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★★★★★
☆☆☆☆☆
USD 100 /hr
Hire Dr. Brendan P.
United States
USD 100 /hr

PhD with 30+ years of experience in Biomedical Research, Cancer Biology, academic publishing and grant writing

Profile Summary
Subject Matter Expertise
Services
Writing Technical Writing, General Proofreading & Editing
Research Scientific and Technical Research, Systematic Literature Review
Consulting Healthcare Consulting, Scientific and Technical Consulting
Data & AI Statistical Analysis
Work Experience

Professor (Associate)

Dana-Farber Cancer Institute, Harvard Medical School, Boston MA 02115, USA

January 1996 - June 2022

Assistant Professor and Researcher

Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA02115, USA

January 1993 - January 1996

Education

PhD, Biochemistry

University of Cambridge, Cambridge, UK

October 1982 - January 1986

Certifications
  • Certification details not provided.
Publications
JOURNAL ARTICLE
Sreekumar, R., Al-Saihati, H., Emaduddin, M., Moutasim, K., Mellone, M., Patel, A., Kilic, S., Cetin, M., Erdemir, S., Navio, M.S., et al.(2021). The ZEB2-dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer . Molecular Oncology. 15. (8). p. 2065-2083.
Layer, J.V., Debaize, L., van Scoyk, A., House, N.C., Brown, A.J., Liu, Y., Stevenson, K.E., Hemann, M., Roberts, S.A., Price, B.D., et al.(2020). Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair . Proceedings of the National Academy of Sciences of the United States of America. 117. (44). p. 27566-27577.
Serafim, R.B., Cardoso, C., Di Cristofaro, L.F.M., Pienna Soares, C., Araújo Silva, W., Espreafico, E.M., Paçó-Larson, M.L., Price, B.D., Valente, V.(2020). HJURP knockdown disrupts clonogenic capacity and increases radiation-induced cell death of glioblastoma cells . Cancer Gene Therapy. 27. (5). p. 319-329.
Zhang, Y., Price, B.D., Tetradis, S., Chakrabarti, S., Maulik, G., Makrigiorgos, G.M.(2020). Reproducible and inexpensive probe preparation for oligonucleotide arrays . Nucleic Acids Research. 29. (13).
House, N.C.M., Parasuram, R., Layer, J.V., Price, B.D.(2020). Site-specific targeting of a light activated dCas9-KillerRed fusion protein generates transient, localized regions of oxidative DNA damage . PLoS ONE. 15. (12 December).
Qi, H., Price, B.D., Day, T.A.(2019). Multiple Roles for Mono- and Poly(ADP-Ribose) in Regulating Stress Responses . Trends in Genetics. 35. (2). p. 159-172.
Zhou, J., Li, J., Serafim, R.B., Ketchum, S., Ferreira, C.G., Liu, J.C., Coe, K.A., Price, B.D., Yusufzai, T.(2018). Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus . Nucleic Acids Research. 46. (8). p. 3891-3905.
Price, B.D.(2017). KDM5A demethylase: Erasing histone modifications to promote repair of DNA breaks . Journal of Cell Biology. 216. (7). p. 1871-1873.
Ströbel, T., Madlener, S., Tuna, S., Vose, S., Lagerweij, T., Wurdinger, T., Vierlinger, K., Wöhrer, A., Price, B.D., Demple, B., et al.(2017). Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma . Scientific Reports. 7. (1).
Gursoy-Yuzugullu, O., Carman, C., Price, B.D.(2017). Spatially restricted loading of BRD2 at DNA double-strand breaks protects H4 acetylation domains and promotes DNA repair . Scientific Reports. 7. (1).
Gursoy-Yuzugullu, O., Carman, C., Serafim, R.B., Myronakis, M., Valente, V., Price, B.D.(2017). Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity . Oncotarget. 8. (15). p. 24518-24532.
Day, T.A., Layer, J.V., Patrick Cleary, J., Guha, S., Stevenson, K.E., Tivey, T., Kim, S., Schinzel, A.C., Izzo, F., Doench, J., et al.(2017). PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA . Nature Communications. 8.
