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USD 80 /hr

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Hire Dr. Reem W.

Egypt

USD 80 /hr

Senior Medicinal Chemist | CADD & Docking Expert | Q1 Manuscript Editor with 20+ Yrs Exp in Oncology Research

Profile Summary

I am a Professor of Medicinal Chemistry with over 20 years of extensive experience in pharmaceutical research, drug design, and academic leadership. My career is defined by a strong international background, including a significant tenure as a Research Scholar at Wake Forest University, USA, where I specialized in cancer research and synthetic organic chemistry. I possess expert technical skills in Computer-Aided Drug Design (CADD), specifically in molecular modeling using MOE and Discovery Studio, focusing on pharmacophore and structure-based design. Additionally, I am proficient in multi-step organic synthesis, Green Chemistry approaches, and the structural elucidation of bioactive compounds using advanced 1D/2D NMR, HRMS/ESI, and IR data.My current research focus lies at the intersection of chemistry and oncology, including leading a funded STDF project to design and synthesize new Uracil derivatives as potential multi-target anti-cancer agents. My previous work includes the development of first-in-class dual-acting PIM-1 kinase/HDAC inhibitors and tubulin inhibitors published in high-impact journals. With over 60 peer-reviewed articles in top-tier Q1 journals and more than 1,090 citations (H-index of 21), I offer specialized expertise in scientific manuscript development and professional peer review for the international pharmaceutical community, ensuring research meets the highest global standards for publication.

Subject Matter Expertise

• ☆ Molecular Modeling
• ☆ Molecular Docking
• ☆ Biochemistry
• ☆ Pharmacy
• ☆ Drug Discovery
• ☆ Medicinal Chemistry

Services

• Writing

Writing Technical Writing, General Proofreading & Editing

Work Experience

Associate Professor

Faculty of Pharmacy, Minia University

July 2013 - Present

Senior Professor | CADD & Drug Discovery Expert

International Research & Academic Institution

September 2002 - Present

Education

PhD (Medicinal Chemistry)

faculty of pharmacy, Minia university

June 2011 - December 2013

Ph.D. in Pharmaceutical Sciences (Medicinal Chemistry)

Minia University (in collaboration with Wake Forest University, USA)

May 2004 - January 2008

Certifications

• PhD Certificate in Pharmaceutical Sciences (Medicinal Chemistry)

  Faculty of Pharmacy, Minia University

  https://muedueg-my.sharepoint.com/:i:/g/personal/shimaanaguib_80_mu_edu_eg/IQCba8rZA2m1RZ1FSdUyjuMVAbEo5DQ1yG706vEo11u6eQU?e=x0Baj2

  October 2013 - Present

Publications

JOURNAL ARTICLE

Heba A. Hofny, Mamdouh F. A. Mohamed, Heba A. Hassan, El‐Shimaa M. N. Abdelhafez, Gamal El‐Din A. Abuo‐Rahma (2025). A review of recent advances in anticancer activity and SAR of pyrazole derivatives . Archiv der Pharmazie.

Michael Atef Fawzy, Karim Hagag Ibrahim, Ashraf A Aly, Asmaa H Mohamed, Sara Mohamed Naguib Abdel Hafez, Walaa Yehia Abdelzaher, Eslam B Elkaeed, Aisha A Alsfouk, El-Shimaa MN Abdelhafez (2024). One-pot synthesis and pharmacological evaluation of new quinoline/pyrimido-diazepines as pulmonary antifibrotic agents . Future Medicinal Chemistry.

Aya Soudi, Onur Bender, Ismail Celik, Amer Ali Abd El-Hafeez, Rumeysa Dogan, Arzu Atalay, Eslam B. Elkaeed, Aisha A. Alsfouk, Elshimaa M. N. Abdelhafez, Omar M. Aly, et al. (2024). Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor . Pharmaceuticals.

Aya Soudi, Onur Bender, Ismail Celik, Amer Ali Abd El-Hafeez, Rumeysa Dogan, Arzu Atalay, Eslam B. Elkaeed, Aisha A. Alsfouk, Elshimaa M. N. Abdelhafez, Omar M. Aly, et al. (2024). Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor . Pharmaceuticals.

Mona S El-Zoghbi, Amr KA Bass, Gamal El-Din A Abuo-Rahma, Mamdouh FA Mohamed, Mohamed Badr, Hanan A AL-Ghulikah, El-Shimaa MN Abdelhafez (2024). Design, Synthesis and Mechanistic Study of New Dual Targeting HDAC/Tubulin Inhibitors . Future Medicinal Chemistry.

