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Hire Dr. Kangyu L.

United States

USD 20 /hr

Data Scientist | Bioinformatician with 15+ years of experience in Biomedicine | Cancer Biology | Clinical research

Profile Summary

I am a data scientist and bioinformatician at MD Anderson Cancer Center, specializing in machine learning and multi-omics analysis for cancer research. I develop scalable NGS pipelines, integrate clinical and genomic data, and build data infrastructures and portals to support biomarker discovery and precision oncology. With a Ph.D. in Biochemistry & Molecular Biology and an M.S. in Computer Science, I combine biology, computational methods, and software engineering to turn complex biomedical data into actionable insights. My work bridges translational research and clinical impact in oncology.

Subject Matter Expertise

• ☆ Molecular Biology
• ☆ Omics
• ☆ Genomics
• ☆ Synthetic Genomics
• ☆ Data Analysis
• ☆ Data Processing
• ☆ Cluster Analysis
• ☆ Data Visualization
• ☆ Big Data Analytics
• ☆ Data Collection
• ☆ Data Management
• ☆ Data Manipulation
• ☆ Machine Learning
• ☆ Data Cleaning
• ☆ Neural Networks
• ☆ Pattern Recognition
• ☆ Deep Learning
• ☆ Python
• ☆ SQL
• ☆ R
• ☆ Scikit-learn
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Medical Writing
• ☆ Research Summaries & Abstracts

Services

• Research
• Data & AI

Research Technology Scouting

Data & AI Statistical Analysis, Algorithm Design-Non ML, Algorithm Design-ML, Data Visualization, Big Data Analytics

Work Experience

Research Investigator

University of Texas MD Anderson Cancer Center

September 2019 - Present

Research Investigator

The University of Texas MD Anderson Cancer Center

September 2019 - Present

Postdoc

University of Texas MD Anderson Cancer Center

October 2013 - September 2019

Postdoctoral Fellow

University of Texas MD Anderson Cancer Center

October 2013 - August 2019

Education

M.Sc (Master of Science)

Georgia Institute of Technology

January 2023 - December 2024

The Master of Science in Computer Science (College of Computing)

Georgia Institute of Technology

January 2023 - December 2024

PhD (Life Science)

Sun Yat-Sen University

September 2008 - July 2013

BS (Life Science)

Southwest University

September 2004 - July 2008

Certifications

• Foundry & AIP Builder Foundations

  Palantir Technologies

  https://verify.skilljar.com/c/cfze9op888eu

  January 2025 - Present

• IBM Data Engineering Specialization

  IBM

  https://www.coursera.org/account/accomplishments/specialization/NJHLY8FRH9SG

  August 2022 - Present

• BI Foundations with SQL, ETL and Data Warehousing

  IBM

  https://www.coursera.org/account/accomplishments/specialization/certificate/R6VW2V7QYC8E

  August 2022 - Present

Publications

PREPRINT

Kangyu Lin, Van K. Morris, Weihong Xiao, Chi Wut Wong, Michael T. Wotman, Emma B. Holliday, Ryan W. Huey, Sonal S. Noticewala, Ethan B. Ludmir, Alisha H. Bent, et al. (2025). Data from Time Dependency for Human Papillomavirus Circulating Tumor DNA Detection after Chemoradiation as a Prognostic Biomarker for Localized Anal Cancer .

Kangyu Lin, Kristen K. Ciombor, Seong-Woo Bae, Jennifer G. Whisenant, Gregory D. Ayers, Quanhu Sheng, Todd E. Peterson, Gary T. Smith, Saikat Chowdhury, Preeti Kanikarla Marie, et al. (2025). Data from Results of the Phase I/II Study and Preliminary B-cell Gene Signature of Combined Inhibition of Glutamine Metabolism and EGFR in Colorectal Cancer .

Kangyu Lin, Van K. Morris, Suyu Liu, Haifeng Zhu, Seema Prasad, Armeen Mahvash, Priya Bhosale, Baohua Sun, Edwin R. Parra, Ignacio Wistuba, et al. (2025). Data from Phase II Trial of Atezolizumab and Bevacizumab for Treatment of HPV-Positive Unresectable or Metastatic Squamous Cell Carcinoma of the Anal Canal .

JOURNAL ARTICLE

Kangyu Lin, Van K. Morris, Weihong Xiao, Chi Wut Wong, Michael T. Wotman, Emma B. Holliday, Ryan W. Huey, Sonal S. Noticewala, Ethan B. Ludmir, Alisha H. Bent, et al. (2025). Time Dependency for Human Papillomavirus Circulating Tumor DNA Detection after Chemoradiation as a Prognostic Biomarker for Localized Anal Cancer . Clinical Cancer Research.

