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Hire Dr. Jérémy C. S.

France

USD 80 /hr

Scientist in immunology/cell biology - 9+years of experience - Scientific writing & content creation - Data analysis

Profile Summary

Profile (version française plus bas): Scientist holding a PhD in Immunology and infectious diseases with extensive experience in fundamental and translational Immunology, cell biology, aging biology, regenerative medicine, onco-immunology and auto-immunity. During my PhD, I worked on in vivo mouse models of auto-immunity and in vitro organoid models. I developed knowledge and expertise on immune development and regulation, in particular T-cell functions. During my postdoctoral experience, I further strengthened my technical expertise in transcriptomics and in in vivo studies by working with mouse models of aging and cancer. I successfully led my own research project demonstrating that immune rejuvenation can improve anti-tumoral responses and vaccine responses in aged individuals. Throughout this period, I authored several scientific articles and reviews, wrote successful grants and animal experimentation proposal, presented my work during scientific events, and participated to scientific outreach to the public at events such as the European research night. I master techniques such as flow cytometry, confocal imaging, single-cell RNA seq, spatial transcriptomic and in vivo models of auto-immunity and cancer. Passionate about science, literature, and communication, I can assist you with various projects, including: -writing and reviewing scientific or medical manuscripts, -grant writing and/or support, -creation of visual materials (graphical abstract, presentations, slides), -designing and writing research protocols, -bibliographic research, -scientific illustration, -scientific marketing, - scientific and technical consulting, - data analysis and interpretation. I look forward to working with you. Best regards. Jérémy Santamaria Scientifique titulaire d'un doctorat en immunologie et en maladies infectieuses, avec une vaste expérience en immunologie fondamentale et translationnelle, en biologie cellulaire, en biologie du vieillissement, en médecine régénérative, en onco-immunologie et en pathologies auto-immunes. Au cours de mon doctorat, j'ai travaillé sur des modèles murins in vivo d'auto-immunité et sur des modèles organoïdes in vitro. J'ai développé des connaissances et une expertise sur le développement et la régulation immunitaire, en particulier sur les fonctions des cellules T. Au cours de mon expérience postdoctorale, j'ai renforcé mon expertise technique en transcriptomique et en études in vivo en travaillant sur des modèles murins de vieillissement et de cancer. J'ai mené avec succès mon propre projet de recherche démontrant que le rajeunissement immunitaire peut améliorer les réponses anti-tumorales et les réponses vaccinales chez les personnes âgées. Tout au long de cette période, j'ai rédigé plusieurs articles et revues scientifiques, j'ai rédigé avec succès des demandes de subventions et des propositions d'expérimentation animale, j'ai présenté mes travaux lors d'événements scientifiques et j'ai participé à des activités de vulgarisation scientifique lors d'événements tels que la Nuit européenne de la recherche. Je maîtrise des techniques telles que la cytométrie de flux, l'imagerie confocale, l’analyse transcriptomique sur ARN en cellules uniques, la transcriptomique spatiale et des modèles in vivo d'auto-immunité et de cancer. Passionnée par la science, la littérature et la communication, je peux vous aider dans divers projets, notamment : - la rédaction et la révision de manuscrits scientifiques ou médicaux, - la rédaction et/ou soutien de subventions, - la création de matériel visuel (résumé graphique, présentations, diapositives), - la conception et la rédaction de protocoles de recherche, - la recherche bibliographique, - l'illustration scientifique, - le marketing scientifique, - le conseil scientifique et technique, - l'analyse et l'interprétation des données. Dans l’attente de travailler avec vous, bien à vous. Jérémy Santamaria Publications: * equal contribution • Santamaria JC, Chevallier J, Dutour L, Picart A, Kergaravat C, Cieslak A, Amrane M, Vincentelli R, Clave E, Sergé A, Cohen-Solal M, Toubert A, Irla M. RANKL treatment rejuvenates thymic function and improves T-cell mediated immune responses during aging. Science Translational Medicine. 2024 Dec 4;16(776):eadp3171. PMID: 39630886. • Borelli A, Santamaria JC, Zamit C, Apert C, Chevallier J, Pierre P, Argüello RJ, Spinelli L, Irla M. Lymphotoxin limits Foxp3+ regulatory T cell development from Foxp3lo precursors via IL-4 signaling, Nature communications. 2024. Aug 14;15(1):6976. PMID: 39143070. • Santamaria JC*, Vuillier S*, Galindo-Albarrán AO, Castan S, Detraves C, Joffre OP, Romagnoli P, van Meerwijk JPM. The type 1 diabetes susceptibility locus Idd5 favours robust neonatal development of highly autoreactive regulatory T cells in the NOD mouse. Frontiers in Immunology. 2024 Feb 9;15:1358459. PMID: 38404576. • Charaix J*, Borelli A*, Santamaria JC, Chasson L, Giraud M, Sergé A, Irla M. Recirculating Foxp3+ regulatory T cells are restimulated in the thymus under Aire control. Cellular and Molecular Life Science. 2022 Jun 9;79(7):355. PMID: 35678896. • Lopes N, Boucherit N*, Santamaria JC*, Provin N*, Charaix J, Ferrier P, Giraud M, Irla M. Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages. Elife. 2022 Feb 21;11:e69982. PMID: 35188458. • Apert C, Galindo-Albarrán AO, Castan S, Detraves C, Michaud H, McJannett N, Haegeman B, Fillatreau S, Malissen B, Holländer G, Žuklys S, Santamaria JC, Joffre OP, Romagnoli P, van Meerwijk JPM. IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes. Frontiers in Immunology. 2022 Sep 8;13:965303. PMID: 36159793. • Galindo-Albarrán A, Castan S, Santamaria JC, Joffre OP, Haegeman B, Romagnoli P, van Meerwijk JPM. The Repertoire of Newly Developing Regulatory T Cells in the Type 1 Diabetes-Prone NOD Mouse Is Very Diverse. Diabetes. 2021 Aug;70(8):1729-1737. PMID: 34035042. • Darrigues J*, Santamaria JC*, Galindo-Albarrán A, Robey EA, Joffre OP, van Meerwijk JPM, Romagnoli P. Robust intrathymic development of regulatory T cells in young NOD mice is rapidly restrained by recirculating cells. European Journal of Immunology. 2021 Mar;51(3):580-593. PMID: 32730634. • Santamaria JC, Borelli A, Irla M. Regulatory T Cell Heterogeneity in the Thymus: Impact on Their Functional Activities. Front Immunol. 2021 Feb 11;12:643153. PMID: 33643324. Review • Santamaria J, Darrigues J, van Meerwijk JPM, Romagnoli P. Antigen-presenting cells and T-lymphocytes homing to the thymus shape T cell development. Immunol Lett. 2018 Dec;204:9-15. PMID: 30308217. Review

