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Hire Julio A.

United States

USD 350 /hr

Microphysiological systems | Biomaterials | Tissue microenvironment | TEDx Speaker | MIT Review 35 under 35

Profile Summary

10 years of research experience in microphysiological systems and biopriting with focus on tissue engineering for drug discovery, personalized medicine, and benchtop devices. Involved in over 30 peer reviewed publications, one book chapter, >20 scientific talks, and a speaker in the 2017 TEDxCluj edition. I have also been recognized as a MIT Technology Review Innovator Under 35

Subject Matter Expertise

• ★ Biotechnology & Bioengineering
• ★ Tissue Engineering
• ★ Science Communication
• ☆ Materials Science & Engineering
• ☆ Biomaterials
• ☆ Collagen
• ☆ Biomedical Engineering
• ☆ Bioprinting
• ☆ Microfluidics
• ☆ Biosensors
• ☆ In vitro Diagnostics
• ☆ Lab-on-a-Chip Devices
• ☆ Endocrinology
• ☆ Diabetes
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Device Fabrication
• ☆ Technical & Scientific Writing
• ☆ 3D Printing/Additive Manufacturing

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Writing Technical Writing, General Proofreading & Editing, Translation

Research Market Research, User Research, Feasibility Study, Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting, Manufacturing Consulting

Data & AI Image Analysis, Data Insights

Product Development Product Evaluation, Material Sourcing, Manufacturing, Prototyping, Device Fabrication

Work Experience

Graduate Researcher

University of Pittsburgh - Drug Discovery Institute

August 2019 - Present

Research manager

Wake Forest School of Medicine- WFIRM/ReMDO

July 2015 - July 2019

Research Assistant

Harvard-MIT Health Science & Technology- BIRC

October 2013 - July 2015

Education

Bioengineering

University of Pittsburgh

August 2019 - Present

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Julio Aleman, Tugba Kilic, Luis S. Mille, Su Ryon Shin, Yu Shrike Zhang(2021). Microfluidic integration of regeneratable electrochemical affinity-based biosensors for continual monitoring of organ-on-a-chip devices . Nature Protocols. Springer Science and Business Media {LLC}

Julio Aleman, Zuyan Lu, Shiny Amala Priya Rajan, Qianqian Song, Yu Zhao, Meimei Wan, Aleksander Skardal, Colin Bishop, Anthony Atala, Baisong Lu (2021). 3D scaffold-free microlivers with drug metabolic function generated by lineage-reprogrammed hepatocytes from human fibroblasts . Biomaterials.

Aleman, J., Kilic, T., Mille, L.S., Shin, S.R., Zhang, Y.S.(2021). Microfluidic integration of regeneratable electrochemical affinity-based biosensors for continual monitoring of organ-on-a-chip devices . Nature Protocols. 16. (5). p. 2564-2593.

Trevisan, B., Morsi, A., Aleman, J., Rodriguez, M., Shields, J., Meares, D., Farland, A.M., Doering, C.B., Spencer, H.T., Atala, A., et al.(2021). Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A . Frontiers in Bioengineering and Biotechnology. 9.

Lu, Z., Priya Rajan, S.A., Song, Q., Zhao, Y., Wan, M., Aleman, J., Skardal, A., Bishop, C., Atala, A., Lu, B.(2021). 3D scaffold-free microlivers with drug metabolic function generated by lineage-reprogrammed hepatocytes from human fibroblasts . Biomaterials. 269.

Julio Aleman, Matthew L. Bedell, Anthony J. Melchiorri, Aleksander Skardal, Antonios G. Mikos(2020). A high-throughput approach to compare the biocompatibility of candidate bioink formulations . Bioprinting. 17. p. e00068. Elsevier {BV}

Julio Aleman, Aleksander Skardal, Steven Forsythe, Shiny Rajan, Sean Murphy, Mahesh Devarasetty, Nima Pourhabibi Zarandi, Goodwell Nzou, Robert Wicks, Hooman Sadri-Ardekani, et al. (2020). Drug compound screening in single and integrated multi-organoid body-on-a-chip systems . Biofabrication.

Julio Aleman, Erin Maloney, Casey Clark, Hemamylammal Sivakumar, KyungMin Yoo, Shiny A. P. Rajan, Steven Forsythe, Andrea Mazzocchi, Adrian W. Laxton, Stephen B. Tatter, et al.(2020). Immersion Bioprinting of Tumor Organoids in Multi-Well Plates for Increasing Chemotherapy Screening Throughput . Micromachines. 11. (2). p. 208. {MDPI} {AG}

Maloney, E., Clark, C., Sivakumar, H., Yoo, K., Aleman, J., Rajan, S.A.P., Forsythe, S., Mazzocchi, A., Laxton, A.W., Tatter, S.B., et al.(2020). Immersion bioprinting of tumor organoids in multi-well plates for increasing chemotherapy screening throughput . Micromachines. 11. (2).

Enck, K., Rajan, S.P., Aleman, J., Castagno, S., Long, E., Khalil, F., Hall, A.R., Opara, E.C.(2020). Design of an Adhesive Film-Based Microfluidic Device for Alginate Hydrogel-Based Cell Encapsulation . Annals of Biomedical Engineering. 48. (3). p. 1103-1111.

