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Senior Scientist – Cancer Nanomedicine and Preclinical Drug Development
Profile Summary
Subject Matter Expertise
Services
Research
Scientific and Technical Research
Consulting
Scientific and Technical Consulting
Product Development
Product Evaluation,
Product Validation,
Concept Development
Work Experience
Senior Scientist / Group Manager
Josep Carreras Leukaemia Research Institute
May 2022 - Present
Researcher
CIBER-BBN
March 2007 - Present 
Senior postdoctoral scientist
CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine)
March 2008 - April 2022
Postdoctoral Researcher
Sant Pau Research Institute
July 2004 - February 2008
Education
PhD Genetics
University of Barcelona
September 1999 - June 2004
BSc Biology
University of Barcelona
September 1993 - June 1998
Certifications
Publications
JOURNAL ARTICLE
Voltà-Durán, E., Serna, N., Sánchez-García, L., Aviñó, A., Sánchez, J.M., López-Laguna, H., Cano-Garrido, O., Casanova, I., Mangues, R., Eritja, R., et al.(2021). Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles . Acta Biomaterialia. 119. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 312-322.
Sánchez, J.M., López-Laguna, H., Álamo, P., Serna, N., Sánchez-Chardi, A., Nolan, V., Cano-Garrido, O., Casanova, I., Unzueta, U., Vazquez, E., et al.(2020). Artificial Inclusion Bodies for Clinical Development . Advanced Science. 7. (3).
Pallarès, V., Unzueta, U., Falgàs, A., Sánchez-Garciá, L., Serna, N., Gallardo, A., Morris, G.A., Alba-Castellón, L., Álamo, P., Sierra, J., et al.(2020). An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination . Journal of Hematology and Oncology. 13. (1).
Falgàs, A., Pallarès, V., Serna, N., Sánchez-García, L., Sierra, J., Gallardo, A., Alba-Castellón, L., Álamo, P., Unzueta, U., Villaverde, A., et al.(2020). Selective delivery of T22-PE24-H6 to CXCR4<sup>+</sup> diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model . Theranostics. 10. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5169-5180.
Álamo, P., Pallarès, V., Céspedes, M.V., Falgàs, A., Sanchez, J.M., Serna, N., Sánchez‐garcía, L., Voltà‐duràn, E., Morris, G.A., Sánchez‐chardi, A., et al.(2020). Fluorescent dye labeling changes the biodistribution of tumor‐targeted nanoparticles . Pharmaceutics. 12. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-18.
Falgàs, A., Pallarès, V., Unzueta, U., Céspedes, M.V., Arroyo-Solera, I., Moreno, M.J., Gallardo, A., Mangues, M.A., Sierra, J., Villaverde, A., et al.(2020). A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models . Haematologica. 105. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 741-753.
Céspedes, M.V., Cano-Garrido, O., Álamo, P., Sala, R., Gallardo, A., Serna, N., Falgàs, A., Voltà-Durán, E., Casanova, I., Sánchez-Chardi, A., et al.(2020). Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci . Advanced Materials. 32. (7).
Recasens-Zorzo, C., Cardesa-Salzmann, T., Petazzi, P., Ros-Blanco, L., Esteve-Arenys, A., Clot, G., Guerrero-Hernández, M., Rodríguez, V., Soldini, D., Valera, A., et al.(2019). Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma . Haematologica. 104. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 778-788.
Casanova, I., Unzueta, U., Arroyo-Solera, I., Céspedes, M.V., Villaverde, A., Mangues, R., Vazquez, E.(2019). Protein-driven nanomedicines in oncotherapy . Current Opinion in Pharmacology. 47. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-7.
Pavón, M.A., Arroyo-Solera, I., León, X., Téllez-Gabriel, M., Virós, D., Gallardo, A., Céspedes, M.V., Casanova, I., Lopez-Pousa, A., Barnadas, A., et al.(2019). The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes . Head and Neck. 41. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1830-1845.
Sala, R., Sánchez-García, L., Serna, N., Céspedes, M.V., Casanova, I., Roldán, M., Sánchez-Chardi, A., Unzueta, U., Vázquez, E., Mangues, R., et al.(2019). Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4<sup>+</sup> colorectal cancer . Acta Biomaterialia. 99. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 426-432.
(2019). A CXCR4-targeted nanocarrier achieves highly selective tumor uptake in diffuse large B-cell lymphoma mouse models . Haematologica.
