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Hire Dr. David M.

United Kingdom

Cell signalling and Immunology

Profile Summary

Scientist with interests in cell signalling and immunology. Previously I have conducted research on immune signal transduction (Millrine et al., PNAS, Millrine et al., J. Immunology) and the biology of ubiquitin like proteins (Millrine et al., Cell Reports). In my current work I lead a team of researchers advancing basic and translational science in the immune oncology field.

Subject Matter Expertise

• ☆ Biochemistry
• ☆ Basic Immunology
• ☆ Adjuvant & Antigen Research
• ☆ Cancer Research
• ☆ Cancer Biology

Services

• Research
• Consulting

Research Fact Checking, Scientific and Technical Research

Consulting Scientific and Technical Consulting

Work Experience

Translational Immunology Team Lead

Cancer Research UK Manchester Institute

March 2023 - Present

Translational Immunology Team Lead

CRUK National Biomarker Centre

March 2021 - Present

Postdoctoral Research Assistant

University of Dundee

October 2019 - March 2023

Research Associate

Cardiff University

February 2017 - October 2019

Specially Appointed Researcher

Osaka University

April 2014 - January 2017

Advanced Research Assistant

Wellcome Trust Sanger Institute

September 2008 - April 2010

Education

PhD (School of Frontier Biosciences)

Osaka University

September 2010 - April 2014

MSc Modern Japanese Studies (Nissan Institute of Japanese Studies)

University of Oxford

September 2007 - September 2008

Genetics (Life Sciences)

University of Manchester

September 2003 - September 2007

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

David Millrine, Joshua Peter, Yogesh Kulathu (2023). A guide to UFMylation, an emerging posttranslational modification . The FEBS Journal.

David Millrine, Anna Cardus, Javier Uceda Fernandez, Robert Andrews, Barbara Szomolay, Benjamin C. Cossins, Christopher Rice, Jasmine Li, Victoria Tyrrell, Louise McLeod, et al. (2023). Th1 Cells Alter the Inflammatory Signature of IL-6 by Channeling STAT Transcription Factors to Alu-like Retroelements . The Journal of Immunology.

David Millrine, Joshua Peter, Helge Magnus Magnussen, Paul A DaRosa, Stephen P Matthews, Frederic Lamoliatte, Ramasubramanian Sundaramoorthy, Ron R Kopito, Yogesh Kulathu (2022). A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation . The EMBO Journal.

Millrine, D., Jenkins, R.H., Hughes, S.T.O., Jones, S.A.(2022). Making sense of IL-6 signalling cues in pathophysiology . FEBS Letters. 596. (5). p. 567-588.

Millrine, D., Cummings, T., Matthews, S.P., Peter, J.J., Magnussen, H.M., Lange, S.M., Macartney, T., Lamoliatte, F., Knebel, A., Kulathu, Y.(2022). Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation . Cell Reports. 40. (5).

(2021). Making sense of IL-6 signalling cues in pathophysiology . FEBS letters.

(2019). Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells . Nature immunology.

Twohig, J.P., Cardus Figueras, A., Andrews, R., Wiede, F., Cossins, B.C., Derrac Soria, A., Lewis, M.J., Townsend, M.J., Millrine, D., Li, J., et al.(2019). Activation of naïve CD4 ⁺ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 ⁺ T cells . Nature Immunology. 20. (4). p. 458-470.

(2018). Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs . Proceedings of the National Academy of Sciences of the United States of America.

(2018). Tracking Competent Host Defence to Chronic Inflammation: An In Vivo Model of Peritonitis . Methods in molecular biology (Clifton, N.J.).

Gemechu, Y., Millrine, D., Hashimoto, S., Prakash, J., Sanchenkova, K., Metwally, H., Gyanu, P., Kang, S., Kishimoto, T.(2018). Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs . Proceedings of the National Academy of Sciences of the United States of America. 115. (46). p. 11802-11807.

(2017). A Brighter Side to Thalidomide: Its Potential Use in Immunological Disorders . Trends in molecular medicine.

et al.(2017). TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a . Nucleic acids research.

(2017). Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury . International immunology.

Nyati, K.K., Masuda, K., Mahabub-Uz Zaman, M., Dubey, P.K., Millrine, D., Chalise, J.P., Higa, M., Li, S., Standley, D.M., Saito, K., et al.(2017). TLR4-induced NF-κB and MAPK signaling regulate the IL-6 mRNA stabilizing protein Arid5a . Nucleic Acids Research. 45. (5). p. 2687-2703.

Dubey, P.K., Masuda, K., Nyati, K.K., Zaman, M.M.-U., Chalise, J.P., Millrine, D., Kai, W., Ripley, B., Kishimoto, T.(2017). Arid5a-deficient mice are highly resistant to bleomycin-induced lung injury . International Immunology. 29. (2). p. 79-85.

Millrine, D., Kishimoto, T.(2017). A Brighter Side to Thalidomide: Its Potential Use in Immunological Disorders . Trends in Molecular Medicine. 23. (4). p. 348-361.

(2016). Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production . Proceedings of the National Academy of Sciences of the United States of America.

(2016). Immunomodulatory drugs inhibit TLR4-induced type-1 interferon production independently of Cereblon via suppression of the TRIF/IRF3 pathway . International immunology.

Millrine, D., Miyata, H., Tei, M., Dubey, P., Nyati, K., Nakahama, T., Gemechu, Y., Ripley, B., Kishimoto, T.(2016). Immunomodulatory drugs inhibit TLR4-induced type-1 interferon production independently of Cereblon via suppression of the TRIF/IRF3 pathway . International Immunology. 28. (6). p. 307-315.

Millrine, D., Tei, M., Gemechu, Y., Kishimoto, T.(2016). Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production . Proceedings of the National Academy of Sciences of the United States of America. 113. (38). p. 10625-10630.

et al.(2015). The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis . International immunology.

(2015). A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining . Biochemical and biophysical research communications.

Chinen, I., Nakahama, T., Kimura, A., Nguyen, N.T., Takemori, H., Kumagai, A., Kayama, H., Takeda, K., Lee, S., Hanieh, H., et al.(2015). The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis . International Immunology. 27. (8). p. 405-415.

Staudt, N., Müller-Sienerth, N., Fane-Dremucheva, A., Yusaf, S.P., Millrine, D., Wright, G.J.(2015). A panel of recombinant monoclonal antibodies against zebrafish neural receptors and secreted proteins suitable for wholemount immunostaining . Biochemical and Biophysical Research Communications. 456. (1). p. 527-533.

et al.(2013). Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17-producing T-helper cell differentiation . Proceedings of the National Academy of Sciences of the United States of America.

Nakahama, T., Hanieh, H., Nguyen, N.T., Chinen, I., Ripley, B., Millrine, D., Lee, S., Nyati, K.K., Dubey, P.K., Chowdhury, K., et al.(2013). Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17-producing T-helper cell differentiation . Proceedings of the National Academy of Sciences of the United States of America. 110. (29). p. 11964-11969.

BOOK CHAPTER

David Millrine, Christopher M. Rice, Javier U. Fernandez, Simon A. Jones (2023). Tracking the Host Response to Infection in Peritoneal Models of Acute Resolving Inflammation . Methods in Molecular Biology.

Fernandez, J.U., Millrine, D., Jones, S.A.(2018). Tracking competent host defence to chronic inflammation: An in vivo model of peritonitis . Methods in Molecular Biology. 1725. p. 65-75.