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USD 185 /hr

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Hire Dr. Khalid M.

United States

USD 185 /hr

Scientific and medical writer with 25+ years of experience in pre-clinical development and clinical research

Profile Summary

Prof. Khalid Matalka is a professional Immunobiologist and professor with more than 25 years of experience. He holds a Ph.D. in Cancer Therapy and Immunology from Ohio State University, MSs, and BSc in Clinical Laboratory Sciences. Following his Ph.D., Dr. Matalka had a Post-Doctoral Fellowship at Harvard Medical School.

Prof. Matalka has developed a breadth and depth of knowledge in Immunology, Cancer Therapy, Pharmacology, Ethnopharmacology, and Clinical Diagnostics while working in the industry, academia and clinical diagnostic set up, which is a unique combination! He has developed several immunoassays, cell-based assays, and designed research studies. Prof. Matalka has authored 63 research and review articles. Besides, he has proofread and facilitated in redesigning many thesis and dissertations for graduate students.

He is a skillful and well-experienced in writing scientific and clinical-related manuscripts, documents for regulatory authorities, common technical document (CTD and eCTD), designing best representations for data, and performing statistical analysis. Besides, Prof. Matalka is an associate editor of BMC Cancer for the past eight years as well as in the editorial board of several peer-reviewed journals.

Subject Matter Expertise

Services

Writing
Consulting
Data & AI
Product Development

Writing Clinical Trial Documentation, Technical Writing

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis

Product Development Formulation

Work Experience

Founder

Matalka's Scientific Writing

June 2020 - Present

Chief Biologist

OncoTherapeutica, Inc.

October 2016 - May 2020

Dean, Chairman, & Professor

American University of Madaba

September 2014 - September 2016

Director, Dean, Professor

University of Petra

February 1995 - August 2014

Education

Post Doctoral Fellow in Radiotherapy of Cancer (Monoclonal Abs & Small Molecules)

Harvard Medical School

October 1992 - January 1994

PhD in Experimental Pathology (Immunology and Cancer Therapy)

The Ohio State University

September 1988 - September 1992

Masters of Science in Medical Technology

University of Wisconsin-Milwaukee

August 1986 - August 1988

BSc in Medical Technology

Yarmouk University

October 1981 - June 1986

Certifications

Certification details not provided.

Publications

JOURNAL ARTICLE

Mikaelian, A.G., Traboulay, E., Zhang, X.M., Yeritsyan, E., Pedersen, P.L., Ko, Y.H., Matalka, K.Z.(2020). Pleiotropic anticancer properties of scorpion venom peptides: Rhopalurus princeps venom as an anticancer agent . Drug Design, Development and Therapy. 14. p. 881-893.

Jawabrah Al-Hourani, B., El-Barghouthi, M.I., Al-Awaida, W., McDonald, R., Fattash, I.A., El Soubani, F., Matalka, K., Wuest, F.(2020). Biomolecular docking, synthesis, crystal structure, and bioassay studies of 1-[4-(2-chloroethoxy)phenyl]-5-[4-(methylsulfonyl)phenyl]-1H-tetrazole and 2-(4-(5-(4-(methylsulfonyl)phenyl)-1H-tetrazol-1-yl)phenoxy)ethyl nitrate . Journal of Molecular Structure. 1202.

Jawabrah Al-Hourani, B., Ali, B.F., Judeh, Z., El-Barghouthi, M.I., Al-Awaida, W., Snobar, Y., El Soubani, F., Matalka, K., Wuest, F.(2018). Unexpected formation of 1-[4-chloromethylphenyl]-5-[4-(methylsulfonyl)benzyl]-1H-tetrazole and 1-[4-chloromethylphenyl]-5-[4-(aminosulfonyl)phenyl]-1H-tetrazole: Crystal structure, bioassay screening and molecular docking studies . Journal of Molecular Structure. 1164. p. 317-327.

Mansoor, K., Qadan, F., Hinum, A., Schneider, C., Hechenbichler, K., Schmidt, M., Linsinger, G., Matalka, K.(2018). An open prospective pilot study of a herbal combination "relief" as a supportive dietetic measure during alcohol withdrawal . Neuroendocrinology Letters. 39. (1). p. 1-8.

Mansoor, K.A., Qadan, F., Schmidt, M., Qinna, N.A., Badr, M., Matalka, K.Z.(2018). A functional food mixture “protector” reinforces the protective immune parameters against viral flu infection in mice . Nutrients. 10. (6).

Al Shaker, H.A., Qinna, N.A., Badr, M., Al Omari, M.M.H., Idkaidek, N., Matalka, K.Z., Badwan, A.A.(2017). Glucosamine modulates propranolol pharmacokinetics via intestinal permeability in rats . European Journal of Pharmaceutical Sciences. 105. p. 137-143.