Arroyo-Solera, I., Pavón, M.Á., León, X., López, M., Gallardo, A., Céspedes, M.V., Casanova, I., Pallarès, V., López-Pousa, A., Mangues, M.A., et al.(2019). Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma . Head and Neck. 41. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 429-439.
Aviñó, A., Unzueta, U., Virtudes Céspedes, M., Casanova, I., Vázquez, E., Villaverde, A., Mangues, R., Eritja, R.(2019). Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy . ChemistryOpen. 8. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 382-387.
(2019). Engineering Secretory Amyloids for Remote and Highly Selective Destruction of Metastatic Foci . Advanced materials (Deerfield Beach, Fla.).
Díaz, R., Pallarès, V., Cano-Garrido, O., Serna, N., Sánchez-García, L., Falgàs, A., Pesarrodona, M., Unzueta, U., Sánchez-Chardi, A., Sánchez, J.M., et al.(2018). Selective CXCR4<sup>+</sup> Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin . Small. 14. (26).
Céspedes, M.V., Unzueta, U., Aviñó, A., Gallardo, A., Álamo, P., Sala, R., Sánchez-Chardi, A., Casanova, I., Mangues, M.A., Lopez-Pousa, A., et al.(2018). Selective depletion of metastatic stem cells as therapy for human colorectal cancer . EMBO Molecular Medicine. 10. (10).
Sánchez-García, L., Serna, N., Álamo, P., Sala, R., Céspedes, M.V., Roldan, M., Sánchez-Chardi, A., Unzueta, U., Casanova, I., Mangues, R., et al.(2018). Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs . Journal of Controlled Release. 274. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 81-92.
Pallarès, V., Hoyos, M., Chillón, M.C., Barragán, E., Conde, M.I.P., Llop, M., Falgàs, A., Céspedes, M.V., Montesinos, P., Nomdedeu, J.F., et al.(2018). Focal adhesion genes refine the intermediate-risk cytogenetic classification of acute myeloid leukemia . Cancers. 10. (11).
Moreno, M.J., Gallardo, A., Novelli, S., Mozos, A., Arago, M., Pavón, M.Á., Céspedes, M.V., Pallarès, V., Falgàs, A., Alcoceba, M., et al.(2018). CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis . PLoS ONE. 13. (6).
(2018). Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin . Small (Weinheim an der Bergstrasse, Germany).
Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs @article{PMID:29408658, Title= {Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs}, Author= {Sánchez-García, Laura and Serna, Naroa and Álamo, Patricia and Sala, Rita and Céspedes, María Virtudes and Roldan, Mònica and Sánchez-Chardi, Alejandro and Unzueta, Ugutz and Casanova, Isolda and Mangues, Ramón and Vázquez, Esther and Villaverde, Antonio}, DOI= {10.1016/j.jconrel.2018.01.031}, Volume= {274}, Month= {March}, Year= {2018}, Journal= {Journal of controlled release : official journal of the Controlled Release Society}, ISSN= {0168-3659}, Pages= {81—92}, URL= {https://doi.org/10.1016/j.jconrel.2018.01.031}} . Journal of controlled release : official journal of the Controlled Release Society.
et al.(2017). NEDD9, an independent good prognostic factor in intermediaterisk acute myeloid leukemia patients . Oncotarget.
Pallarès, V., Hoyos, M., Chillón, M.C., Barragán, E., Conde, M.I.P., Llop, M., Céspedes, M.V., Nomdedeu, J.F., Brunet, S., Sanz, M.Á., et al.(2017). NEDD 9 an independent good prognostic factor in intermediaterisk acute myeloid leukemia patients . Oncotarget. 8. (44). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 76003-76014.
Body, S., Esteve-Arenys, A., Miloudi, H., Recasens-Zorzo, C., Tchakarska, G., Moros, A., Bustany, S., Vidal-Crespo, A., Rodriguez, V., Lavigne, R., et al.(2017). Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells . Scientific Reports. 7. (1).
et al.(2016). Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4(+) colorectal cancer models . Nanomedicine : nanotechnology, biology, and medicine.
(2016). uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy . Oncotarget.
et al.(2016). CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma . Head & neck.
Pavón, M.A., Parreño, M., Téllez-Gabriel, M., León, X., Arroyo-Solera, I., López, M., Céspedes, M.V., Casanova, I., Gallardo, A., López-Pousa, A., et al.(2016). CKMT1 and NCOA1 expression as a predictor of clinical outcome in patients with advanced-stage head and neck squamous cell carcinoma . Head and Neck. 38. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString E1392-E1403.
