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Hire Alfonso U.

Norway

Group leader in functional genomics wet/dry lab. Exp. LifeScience, tech, cancer, prostate cancer, genomics, epigenetics.

Profile Summary

Alfonso Urbanucci graduated from the University of Perugia, in Italy, and got his PhD in cancer genetics and molecular biology of cancer in Finland, at the University of Tampere, in 2012. Dr. Urbanucci personal research interest is on the transcriptional and chromatin drivers underpinning prostate cancer progression with the androgen receptor as a focal point. He published a series of papers regarding the molecular effects of the deregulation of the androgen receptor on the chromatin and transcription, and how these drive prostate cancer progression. He then moved to Oslo at the Centre for Molecular Medicine Norway (EMBL partnership), and subsequently at the Oslo University Hospital, where he investigated the mechanism of action of bromodomain inhibitors and derived novel prognostic tools for patient stratification. He is currently a researcher at the Norwegian Radium Hospital, within the Institute of Cancer Research.

Subject Matter Expertise

• ★ Cancer Research
• ☆ Biology/Life Sciences
• ☆ Genetics
• ☆ Epigenetics
• ☆ Oncology

Services

• Writing
• Research

Writing Clinical Trial Documentation, Technical Writing

Research Fact Checking, Gray Literature Search, Systematic Literature Review

Work Experience

Oslo Universitetssykehus

- Present

Education

Oslo Universitetssykehus

- Present

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Alfonso Urbanucci, Harri M. Itkonen, Ninu Poulose, Rebecca E. Steele, Sara E.S. Martin, Zebulon G. Levine, Damien Y. Duveau, Ryan Carelli, Reema Singh, Massimo Loda, et al.(2020). Inhibition of O-{GlcNAc} Transferase Renders Prostate Cancer Cells Dependent on {CDK}9 . Molecular Cancer Research. American Association for Cancer Research ({AACR})

Alfonso Urbanucci, Annika Kohvakka, Mina Sattari, Anastasia Shcherban, Matti Annala, Juha Kesseli, Teuvo L. J. Tammela, Kati Kivinummi, Leena Latonen, Matti Nykter, et al.(2020). {AR} and {ERG} drive the expression of prostate cancer specific long noncoding {RNAs} . Oncogene. Springer Science and Business Media {LLC}

Alfonso Urbanucci, Timothy J. Lavelle, Tine Norman Alver, Karen-Marie Heintz, Patrik Wernhoff, Vegard Nygaard, Sigve Nakken, Geir Frode Øy, Sigurd Leinæs Bøe, Eivind Hovig(2020). Dysregulation of {MITF} Leads to Transformation in {MC}1R-Defective Melanocytes . Cancers. 12. (7). p. 1719. {MDPI} {AG}

Alfonso Urbanucci, Florian Handle, Stefan Prekovic, Christine Helsen, Thomas Van den Broeck, Elien Smeets, Lisa Moris, Roy Eerlings, Sarah El Kharraz, Ian G. Mills, et al.(2019). Drivers of {AR} indifferent anti-androgen resistance in prostate cancer cells . Scientific Reports. 9. (1). Springer Science and Business Media {LLC}

Alfonso Urbanucci, Peder R. Braadland, Håkon Ramberg, Helene Hartvedt Grytli, Heidi Kristin Nielsen, Ingrid Jenny Guldvik, Andreas Engedal, Kirsi Ketola, Wanzhong Wang, Aud Svindland, et al.(2019). The $\upbeta$2-Adrenergic Receptor Is a Molecular Switch for Neuroendocrine Transdifferentiation of Prostate Cancer Cells . Molecular Cancer Research. American Association for Cancer Research ({AACR})

Urbanucci, A., Mills, I.G.(2018). Bromodomain-containing proteins in prostate cancer . Molecular and Cellular Endocrinology. 462. p. 31-40.

Zuber, V., Bettella, F., Witoelar, A., Andreassen, O.A., Mills, I.G., Urbanucci, A., Eeles, R., Easton, D., Kote-Jarai, Z., Al Olama, A.A., et al.(2017). Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer . BMC Genomics. 18. (1).

McNair, C., Urbanucci, A., Comstock, C.E.S., Augello, M.A., Goodwin, J.F., Launchbury, R., Zhao, S.G., Schiewer, M.J., Ertel, A., Karnes, J., et al.(2017). Cell cycle-coupled expansion of AR activity promotes cancer progression . Oncogene. 36. (12). p. 1655-1668.

Itkonen, H.M., Brown, M., Urbanucci, A., Tredwell, G., Lau, C.H., Barfeld, S., Hart, C., Guldvik, I.J., Takhar, M., Heemers, H.V., et al.(2017). Lipid degradation promotes prostate cancer cell survival . Oncotarget. 8. (24). p. 38264-38275.

Barfeld, S.J., Urbanucci, A., Itkonen, H.M., Fazli, L., Hicks, J.L., Thiede, B., Rennie, P.S., Yegnasubramanian, S., DeMarzo, A.M., Mills, I.G.(2017). c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks . EBioMedicine. 18. p. 83-93.

