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Spain

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Senior Scientist – Cancer Nanomedicine and Preclinical Drug Development

Profile Summary

I am a senior biomedical scientist with over 20 years of experience in cancer research, preclinical drug development and nanomedicine. I currently work at the Josep Carreras Leukaemia Research Institute, where my research focuses on the development and preclinical evaluation of targeted anticancer therapies, including nanoparticle-based drug delivery systems. I also serve as Scientific Coordinator of the Nanotoxicology Unit of the NANBIOSIS research infrastructure, where we evaluate the safety and efficacy of nanomaterials and nanomedicines using in vitro and in vivo models. My expertise includes cancer biology, mouse tumor models, nanoparticle-based therapeutics, nanotoxicology and translational preclinical research. I have authored over 75 peer-reviewed publications and hold 8 patents related to anticancer therapies and targeted antitumor nanomedicines. I support biotech companies and research groups in designing and evaluating preclinical strategies for anticancer drug development, including experimental design, model selection and translational development.

Subject Matter Expertise

• ☆ Drug Discovery
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical Research
• ☆ Preclinical Pharmacology
• ☆ In vitro Preclinical Toxciology
• ☆ In vivo Preclinical Toxicology
• ☆ Drug Efficacy Testing
• ☆ Oncology
• ☆ Chemotherapy
• ☆ Precision Medicine
• ☆ Hematology
• ☆ Hematology-Oncology
• ☆ Leukemia & Lymphoma
• ☆ Cancer Research
• ☆ Cancer Biology
• ☆ Carcinogenesis
• ☆ Pharmaceutical Technology
• ☆ Hypothesis
• ☆ Peer Review
• ☆ Research Methodology
• ☆ Survey Design & Methodology
• ☆ Literature Search
• ☆ Scientific Proofreading & Editing
• ☆ Proofreading & Editing

Services

• Research
• Consulting
• Product Development

Research Scientific and Technical Research

Consulting Scientific and Technical Consulting

Product Development Product Evaluation, Product Validation, Concept Development

Work Experience

Senior Scientist / Group Manager

Josep Carreras Leukaemia Research Institute

May 2022 - Present

Researcher

CIBER-BBN

March 2007 - Present

Senior postdoctoral scientist

CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine)

March 2008 - April 2022

Postdoctoral Researcher

Sant Pau Research Institute

July 2004 - February 2008

Education

PhD Genetics

University of Barcelona

September 1999 - June 2004

BSc Biology

University of Barcelona

September 1993 - June 1998

Certifications

• Certification for Laboratory Animal Science and Experimental Animal Handling

  FELASA (Federation of European Laboratory Animal Science Associations)

  March 2013 - Present

Publications

JOURNAL ARTICLE

Voltà-Durán, E., Serna, N., Sánchez-García, L., Aviñó, A., Sánchez, J.M., López-Laguna, H., Cano-Garrido, O., Casanova, I., Mangues, R., Eritja, R., et al.(2021). Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles . Acta Biomaterialia. 119. p. 312-322.

Sánchez, J.M., López-Laguna, H., Álamo, P., Serna, N., Sánchez-Chardi, A., Nolan, V., Cano-Garrido, O., Casanova, I., Unzueta, U., Vazquez, E., et al.(2020). Artificial Inclusion Bodies for Clinical Development . Advanced Science. 7. (3).

Pallarès, V., Unzueta, U., Falgàs, A., Sánchez-Garciá, L., Serna, N., Gallardo, A., Morris, G.A., Alba-Castellón, L., Álamo, P., Sierra, J., et al.(2020). An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination . Journal of Hematology and Oncology. 13. (1).

Falgàs, A., Pallarès, V., Serna, N., Sánchez-García, L., Sierra, J., Gallardo, A., Alba-Castellón, L., Álamo, P., Unzueta, U., Villaverde, A., et al.(2020). Selective delivery of T22-PE24-H6 to CXCR4⁺ diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model . Theranostics. 10. (12). p. 5169-5180.