Bahaa G. M. Youssif, Martha M. Morcoss, Stefan Bräse, Mohamed Abdel-Aziz, Hamdy M. Abdel-Rahman, Dalal A. Abou El-Ella, El Shimaa M. N. Abdelhafez (2024). Benzimidazole-Based Derivatives as Apoptotic Antiproliferative Agents: Design, Synthesis, Docking, and Mechanistic Studies . Molecules.

Bahaa G. M. Youssif, Martha M. Morcoss, Stefan Bräse, Mohamed Abdel-Aziz, Hamdy M. Abdel-Rahman, Dalal A. Abou El-Ella, El Shimaa M. N. Abdelhafez (2024). Benzimidazole-Based Derivatives as Apoptotic Antiproliferative Agents: Design, Synthesis, Docking, and Mechanistic Studies . Molecules.

Samar A. El-Kalyoubi, Hesham A. M. Gomaa, Elshimaa M. N. Abdelhafez, Mohamed Ramadan, Fatimah Agili, Bahaa G. M. Youssif (2023). Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAFV600E . Pharmaceuticals.

Samar A. El-Kalyoubi, Hesham A. M. Gomaa, Elshimaa M. N. Abdelhafez, Mohamed Ramadan, Fatimah Agili, Bahaa G. M. Youssif (2023). Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAF^V600E . Pharmaceuticals.

El-Kalyoubi, Samar A., Gomaa, Hesham A. M., Abdelhafez, Elshimaa M. N., Ramadan, Mohamed, Agili, Fatimah, Youssif, Bahaa G. M. (2023). Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAF<SUP>V600E</SUP> . Pharmaceuticals.

Abdelhafez, Elshimaa Mohamed Naguib, Elgedamy, Arowa, Shoman, Mai, others(2023). Antimicrobial Activity of New Amide/thioamides Derivatives of Ciprofloxacin. Journal of advanced Biomedical and Pharmaceutical Sciences. 6. (1). p. 12--15. Minia University, Faculty of Pharmacy

El-Kalyoubi, Samar A, Gomaa, Hesham AM, Abdelhafez, Elshimaa MN, Ramadan, Mohamed, Agili, Fatimah, Youssif, Bahaa GM(2023). Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAFV600E. Pharmaceuticals. 16. (5). p. 716. MDPI

Mohamed, Asmaa H, Mostafa, Sara M, Aly, Ashraf A, Hassan, Alaa A, Osman, Esraa M, Nayl, AbdElAziz A, Brown, Alan B, Abdelhafez, Elshimaa MN(2023). Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA. RSC advances. 13. (21). p. 14631--14640. Royal Society of Chemistry

Asmaa H. Mohamed, Sara M. Mostafa, Ashraf A. Aly, Alaa A. Hassan, Esraa M. Osman, AbdElAziz A. Nayl, Alan B. Brown, Elshimaa M. N. Abdelhafez (2023). Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA . RSC Advances.

Mohamed, Asmaa H., Mostafa, Sara M., Aly, Ashraf A., Hassan, Alaa A., Osman, Esraa M., Nayl, AbdElAziz A., Brown, Alan B., Abdelhafez, Elshimaa M. N. (2023). Novel quinoline/thiazinan-4-one hybrids; design, synthesis, and molecular docking studies as potential anti-bacterial candidates against MRSA . RSC Advances.

Hafez, Sara Mohamed Naguib Abdel, Saber, Entesar Ali, Aziz, Neven Makram, Kamel, Maha Yehia, Aly, Ashraf A, Abdelhafez, El-Shimaa MN, Ibrahim, Manar Fouli Gaber(2023). Potential protective effect of 3, 3′-methylenebis (1-ethyl-4-hydroxyquinolin-2 (1 H)-one) against bleomycin-induced lung injury in male albino rat via modulation of Nrf2 pathway: biochemical, histological, and immunohistochemical study. Naunyn-Schmiedeberg's Archives of Pharmacology. 396. (4). p. 771--788. Springer Berlin Heidelberg Berlin/Heidelberg

Hafez, Sara Mohamed Naguib Abdel, Saber, Entesar Ali, Aziz, Neven Makram, Kamel, Maha Yehia, Aly, Ashraf A., Abdelhafez, El-Shimaa M. N., Ibrahim, Manar Fouli Gaber (2023). Potential protective effect of 3,3'-methylenebis(1-ethyl-4-hydroxyquinolin-2(1<i>H</i>)-one) against bleomycin-induced lung injury in male albino rat via modulation of Nrf2 pathway: biochemical, histological, and immunohistochemical study . Naunyn-Schmiedeberg's Archives of Pharmacology.

Samaher S. A. Mahmoud, Eslam B. Elkaeed, Aisha A. Alsfouk, Elshimaa M. N. Abdelhafez, Kazim Husain (2022). Molecular Docking and Dynamic Simulation Revealed the Potential Inhibitory Activity of Opioid Compounds Targeting the Main Protease of SARS‐CoV‐2 . BioMed Research International.