Mansoor, K., Qadan, F., Schmidt, M., Mallah, E., Abudayyih, W., Matalka, K.(2017). Stability study and a 14-day oral dose toxicity in rats of plantain leaf extract (Plantago lanceolata L.) syrup . Scientia Pharmaceutica. 85. (1).

Mansoor, K.A., Matalka, K.Z., Qa’dan, F.S., Awad, R., Schmidt, M.(2016). Two new proanthocyanidin trimers isolated from Cistus incanus L. demonstrate potent anti-inflammatory activity and selectivity to cyclooxygenase isoenzymes inhibition . Natural Product Research. 30. (17). p. 1919-1926.

Awad, R., Mallah, E., Alkhawaja, B., Abudayyih, W., El-Hajji, F., Matalka, K.Z., Arafat, T.(2016). Pomegranate and licorice juices modulate metformin pharmacokinetics in rats . Neuroendocrinology Letters. 37. (3). p. 202-206.

Jawabrah Al-Hourani, B., Al-Awaida, W., Matalka, K.Z., El-Barghouthi, M.I., Alsoubani, F., Wuest, F.(2016). Structure–activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies . Bioorganic and Medicinal Chemistry Letters. 26. (19). p. 4757-4762.

Matalka, K.Z., Abdulridha, N.A., Badr, M.M., Mansoor, K., Qinna, N.A., Qadan, F.(2016). Eriobotrya japonica water extract characterization: An inducer of interferon-gamma production mainly by the JAK-STAT pathway . Molecules. 21. (6).

Qinna, N.A., Shubbar, M.H., Matalka, K.Z., Al-Jbour, N., Ghattas, M.A., Badwan, A.A.(2015). Glucosamine enhances paracetamol bioavailability by reducing its metabolism . Journal of Pharmaceutical Sciences. 104. (1). p. 257-265.

Bustami, M.R., Dakkak, N., Abu-Qatouseh, L.F., Khalil, R., Matalka, K.Z.(2014). Value of phenotypic and genotypic identification of Acinetobacter baumannii isolates from two hospitals in Jordan . International Arabic Journal of Antimicrobial Agents. 4. (4).

Badr, M.M., Qinna, N.A., Qadan, F., Matalka, K.Z.(2014). Dichloroacetate modulates cytokines toward T helper 1 function via induction of the interleukin-12-interferon-γ pathway . OncoTargets and Therapy. 7. p. 193-201.

Al-Qaisi, J.A., Alhussainy, T.M., Qinna, N.A., Matalka, K.Z., Al-Kaissi, E.N., Muhi-Eldeen, Z.A.(2014). Synthesis and pharmacological evaluation of aminoacetylenic isoindoline-1,3-dione derivatives as anti-inflammatory agents . Arabian Journal of Chemistry. 7. (6). p. 1024-1030.

Matalka, K.Z., Alsaadi, M.T., Qinna, N., Mallah, E., Awad, R., Dayyih, W.A., Alhussainy, T., Qadan, F.(2013). Enhancing doxorubicin-induced MCA-fibrosarcoma cytotoxicity by an Eriobotrya japonica hydrophilic butanol-treated extract through natural killer cells activation . Journal of Cancer Science and Therapy. 5. (6).

Matalka, K.Z., Alfarhoud, F., Qinna, N.A., Mallah, E.M., Abu-Dayyih, W.A., Muhi-Eldeen, Z.A.(2012). Anti-inflammatory aminoacetylenic isoindoline-1,3-dione derivatives modulate cytokines production from different spleen cell populations . International Immunopharmacology. 14. (3). p. 296-301.

Qinna, N.A., Muhi-eldeen, Z.A., Ghattas, M., Alhussainy, T.M., Al-Qaisi, J., Matalka, K.Z.(2012). Non-selective inhibition of cyclooxygenase enzymes by aminoacetylenic isoindoline 1,3-Diones . Inflammation and Allergy - Drug Targets. 11. (5). p. 369-374.

Alshaker, H.A., Matalka, K.Z.(2011). IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors . Cancer Cell International. 11.

Matalka, K.Z., Attallah, L.J., Qinna, N.A., Alhussainy, T.(2011). Dopamine selectively modulates lipopolysaccharide-induced TNF-alpha, IFN-qamma and IL-10 within mice tissues . Neuroendocrinology Letters. 32. (2). p. 176-186.

Alshaker, H.A., Qinna, N.A., Qadan, F., Bustami, M., Matalka, K.Z.(2011). Eriobotrya japonica hydrophilic extract modulates cytokines in normal tissues, in the tumor of Meth-A-fibrosarcoma bearing mice, and enhances their survival time . BMC Complementary and Alternative Medicine. 11.