Kangyu Lin, Van K. Morris, Suyu Liu, Haifeng Zhu, Seema Prasad, Armeen Mahvash, Priya Bhosale, Baohua Sun, Edwin R. Parra, Ignacio Wistuba, et al. (2025). Phase II Trial of Atezolizumab and Bevacizumab for Treatment of HPV-Positive Unresectable or Metastatic Squamous Cell Carcinoma of the Anal Canal . Clinical Cancer Research.

Kangyu Lin, Kristen K. Ciombor, Seong-Woo Bae, Jennifer G. Whisenant, Gregory D. Ayers, Quanhu Sheng, Todd E. Peterson, Gary T. Smith, Saikat Chowdhury, Preeti Kanikarla Marie, et al. (2025). Results of the Phase I/II Study and Preliminary B-cell Gene Signature of Combined Inhibition of Glutamine Metabolism and EGFR in Colorectal Cancer . Clinical Cancer Research.

Kangyu Lin, Arjun S. Peddireddy, Ryan Huey, Robert A. Wolff, Jocelyn Mitchell, Lisa Scofield, Sophia Jacob, Diem V. Nguyen, Jane Rogers, Shaelynn Portier, et al. (2025). Clinicopathologic Features Associated with Survival for Immune Checkpoint Blockade in Patients with Metastatic Anal Cancer . Cancers.

Kangyu Lin, Arjun S. Peddireddy, Ryan Huey, Robert A. Wolff, Jocelyn Mitchell, Lisa Scofield, Sophia Jacob, Diem V. Nguyen, Jane Rogers, Shaelynn Portier, et al. (2025). Clinicopathologic Features Associated with Survival for Immune Checkpoint Blockade in Patients with Metastatic Anal Cancer . Cancers.

Kangyu Lin, Deepak Bhamidipati, Jay R. Johnson, Helene Pelicano, Cathy Eng, Ryan Huey, Robert A. Wolff, Daniel M. Halperin, Michael F. Frumovitz, Ignacio I. Wistuba, et al. (2025). The Clinical Utility of a Next-Generation Sequencing-Based Approach to Detecting Circulating HPV DNA in Patients with Advanced Anal Cancer . Cancers.

Kangyu Lin, Deepak Bhamidipati, Jay R. Johnson, Helene Pelicano, Cathy Eng, Ryan Huey, Robert A. Wolff, Daniel M. Halperin, Michael F. Frumovitz, Ignacio I. Wistuba, et al. (2025). The Clinical Utility of a Next-Generation Sequencing-Based Approach to Detecting Circulating HPV DNA in Patients with Advanced Anal Cancer . Cancers.

Kangyu Lin, Saikat Chowdhury, Mohammad A. Zeineddine, Fadl A. Zeineddine, Nicholas J. Hornstein, Oscar E. Villarreal, Dipen M. Maru, Cara L. Haymaker, Jean-Nicolas Vauthey, George J. Chang, et al. (2024). Identification of Colorectal Cancer Cell Stemness from Single-Cell RNA Sequencing . Molecular Cancer Research.

Hsu WH, LaBella KA, Lin Y, Xu P, Lee R, Hsieh CE, Yang L, Zhou A, Blecher JM, Wu CJ, et al. (2023). Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression . Cancer discovery.

Kangyu Lin, Saikat Chowdhury, Ria Gupta, Joshua Millstein, Valsala Haridas, Mohammad A. Zeineddine, Christine Parseghian, Heinz-Josef Lenz, Scott Kopetz, John Paul Shen (2023). Transcriptional Profiling and Consensus Molecular Subtype Assignment to Understand Response and Resistance to Anti–Epidermal Growth Factor Receptor Therapy in Colorectal Cancer . JCO Precision Oncology.

Kangyu Lin, Caishang Zheng, Yanjun Wei, Peng Zhang, Longyong Xu, Zhenzhen Zhang, Jiakai Hou, Xiangdong Lv, Yao Ding, Yulun Chiu, et al. (2023). CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer . Journal of Clinical Investigation.

Kangyu Lin, Aidong Zhou, Sicong Zhang, Li Ma, Jianfei Xue, Saint‐Aaron Morris, Kenneth D Aldape, Suyun Huang (2017). Gli1‐induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1 . EMBO reports.