Kivinummi, K., Urbanucci, A., Leinonen, K., Tammela, T.L.J., Annala, M., Isaacs, W.B., Bova, G.S., Nykter, M., Visakorpi, T.(2017). The expression of AURKA is androgen regulated in castration-resistant prostate cancer . Scientific Reports. 7. (1).

Urbanucci, A., Barfeld, S.J., Kytölä, V., Itkonen, H.M., Coleman, I.M., Vodák, D., Sjöblom, L., Sheng, X., Tolonen, T., Minner, S., et al.(2017). Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer . Cell Reports. 19. (10). p. 2045-2059.

Fiorito, E., Sharma, Y., Gilfillan, S., Wang, S., Singh, S.K., Satheesh, S.V., Katika, M.R., Urbanucci, A., Thiede, B., Mills, I.G., et al.(2016). CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions . Nucleic Acids Research. 44. (22). p. 10588-10602.

Tekpli, X., Urbanucci, A., Hashim, A., Vågbø, C.B., Lyle, R., Kringen, M.K., Staff, A.C., Dybedal, I., Mills, I.G., Klungland, A., et al.(2016). Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells . Epigenetics and Chromatin. 9. (1).

Khanna, A., Rane, J.K., Kivinummi, K.K., Urbanucci, A., Helenius, M.A., Tolonen, T.T., Saramäki, O.R., Latonen, L., Manni, V., Pimanda, J.E., et al.(2015). CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations . Oncotarget. 6. (23). p. 19661-19670.

Lund, K., Dembinski, J.L., Solberg, N., Urbanucci, A., Mills, I.G., Krauss, S.(2015). Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment . PLoS ONE. 10. (4).

Barfeld, S.J., Fazli, L., Persson, M., Marjavaara, L., Urbanucci, A., Kaukoniemi, K.M., Rennie, P.S., Ceder, Y., Chabes, A., Visakorpi, T., et al.(2015). Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer . Oncotarget. 6. (14). p. 12587-12602.

Barfeld, S.J., Itkonen, H.M., Urbanucci, A., Mills, I.G.(2014). Androgen-regulated metabolism and biosynthesis in prostate cancer . Endocrine-Related Cancer. 21. (4).

Lehmusvaara, S., Erkkilä, T., Urbanucci, A., Jalava, S., Seppälä, J., Kaipia, A., Kujala, P., Lähdesmäki, H., Tammela, T.L.J., Visakorpi, T.(2013). Goserelin and bicalutamide treatments alter the expression of microRNAs in the prostate . Prostate. 73. (1). p. 101-112.

Urbanucci, A., Sahu, B., Seppälä, J., Larjo, A., Latonen, L.M., Waltering, K.K., Tammela, T.L.J., Vessella, R.L., Lähdesmäki, H., Jänne, O.A., et al.(2012). Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer . Oncogene. 31. (17). p. 2153-2163.

Jalava, S.E., Urbanucci, A., Latonen, L., Waltering, K.K., Sahu, B., Jänne, O.A., Seppälä, J., Lähdesmäki, H., Tammela, T.L.J., Visakorpi, T.(2012). Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer . Oncogene. 31. (41). p. 4460-4471.

Urbanucci, A., Marttila, S., Jänne, O.A., Visakorpi, T.(2012). Androgen receptor overexpression alters binding dynamics of the receptor to chromatin and chromatin structure . Prostate. 72. (11). p. 1223-1232.

Waltering, K.K., Urbanucci, A., Visakorpi, T.(2012). Androgen receptor (AR) aberrations in castration-resistant prostate cancer . Molecular and Cellular Endocrinology. 360. (1-2). p. 38-43.

Lehmusvaara, S., Erkkilä, T., Urbanucci, A., Waltering, K., Seppälä, J., Larjo, A., Tuominen, V.J., Isola, J., Kujala, P., Lähdesmäki, H., et al.(2012). Chemical castration and anti-androgens induce differential gene expression in prostate cancer . Journal of Pathology. 227. (3). p. 336-345.

Waltering, K.K., Porkka, K.P., Jalava, S.E., Urbanucci, A., Kohonen, P.J., Latonen, L.M., Kallioniemi, O.P., Jenster, G., Visakorpi, T.(2011). Androgen regulation of micro-RNAs in prostate cancer . Prostate. 71. (6). p. 604-614.

Urbanucci, A., Myrmel, M., Berg, I., von Bonsdorff, C.-H., Maunula, L.(2009). Potential internalisation of caliciviruses in lettuce . International Journal of Food Microbiology. 135. (2). p. 175-178.

Urbanucci, A., Waltering, K.K., Suikki, H.E., Helenius, M.A., Visakorpi, T.(2008). Androgen regulation of the androgen receptor coregulators . BMC Cancer. 8.

BOOK

Urbanucci, A., Waltering, K.K., Mills, I.G., Visakorpi, T.(2012). The effect of AR overexpression on androgen signaling in prostate cancer . Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications. p. 187-200.