Mahmoud, Samaher S. A., Elkaeed, Eslam B., Alsfouk, Aisha A., Abdelhafez, Elshimaa M. N. (2022). Molecular Docking and Dynamic Simulation Revealed the Potential Inhibitory Activity of Opioid Compounds Targeting the Main Protease of SARS-CoV-2 . BioMed Research International.

Mustafa, Muhamad, Mostafa, Yaser A, Abd Elbaky, Atef E, Mohamed, Mahmoud, Abdelhamid, Dalia, Abdelhafez, EMN, Aly, Omar M(2022). Combretastatin A-4 analogs: Past, present, and future directions. Octahedron Drug Research. 1. (1). p. 55--64. Port Said University, Faculty of Pharmacy

Aly, Ashraf A, Abdallah, Elham M, Ahmed, Salwa A, Rabee, Mai M, Abdelhafez, El-Shimaa MN(2022). Metal complexes of thiosemicarbazones derived by 2-quinolones with Cu (I), Cu (II) and Ni (II); Identification by NMR, IR, ESI mass spectra and in silico approach as potential tools against SARS-CoV-2. Journal of Molecular Structure. 1265. p. 133480. Elsevier

Aly, Ashraf A., Abdallah, Elham M., Ahmed, Salwa A., Rabee, Mai M., Abdelhafez, El-Shimaa M. N. (2022). Metal complexes of thiosemicarbazones derived by 2-quinolones with Cu(I), Cu(II) and Ni(II); Identification by NMR, IR, ESI mass spectra and in silico approach as potential tools against SARS-CoV-2 . Journal of Molecular Structure.

Mahmoud, Samaher SA, Elkaeed, Eslam B, Alsfouk, Aisha A, Abdelhafez, Elshimaa, others(2022). Molecular Docking and Dynamic Simulation Revealed the Potential Inhibitory Activity of Opioid Compounds Targeting the Main Protease of SARS-CoV-2. BioMed Research International. 2022. Hindawi

Mostafa, Sara M, Aly, Ashraf A, Br&#228;se, Stefan, Nieger, Martin, Abdelhafez, Sara Mohamed Naguib, Abdelzaher, Walaa Yehia, Abdelhafez, El-Shimaa MN(2022). Synthesis, Characterization, and In Vivo Study of Some Novel 3, 4, 5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors. Molecules. 27. (7). p. 2266. MDPI

Mostafa, Sara M., Aly, Ashraf A., Brase, Stefan, Nieger, Martin, Abdelhafez, Sara Mohamed Naguib, Abdelzaher, Walaa Yehia, Abdelhafez, El-Shimaa M. N. (2022). Synthesis, Characterization, and In Vivo Study of Some Novel 3,4,5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors . Molecules.

Bass, Amr KA, Nageeb, El-Shimaa M, El-Zoghbi, Mona S, Mohamed, Mamdouh FA, Badr, Mohamed, Abuo-Rahma, Gamal El-Din A(2022). Utilization of cyanopyridine in design and synthesis of first-in-class anticancer dual acting PIM-1 kinase/HDAC inhibitors. Bioorganic Chemistry. 119. p. 105564. Elsevier

Bass, Amr Kamal, Abdelhafez, Elshimaa, El-Zoghbi, Mona, Mohamed, Mamdouh FA, Badr, Mohamed, Abuo-Rahma, Gamal El-Din AA(2021). 3-Cyano-2-oxa-pyridines: a promising template for diverse pharmacological activities. Journal of advanced Biomedical and Pharmaceutical Sciences. 4. (2). p. 81--86. Minia University, Faculty of Pharmacy

Zaki, Adham M. M., Ahmed, Yasmin Moustafa, Abdelhafez, El-Shimaa M. N. (2021). CANDIDATURE OF THE SYNTHETIC CASPASE INHIBITORS AS NEW ANTI-SARS-COV-2 DRUG DISCOVERY, IN-SILICO MOLECULAR DOCKING . International Journal of Pharmaceutical Sciences and Research.

Zaki, Adham MM, Ahmed, Yasmin Moustafa, Abdelhafez, El-Shimaa MN(2021). Candidature of the Synthetic Caspase Inhibitors as New Anti-SARS-COV-2 Drug Discovery, In-Silico Molecular Docking. International Journal of Pharmaceutical Sciences and Research. p. 104--119.