Votanopoulos, K.I., Forsythe, S., Sivakumar, H., Mazzocchi, A., Aleman, J., Miller, L., Levine, E., Triozzi, P., Skardal, A.(2020). Model of Patient-Specific Immune-Enhanced Organoids for Immunotherapy Screening: Feasibility Study . Annals of Surgical Oncology. 27. (6). p. 1956-1967.

Skardal, A., Aleman, J., Forsythe, S., Rajan, S., Murphy, S., Devarasetty, M., Pourhabibi Zarandi, N., Nzou, G., Wicks, R., Sadri-Ardekani, H., et al.(2020). Drug compound screening in single and integrated multi-organoid body-on-a-chip systems . Biofabrication. 12. (2).

Rajan, S.A.P., Aleman, J., Wan, M., Pourhabibi Zarandi, N., Nzou, G., Murphy, S., Bishop, C.E., Sadri-Ardekani, H., Shupe, T., Atala, A., et al.(2020). Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform . Acta Biomaterialia. 106. p. 124-135.

Bedell, M.L., Melchiorri, A.J., Aleman, J., Skardal, A., Mikos, A.G.(2020). A high-throughput approach to compare the biocompatibility of candidate bioink formulations . Bioprinting. 17.

Clark, C.C., Aleman, J., Mutkus, L., Skardal, A.(2019). A mechanically robust thixotropic collagen and hyaluronic acid bioink supplemented with gelatin nanoparticles . Bioprinting. 16.

Votanopoulos, K.I., Mazzocchi, A., Sivakumar, H., Forsythe, S., Aleman, J., Levine, E.A., Skardal, A.(2019). Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study . Annals of Surgical Oncology. 26. (1). p. 139-147.

Aleman, J., George, S.K., Herberg, S., Devarasetty, M., Porada, C.D., Skardal, A., Almeida-Porada, G.(2019). Deconstructed Microfluidic Bone Marrow On-A-Chip to Study Normal and Malignant Hemopoietic Cell–Niche Interactions . Small. 15. (43).

Aleman, J., Skardal, A.(2019). A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells . Biotechnology and Bioengineering. 116. (4). p. 936-944.

Julio Aleman, Su Ryon Shin, Tugba Kilic, Yu Shrike Zhang, Huseyin Avci, Ning Hu, Duckjin Kim, Cristina Branco, Solange Massa, Antonia Silvestri, et al.(2017). Label-Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes . Advanced Science. 4. (5). p. 1600522. Wiley

Julio Aleman, Yu Shrike Zhang, Su Ryon Shin, Tugba Kilic, Duckjin Kim, Seyed Ali Mousavi Shaegh, Solange Massa, Reza Riahi, Sukyoung Chae, Ning Hu, et al.(2017). Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors . Proceedings of the National Academy of Sciences. 114. (12). p. E2293--E2302. Proceedings of the National Academy of Sciences

Skardal, A., Murphy, S.V., Devarasetty, M., Mead, I., Kang, H.-W., Seol, Y.-J., Zhang, Y.S., Shin, S.-R., Zhao, L., Aleman, J., et al.(2017). Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform . Scientific Reports. 7. (1).

Zhang, Y.S., Yue, K., Aleman, J., Mollazadeh-Moghaddam, K., Bakht, S.M., Yang, J., Jia, W., Dell’Erba, V., Assawes, P., Shin, S.R., et al.(2017). 3D Bioprinting for Tissue and Organ Fabrication . Annals of Biomedical Engineering. 45. (1). p. 148-163.

Shin, S.R., Kilic, T., Zhang, Y.S., Avci, H., Hu, N., Kim, D., Branco, C., Aleman, J., Massa, S., Silvestri, A., et al.(2017). Label-Free and Regenerative Electrochemical Microfluidic Biosensors for Continual Monitoring of Cell Secretomes . Advanced Science. 4. (5).

Zhang, Y.S., Aleman, J., Shin, S.R., Kilic, T., Kim, D., Shaegh, S.A.M., Massa, S., Riahi, R., Chae, S., Hu, N., et al.(2017). Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors . Proceedings of the National Academy of Sciences of the United States of America. 114. (12). p. E2293-E2302.

Julio Aleman, Yu Shrike Zhang, Kan Yue, Kamyar Mollazadeh-Moghaddam, Syeda Mahwish Bakht, Jingzhou Yang, Weitao Jia, Valeria Dell’Erba, Pribpandao Assawes, Su Ryon Shin, et al.(2016). 3D Bioprinting for Tissue and Organ Fabrication . Annals of Biomedical Engineering. 45. (1). p. 148--163. Springer Nature

Julio Aleman, Weijia Zhang, Yu Shrike Zhang, Syeda Mahwish Bakht, Su Ryon Shin, Kan Yue, Marco Sica, João Ribas, Margaux Duchamp, Jie Ju, et al.(2016). Elastomeric free-form blood vessels for interconnecting organs on chip systems . Lab on a Chip. 16. (9). p. 1579--1586. Royal Society of Chemistry ({RSC})

Zhang, Y.S., Chang, J.-B., Alvarez, M.M., Trujillo-De Santiago, G., Aleman, J., Batzaya, B., Krishnadoss, V., Ramanujam, A.A., Kazemzadeh-Narbat, M., Chen, F., et al.(2016). Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications . Scientific Reports. 6.