Subject Matter Expertise

• ★ Cell Biology
• ★ Basic Immunology
• ★ Scientific Proofreading & Editing
• ☆ Biochemistry
• ☆ Immunoassay
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Omics
• ☆ Transcriptomics
• ☆ Genomics
• ☆ PCR
• ☆ Next Generation Sequencing (NGS)
• ☆ RNA Sequencing
• ☆ Cell-Based Assays
• ☆ Cell Signaling Pathways
• ☆ Gene Regulation
• ☆ Adjuvant & Antigen Research
• ☆ Microscopy
• ☆ Cryosectioning
• ☆ Fluorescence Microscopy
• ☆ Cell Culture
• ☆ Cell Surface Receptors
• ☆ Cytometry
• ☆ Cell Aging
• ☆ Library & Information Science
• ☆ Drug Development
• ☆ Allergy & Clinical Immunology
• ☆ Clinical Immunology
• ☆ Medical Genetics
• ☆ Immunogenetics
• ☆ Human Biology
• ☆ Infectious Disease
• ☆ Traditional Medicine
• ☆ Immunotherapy
• ☆ Autoimmune Disease
• ☆ Lupus
• ☆ Cancer Research
• ☆ Proofreading & Editing

Services

• Writing
• Research
• Consulting

Writing Clinical Trial Documentation, Medical Writing, Non-Medical Regulatory Writing, Technical Writing, Copywriting, Creative Writing, Newswriting, Audio Transcription, General Proofreading & Editing, Translation

Research User Research, Feasibility Study, Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Work Experience

Postdoctoral Researcher

Centre d'Immunologie de Marseille-Luminy

December 2020 - Present

PhD student

Centre de Physiopathologie de Toulouse-Purpan, Inserm

October 2016 - September 2020

Education

PhD in Biology/Immunology

Université Toulouse III - Paul Sabatier

October 2016 - October 2020

MSc Immunology and Infectious diseases

Université Paul Sabatier

September 2014 - June 2016

Certifications

• Animal experimentation operator and conceptor levels

  CNRS

  September 2022 - Present

Publications

JOURNAL ARTICLE

Jérémy C. Santamaria, Jessica Chevallier, Léa Dutour, Amandine Picart, Camille Kergaravat, Agata Cieslak, Mourad Amrane, Renaud Vincentelli, Denis Puthier, Emmanuel Clave, et al. (2024). RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice . Science Translational Medicine.

