Profile Details

Create Project

★★★★★

☆☆☆☆☆

USD 100 /hr

★★★★★

☆☆☆☆☆

Hire Dr. Farhad V.

United States

USD 100 /hr

Scientist with 15+ years of experience in preclinical cancer research

Profile Summary

Experienced in cancer research with a focus on gene regulation in metastasis. Also experienced in functional validation of pre-IND drug development including small animal research and optical imaging. Demonstrated history of writing and editing publications as well as grant review.

Subject Matter Expertise

• ★ Cancer Research
• ☆ Biochemistry
• ☆ Molecular Biology
• ☆ Genetics
• ☆ Drug Development

Services

• Research
• Consulting
• Product Development

Research Gray Literature Search, Systematic Literature Review, Secondary Data Collection

Consulting Scientific and Technical Consulting

Product Development Formulation

Work Experience

Faculty

Johns Hopkins University

January 2009 - Present

Post Doctoral Fellow

Johns Hopkins University

January 2004 - January 2009

Education

Ph.D. (Life Sciences)

University of Bombay

January 2020 - January 2020

M.S. (Plant Physiology)

Institute of Science

January 2020 - January 2020

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

(2019). Targeting RNA helicase DDX3 in stem cell maintenance and teratoma formation . Genes & cancer.

(2018). Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33 . Translational oncology.

(2018). Global Effects of DDX3 Inhibition on Cell Cycle Regulation Identified by a Combined Phosphoproteomics and Single Cell Tracking Approach . Translational oncology.

(2017). Role of DDX3 in the pathogenesis of inflammatory bowel disease . Oncotarget.

(2017). Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer . OncoTargets and therapy.

(2017). Organ-specific isogenic metastatic breast cancer cell lines exhibit distinct Raman spectral signatures and metabolomes . Oncotarget.

(2017). Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer . Medical oncology (Northwood, London, England).

(2017). Genomic pathways modulated by Twist in breast cancer . BMC cancer.

M R Heerma van Voss, F Vesuna, G M Bol, J Afzal, S Tantravedi, Y Bergman, K Kammers, M Lehar, R Malek, M Ballew, et al.(2017). Targeting mitochondrial translation by inhibiting {DDX}3: a novel radiosensitization strategy for cancer treatment . Oncogene. 37. (1). p. 63--74. Springer Science and Business Media {LLC}

(2016). RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3 . Cancer research.

Heerma van Voss, M.R., Vesuna, F., Trumpi, K., Brilliant, J., Berlinicke, C., de Leng, W., Kranenburg, O., Offerhaus, J.G., Bürger, H., van der Wall, E., et al.(2015). Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer . Oncotarget. 6. (29). p. 28312-28326.

Xie, M., Vesuna, F., Botlagunta, M., Bol, G.M., Irving, A., Bergman, Y., Hosmane, R.S., Kato, Y., Winnard, P.T., Raman, V.(2015). NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3 . Oncotarget. 6. (30). p. 29901-29913.

Bol, G.M., Vesuna, F., Xie, M., Zeng, J., Aziz, K., Gandhi, N., Levine, A., Irving, A., Korz, D., Tantravedi, S., et al.(2015). Targeting DDX3 with a small molecule inhibitor for lung cancer therapy . EMBO Molecular Medicine. 7. (5). p. 648-669.

Vos, S., Vesuna, F., Raman, V., van Diest, P.J., van der Groep, P.(2015). miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers . Oncotarget. 6. (31). p. 32115-32137.

Gajula, R.P., Chettiar, S.T., Williams, R.D., Thiyagarajan, S., Kato, Y., Aziz, K., Wang, R., Gandhi, N., Wild, A.T., Vesuna, F., et al.(2013). The Twist box domain is required for Twist1-induced prostate cancer metastasis . Molecular Cancer Research. 11. (11). p. 1387-1400.

Cao, M.D., Döpkens, M., Krishnamachary, B., Vesuna, F., Gadiya, M.M., Lønning, P.E., Bhujwalla, Z.M., Gribbestad, I.S., Glunde, K.(2012). Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer . NMR in Biomedicine. 25. (9). p. 1033-1042.

Vesuna, F., Lisok, A., Kimble, B., Domek, J., Kato, Y., Van Der Groep, P., Artemov, D., Kowalski, J., Carraway, H., Van Diest, P., et al.(2012). Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α . Oncogene. 31. (27). p. 3223-3234.