Álamo, P., Pallarès, V., Céspedes, M.V., Falgàs, A., Sanchez, J.M., Serna, N., Sánchez‐garcía, L., Voltà‐duràn, E., Morris, G.A., Sánchez‐chardi, A., et al.(2020). Fluorescent dye labeling changes the biodistribution of tumor‐targeted nanoparticles . Pharmaceutics. 12. (11). p. 1-18.

Falgàs, A., Pallarès, V., Unzueta, U., Céspedes, M.V., Arroyo-Solera, I., Moreno, M.J., Gallardo, A., Mangues, M.A., Sierra, J., Villaverde, A., et al.(2020). A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models . Haematologica. 105. (3). p. 741-753.

Céspedes, M.V., Cano-Garrido, O., Álamo, P., Sala, R., Gallardo, A., Serna, N., Falgàs, A., Voltà-Durán, E., Casanova, I., Sánchez-Chardi, A., et al.(2020). Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci . Advanced Materials. 32. (7).

Recasens-Zorzo, C., Cardesa-Salzmann, T., Petazzi, P., Ros-Blanco, L., Esteve-Arenys, A., Clot, G., Guerrero-Hernández, M., Rodríguez, V., Soldini, D., Valera, A., et al.(2019). Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma . Haematologica. 104. (4). p. 778-788.

Casanova, I., Unzueta, U., Arroyo-Solera, I., Céspedes, M.V., Villaverde, A., Mangues, R., Vazquez, E.(2019). Protein-driven nanomedicines in oncotherapy . Current Opinion in Pharmacology. 47. p. 1-7.

Pavón, M.A., Arroyo-Solera, I., León, X., Téllez-Gabriel, M., Virós, D., Gallardo, A., Céspedes, M.V., Casanova, I., Lopez-Pousa, A., Barnadas, A., et al.(2019). The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes . Head and Neck. 41. (6). p. 1830-1845.

Protein-driven nanomedicines in oncotherapy @article{PMID:30685732, Title= {Protein-driven nanomedicines in oncotherapy}, Author= {Casanova, Isolda and Unzueta, Ugutz and Arroyo-Solera, Irene and Céspedes, Maria Virtudes and Villaverde, Antonio and Mangues, Ramon and Vazquez, Esther}, DOI= {10.1016/j.coph.2018.12.004}, Volume= {47}, Month= {August}, Year= {2019}, Journal= {Current opinion in pharmacology}, ISSN= {1471-4892}, Pages= {1—7}, URL= {https://doi.org/10.1016/j.coph.2018.12.004}} . Current opinion in pharmacology.

The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes @article{PMID:30652380, Title= {The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes}, Author= {Pavón, Miguel Angel and Arroyo-Solera, Irene and León, Xavier and Téllez-Gabriel, Marta and Virós, David and Gallardo, Alberto and Céspedes, Maria Virtudes and Casanova, Isolda and Lopez-Pousa, Antonio and Barnadas, Agustí and Quer, Miquel and Mangues, Ramón and Mangues, Ramón}, DOI= {10.1002/hed.25623}, Number= {6}, Volume= {41}, Month= {June}, Year= {2019}, Journal= {Head & neck}, ISSN= {1043-3074}, Pages= {1830—1845}, URL= {https://doi.org/10.1002/hed.25623}} . Head & neck.

Sala, R., Sánchez-García, L., Serna, N., Céspedes, M.V., Casanova, I., Roldán, M., Sánchez-Chardi, A., Unzueta, U., Vázquez, E., Mangues, R., et al.(2019). Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4⁺ colorectal cancer . Acta Biomaterialia. 99. p. 426-432.

(2019). A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models . Haematologica.

Arroyo-Solera, I., Pavón, M.Á., León, X., López, M., Gallardo, A., Céspedes, M.V., Casanova, I., Pallarès, V., López-Pousa, A., Mangues, M.A., et al.(2019). Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma . Head and Neck. 41. (2). p. 429-439.

Aviñó, A., Unzueta, U., Virtudes Céspedes, M., Casanova, I., Vázquez, E., Villaverde, A., Mangues, R., Eritja, R.(2019). Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy . ChemistryOpen. 8. (3). p. 382-387.

(2019). Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci . Advanced materials (Deerfield Beach, Fla.).

Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer @article{PMID:31494293, Title= {Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer}, Author= {Sala, Rita and Sánchez-García, Laura and Serna, Naroa and Céspedes, María Virtudes and Casanova, Isolda and Roldán, Mònica and Sánchez-Chardi, Alejandro and Unzueta, Ugutz and Vázquez, Esther and Mangues, Ramón and Villaverde, Antonio}, DOI= {10.1016/j.actbio.2019.09.002}, Volume= {99}, Month= {November}, Year= {2019}, Journal= {Acta biomaterialia}, ISSN= {1742-7061}, Pages= {426—432}, URL= {https://doi.org/10.1016/j.actbio.2019.09.002}} . Acta biomaterialia.

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma @article{PMID:30548470, Title= {Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma}, Author= {Arroyo-Solera, Irene and Pavón, Miguel Ángel and Pavón, Miguel Ángel and León, Xavier and López, Montserrat and Gallardo, Alberto and Céspedes, María Virtudes and Casanova, Isolda and Pallarès, Víctor and López-Pousa, Antonio and Mangues, María Antonia and Barnadas, Agustí and Quer, Miquel and Mangues, Ramón}, DOI= {10.1002/hed.25437}, Number= {2}, Volume= {41}, Month= {February}, Year= {2019}, Journal= {Head & neck}, ISSN= {1043-3074}, Pages= {429—439}, URL= {https://doi.org/10.1002/hed.25437}} . Head & neck.

Díaz, R., Pallarès, V., Cano-Garrido, O., Serna, N., Sánchez-García, L., Falgàs, A., Pesarrodona, M., Unzueta, U., Sánchez-Chardi, A., Sánchez, J.M., et al.(2018). Selective CXCR4⁺ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin . Small. 14. (26).

Céspedes, M.V., Unzueta, U., Aviñó, A., Gallardo, A., Álamo, P., Sala, R., Sánchez-Chardi, A., Casanova, I., Mangues, M.A., Lopez-Pousa, A., et al.(2018). Selective depletion of metastatic stem cells as therapy for human colorectal cancer . EMBO Molecular Medicine. 10. (10).

Sánchez-García, L., Serna, N., Álamo, P., Sala, R., Céspedes, M.V., Roldan, M., Sánchez-Chardi, A., Unzueta, U., Casanova, I., Mangues, R., et al.(2018). Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs . Journal of Controlled Release. 274. p. 81-92.

Pallarès, V., Hoyos, M., Chillón, M.C., Barragán, E., Conde, M.I.P., Llop, M., Falgàs, A., Céspedes, M.V., Montesinos, P., Nomdedeu, J.F., et al.(2018). Focal adhesion genes refine the intermediate-risk cytogenetic classification of acute myeloid leukemia . Cancers. 10. (11).

Moreno, M.J., Gallardo, A., Novelli, S., Mozos, A., Arago, M., Pavón, M.Á., Céspedes, M.V., Pallarès, V., Falgàs, A., Alcoceba, M., et al.(2018). CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis . PLoS ONE. 13. (6).

(2018). Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin . Small (Weinheim an der Bergstrasse, Germany).

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs @article{PMID:29408658, Title= {Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs}, Author= {Sánchez-García, Laura and Serna, Naroa and Álamo, Patricia and Sala, Rita and Céspedes, María Virtudes and Roldan, Mònica and Sánchez-Chardi, Alejandro and Unzueta, Ugutz and Casanova, Isolda and Mangues, Ramón and Vázquez, Esther and Villaverde, Antonio}, DOI= {10.1016/j.jconrel.2018.01.031}, Volume= {274}, Month= {March}, Year= {2018}, Journal= {Journal of controlled release : official journal of the Controlled Release Society}, ISSN= {0168-3659}, Pages= {81—92}, URL= {https://doi.org/10.1016/j.jconrel.2018.01.031}} . Journal of controlled release : official journal of the Controlled Release Society.

et al.(2017). NEDD9, an independent good prognostic factor in intermediaterisk acute myeloid leukemia patients . Oncotarget.

Pallarès, V., Hoyos, M., Chillón, M.C., Barragán, E., Conde, M.I.P., Llop, M., Céspedes, M.V., Nomdedeu, J.F., Brunet, S., Sanz, M.Á., et al.(2017). NEDD 9 an independent good prognostic factor in intermediaterisk acute myeloid leukemia patients . Oncotarget. 8. (44). p. 76003-76014.