Taurino, I., Massa, S., Sanzó, G., Aleman, J., Flavia, B., Shin, S.R., Zhang, Y.S., Dokmeci, M.R., De Micheli, G., Carrara, S., et al.(2016). Platinum nanopetal-based potassium sensors for acute cell death monitoring . RSC Advances. 6. (46). p. 40517-40526.

Julio Aleman, Irene Taurino, Solange Massa, Gabriella Sanzó, Basilotta Flavia, Su Ryon Shin, Yu Shrike Zhang, Mehmet Remzi Dokmeci, Giovanni De Micheli, Sandro Carrara, et al.(2016). Platinum nanopetal-based potassium sensors for acute cell death monitoring . RSC Advances. 6. (46). p. 40517--40526. Royal Society of Chemistry ({RSC})

Shin, S.R., Zhang, Y.S., Kim, D.-J., Manbohi, A., Avci, H., Silvestri, A., Aleman, J., Hu, N., Kilic, T., Keung, W., et al.(2016). Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers . Analytical Chemistry. 88. (20). p. 10019-10027.

Riahi, R., Shaegh, S.A.M., Ghaderi, M., Zhang, Y.S., Shin, S.R., Aleman, J., Massa, S., Kim, D., Dokmeci, M.R., Khademhosseini, A.(2016). Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers . Scientific Reports. 6.

Julio Aleman, Yu Shrike Zhang, Andrea Arneri, Simone Bersini, Su-Ryon Shin, Kai Zhu, Zahra Goli-Malekabadi, Cristina Colosi, Fabio Busignani, Valeria Dell'Erba, et al.(2016). Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip . Biomaterials. 110. p. 45--59. Elsevier {BV}

Zhang, Y.S., Arneri, A., Bersini, S., Shin, S.-R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell'Erba, V., et al.(2016). Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip . Biomaterials. 110. p. 45-59.

Zhang, W., Zhang, Y.S., Bakht, S.M., Aleman, J., Shin, S.R., Yue, K., Sica, M., Ribas, J., Duchamp, M., Ju, J., et al.(2016). Elastomeric free-form blood vessels for interconnecting organs on chip systems . Lab on a Chip. 16. (9). p. 1579-1586.

Zhang, Y.S., Busignani, F., Ribas, J., Aleman, J., Rodrigues, T.N., Shaegh, S.A.M., Massa, S., Rossi, C.B., Taurino, I., Shin, S.-R., et al.(2016). Google Glass-Directed Monitoring and Control of Microfluidic Biosensors and Actuators . Scientific Reports. 6.

Julio Aleman, Yu Shrike Zhang, Andrea Arneri, Simone Bersini, Francesco Piraino, Su Ryon Shin, Mehmet Remzi Dokmeci, Ali Khademhosseini(2015). From cardiac tissue engineering to heart-on-a-chip: beating challenges . Biomedical Materials. 10. (3). p. 034006. {IOP} Publishing

Zhang, Y.S., Ribas, J., Nadhman, A., Aleman, J., Selimović, S., Lesher-Perez, S.C., Wang, T., Manoharan, V., Shin, S.-R., Damilano, A., et al.(2015). A cost-effective fluorescence mini-microscope for biomedical applications . Lab on a Chip. 15. (18). p. 3661-3669.

Julio Aleman, Yu Shrike Zhang, João Ribas, Akhtar Nadhman, Šeila Selimović, Sasha Cai Lesher-Perez, Ting Wang, Vijayan Manoharan, Su-Ryon Shin, Alessia Damilano, et al.(2015). A cost-effective fluorescence mini-microscope for biomedical applications . Lab on a Chip. 15. (18). p. 3661--3669. Royal Society of Chemistry ({RSC})

Zhang, Y.S., Aleman, J., Arneri, A., Bersini, S., Piraino, F., Shin, S.R., Dokmeci, M.R., Khademhosseini, A.(2015). From cardiac tissue engineering to heart-on-a-chip: Beating challenges . Biomedical Materials (Bristol). 10. (3).

OTHER

Aleman, J., Sivakumar, H., DePalma, T., Zhou, Y., Mazzocchi, A., Huntwork, R.C., Yoo, K., Banks, S., Clark, C., Maycock, A., et al.(2021). Engineering a thixotropic and biochemically tunable hyaluronan and collagen bioink for biofabrication of multiple tissue construct types . bioRxiv.

CONFERENCE PAPER

Morales, A.W., Zhang, Y.S., Aleman, J., Alerasool, P., Dokmeci, M.R., Khademhosseini, A., Ye, J.Y.(2016). Label-free detection of protein molecules secreted from an organ-on-a-chip model for drug toxicity assays . Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 9725.