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Hire Dr. Zeinab A.

Iran

My research areas are concerned with cancer studies.

Profile Summary

Education 3 SEP 2005 – 22 JUL 2009 B.SC. – Shahrekord University,Shahrekord, Iran Field(s) of study Cellular and Molecular Biology-Genetics Average 17.67 out of 20 23 SEP 2009 – 20 SEP 2011 M.SC. – Islamic Azad University science and research branch, Tehran, Iran. Field(s) of study Biology- Genetics Average 18.70 out of 20 22 SEP 2012 – 7 OCT 2017 – Iran PHD – University of Sistan and Baluchestan, Zahedan, Iran Thesis: Exploring the Effect of Valproic acid on H19 and MiR-221/222 Noncoding RNA Expressions and Increased Apoptosis in Cisplatin-resistant Ovarian Cancer Cell Line Field(s) of study Cellular and Molecular Biology- Genetics 18.80 out of 20 Mother tongue(s): PERSIAN Other language(s): UNDERSTANDING SPEAKING WRITING Listening Reading Spoken production Spoken interaction ENGLISH B1 B1 B1 B1 B2 Technical Skills and Proficiencies Cellular and molecular biology Human cell culture, MTT assay (Drugs, Natural product, Nanoparticles), DNA and RNA extraction, Apoptosis assay, ROS assay, Electrophoresis; Quantitative PCR; Conventional PCR; Sonication; Nanodrop, Gene knock down, SSCP, RFLP Application and Bioinformatics Databases Cytoscape, Mendely, Microsoft Office, MicroRNA data bases (Target scan, MirTarBase, PicTar, miRcancer and so on),KEGG Pathway,NCBI, STRINGDB Biostatistics GraphPad prism, Roc curve, parametric and non-parametric tests analysis Publications 1- Nastaran Injinari, Zeinab Amini-Farsani, Mahtab Yadollahi Farsani, Hossein Teimori. Apoptotic effects of valproic acid on miR-34a, miR-520h and HDAC1 gene in breast cancer. Life Sciences. Volume 269, 15 March 2021, 119027. 2. Somayeh Hashemi Sheikh Shabani; Zeinab Amini-Farsani; Ali Jazaeri; Samira Asgharzade. Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic pathway regulators. Life science journal.2021,119525. 3. Zeinab Amini-Farsani, Samira Asgharzade. The impact of miR-183/182/96 gene regulation on the maturation, survival, and function of photoreceptor cells in the retina. Journal of Comparative Neurology, 2020; 528 (9), 1616-1625. 4. Samira Asgharzade, Somayeh Hashemi Sheikhshabani, Elham Ghasempour, Razieh Heidari, Shima Rahmati, Mahsa Mohammadi, Ali Jazaeri, Zeinab Amini-Farsani (Corresponding Author). The effect of oleuropein on apoptotic pathway regulators in breast cancer cells. European Journal of Pharmacology, 2020; 886, 173509 5. Zahra Sajadpour, Zeinab Amini-Farsani, Majid Motovali-Bashi, Mitra Yadollahi, Nariman Khosravi 02 Farsani. Association between Different Polymorphic Markers and β-Thalassemia Intermedia in Central Iran. Hemoglobin 2020; 44 (1), 27-30. 6. Zahra Sajadpour, Zeinab Amini-Farsani, M Motovali-Bashi, M Yadollahi, F Yadollahi. Investigation of RFLP haplotypes βglobin gene cluster in beta thalassemia patients in central Iran International journal of hematology-oncology and stem cell research. 2020; 13 (2), 61. 7. Nastaran Injinari, Zeinab Amini-Farsani, H Teimori. Expression of miR-125 and MCL-1 and BCL-2 Anti 02 apoptotic Genes under the Influence of Valproic Acid Treatment in Breast Cancer Cell Lines. JOURNAL OF ISFAHAN MEDICAL SCHOOL (IUMS), 2019, 37 (542), 1061-1067 8. Somayeh Hashemi-Sheikhshabani, Zeinab Amini-Farsani, Mehdi Shamsara, Zahra Sajadpoor, Mohammad Hossein Sangtarash, Hossein Teimori Effect of valproic acid on cisplatin resistance in ovarian cancer cell lines A2780 S/CP. Journal of Shahrekord University of Medical Sciences. 2019/2/6.4. 