(2012). GDPD5 inhibition alters the choline phospholipid metabolite profile of breast cancer cells toward a less malignant metabolic profile . Biomedical Spectroscopy and Imaging.

Yusuf, D., Butland, S.L., Swanson, M.I., Bolotin, E., Ticoll, A., Cheung, W.A., Zhang, X.Y.C., Dickman, C.T.D., Fulton, D.L., Lim, J.S., et al.(2012). The Transcription Factor Encyclopedia . Genome Biology.

Botlagunta, M., Krishnamachary, B., Vesuna, F., Winnard Jr., P.T., Bol, G.M., Patel, A.H., Raman, V.(2011). Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells . PLoS ONE. 6. (3).

Kondaskar, A., Kondaskar, S., Kumar, R., Fishbein, J.C., Muvarak, N., Lapidus, R.G., Sadowska, M., Edelman, M.J., Bol, G.M., Vesuna, F., et al.(2011). Novel, broad spectrum anticancer agents containing the tricyclic 5:7:5-fused diimidazodiazepine ring system . ACS Medicinal Chemistry Letters. 2. (3). p. 252-256.

Koskimaki, J.E., Karagiannis, E.D., Rosca, E.V., Vesuna, F., Winnard Jr., P.T., Raman, V., Bhujwalla, Z.M., Popel, A.S.(2009). Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts . Neoplasia. 11. (12). p. 1285-1291.

Sullivan, N.J., Sasser, A.K., Axel, A.E., Vesuna, F., Raman, V., Ramirez, N., Oberyszyn, T.M., Hall, B.M.(2009). Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells . Oncogene. 28. (33). p. 2940-2947.

Vesuna, F., Lisok, A., Kimble, B., Raman, V.(2009). Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression . Neoplasia. 11. (12). p. 1318-1328.

Glunde, K., Shah, T., Winnard Jr., P.T., Raman, V., Takagi, T., Vesuna, F., Artemov, D., Bhujwalla, Z.M.(2008). Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1α signaling in a human prostate cancer model . Cancer Research. 68. (1). p. 172-180.

Botlagunta, M., Vesuna, F., Mironchik, Y., Raman, A., Lisok, A., Winnard Jr., P., Mukadam, S., Van Diest, P., Chen, J.H., Farabaugh, P., et al.(2008). Oncogenic role of DDX3 in breast cancer biogenesis . Oncogene. 27. (28). p. 3912-3922.

Winnard Jr., P.T., Botlagunta, M., Kluth, J.B., Mukadam, S., Krishnamachary, B., Vesuna, F., Raman, V.(2008). Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model . Cancer Gene Therapy. 15. (10). p. 645-654.

Vesuna, F., van Diest, P., Chen, J.H., Raman, V.(2008). Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer . Biochemical and Biophysical Research Communications. 367. (2). p. 235-241.

Kato, Y., Okollie, B., Raman, V., Vesuna, F., Zhao, M., Baker, S.D., Bhujwalla, Z.M., Artemov, D.(2007). Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models . Cancer Biology and Therapy. 6. (6). p. 891-897.

Raman, V., Vesuna, F.(2006). Histamine: A potential therapeutic agent for breast cancer treatment? . Cancer Biology and Therapy. 5. (11). p. 1472-1473.

Vesuna, F., Winnard Jr., P., Raman, V., Glackin, C.(2006). Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7 . Cancer Genetics and Cytogenetics. 167. (2). p. 189-191.

Duriseti, S., Winnard Jr., P.T., Mironchik, Y., Vesuna, F., Raman, A., Raman, V.(2006). HOXA5 regulates hMLH1 expression in breast cancer cells . Neoplasia. 8. (4). p. 250-258.

Vesuna, F., Winnard Jr., P., Raman, V.(2005). Enhanced green fluorescent protein as an alternative control reporter to Renilla luciferase . Analytical Biochemistry. 342. (2). p. 345-347.

Mironchik, Y., Winnard Jr., P.T., Vesuna, F., Kato, Y., Wildes, F., Pathak, A.P., Kominsky, S., Artemov, D., Bhujwalla, Z., Van Diest, P., et al.(2005). Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer . Cancer Research. 65. (23). p. 10801-10809.

Bandyopadhyay, D., Vesuna, F.D.(2002). Detection and evaluation of non-recombinants in cDNA libraries by multiple cloning region PCR . BioTechniques. 32. (1). p. 88-92.