Mallah, E.M., Hamad, M.F., Elmanaseer, M.A., Qinna, N.A., Idkaidek, N.M., Arafat, T.A., Matalka, K.Z.(2011). Plasma concentrations of 25-hydroxyvitamin D among Jordanians: Effect of biological and habitual factors on vitamin D status . BMC Clinical Pathology. 11.

Tawaha, K., Sadi, R., Qa'dan, F., Matalka, K.Z., Nahrstedt, A.(2010). A bioactive prodelphinidin from Mangifera indica leaf extract . Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 65 C. (5-6). p. 322-326.

Al-Hanbali, M., Ali, D., Bustami, M., Abdel-Malek, S., Al-Hanbali, R., Alhussainy, T., Qadan, F., Matalka, K.Z.(2009). Epicatechin suppresses IL-6, IL-8 and enhances IL-10 production with NF-κB nuclear translocation in whole blood stimulated system . Neuroendocrinology Letters. 30. (1). p. 131-138.

Qinna, N., Taha, H., Matalka, K.Z., Badwan, A.A.(2009). A new herbal combination, Etana, for enhancing erectile function: An efficacy and safety study in animals . International Journal of Impotence Research. 21. (5). p. 315-320.

Abdel Malek, S.M., Al-Adham, I.S., Matalka, K.Z., Collier, P.J.(2009). Pseudomonas aeruginosa PAO1 resistance to zinc pyrithione: Phenotypic changes suggest the involvement of efflux pumps . Current Microbiology. 59. (2). p. 95-100.

Qa'dan, F., Verspohl, Eugen.J., Nahrstedt, A., Petereit, F., Matalka, K.Z.(2009). Cinchonain Ib isolated from Eriobotrya japonica induces insulin secretion in vitro and in vivo . Journal of Ethnopharmacology. 124. (2). p. 224-227.

Matalka, K.Z., Ali, D., Khawad, A.E., Qa'dan, F.(2007). The differential effect of Eriobotrya japonica hydrophilic leaf extract on cytokines production and modulation . Cytokine. 40. (3). p. 235-240.

Matalka, K.Z., Ali, D.A.(2006). Stress-induced versus preovulatory and pregnancy hormonal levels in modulating cytokine production following whole blood stimulation . NeuroImmunoModulation. 12. (6). p. 366-374.

Qa'dan, F., Thewaini, A.-J., Ali, D.A., Afifi, R., Elkhawad, A., Matalka, K.Z.(2005). The antimicrobial activities of Psidium guajava and Juglans regia leaf extracts to acne-developing organisms . American Journal of Chinese Medicine. 33. (2). p. 197-204.

Arafat, T., Awad, R., Hamad, M., Azzam, R., Al-Nasan, A., Jehanli, A., Matalka, K.(2005). Pharmacokinetics and pharmacodynamics profiles of enalapril maleate in healthy volunteers following determination of enalapril and enalaprilat by two specific enzyme immunoassays . Journal of Clinical Pharmacy and Therapeutics. 30. (4). p. 319-328.

Matalka, K.Z., Tutunji, M.F., Abu-Baker, M., Abu Baker, Y.(2005). Measurement of protein cytokines in tissue extracts by enzyme-linked immunosorbent assays: Application to lipopolysaccharide-induced differential milieu of cytokines . Neuroendocrinology Letters. 26. (3). p. 231-236.

Matalka, K.Z.(2003). The effect of estradiol, but not progesterone, on the production of cytokines in stimulated whole blood, is concentration-dependent . Neuroendocrinology Letters. 24. (3-4). p. 185-191.

Matalka, K.Z.(2003). Neuroendocrine and cytokines-induced responses to minutes, hours, and days of mental stress . Neuroendocrinology Letters. 24. (5). p. 283-292.

Matalka, K.Z.(2003). Prolactin enhances production of interferon-γ, interleukin-12, and interleukin-10, but not of tumor necrosis factor-α, in a stimulus-specific manner . Cytokine. 21. (4). p. 187-194.

Matalka, K.Z.(2003). Neuroendocrine and cytokines-induced responses to minutes, hours, and days of mental stress . Neuroendocrinology Letters. 24. (5). p. 283-292.

Matalka, K., Arafat, T., Hamad, M., Jehanli, A.(2002). Determination of enalapril and enalaprilat by enzyme linked immunosorbent assays: Application to pharmacokinetic and pharmacodynamic analysis . Fundamental and Clinical Pharmacology. 16. (3). p. 237-244.

