 5. (8). p. 1277--1301. Future Medicine Ltd London, UK

Das, Manasmita and Mishra, Debasish and Dhak, Prasanta and Gupta, Satyajit and Maiti, Tapas Kumar and Basak, Amit and Pramanik, Panchanan(2009). Biofunctionalized, phosphonate-grafted, ultrasmall iron oxide nanoparticles for combined targeted cancer therapy and multimodal imaging. Small. 5. (24). p. 2883--2893. Wiley Online Library

Dhak, Prasanta and Dhak, Debasis and Das, Manasmita and Pramanik, Kausikisankar and Pramanik, Panchanan(2009). Impedance spectroscopy study of LaMnO3 modified BaTiO3 ceramics. Materials Science and Engineering: B. 164. (3). p. 165--171. Elsevier

Das, Manasmita and Mishra, Debasish and Maiti, TK and Basak, A and Pramanik, P(2008). Bio-functionalization of magnetite nanoparticles using an aminophosphonic acid coupling agent: new, ultradispersed, iron-oxide folate nanoconjugates for cancer-specific targeting. Nanotechnology. 19. (41). p. 415101. IOP Publishing

CONFERENCE PAPER

Manasmita Das, Heather K Decot, Yu-Chieh Kao, Oyarzabal Esteban, Yen-Yu Ian Shih(2015). Probing Gq-GPCR Signaling in Rat Primary Motor Cortex with Pharmacogenetic fMRI. International Society of Magnetic Resonance in Medicine.