Dhar, S., Gursoy-Yuzugullu, O., Parasuram, R., Price, B.D.(2017). The tale of a tail: Histone H4 acetylation and the repair of DNA breaks . Philosophical Transactions of the Royal Society B: Biological Sciences. 372. (1731).
Gursoy-Yuzugullu, O., House, N., Price, B.D.(2016). Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks . Journal of Molecular Biology. 428. (9). p. 1846-1860.
Gursoy-Yuzugullu, O., Ayrapetov, M.K., Price, B.D.(2015). Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair . Proceedings of the National Academy of Sciences of the United States of America. 112. (24). p. 7507-7512.
Ayrapetov, M.K., Gursoy-Yuzugullu, O., Xu, C., Xu, Y., Price, B.D.(2014). DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin . Proceedings of the National Academy of Sciences of the United States of America. 111. (25). p. 9169-9174.
Du, F., Zhang, M., Li, X., Yang, C., Meng, H., Wang, D., Chang, S., Xu, Y., Price, B., Sun, Y.(2014). Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair . Biochemical and Biophysical Research Communications. 452. (4). p. 1034-1039.
Madlener, S., Ströbel, T., Vose, S., Saydam, O., Price, B.D., Demple, B., Saydam, N.(2013). Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance . Proceedings of the National Academy of Sciences of the United States of America. 110. (44). p. 17844-17849.
Price, B.D., D'Andrea, A.D.(2013). Chromatin remodeling at DNA double-strand breaks . Cell. 152. (6). p. 1344-1354.
Park, E., Kim, H., Kim, J.M., Primack, B., Vidal-Cardenas, S., Xu, Y., Price, B.D., Mills, A.A., D'Andrea, A.D.(2013). FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis . Molecular Cell. 50. (6). p. 908-918.
Berbeco, R., Korideck, H., Ngwa, W., Kumar, R., Patel, J., Sridhar, S., Johnson, S., Price, B., Kimmelman, A., Makrigiorgos, M.(2012). TU‐C‐BRB‐11: In Vitro Dose Enhancement from Gold Nanoparticles under Different Clinical MV Photon Beam Configurations . Medical Physics. 39. (6). p. 3900-3901.
Berbeco, R.I., Korideck, H., Ngwa, W., Kumar, R., Patel, J., Sridhar, S., Johnson, S., Price, B.D., Kimmelman, A., Makrigiorgos, G.M.(2012). DNA damage enhancement from gold nanoparticles for clinical MV photon beams . Radiation Research. 178. (6). p. 604-608.
Xu, Y., Ayrapetov, M.K., Xu, C., Gursoy-Yuzugullu, O., Hu, Y., Price, B.D.(2012). Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair . Molecular Cell. 48. (5). p. 723-733.
Xu, C., Xu, Y., Gursoy-Yuzugullu, O., Price, B.D.(2012). The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1 . FEBS Letters. 586. (21). p. 3920-3925.
Ayrapetov, M.K., Xu, C., Sun, Y., Zhu, K., Parmar, K., D'Andrea, A.D., Price, B.D.(2011). Activation of hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity . PLoS ONE. 6. (10).
Xu, Y., Price, B.D.(2011). Chromatin dynamics and the repair of DNA double strand breaks . Cell Cycle. 10. (2). p. 261-267.
Xu, Y., Parmar, K., Du, F., Price, B.D., Sun, Y.(2011). The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the tip60 acetyltransferase . International Journal of Biochemistry and Molecular Biology. 2. (4). p. 295-302.
Lin, C.-I., Whang, E.E., Donner, D.B., Du, J., Lorch, J., He, F., Jiang, X., Price, B.D., Moore Jr., F.D., Ruan, D.T.(2010). Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through met inhibition in papillary thyroid cancer . Molecular Cancer Research. 8. (9). p. 1217-1226.
Xu, Y., Sun, Y., Jiang, X., Ayrapetov, M.K., Moskwa, P., Yang, S., Weinstock, D.M., Price, B.D.(2010). The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair . Journal of Cell Biology. 191. (1). p. 31-43.