Matalka, K., El-Thaher, T., Saleem, M., Arafat, T., Jehanli, A., Badwan, A.(2001). Enzyme linked immunosorbent assay for determination of amlodipine in plasma . Journal of Clinical Laboratory Analysis. 15. (1). p. 47-53.

El-Thaher, T.S., Matalka, K.Z., Taha, H.A., Badwan, A.A.(2001). Ferula harmonis 'zallouh' and enhancing erectile function in rats: Efficacy and toxicity study . International Journal of Impotence Research. 13. (4). p. 247-251.

Albarghouthi, M., Fara, D.A., Saleem, M., El-Thaher, T., Matalka, K., Badwan, A.(2000). Immobilization of antibodies on alginate-chitosan beads . International Journal of Pharmaceutics. 206. (1-2). p. 23-34.

Matalka, K., Arafat, T., El-Thaher, T., Qawasmeh, K., Shebli, S., Hamad, M., Badwan, A.(2000). Pharmacokinetic and pharmacodynamic profiles of two brands of amlodipine determined by enzyme linked immunosorbent assay . Pharmacy and Pharmacology Communications. 6. (12). p. 539-544.

Matalka, K.Z., Sidki, A., Abdul-Malik, S.M., Thewaini, A.-J.(2000). Academic stress - Influence on Epstein-Barr virus and cytomegalovirus reactivation, cortisol, and prolactin . Laboratory Medicine. 31. (3). p. 163-168.

Harapanhalli, R.S., Matalka, K.Z., Jones, P.L., Mahmood, A., Adelstein, S.J., Kassis, A.I.(1998). Lysine-directed conjugation of ethidium homodimer to B72.3 antibody: Retention of immunoreactivity but altered tumor targeting . Nuclear Medicine and Biology. 25. (3). p. 267-278.

Matalka, K.Z., Sidki, A.(1998). Academic stress - Influence on leukocyte distribution, cortisol, and prolactin . Laboratory Medicine. 29. (11). p. 697-702.

Kassis, A.I., Wen, P.Y., Van Den Abbeele, A.D., Baranowska-Kortylewicz, J., Makrigiorgos, G.M., Metz, K.R., Matalka, K.Z., Cook, C.U., Sahu, S.K., Black, P.McL., et al.(1998). 5-[<sup>125</sup>I]iodo-2'-deoxyuridine in the radiotherapy of brain tumors in rats . Journal of Nuclear Medicine. 39. (7). p. 1148-1154.

Harapanhalli, R.S., Matalka, K.Z., Jones, P.L., Mahmood, A., Adelstein, S.J., Kassis, A.I.(1997). Lysine-Directed Conjugation of Ethidium Homodimer to B72.3 mAb: Retention of Immunoreactivity and Altered Tumor Targeting . Radiochimica Acta. 79. (2). p. 77-82.

Kassis, A.I., Jones, P.L., Matalka, K.Z., Adelstein, S.J.(1996). Antibody-dependent signal amplification in tumor xenografts after pretreatment with biotinylated monoclonal antibody and avidin or streptavidin . Journal of Nuclear Medicine. 37. (2). p. 343-352.

Matalka, K.Z., Barth, R.F., Maruyama, Y., Bailey, M.Q., Moeschberger, M.L., Feola, J.M., Wierzbicki, J.(1995). Californium-252 boron-10 neutron capture brachytherapy of human intracerebral melanoma in a nude rat model . Endocurietherapy/Hyperthermia Oncology. 11. (1). p. 57-65.

Barth, R.F., Matalka, K.Z., Bailey, M.Q., Staubus, A.E., Soloway, A.H., Moeschberger, M.L., Coderre, J.A., Rofstad, E.K.(1994). A nude rat model for neutron capture therapy of human intracerebral melanoma . International Journal of Radiation Oncology, Biology, Physics. 28. (5). p. 1079-1088.

Matalka, K.Z., Barth, R.F., Staubus, A.E., Moeschberger, M.L., Coderre, J.A.(1994). Neutron capture therapy of a rat glioma using boronophenylalanine as a capture agent . Radiation Research. 137. (1). p. 44-51.

Matalka, K.Z., Barth, R.F., Bailey, M.Q., Wilkie, D.A., Koestner, A., Hopewell, J.W.(1994). Radiation effects of boron neutron capture therapy on brain, skin, and eye of rats . International Journal of Radiation Oncology, Biology, Physics. 28. (5). p. 1089-1097.

Matalka, K.Z., Bailey, M.Q., Barth, R.F., Staubus, A.E., Soloway, A.H., Moeschberger, M.L., Coderre, J.A., Rofstad, E.K.(1993). Boron Neutron Capture Therapy of Intracerebral Melanoma Using Boronophenylalanine as a Capture Agent . Cancer Research. 53. (14). p. 3308-3313.