Céspedes, M.V., Unzueta, U., Álamo, P., Gallardo, A., Sala, R., Casanova, I., Pavón, M.A., Mangues, M.A., Trías, M., López-Pousa, A., et al.(2016). Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4<sup>+</sup> colorectal cancer models . Nanomedicine: Nanotechnology, Biology, and Medicine. 12. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1987-1996.
Pavón, M.A., Arroyo-Solera, I., Céspedes, M.V., Casanova, I., León, X., Mangues, R.(2016). uPA/uPAR and SERPINE1 in head and neck cancer: Role in tumor resistance, metastasis, prognosis and therapy . Oncotarget. 7. (35). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 57351-57366.
et al.(2015). Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients . Oncotarget.
et al.(2015). CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival . The Journal of pathology.
et al.(2015). Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model . The FASEB Journal.
Alamo, P., Gallardo, A., Di Nicolantonio, F., Pavón, M.A., Casanova, I., Trias, M., Mangues, M.A., Lopez-Pousa, A., Villaverde, A., Vázquez, E., et al.(2015). Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model . FASEB Journal. 29. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 464-476.
De La Torre, C., Casanova, I., Acosta, G., Coll, C., Moreno, M.J., Albericio, F., Aznar, E., Mangues, R., Royo, M., Sancenón, F., et al.(2015). Gated mesoporous silica nanoparticles using a double-role circular peptide for the controlled and target-preferential release of doxorubicin in CXCR4-expresing lymphoma cells . Advanced Functional Materials. 25. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 687-695.
Moreno, M.J., Bosch, R., Dieguez-Gonzalez, R., Novelli, S., Mozos, A., Gallardo, A., Pavón, M.Á., Céspedes, M.V., Grañena, A., Alcoceba, M., et al.(2015). CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival . Journal of Pathology. 235. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 445-455.
Pavón, M.A., Arroyo-Solera, I., Téllez-Gabriel, M., León, X., Virós, D., López, M., Gallardo, A., Céspedes, M.V., Casanova, I., López-Pousa, A., et al.(2015). Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients . Oncotarget. 6. (30). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 29016-29033.
et al.(2014). Focal adhesion protein expression in human diffuse large B-cell lymphoma . Histopathology.
et al.(2014). In vivo architectonic stability of fully de novo designed protein-only nanoparticles . ACS nano.
et al.(2014). Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models . Disease models & mechanisms.
Alamo, P., Gallardo, A., Pavón, M.A., Casanova, I., Trias, M., Mangues, M.A., Vázquez, E., Villaverde, A., Mangues, R., Céspedes, M.V.(2014). Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models . DMM Disease Models and Mechanisms. 7. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 387-396.
Céspedes, M.V., Unzueta, U., Tatkiewicz, W., Sánchez-Chardi, A., Conchillo-Solé, O., Álamo, P., Xu, Z., Casanova, I., Corchero, J.L., Pesarrodona, M., et al.(2014). In vivo architectonic stability of fully de novo designed protein-only nanoparticles . ACS Nano. 8. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4166-4176.
Bosch, R., Dieguez-Gonzalez, R., Moreno, M.J., Gallardo, A., Novelli, S., Espinosa, I., Céspedes, M.V., Pavón, M.A., Briones, J., Grañena, A., et al.(2014). Focal adhesion protein expression in human diffuse large B-cell lymphoma . Histopathology. 65. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 119-131.
et al.(2013). High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma . Cancer medicine.
Bosch, R., Moreno, M.J., Dieguez-Gonzalez, R., Céspedes, M.V., Gallardo, A., Trias, M., Grañena, A., Sierra, J., Casanova, I., Mangues, R.(2013). A novel orally available inhibitor of focal adhesion signaling increases survival in a xenograft model of diffuse large B-cell lymphoma with central nervous system involvement . Haematologica. 98. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1242-1249.
Téllez-Gabriel, M., Arroyo-Solera, I., León, X., Gallardo, A., López, M., Céspedes, M.V., Casanova, I., López-Pousa, A., Quer, M., Mangues, M.A., et al.(2013). High RAB25 expression is associated with good clinical outcome in patients with locally advanced head and neck squamous cell carcinoma . Cancer Medicine. 2. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 950-963.
et al.(2012). Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma . Carcinogenesis.