Weng, D., Cunin, M.C., Song, B., Price, B.D., Eller, M.S., Gilchrest, B.A., Calderwood, S.K., Gong, J.(2010). Radiosensitization of mammary carcinoma cells by telomere homolog oligonucleotide pretreatment . Breast Cancer Research. 12. (5).
Sun, Y., Jiang, X., Price, B.D.(2010). Tip60: Connecting chromatin to DNA damage signaling . Cell Cycle. 9. (5). p. 930-936.
Jiang, X., Xu, Y., Price, B.D.(2010). Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway . FEBS Letters. 584. (13). p. 2926-2930.
Lin, C.-I., Whang, E.E., Abramson, M.A., Jiang, X., Price, B.D., Donner, D.B., Moore Jr., F.D., Ruan, D.T.(2009). Autophagy: A new target for advanced papillary thyroid cancer therapy . Surgery. 146. (6). p. 1208-1214.
Kim, K., Pollard, J.M., Norris, A.J., McDonald, J.T., Sun, Y., Micewicz, E., Pettijohn, K., Damoiseaux, R., Iwamoto, K.S., Sayre, J.W., et al.(2009). High-throughput screening identifies two classes of antibiotics as radioprotectors: Tetracyclines and fluoroquinolones . Clinical Cancer Research. 15. (23). p. 7238-7245.
Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M.K., Moreau, L.A., Whetstine, J.R., Price, B.D.(2009). Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60 . Nature Cell Biology. 11. (11). p. 1376-1382.
Lin, C.-I., Whang, E.E., Donner, D.B., Jiang, X., Price, B.D., Carothers, A.M., Delaine, T., Leffler, H., Nilsson, U.J., Nose, V., et al.(2009). Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer . Molecular Cancer Research. 7. (10). p. 1655-1662.
Fernandes, N.D., Sun, Y., Price, B.D.(2007). Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells . Journal of Biological Chemistry. 282. (22). p. 16577-16584.
Sun, Y., Xu, Y., Roy, K., Price, B.D.(2007). DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity . Molecular and Cellular Biology. 27. (24). p. 8502-8509.
Sun, Y., Jiang, X., Chen, S., Price, B.D.(2006). Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation . FEBS Letters. 580. (18). p. 4353-4356.
Roy, K., Wang, L., Makrigiorgos, G.M., Price, B.D.(2006). Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity . Biochemical and Biophysical Research Communications. 344. (3). p. 821-826.
Jiang, X., Sun, Y., Chen, S., Roy, K., Price, B.D.(2006). The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM . Journal of Biological Chemistry. 281. (23). p. 15741-15746.
Sun, Y., Jiang, X., Chen, S., Fernandes, N., Price, B.D.(2005). A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM . Proceedings of the National Academy of Sciences of the United States of America. 102. (37). p. 13182-13187.
Fernandes, N., Sun, Y., Chen, S., Paul, P., Shaw, R.J., Cantley, L.C., Price, B.D.(2005). DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM . Journal of Biological Chemistry. 280. (15). p. 15158-15164.
Wang, G., Brennan, C., Rook, M., Wolfe, J.L., Leo, C., Chin, L., Pan, H., Liu, W.H., Price, B., Makrigiorgos, G.M.(2004). Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples . Nucleic acids research. 32. (9).
Chen, S., Wang, G., Makrigiorgos, G.M., Price, B.D.(2004). Stable siRNA-mediated silencing of ATM alters the transcriptional profile of HeLa cells . Biochemical and Biophysical Research Communications. 317. (4). p. 1037-1044.
Chen, S., Paul, P., Price, B.D.(2003). ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response . Oncogene. 22. (41). p. 6332-6339.
Makrigiorgos, G.M., Chakrabarti, S., Zhang, Y., Kaur, M., Price, B.D.(2002). A PCR-based amplification method retaining the quantitative difference between two complex genomes . Nature Biotechnology. 20. (9). p. 936-939.