9. Amini-Farsani Z, Sangtarash MH, Shamsara M, Teimori H. MiR-221/222 promote chemoresistance to cisplatin in ovarian cancer cells by targeting PTEN/PI3K/AKT signaling pathway. Cytotechnology. 2018 Feb;70(1):203-213. 10. Sajadpoor Z, Amini-Farsani Z, Teimori H, Shamsara M, Sangtarash MH, Ghasemi Dehkordi P, Yadollahi F. Valproic Acid Promotes Apoptosis and Cisplatin Sensitivity Through 3 Downregulation of H19 Noncoding RNA in Ovarian A2780 Cells. Appl Biochem Biotechnol. 2018 Aug;185(4):1132-1144. 11. Nariman Khosravi Farsani, Masoud Mashhadi Akbar Boojar, Hossein Teimori, Zeinab Amini Farsani, Delnia Gholami, Zahra Sajadpoor.The study of hyoscyamine in oxidative stress of liver cells in male rat. Journal of Shahrekord Uuniversity of Medical Sciences 2017, 19. 12. Z Amini-Farsani, MH Sangtarash, H Teimori, M Shamsara. Effect of valproic acid on Expression of Bim gene and viability of ovarian cancer cell line A2780. Journal of Gorgan University of Medical Sciences 2017; 19 (3). 13. Nariman Khosravi-Farsani, Masoud Mashhadi Akbar Boojar, Zeinab Amini-Farsani, Soraya Heydari and Hossein Teimori. Antioxidant and antiglycation effects of scopolamine in rat liver cells. Scholars Research Library. Der Pharmacia Lettre, 2016,8(1):169-174. 14. Soraya Heydari, Razieh Pourahmad, Arsalan Khaledifar, Morteza Hashemzadeh, Zeinab Amini,P4P Soheila Badfar, Nariman Khosravi-Farsani. Investigation of Mutations in Exons 12-15 MYH7 Gene in Hypertrophic Cardiomyopathie Patients Using PCR-SSCP Technique. Zahedan journal of research in medical sciences. 2013; 15(10):16-20. 15. Z Amini-Farsani, AM Ahadi, H Teimori, A Haeri-Ruhani. Investigation of mutation in cystatin B gene in patients affected by idiopathic generalized epilepsy in Chaharmahal and Bakhtiari province. Journal of shahrekord university of medical sciences. 2013; 15 (1). Articles in process 1- Zeinab Amini-Farsani, Mahtab Yadollahi Farsani, Samaneh Arab, Fatemeh Forouzanfar, Mitra Yadollahi, Samira Asgharzade. The role of miRNAs in the regulation of inflammatory processes during coronavirus disease 2019. ( Revise). International immunopharmacology. 2- Zeinab Amini-Farsani, PhD; Somayeh Hashemi Sheikh Shabani, MSc; Shima Rahmati, PhD; Razieh Heidari, PhD. The effect of oleuropein on miRNAs regulating apoptosis signaling pathway in human cervical cancer cells ( With editor) 3. Moradi, Zahra; rabiei, zahra; Anjomshoa, Maryam; Amini-Farsani, Zeinab; Massahzadeh, Vahid; Asgharzade, Samira Neuroprotective Effect of Blueberries (Vacciniumangustifolium) in Global Cerebral Ischemia/Reperfusion Rats: Down - Regulated iNOS and TNF-α /Up - Regulated miR-146a and miR-21 Expression ( Under review) 4. Non-chromatographic laccase purification using a dual ELK16-tagged split intein system in Escherichia.coli BL21(DE3) plysS. 5. Elham Ghasempour (MSc), Zeinab Amini-Farsani(PhD). Autophagy pathway genes and miRNAs function in treatment resistance of breast cancer5 7. Evaluation of the expression levels of miR-1245b-5p and miR-92a-3p in breast cancer patients ( in Process). Research projects 1. Study effect of oleuropein on miR-181b and miR-21 and probable target Genes, MCL1 and FAS, expression in breast cancer cell line MDA-MB-23 (Advisor). 2. Study effect of valproic acid on miR-520h and miR-34a and potential target gene expression in breast cancer cell line MDA-MB-231 (Advisor). 3. Study effect of oleuropein on miR-181b and miR-21 and probable target Genes, MCL1 and FAS, expression in breast cancer cell line MDA-MB-23 (Advisor). 4. Study effect of oleuropein on miR-125b and miR-34a and probable target Genes, MCL1 and Bcl2, expression in cisplatin sensitive and resistance ovarian cancer cell lines (Advisor). 