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Hire Dr. Doorgesh Sharma J.

Singapore

Interdisciplinary scientist with expertise in Life Sciences, Biomedical Engineering, Computer Vision & Machine Learning

Profile Summary

| Domain expert in biomedical and health sciences. | Strong foundation in biological sciences: - BSc (Hons) in Life Sciences with specialization in Cell and Molecular Biology from the National University of Singapore (NUS) | Expert in interdisciplinary applied sciences: - PhD in Mechanobiology from the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) - Currently a postdoctoral fellow in the Department of Biomedical Engineering at NUS | Extensive experience in hypothesis formulation and testing as well as experimental design and execution. | Proven collaborative aptitudes which led to the development of novel AI-based diagnostic strategies. | Excellent publication record in peer-reviewed journals.

Subject Matter Expertise

• ★ Biology/Life Sciences
• ★ Machine Learning
• ★ Computer Vision
• ☆ STEM
• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Biophysics
• ☆ Biomedical Engineering
• ☆ Data Science
• ☆ Data Analysis
• ☆ Image Processing
• ☆ Data Visualization
• ☆ Data Mining
• ☆ Artificial Intelligence
• ☆ Deep Learning
• ☆ Biosensors
• ☆ Medical Sciences
• ☆ Hypothesis

Services

• Research
• Consulting
• Data & AI
• Product Development

Research Market Research, Feasibility Study

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Algorithm Design-Non ML, Data Visualization

Product Development Formulation

Work Experience

Postdoctoral fellow

National University of Singapore (NUS)

March 2020 - Present

PhD Scholar

National University of Singapore (NUS), Mechanobiology Institute (MBI)

August 2014 - July 2019

Education

PhD

National University of Singapore (NUS), Mechanobiology Institute (MBI)

August 2014 - July 2019

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Venkatachalapathy, S., Jokhun, D.S., Shivashankar, G.V., Venkatachalapathy, S., Jokhun, D.S., Shivashankar, G.V.(2020). Multivariate analysis reveals activation-primed fibroblast geometric states in engineered 3D tumor microenvironments . Molecular biology of the cell. 31. (8). p. 803-812.

Doorgesh Sharma Jokhun, Farid Alisafaei, G. V. Shivashankar, Vivek B. Shenoy(2019). Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints . Proceedings of the National Academy of Sciences. 116. (27). p. 13200--13209. Proceedings of the National Academy of Sciences

Alisafaei, F., Jokhun, D.S., Shivashankar, G.V., Shenoy, V.B., Alisafaei, F., Jokhun, D.S., Shivashankar, G.V., Shenoy, V.B.(2019). Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints . Proceedings of the National Academy of Sciences of the United States of America. 116. (27). p. 13200-13209.

Damodaran, K., Crestani, M., Jokhun, D.S., Shivashankar, G.V., Damodaran, K., Crestani, M., Jokhun, D.S., Shivashankar, G.V.(2019). Nuclear morphometrics and chromatin condensation patterns as disease biomarkers using a mobile microscope . PLoS ONE. 14. (7).

Doorgesh Sharma Jokhun, Bibhas Roy, Saradha Venkatachalapathy, Prasuna Ratna, Yejun Wang, Mallika Nagarajan, G. V. Shivashankar(2018). Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors . Proceedings of the National Academy of Sciences. 115. (21). p. E4741--E4750. Proceedings of the National Academy of Sciences

Jokhun, D.S., Shang, Y., Shivashankar, G.V., Jokhun, D.S., Shang, Y., Shivashankar, G.V.(2018). Actin Dynamics Couples Extracellular Signals to the Mobility and Molecular Stability of Telomeres . Biophysical Journal. 115. (7). p. 1166-1179.

Monticelli, M., Jokhun, D.S., Petti, D., Shivashankar, G.V., Bertacco, R., Monticelli, M., Jokhun, D.S., Petti, D., Shivashankar, G.V., Bertacco, R.(2018). Localized mechanical stimulation of single cells with engineered spatio-temporal profile . Lab on a Chip. 18. (19). p. 2955-2965.

Damodaran, K., Venkatachalapathy, S., Alisafaei, F., Radhakrishnan, A.V., Jokhun, D.S., Shenoy, V.B., Shivashankar, G.V., Damodaran, K., Venkatachalapathy, S., Alisafaei, F., et al.(2018). Compressive force induces reversible chromatin condensation and cell geometry–dependent transcriptional response . Molecular Biology of the Cell. 29. (25). p. 3039-3051.

Krishnan, V., Chong, Y.L., Tan, T.Z., Kulkarni, M., Bin Rahmat, M.B., Tay, L.S., Sankar, H., Jokhun, D.S., Ganesan, A., Chuang, L.S.H., et al.(2018). TGFβ promotes genomic instability after loss of RUNX3 . Cancer Research. 78. (1). p. 88-102.

Roy, B., Venkatachalapathy, S., Ratna, P., Wang, Y., Jokhun, D.S., Nagarajan, M., Shivashankar, G.V., Roy, B., Venkatachalapathy, S., Ratna, P., et al.(2018). Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors . Proceedings of the National Academy of Sciences of the United States of America. 115. (21). p. E4741-E4750.