Kangyu Lin, Aidong Zhou, Sicong Zhang, Yaohui Chen, Nu Zhang, Jianfei Xue, Zhongyong Wang, Kenneth D. Aldape, Keping Xie, James R. Woodgett, et al.(2016). Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22 . Nature Cell Biology. 18. (9). p. 954--966. Springer Nature

Shi, Pei-Jie and Xu, Lu-Hong and Lin, Kang-Yu and Weng, Wen-jun and Fang, Jian-Pei(2016). Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia. Journal of hematology & oncology. 9. (1). p. 1. BioMed Central

Chen, Yaohui and Li, Yu and Xue, Jianfei and Gong, Aihua and Yu, Guanzhen and Zhou, Aidong and Lin, Kangyu and Zhang, Sicong and Zhang, Nu and Gottardi, Cara J and others(2016). Wnt-induced deubiquitination FoxM1 ensures nucleus $β$-catenin transactivation. The EMBO journal. p. e201592810. EMBO Press

Lin, KY and Ye, H and Han, BW and Wang, WT and Wei, PP and He, B and Li, XJ and Chen, YQ(2015). Genome-wide screen identified let-7c/miR-99a/miR-125b regulating tumor progression and stem-like properties in cholangiocarcinoma. Oncogene. Nature Publishing Group

Xue, Jianfei and Chen, Yaohui and Wu, Yamei and Wang, Zhongyong and Zhou, Aidong and Zhang, Sicong and Lin, Kangyu and Aldape, Kenneth and Majumder, Sadhan and Lu, Zhimin and others(2015). Tumour suppressor TRIM33 targets nuclear $β$-catenin degradation. Nature communications. 6. Nature Publishing Group

Zeng, Cheng-Wu and Chen, Zhen-Hua and Zhang, Xing-Ju and Han, Bo-Wei and Lin, Kang-Yu and Li, Xiao-Juan and Wei, Pan-Pan and Zhang, Hua and Li, Yangqiu and Chen, Yue-Qin(2014). MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia. Autophagy. 10. (10). p. 1726--1737. Taylor \& Francis

Fang, Ke and Han, Bo-Wei and Chen, Zhen-Hua and Lin, Kang-Yu and Zeng, Cheng-Wu and Li, Xiao-Juan and Li, Jun-Hao and Luo, Xue-Qun and Chen, Yue-Qin(2014). A distinct set of long non-coding RNAs in childhood MLL-rearranged acute lymphoblastic leukemia: biology and epigenetic target. Human molecular genetics. 23. (12). p. 3278--3288. Oxford Univ Press

Sun, Yu-Meng and Lin, Kang-Yu and Chen, Yue-Qin(2013). Diverse functions of miR-125 family in different cell contexts. J Hematol Oncol. 6. (6).

Duan, Fang-Ting and Qian, Feng and Fang, Ke and Lin, Kang-Yu and Wang, Wen-Tao and Chen, Yue-Qin(2013). miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression. Molecular cancer. 12. (1). p. 1. BioMed Central

Zeng, Cheng-Wu and Zhang, Xing-Ju and Lin, Kang-Yu and Ye, Hua and Feng, Shu-Ying and Zhang, Hua and Chen, Yue-Qin(2012). Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Molecular pharmacology. 81. (4). p. 578--586. ASPET

Zheng, YS and Zhang, H and Zhang, XJ and Feng, DD and Luo, XQ and Zeng, CW and Lin, KY and Zhou, H and Qu, LH and Zhang, P and others(2012). MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Oncogene. 31. (1). p. 80--92. Nature Publishing Group

Han, Bo-Wei and Feng, Dan-Dan and Li, Zhi-Gang and Luo, Xue-Qun and Zhang, Hua and Li, Xiao-Juan and Zhang, Xing-Ju and Zheng, Ling-Ling and Zeng, Cheng-Wu and Lin, Kang-Yu and others(2011). A set of miRNAs that involve in the pathways of drug resistance and leukemic stem-cell differentiation is associated with the risk of relapse and glucocorticoid response in childhood ALL. Human molecular genetics. 20. (24). p. 4903--4915. Oxford Univ Press

Lin, Kang-Yu and Zhang, Xing-Ju and Feng, Dan-Dan and Zhang, Hua and Zeng, Cheng-Wu and Han, Bo-Wei and Zhou, Ai-Dong and Qu, Liang-Hu and Xu, Ling and Chen, Yue-Qin(2011). miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies. Journal of Biological Chemistry. 286. (44). p. 38253--38263. ASBMB