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Hire Mariajose M.

United States

USD 200 /hr

Neuroscience & Life Sciences Consultant | Preclinical Research, Scientific Writing & Grant Strategy

Profile Summary

PhD neuroscientist and NIH-funded principal investigator with 15+ years of biomedical research experience. My expertise includes neuroscience, CNS injury and repair, gene therapy, viral vectors, and preclinical therapeutic development. I provide scientific writing and editing, grant review and strategy, literature reviews, study design, data interpretation, and scientific consulting. I also have experience integrating AI-based tools into research and data-analysis workflows. I work with biotech, healthcare, and research organizations to evaluate complex science and translate it into clear, actionable recommendations.

Subject Matter Expertise

• ★ Gene Therapy
• ☆ Molecular Biology
• ☆ Gene Expression Analysis
• ☆ Systems Science
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ Neurology
• ☆ Spinal Cord Injury
• ☆ Technical & Scientific Writing
• ☆ Manuscript & Journal Article Writing
• ☆ Experimental Protocols
• ☆ SOP & Protocol Writing
• ☆ Science Communication
• ☆ Literature Review
• ☆ Traditional/Narrative Literature Review
• ☆ Grant Writing

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Medical Writing, Technical Writing, General Proofreading & Editing

Research Feasibility Study, Technology Scouting, Fact Checking, Gap Analysis, Gray Literature Search, Scientific and Technical Research, Secondary Data Collection

Consulting Business Strategy Consulting, Healthcare Consulting, Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Analysis, Data Visualization, Data Insights

Product Development Product Evaluation, Product Validation, Concept Development

Work Experience

Assistant Professor

University of Louisville

August 2024 - Present

Project Scientist

University of California Irvine

June 2019 - August 2024

Specialist

University of California Irvine

December 2011 - April 2019

Postdoctoral Fellow

Burke Medical Research Institute

August 2011 - November 2014

Research Assistant

Rockefeller University

November 2004 - July 2007

Education

PhD (Neuroscience)

The Graduate Center, CUNY

September 2007 - May 2012

MS (Neuroscience)

The Graduate Center, CUNY

September 2008 - August 2009

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Brian T. David, Jessica J. Curtin, Jennifer L. Brown, Kerri Scorpio, Veena Kandaswamy, David J. C. Coutts, Ana Vivinetto, Paola Bianchimano, Saravanan S. Karuppagounder, Mariajose Metcalfe, et al. (2023). Temporary induction of hypoxic adaptations by preconditioning fails to enhance Schwann cell transplant survival after spinal cord injury . Glia.

Front. Integr. Neurosci., 08 February 2023 Volume 17 - 2023 .

(2021). Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury . Experimental neurology.

Oswald Steward, Aminata P. Coulibaly, Mariajose Metcalfe, Jamie M. Dam, Kelly M. Yee(2021). AAV vectors accumulate in the pineal gland after injections into the brain or spinal cord . Molecular Therapy - Methods & Clinical Development. 23. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 406--417. Elsevier {BV}

(2021). Rostro-Caudal Specificity of Corticospinal Tract Projections in Mice . Cerebral cortex (New York, N.Y. : 1991).

(2019). AAVshRNA-mediated PTEN knockdown in adult neurons attenuates activity-dependent immediate early gene induction . Experimental neurology.

(2012). Coordination between proteasome impairment and caspase activation leading to tau pathology: neuroprotection by cAMP . Cell Death Dis.

(2011). Assessment of proteasome impairment and accumulation/aggregation of ubiquitinated proteins in neuronal cultures . Methods Mol Biol.

(2010). Relationship between tau pathology and neuroinflammation in Alzheimer’s disease .

(2008). Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons . J Biol Chem.

(2005). Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway . J Biol Chem.

PREPRINT

Mariajose Metcalfe, Brian T. David, Brett C. Langley, Caitlin E. Hill (2023). Elevation of NAD+ by nicotinamide riboside spares spinal cord tissue from injury and promotes locomotor recovery .