Body, S., Esteve-Arenys, A., Miloudi, H., Recasens-Zorzo, C., Tchakarska, G., Moros, A., Bustany, S., Vidal-Crespo, A., Rodriguez, V., Lavigne, R., et al.(2017). Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells . Scientific Reports. 7. (1).

et al.(2016). Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4(+) colorectal cancer models . Nanomedicine : nanotechnology, biology, and medicine.

(2016). uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy . Oncotarget.

et al.(2016). CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma . Head & neck.

Pavón, M.A., Parreño, M., Téllez-Gabriel, M., León, X., Arroyo-Solera, I., López, M., Céspedes, M.V., Casanova, I., Gallardo, A., López-Pousa, A., et al.(2016). CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma . Head and Neck. 38. p. E1392-E1403.

Céspedes, M.V., Unzueta, U., Álamo, P., Gallardo, A., Sala, R., Casanova, I., Pavón, M.A., Mangues, M.A., Trías, M., López-Pousa, A., et al.(2016). Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4⁺ colorectal cancer models . Nanomedicine: Nanotechnology, Biology, and Medicine. 12. (7). p. 1987-1996.

Pavón, M.A., Arroyo-Solera, I., Céspedes, M.V., Casanova, I., León, X., Mangues, R.(2016). uPA/uPAR and SERPINE1 in head and neck cancer: Role in tumor resistance, metastasis, prognosis and therapy . Oncotarget. 7. (35). p. 57351-57366.

et al.(2015). Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients . Oncotarget.

et al.(2015). CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival . The Journal of pathology.

et al.(2015). Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model . The FASEB Journal.

Alamo, P., Gallardo, A., Di Nicolantonio, F., Pavón, M.A., Casanova, I., Trias, M., Mangues, M.A., Lopez-Pousa, A., Villaverde, A., Vázquez, E., et al.(2015). Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model . FASEB Journal. 29. (2). p. 464-476.

De La Torre, C., Casanova, I., Acosta, G., Coll, C., Moreno, M.J., Albericio, F., Aznar, E., Mangues, R., Royo, M., Sancenón, F., et al.(2015). Gated mesoporous silica nanoparticles using a double-role circular peptide for the controlled and target-preferential release of doxorubicin in CXCR4-expresing lymphoma cells . Advanced Functional Materials. 25. (5). p. 687-695.

Moreno, M.J., Bosch, R., Dieguez-Gonzalez, R., Novelli, S., Mozos, A., Gallardo, A., Pavón, M.Á., Céspedes, M.V., Grañena, A., Alcoceba, M., et al.(2015). CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival . Journal of Pathology. 235. (3). p. 445-455.

Pavón, M.A., Arroyo-Solera, I., Téllez-Gabriel, M., León, X., Virós, D., López, M., Gallardo, A., Céspedes, M.V., Casanova, I., López-Pousa, A., et al.(2015). Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients . Oncotarget. 6. (30). p. 29016-29033.

et al.(2014). Focal adhesion protein expression in human diffuse large B-cell lymphoma . Histopathology.

et al.(2014). In vivo architectonic stability of fully de novo designed protein-only nanoparticles . ACS nano.

et al.(2014). Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models . Disease models & mechanisms.

Alamo, P., Gallardo, A., Pavón, M.A., Casanova, I., Trias, M., Mangues, M.A., Vázquez, E., Villaverde, A., Mangues, R., Céspedes, M.V.(2014). Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models . DMM Disease Models and Mechanisms. 7. (3). p. 387-396.

Céspedes, M.V., Unzueta, U., Tatkiewicz, W., Sánchez-Chardi, A., Conchillo-Solé, O., Álamo, P., Xu, Z., Casanova, I., Corchero, J.L., Pesarrodona, M., et al.(2014). In vivo architectonic stability of fully de novo designed protein-only nanoparticles . ACS Nano. 8. (5). p. 4166-4176.