Bosch, R., Moreno, M.J., Dieguez-Gonzalez, R., Céspedes, M.V., Gallardo, A., Nomdedeu, J., Pavón, M.Á., Espinosa, I., Mangues, M.A., Sierra, J., et al.(2012). Subcutaneous passage increases cell aggressiveness in a xenograft model of diffuse large B cell lymphoma . Clinical and Experimental Metastasis. 29. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 339-347.
Unzueta, U., Céspedes, M.V., Ferrer-Miralles, N., Casanova, I., Cedano, J., Corchero, J.L., Domingo-Espín, J., Villaverde, A., Mangues, R., Vázquez, E.(2012). Intracellular CXCR4<sup>+</sup> cell targeting with T22-empowered protein-only nanoparticles . International Journal of Nanomedicine. 7. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4533-4544.
Pavón, M.A., Parreño, M., Téllez-Gabriel, M., Sancho, F.J., López, M., Céspedes, M.V., Casanova, I., Lopez-Pousa, A., Mangues, M.A., Quer, M., et al.(2012). Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma . Carcinogenesis. 33. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1707-1716.
Bosch, R., Dieguez-Gonzalez, R., Céspedes, M.V., Parreño, M., Pavón, M.Á., Grañena, A., Sierra, J., Mangues, R., Casanova, I.(2011). A novel inhibitor of focal adhesion signaling induces caspase-independent cell death in diffuse large B-cell lymphoma . Blood. 118. (16). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4411-4420.
Céspedes, M.V., Larriba, M.J., Pavón, M.A., Álamo, P., Casanova, I., Parreño, M., Feliu, A., Sancho, F.J., Muñoz, A., Mangues, R.(2010). Site-dependent E-cadherin cleavage and nuclear translocation in a metastatic colorectal cancer model . American Journal of Pathology. 177. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2067-2079.
Casanova, I., Bosch, R., Lasa, A., Parreño, M., Céspedes, M.V., Brunet, S., Nomdedéu, J.F., Mangues, M.A., Sierra, J., Mangues, R.(2008). A celecoxib derivative inhibits focal adhesion signaling and induces caspase-8-dependent apoptosis in human acute myeloid leukemia cells . International Journal of Cancer. 123. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 217-226.
Parreño, M., Casanova, I., Céspedes, M.V., Vaqué, J.P., Pavón, M.A., Leon, J., Mangues, R.(2008). Bobel-24 and derivatives induce caspase-independent death in pancreatic cancer regardless of apoptotic resistance . Cancer Research. 68. (15). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6313-6323.
Pavón, M.A., Parreño, M., León, X., Sancho, F.J., Céspedes, M.V., Casanova, I., Lopez-Pousa, A., Mangues, M.A., Quer, M., Barnadas, A., et al.(2008). Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer . International Journal of Cancer. 123. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1068-1079.
(2006). Mouse models in oncogenesis and cancer therapy . Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.
Parreño, M., Vaqué, J.P., Casanova, I., Frade, P., Céspedes, M.V., Pavón, M.A., Molins, A., Camacho, M., Vila, L., Nomdedeu, J.F., et al.(2006). Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cell inhibited by Myc . Molecular Cancer Therapeutics. 5. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1166-1175.
Casanova, I., Parreño, M., Farré, L., Guerrero, S., Céspedes, M.V., Pavon, M.A., Sancho, F.J., Marcuello, E., Trias, M., Mangues, R.(2006). Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas . International Journal of Cancer. 118. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2381-2389.
Céspedes, M.V., Casanova, I., Parreño, M., Mangues, R.(2006). Mouse models in oncogenesis and cancer therapy . Clinical and Translational Oncology. 8. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 318-329.
Céspedes, M.V., Sancho, F.J., Guerrero, S., Parreño, M., Casanova, I., Pavón, M.A., Marcuello, E., Trias, M., Cascante, M., Capellà, G., et al.(2006). K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12 . Carcinogenesis. 27. (11). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2190-2200.
Guerrero, S., Figueras, A., Casanova, I., Farré, L., Lloveras, B., Capellà, G., Trias, M., Mangues, R.(2002). Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 16. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1642-1644.
Farré, L., Casanova, I., Guerrero, S., Trias, M., Capellà, G., Mangues, R.(2002). Heterotopic implantation alters the regulation of apoptosis and the cell cycle and generates a new metastatic site in a human pancreatic tumor xenograft model . FASEB Journal. 16. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 975-982.
(2000). K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression . Cancer research.
Guerrero, S., Casanova, I., Farre, L., Mazo, A., Capella, G., Mangues, R.(2000). K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression . Cancer Research. 60. (23). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6750-6756.
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