Zhang, Y., Kaur, M., Price, B.D., Tetradis, S., Makrigiorgos, G.M.(2002). An amplification and ligation-based method to scan for unknown mutations in DNA . Human Mutation. 20. (2). p. 139-147.
Kaur, M., Zhang, Y., Liu, W.-H., Tetradis, S., Price, B.D., Makrigiorgos, G.M.(2002). Ligation of a primer at a mutation: A method to detect low level mutations in DNA . Mutagenesis. 17. (5). p. 365-373.
Turenne, G.A., Paul, P., Laflair, L., Price, B.D.(2001). Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53 . Oncogene. 20. (37). p. 5100-5110.
Turenne, G.A., Price, B.(2001). Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity . BMC Cell Biology. 2.
Chakrabarti, S., Price, B.D., Tetradis, S., Fox, E.A., Zhang, Y., Maulik, G., Makrigiorgos, G.M.(2000). Highly selective isolation of unknown mutations in diverse DNA fragments: Toward new multiplex screening in cancer . Cancer Research. 60. (14). p. 3732-3737.
Blasina, A., Price, B.D., Turenne, G.A., McGowan, C.H.(1999). Caffeine inhibits the checkpoint kinase ATM . Current Biology. 9. (19). p. 1135-1138.
Palayoor, S.T., Youmell, M.Y., Calderwood, S.K., Coleman, C.N., Price, B.D.(1999). Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen . Oncogene. 18. (51). p. 7389-7394.
Maulik, G., Botchway, S., Chakrabarti, S., Tetradis, S., Price, B., Makrigiorgos, G.M.(1999). Novel non-isotopic detection of MutY enzyme-recognized mismatches in DNA via ultrasensitive detection of aldehydes . Nucleic Acids Research. 27. (5). p. 1316-1322.
Maulik, N., Sato, M., Price, B.D., Das, D.K.(1998). An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia . FEBS Letters. 429. (3). p. 365-369.
Youmell, M., Park, S.J., Basu, S., Price, B.D.(1998). Regulation of the p53 protein by protein kinase Cα and protein kinase Cζ . Biochemical and Biophysical Research Communications. 245. (2). p. 514-518.
Basu, S., Rosenzweig, K.R., Youmell, M., Price, B.D.(1998). The DNA-dependent protein kinase participates in the activation of NFκB following DNA damage . Biochemical and Biophysical Research Communications. 247. (1). p. 79-83.
Rosenzweig, K.E., Youmell, M.B., Palayoor, S.T., Price, B.D.(1997). Radiosensitization of human tumor cells by the phosphatidylinositol 3- kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA- dependent protein kinase and prolonged G<sub>2</sub>-M delay . Clinical Cancer Research. 3. (7). p. 1149-1156.
Chu, B., Soncin, F., Price, B.D., Stevenson, M.A., Calderwood, S.K.(1996). Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1 . Journal of Biological Chemistry. 271. (48). p. 30847-30857.
Howard, S.P., Park, S.J., Hughes-Davies, L., Coleman, C.N., Price, B.D.(1996). Suramin increases p53 protein levels but does not activate the p53-dependent G<sub>1</sub> checkpoint . Clinical Cancer Research. 2. (2). p. 269-276.
Price, B.D., Youmell, M.B.(1996). The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage . Cancer Research. 56. (2). p. 246-250.
Tishler, R.B., Lamppu, D.M., Park, S., Price, B.D.(1995). Microtubule-active Drugs Taxol, Vinblastine, and Nocodazole Increase the Levels of Transcriptionally Active p53 . Cancer Research. 55. (24). p. 6021-6025.
Price, B.D., Hughes-Davies, L., Park, S.J.(1995). cdk2 kinase phosphorylates serine 315 of human p53 in vitro . Oncogene. 11. (1). p. 73-80.
Price, B.D., Park, S.J.(1994). DNA Damage Increases the Levels of MDM2 Messenger RNA in wtp53 Human Cells . Cancer Research. 54. (4). p. 896-899.
Calderwood, S.K., Stevenson, M.A., Price, B.D.(1993). Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin . Journal of Cellular Physiology. 156. (1). p. 153-159.