Bosch, R., Dieguez-Gonzalez, R., Moreno, M.J., Gallardo, A., Novelli, S., Espinosa, I., Céspedes, M.V., Pavón, M.A., Briones, J., Grañena, A., et al.(2014). Focal adhesion protein expression in human diffuse large B-cell lymphoma . Histopathology. 65. (1). p. 119-131.

et al.(2013). High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma . Cancer medicine.

Bosch R, Moreno MJ, Dieguez-Gonzalez R, Céspedes MV, Gallardo A, Trias M, Grañena A, Sierra J, Casanova I, Mangues R, Haematologica, 2013, vol. 98, no. 8, pp. 1242-1249 .

Bosch, R., Moreno, M.J., Dieguez-Gonzalez, R., Céspedes, M.V., Gallardo, A., Trias, M., Grañena, A., Sierra, J., Casanova, I., Mangues, R.(2013). A novel orally available inhibitor of focal adhesion signaling increases survival in a xenograft model of diffuse large B-cell lymphoma with central nervous system involvement . Haematologica. 98. (8). p. 1242-1249.

Téllez-Gabriel, M., Arroyo-Solera, I., León, X., Gallardo, A., López, M., Céspedes, M.V., Casanova, I., López-Pousa, A., Quer, M., Mangues, M.A., et al.(2013). High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma . Cancer Medicine. 2. (6). p. 950-963.

et al.(2012). Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma . Carcinogenesis.

Bosch R, Moreno MJ, Dieguez-Gonzalez R, Céspedes MV, Gallardo A, Nomdedeu J, Pavón MA, Espinosa I, Mangues MA, Sierra J, Casanova I, Mangues R, Clinical & experimental metastasis, 2012, vol. 29, no. 4, pp. 339-347 .

Bosch, R., Moreno, M.J., Dieguez-Gonzalez, R., Céspedes, M.V., Gallardo, A., Nomdedeu, J., Pavón, M.Á., Espinosa, I., Mangues, M.A., Sierra, J., et al.(2012). Subcutaneous passage increases cell aggressiveness in a xenograft model of diffuse large B cell lymphoma . Clinical and Experimental Metastasis. 29. (4). p. 339-347.

Unzueta U, Céspedes MV, Ferrer-Miralles N, Casanova I, Cedano J, Corchero JL, Domingo-Espín J, Villaverde A, Mangues R, Vázquez E, International journal of nanomedicine, 2012, vol. 7, pp. 4533-4544 .

Unzueta, U., Céspedes, M.V., Ferrer-Miralles, N., Casanova, I., Cedano, J., Corchero, J.L., Domingo-Espín, J., Villaverde, A., Mangues, R., Vázquez, E.(2012). Intracellular CXCR4⁺ cell targeting with T22-empowered protein-only nanoparticles . International Journal of Nanomedicine. 7. p. 4533-4544.

Pavón, M.A., Parreño, M., Téllez-Gabriel, M., Sancho, F.J., López, M., Céspedes, M.V., Casanova, I., Lopez-Pousa, A., Mangues, M.A., Quer, M., et al.(2012). Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma . Carcinogenesis. 33. (9). p. 1707-1716.

Bosch R, Dieguez-Gonzalez R, Céspedes MV, Parreño M, Pavón MÁ, Grañena A, Sierra J, Mangues R, Casanova I, Blood, 2011, vol. 118, no. 16, pp. 4411-4420 .

Bosch, R., Dieguez-Gonzalez, R., Céspedes, M.V., Parreño, M., Pavón, M.Á., Grañena, A., Sierra, J., Mangues, R., Casanova, I.(2011). A novel inhibitor of focal adhesion signaling induces caspase-independent cell death in diffuse large B-cell lymphoma . Blood. 118. (16). p. 4411-4420.

Céspedes MV, Larriba MJ, Pavón MA, Alamo P, Casanova I, Parreño M, Feliu A, Sancho FJ, Muñoz A, Mangues R, The American journal of pathology, 2010, vol. 177, no. 4, pp. 2067-2079 .

Céspedes, M.V., Larriba, M.J., Pavón, M.A., Álamo, P., Casanova, I., Parreño, M., Feliu, A., Sancho, F.J., Muñoz, A., Mangues, R.(2010). Site-dependent E-cadherin cleavage and nuclear translocation in a metastatic colorectal cancer model . American Journal of Pathology. 177. (4). p. 2067-2079.

