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Hire Dr. Karthik M.

Japan

Molecular Microbiologist & AMR Specialist, Expert in Phage Therapy, WGS, and Genomic Analysis

Profile Summary

I am Dr. Karthik Maruthan, a molecular microbiologist and postdoctoral researcher specializing in antimicrobial resistance (AMR), microbial genomics, and phage therapy. I have extensive experience in whole-genome sequencing (WGS) pipelines, mutational and structural analysis, AMR gene profiling, phage-based antimicrobial development, and bacterial infection models. My research has led to the discovery and characterization of multiple novel β-lactamases and genomic insights into hybrid and hypervirulent E. coli strains. I also work with non-replicating therapeutic phages, in vitro antibacterial assays, and in vivo murine infection studies with PK/PD analysis. I offer expert support in: Microbial genomics & bioinformatics (WGS, SNP analysis, pangenomics) AMR mechanism analysis & interpretation Molecular biology workflows (PCR, cloning, gene expression, mutational studies) Phage research & infection model design Scientific writing, data interpretation, and manuscript review With a strong publication record and experience as a reviewer for major journals, I provide accurate, high-quality scientific analysis and clear, publication-ready deliverables for academic, clinical, and industry clients.

Subject Matter Expertise

• ☆ Microbiology
• ☆ Bacteriology
• ☆ Molecular Biology
• ☆ Genomics
• ☆ DNA Sequencing
• ☆ Genome Sequencing
• ☆ Bioinformatics
• ☆ Clinical Microbiology
• ☆ Drug Development
• ☆ Infectious Disease
• ☆ Antibiotic Resistance Research
• ☆ Gene Therapy

Services

• Writing

Writing Medical Writing, Technical Writing, Translation

Work Experience

post - doctoral researcher

Jichi Medical University, Shimotsuke, Japan

May 2025 - Present

Post doctoral researcher

Jichi Medical University

May 2025 - Present

Reseacher

Christian Medical College, Vellore

March 2022 - April 2025

Research Associate

Christian Medical College, Vellore

May 2022 - March 2025

Education

Ph.D.

Madurai Kamaraj University, India

February 2014 - February 2022

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Karthik M, Panchal NK, T M, Bakthavatchalam YD, Neeravi A, Abirami B, Walia K, Veeraraghavan B (2025). Evolutionary insights into NDM variants: Identification and functional analysis of novel NDM-58 in Pseudomonas aeruginosa . Microbial pathogenesis.

Karthik M, Kacha S, Rajendran S, Bakthavatchalam YD, Lal B, Walia K, Veeraraghavan B (2024). Genetic characteristics and diversity of PDC variants of Pseudomonas aeruginosa and its clinical relevance . Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

Pal A, Ghosh D, Thakur P, Nagpal P, Irulappan M, Maruthan K, Mukherjee S, Patil NG, Dutta T, Veeraraghavan B, et al. (2024). Clinically relevant mutations in regulatory regions of metabolic genes facilitate early adaptation to ciprofloxacin in Escherichia coli . Nucleic acids research.

Sethuvel DPM, Bakthavatchalam YD, Karthik M, Irulappan M, Shrivastava R, Periasamy H, Veeraraghavan B (2023). β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview . Infectious diseases and therapy.

Kumaran NAM, Karthik M, Kumar V, Jebasingh T, Munavar MH (2019). Two new mutations in dnaJ suppress DNA damage hypersensitivity and capsule overproduction phenotypes of Δlon mutant of Escherichia coli by modulating the expression of clpYQ (hslUV) and rcsA genes . Gene.

Karthik M, Meenakshi S, Munavar MH (2019). Unveiling the molecular basis for pleiotropy in selected rif mutants of Escherichia coli: Possible role for Tyrosine in the Rif binding pocket and fast movement of RNA polymerase . Gene.

Meenakshi S, Karthik M, Munavar MH (2018). A putative curved DNA region upstream of rcsA in <i>Escherichia coli</i> plays a key role in transcriptional regulation by H-NS . FEBS open bio.

Velmurugan G, Ramprasath T, Swaminathan K, Mithieux G, Rajendhran J, Dhivakar M, Parthasarathy A, Babu DD, Thumburaj LJ, Freddy AJ, et al. (2017). Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis . Genome biology.