Price, B.D., Calderwood, S.K.(1993). Increased sequence-specific p53-DNA binding activity after DNA damage is attenuated by phorbol esters . Oncogene. 8. (11). p. 3055-3062.
Tishler, R.B., Calderwood, S.K., Coleman, C.N., Price, B.D.(1993). Increases in Sequence Specific DNA Binding by p53 following Treatment with Chemotherapeutic and DNA Damaging Agents1 . Cancer Research. 53. (10). p. 2212-2216.
Bruce, J.L., Price, B.D., Coleman, C.N., Calderwood, S.K.(1993). Oxidative Injury Rapidly Activates the Heat Shock Transcription Factor but Fails to Increase Levels of Heat Shock Proteins . Cancer Research. 53. (1). p. 12-15.
Price, B.D., Mannheim‐Rodman, L.A., Calderwood, S.K.(1992). Brefeldin A, thapsigargin, and AlF 4− stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis . Journal of Cellular Physiology. 152. (3). p. 545-552.
Price, B.D., Calderwood, S.K.(1992). Gadd45 and Gaddl53 Messenger RNA Levels Are Increased during Hypoxia and after Exposure of Cells to Agents Which Elevate the Levels of the Glucose-regulated Proteins . Cancer Research. 52. (13). p. 3814-3817.
Price, B.D., Calderwood, S.K.(1992). Heat‐induced transcription from RNA polymerases II and III and HSF binding activity are co‐ordinately regulated by the products of the heat shock genes . Journal of Cellular Physiology. 153. (2). p. 392-401.
Bader, S.B., Price, B.D., Mannheim‐Rodman, L.A., Calderwood, S.K.(1992). Inhibition of heat shock gene expression does not block the development of thermotolerance . Journal of Cellular Physiology. 151. (1). p. 56-62.
Price, B.D.(1992). Signalling across the endoplasmic reticulum membrane: Potential mechanisms . Cellular Signalling. 4. (5). p. 465-470.
Price, B.D., Calderwood, S.K.(1991). Ca<sup>2+</sup> is essential for multistep activation of the heat shock factor in permeabilized cells . Molecular and Cellular Biology. 11. (6). p. 3365-3368.
Price, B., Pyne, N.J., Houslay, M.D.(1987). Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue . Biochemical Pharmacology. 36. (23). p. 4047-4054.
Brand, M.D., Al-Shawi, M.K., Brown, G.C., Price, B.D.(1985). Thermodynamic and steady-state-kinetic investigation of the effect of NN'-dicyclohexylcarbodi-imide on H+ translocation by the mitochondrial cytochrome bc1 complex . The Biochemical journal. 225. (2). p. 407-411.
PRICE, B.D., BRAND, M.D.(1983). Chemical Modification of the Mitochodrial bc<sub>1</sub> by N,N′ ‐Dicyclohexylcarbodiimide Inhibits Proton Translocation . European Journal of Biochemistry. 132. (3). p. 595-601.
Price, B.D., Brand, M.D.(1982). Proton translocation by the mitochondrial cytochrome b-c1 complex is inhibited by NN'-dicyclohexylcarbodi-imide . The Biochemical journal. 206. (2). p. 419-421.
BOOK CHAPTER
Xu, Y., Xu, C., Price, B.D.(2012). Mechanistic links between ATM and histone methylation codes during DNA repair . Progress in Molecular Biology and Translational Science. 110. p. 263-288.
Wang, G., Price, B.D., Makrigiorgos, G.M.(2006). Polymerase Chain Reaction-Based Amplification Method of Retaining the Quantitative Difference between Two Complex Genomes . Cell Biology, Four-Volume Set. 3. p. 477-482.
Wang, G., Price, B.D., Makrigiorgos, G.M.(2005). Polymerase chain reaction-based amplification method of retaining the quantitative difference between two complex genomes . Cell Biology: A Laboratory Handbook. p. 477-482.
BOOK
Cahill, C.M., Lin, H.S., Price, B.D., Bruce, J.L., Calderwood, S.K.(1997). Potential role of heat shock transcription factor in the expression of inflammatory cytokines . Advances in Experimental Medicine and Biology. 400. (B). p. 625-630.