Pavón MA, Parreño M, León X, Sancho FJ, Céspedes MV, Casanova I, Lopez-Pousa A, Mangues MA, Quer M, Barnadas A, Mangues R, International journal of cancer. Journal international du cancer, 2008, vol. 123, no. 5, pp. 1068-1079 .

Parreño M, Casanova I, Céspedes MV, Vaqué JP, Pavón MA, Leon J, Mangues R, Cancer research, 2008, vol. 68, no. 15, pp. 6313-6323 .

Casanova I, Bosch R, Lasa A, Parreño M, Céspedes MV, Brunet S, Nomdedéu JF, Mangues MA, Sierra J, Mangues R, International journal of cancer. Journal international du cancer, 2008, vol. 123, no. 1, pp. 217-226 .

Casanova, I., Bosch, R., Lasa, A., Parreño, M., Céspedes, M.V., Brunet, S., Nomdedéu, J.F., Mangues, M.A., Sierra, J., Mangues, R.(2008). A celecoxib derivative inhibits focal adhesion signaling and induces caspase-8-dependent apoptosis in human acute myeloid leukemia cells . International Journal of Cancer. 123. (1). p. 217-226.

Parreño, M., Casanova, I., Céspedes, M.V., Vaqué, J.P., Pavón, M.A., Leon, J., Mangues, R.(2008). Bobel-24 and derivatives induce caspase-independent death in pancreatic cancer regardless of apoptotic resistance . Cancer Research. 68. (15). p. 6313-6323.

Pavón, M.A., Parreño, M., León, X., Sancho, F.J., Céspedes, M.V., Casanova, I., Lopez-Pousa, A., Mangues, M.A., Quer, M., Barnadas, A., et al.(2008). Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer . International Journal of Cancer. 123. (5). p. 1068-1079.

Céspedes MV, Sancho FJ, Guerrero S, Parreño M, Casanova I, Pavón MA, Marcuello E, Trias M, Cascante M, Capellà G, Mangues R, Carcinogenesis, 2006, vol. 27, no. 11, pp. 2190-2200 .

Casanova I, Parreño M, Farré L, Guerrero S, Céspedes MV, Pavon MA, Sancho FJ, Marcuello E, Trias M, Mangues R, International journal of cancer. Journal international du cancer, 2006, vol. 118, no. 10, pp. 2381-2389 .

(2006). Mouse models in oncogenesis and cancer therapy . Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.

Parreño M, Vaqué JP, Casanova I, Frade P, Céspedes MV, Pavón MA, Molins A, Camacho M, Vila L, Nomdedeu JF, Mangues R, León J, Molecular cancer therapeutics, 2006, vol. 5, no. 5, pp. 1166-1175 .

Parreño, M., Vaqué, J.P., Casanova, I., Frade, P., Céspedes, M.V., Pavón, M.A., Molins, A., Camacho, M., Vila, L., Nomdedeu, J.F., et al.(2006). Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cell inhibited by Myc . Molecular Cancer Therapeutics. 5. (5). p. 1166-1175.

Casanova, I., Parreño, M., Farré, L., Guerrero, S., Céspedes, M.V., Pavon, M.A., Sancho, F.J., Marcuello, E., Trias, M., Mangues, R.(2006). Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas . International Journal of Cancer. 118. (10). p. 2381-2389.

Céspedes, M.V., Casanova, I., Parreño, M., Mangues, R.(2006). Mouse models in oncogenesis and cancer therapy . Clinical and Translational Oncology. 8. (5). p. 318-329.

Céspedes, M.V., Sancho, F.J., Guerrero, S., Parreño, M., Casanova, I., Pavón, M.A., Marcuello, E., Trias, M., Cascante, M., Capellà, G., et al.(2006). K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12 . Carcinogenesis. 27. (11). p. 2190-2200.

Guerrero S, Figueras A, Casanova I, Farré L, Lloveras B, Capellà G, Trias M, Mangues R, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, vol. 16, no. 12, pp. 1642-1644 .

Farré L, Casanova I, Guerrero S, Trias M, Capellá G, Mangues R, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, vol. 16, no. 9, pp. 975-982 .

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