Alexia Borelli, Jérémy C. Santamaria, Cloé Zamit, Cécile Apert, Jessica Chevallier, Philippe Pierre, Rafael J. Argüello, Lionel Spinelli, Magali Irla (2024). Lymphotoxin limits Foxp3+ regulatory T cell development from Foxp3lo precursors via IL-4 signaling . Nature Communications.

Jérémy C. Santamaria, Sylvia Vuillier, Ariel O. Galindo-Albarrán, Sarah Castan, Claire Detraves, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk (2024). The type 1 diabetes susceptibility locus Idd5 favours robust neonatal development of highly autoreactive regulatory T cells in the NOD mouse . Frontiers in Immunology.

Jeremy C. Santamaria(2022). IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes . Frontiers in Immunology. 13. Frontiers Media {SA}

Recirculating Foxp3+ regulatory T cells are restimulated in the thymus under Aire control <head> <META HTTP-EQUIV="Refresh" CONTENT="0;URL=/servlet/useragent"> </head> . Cellular and Molecular Life Sciences.

Noella Lopes and Nicolas Boucherit and J{\'{e}}r{\'{e}}my C Santamaria and Nathan Provin and Jonathan Charaix and Pierre Ferrier and Matthieu Giraud and Magali Irla(2022). Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages . eLife. 11. {eLife} Sciences Publications, Ltd

Ariel Galindo-Albarr{\'{a}}n and Sarah Castan and J{\'{e}}r{\'{e}}my C. Santamaria and Olivier P. Joffre and Bart Haegeman and Paola Romagnoli and Joost P.M. van Meerwijk(2021). The repertoire of newly developing regulatory T cells in the type I diabetes-prone NOD mouse is very diverse . Diabetes. p. db201072. American Diabetes Association

Ariel Galindo-Albarr&#225;n, Sarah Castan, J&#233;r&#233;my C. Santamaria, Olivier P. Joffre, Bart Haegeman, Paola Romagnoli, Joost P.M. van Meerwijk(2021). The Repertoire of Newly Developing Regulatory T Cells in the Type 1 Diabetes–Prone NOD Mouse Is Very Diverse . Diabetes. 70. (8). p. 1729--1737. American Diabetes Association

Julie Darrigues, Jeremy C. Santamaria, Ariel Galindo‐Albarr&#225;n, Ellen A. Robey, Olivier P. Joffre, Joost P.M. van Meerwijk, Paola Romagnoli (2021). Robust intrathymic development of regulatory T cells in young NOD mice is rapidly restrained by recirculating cells . European Journal of Immunology.

J{\'{e}}r{\'{e}}my C. Santamaria and Alexia Borelli and Magali Irla(2021). Regulatory T Cell Heterogeneity in the Thymus: Impact on Their Functional Activities . Frontiers in Immunology. 12. Frontiers Media {SA}

Darrigues, J., Santamaria, J.C., Galindo-Albarr&#225;n, A., Robey, E.A., Joffre, O.P., van Meerwijk, J.P.M., Romagnoli, P.(2021). Robust intrathymic development of regulatory T cells in young NOD mice is rapidly restrained by recirculating cells . European Journal of Immunology. 51. (3). p. 580-593.

Santamaria, J.C., Borelli, A., Irla, M.(2021). Regulatory T Cell Heterogeneity in the Thymus: Impact on Their Functional Activities . Frontiers in Immunology. 12.

(2020). Robust intrathymic development of regulatory T cells in young NOD mice is rapidly restrained by recirculating cells . European Journal of Immunology.

Jeremy Santamaria, Julie Darrigues, Joost P.M. van Meerwijk, Paola Romagnoli(2018). Antigen-presenting cells and T-lymphocytes homing to the thymus shape T cell development . Immunology Letters. 204. p. 9--15. Elsevier {BV}

Santamaria, J., Darrigues, J., van Meerwijk, J.P.M., Romagnoli, P.(2018). Antigen-presenting cells and T-lymphocytes homing to the thymus shape T cell development . Immunology Letters. 204. p. 9-15.