5. Study effect of oleuropein on the expression of genes involved in apoptosis (p53, bcl2, p21) in cisplatin-resistant ovarian cell line (Advisor). 6. Study effect of valproic acid on P21 and PTEN gene expression, cisplatin resistance and apoptosis in ovarian cancer cell line A2780. 7. Comparison of the expression of 221 and 222 microRNAs in cisplatin-sensitive cells resistant to ovarian cancer treated with valproic acid. 8. Design of Intein-ELP system for purification of recombinant proteins. 9. Study effect of nanoparticles containing altretiamine and arstin on ferroptosis through expression of P53 and Bid genes in A2780 ovarian cancer cell line. 10. Bim gene expression analysis of ovarian cancer cells with cisplatin resistance 6 11. Study effect of GM-CSF cytokine on motility parameters of sperm extracted from testicular tissue after cryopreservation and post-ICSI pregnancy outcomes in obstructive azoospermia patients undergoing ICSI referred to IVF clinic of Mousavi Hospital in Zanjan in 1398 CONFERENCES AND SEMINARS 1. VPA enhances apoptosis in cisplatin resistant ovarian cancer cell lines via upregulation of Bim and Fas genes. 3rd International and 15th Iranian Genetics Congress . 2. The Study of valproic acid effects on H19 noncoding RNA expression and apoptosis in cisplatin-resistant ovarian cancer cells. 3rd International and 15th Iranian Genetics. 3. Investigation of mutation in cystatin B gene in patients affected by idiopathic generalized epilepsy in Chaharmahal and Bakhtiari province. The 17th National & 5th International Iranian Biology Conference. 4. Investigation of Mutations in Exons 12-15 MYH7 Gene in Hypertrophic Cardiomyopathie Patients Using PCR-SSCP Technique. The 17th National & 5th International Iranian Biology Conference. 5. Evaluation of HER 2 gene amplification in patients with invasive breast cancer by in situ fluorescent hybridization technique. The 17th National & 5th International Iranian Biology Conference7 6. Investigating the role of non-coding RNAs in human diseases, Shahrekord University of Medical Sciences jointly with Royan Isfahan. REVIEWER Journal of Materials Science Research and Reviews Phytotherapy Research Brazilian Journal of Pharmaceutical Sciences American Journal of Translational Research REFERENCES Dr. Mehdi Shamsara Assistant Professor of Molecular genetics (shamsam2000@gmail.com) National Institute for Genetic Engineering and Biotechnology, Tehran, Iran Dr Hajar yaghoobi, Assistant Professor of Biotechnology, (hajar.yaghoobi64@gmail.com), Shahrekord University of Medical Sciences, Shahrekord , Iran Dr. Samira Asgharzade Assistant Professor of Molecular Medicine (asgharzade2336@gmail.com) Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran Dr. Dor mohammad Kordi –Tammandani Professor of Molecular Genetics (dor_kordi@yahoo.com) University of Sistan and Baluchestan, Zahedan Department of Biology, Iran

Subject Matter Expertise

• ★ Molecular Biology
• ★ Genetics

Services

• Writing
• Research
• Data & AI
• Product Development

Writing Technical Writing

Research Meta-Research, Gap Analysis, Gray Literature Search

Data & AI Statistical Analysis

Product Development Manufacturing

Work Experience

I has been working as an advisor of 5 Masters and MD theses from about 2 years ago in cellular and molecular research center, Shahrekord university of medical sciences, Shahrekord, Iran

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

January 2019 - May 2021

Education

PhD

University of Sistan and Baluchestan, Zahedan, Iran

September 2012 - October 2017

Certifications

• Certification details not provided.