Doorgesh Sharma Jokhun, Aninda Mitra, Saradha Venkatachalapathy, Prasuna Ratna, Yejun Wang, G. V. Shivashankar(2017). Cell geometry dictates {TNF}$\upalpha$-induced genome response . Proceedings of the National Academy of Sciences. 114. (20). p. E3882--E3891. Proceedings of the National Academy of Sciences

A.V. Radhakrishnan, Doorgesh S. Jokhun, Saradha Venkatachalapathy, G.V. Shivashankar(2017). Nuclear Positioning and Its Translational Dynamics Are Regulated by Cell Geometry . Biophysical Journal. 112. (9). p. 1920--1928. Elsevier {BV}

Mitra, A., Venkatachalapathy, S., Ratna, P., Wang, Y., Jokhun, D.S., Shivashankar, G.V., Mitra, A., Venkatachalapathy, S., Ratna, P., Wang, Y., et al.(2017). Cell geometry dictates TNFα-induced genome response . Proceedings of the National Academy of Sciences of the United States of America. 114. (20). p. E3882-E3891.

Radhakrishnan, A.V., Jokhun, D.S., Venkatachalapathy, S., Shivashankar, G.V., Radhakrishnan, A.V., Jokhun, D.S., Venkatachalapathy, S., Shivashankar, G.V.(2017). Nuclear Positioning and Its Translational Dynamics Are Regulated by Cell Geometry . Biophysical Journal. 112. (9). p. 1920-1928.

Makhija, E., Jokhun, D.S., Shivashankar, G.V., Makhija, E., Jokhun, D.S., Shivashankar, G.V.(2016). Nuclear deformability and telomere dynamics are regulated by cell geometric constraints . Proceedings of the National Academy of Sciences of the United States of America. 113. (1). p. E32-E40.

Movahednia, M.M., Kidwai, F.K., Jokhun, D.S., Squier, C.A., Toh, W.S., Cao, T., Movahednia, M.M., Kidwai, F.K., Jokhun, D.S., Squier, C.A., et al.(2016). Potential applications of keratinocytes derived from human embryonic stem cells . Biotechnology Journal. 11. (1). p. 58-70.

Ekta Makhija, D.S. Jokhun, G.V. Shivashankar(2015). Acto-Myosin Contractility Regulates Nuclear and Chromatin Plasticity . Biophysical Journal. 108. (2). p. 541a--542a. Elsevier {BV}

Mohammad M. Movahednia, Fahad K. Kidwai, Doorgesh S. Jokhun, Christopher A. Squier, Wei Seong Toh, Tong Cao(2015). Potential applications of keratinocytes derived from human embryonic stem cells . Biotechnology Journal. 11. (1). p. 58--70. Wiley-Blackwell

Ekta Makhija, D. S. Jokhun, G. V. Shivashankar(2015). Nuclear deformability and telomere dynamics are regulated by cell geometric constraints . Proceedings of the National Academy of Sciences. 113. (1). p. E32--E40. Proceedings of the National Academy of Sciences

Kidwai, F.K., Movahednia, M.M., Iqbal, K., Jokhun, D.S., Cao, T., Fawzy, A.S., Kidwai, F.K., Movahednia, M.M., Iqbal, K., Jokhun, D.S., et al.(2014). Human embryonic stem cell differentiation into odontoblastic lineage: An in vitro study . International Endodontic Journal. 47. (4). p. 346-355.

F. K. Kidwai, M. M. Movahednia, K. Iqbal, D. S. Jokhun, T. Cao, A. S. Fawzy(2013). Human embryonic stem cell differentiation into odontoblastic lineage: anin vitrostudy . International Endodontic Journal. 47. (4). p. 346--355. Wiley-Blackwell

Doorgesh Sharma Jokhun, Fahad Karim Kidwai, Mohammad Mehdi Movahednia, Jin Fei Yeo, Kai Soo Tan, Tong Cao(2013). Human embryonic stem cells derived keratinocyte as anin vitroresearch model for the study of immune response . Journal of Oral Pathology {\&} Medicine. 42. (8). p. 627--634. Wiley-Blackwell

Fahad K. Kidwai, Hua Liu, Wei Seong Toh, Xin Fu, Doorgesh S. Jokhun, Mohammad M. Movahednia, Mingming Li, Yu Zou, Christopher A. Squier, Toan T. Phan, et al.(2013). Differentiation of Human Embryonic Stem Cells into Clinically Amenable Keratinocytes in an Autogenic Environment . Journal of Investigative Dermatology. 133. (3). p. 618--628. Elsevier {BV}

Kidwai, F.K., Jokhun, D.S., Movahednia, M.M., Yeo, J.F., Tan, K.S., Cao, T., Kidwai, F.K., Jokhun, D.S., Movahednia, M.M., Yeo, J.F., et al.(2013). Human embryonic stem cells derived keratinocyte as an in vitro research model for the study of immune response . Journal of Oral Pathology and Medicine. 42. (8). p. 627-634.

Kidwai, F.K., Liu, H., Toh, W.S., Fu, X., Jokhun, D.S., Movahednia, M.M., Li, M., Zou, Y., Squier, C.A., Phan, T.T., et al.(2013). Differentiation of human embryonic stem cells into clinically amenable keratinocytes in an autogenic environment . Journal of Investigative Dermatology. 133. (3). p. 618-628.

BOOK CHAPTER

(2018). Cell Geometric Control of Nuclear Dynamics and Its Implications . Mechanobiology in Health and Disease.

Kumar, A., Makhija, E., Radhakrishnan, A.V., Jokhun, D.S., Shivashankar, G.V., Kumar, A., Makhija, E., Radhakrishnan, A.V., Jokhun, D.S., Shivashankar, G.V.(2018). Cell geometric control of nuclear dynamics and its implications . Mechanobiology in Health and Disease. p. 55-76.