Abdelhafez, EM, Elgohary, HG, Ali, HE, Ghalab, AMAM(2021). Comparing Open Preperitoneal Versus Laparoscopic Totally Extra Peritoneal Repair of Inguinal Hernia. Benha Journal of Applied Sciences. 6. (5). p. 155--161. Benha University

Bass, Amr KA, El-Zoghbi, Mona S, Nageeb, El-Shimaa M, Mohamed, Mamdouh FA, Badr, Mohamed, Abuo-Rahma, Gamal El-Din A(2021). Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors. European journal of medicinal chemistry. 209. p. 112904. Elsevier

Adel M. AbdelHakem, El-Shimaa M.N. Abdelhafez (2021). Current Trends and Future Perspectives of Antimutagenic Agents . Genotoxicity and Mutagenicity - Mechanisms and Test Methods.

Shabib, Aya, Shoman, Mai, Abdelhafez, Elshimaa Mohamed Naguib, others(2021). Current Trends and Future Perspectives of Hydrogen Sulfide Donors. Journal of advanced Biomedical and Pharmaceutical Sciences. 4. (4). p. 231--245. Minia University, Faculty of Pharmacy

Mostafa, Sara M., Aly, Ashraf A., Sayed, Samia M., Raslan, Mohamed A., Ahmed, Amira E., Nafady, Ayman, Ishak, Esam A., Shawky, Ahmed M., Abdelhafez, El-Shimaa M. N. (2021). New Quinoline-2-one/thiazolium bromide Derivatives; Synthesis, Characterization and Mechanism of Formation . Journal of Molecular Structure.

Mostafa, Sara M, Aly, Ashraf A, Sayed, Samia M, Raslan, Mohamed A, Ahmed, Amira E, Nafady, Ayman, Ishak, Esam A, Shawky, Ahmed M, Abdelhafez, El-Shimaa MN(2021). New quinoline-2-one/thiazolium bromide derivatives; synthesis, characterization and mechanism of formation. Journal of Molecular Structure. 1239. p. 130501. Elsevier

Abdel Hafez, SMN, Ali, ESMN, Naguib, SM(2021). The role of mast cells in accelerating our skin aging. J Clin Images Med Case Rep. 2. (5). p. 1345.

Essmat M. El-Sheref, Ashraf A. Aly, Mohammed B. Alshammari, Alan B. Brown, Sara Mohamed Naguib Abdel-Hafez, Walaa Yehia Abdelzaher, Stefan Br&#228;se, ElShimaa M. N. Abdelhafez(2020). Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/Bis-2(1H)-Quinolinone Hybrids . Molecules. 25. (21). p. 5057. {MDPI} {AG}

Essmat M. El-Sheref, Ashraf A. Aly, Mohammed B. Alshammari, Alan B. Brown, Sara Mohamed Naguib Abdel-Hafez, Walaa Yehia Abdelzaher, Stefan Br&#228;se, ElShimaa M. N. Abdelhafez (2020). Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/<i>Bis</i>-2(1<i>H</i>)-Quinolinone Hybrids . Molecules.

El-Sheref, Essmat M., Aly, Ashraf A., Alshammari, Mohammed B., Brown, Alan B., Abdel-Hafez, Sara Mohamed Naguib, Abdelzaher, Walaa Yehia, Braese, Stefan, Abdelhafez, ElShimaa M. N. (2020). Design, Synthesis, Molecular Docking, Antiapoptotic and Caspase-3 Inhibition of New 1,2,3-Triazole/Bis-2(1H)-Quinolinone Hybrids . Molecules.

Aly, Ashraf A., Braese, Stefan, Hassan, Alaa A., Mohamed, Nasr K., Abd El-Haleem, Lamiaa E., Nieger, Martin, Morsy, Nesrin M., Alshammari, Mohammed B., Ibrahim, Mahmoud A. A., Abdelhafez, Elshimaa M. N. (2020). Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents . Molecules.

Aly, Ashraf A, Br&#228;se, Stefan, Hassan, Alaa A, Mohamed, Nasr K, El-Haleem, Lamiaa E Abd, Nieger, Martin, Morsy, Nesrin M, Alshammari, Mohammed B, Ibrahim, Mahmoud AA, Abdelhafez, Elshimaa MN(2020). Design, synthesis, and molecular docking of paracyclophanyl-thiazole hybrids as novel CDK1 inhibitors and apoptosis inducing anti-melanoma agents. Molecules. 25. (23). p. 5569. MDPI

Morcoss, Martha M., Abdelhafez, El Shimaa M. N., Ibrahem, Reham A., Abdel-Rahman, Hamdy M., Abdel-Aziz, Mohamed, Abou El-Ella, Dalal A. (2020). Design, synthesis, mechanistic studies and <i>in silico</i> ADME predictions of benzimidazole derivatives as novel antifungal agents . Bioorganic Chemistry.

Morcoss, Martha M, El Shimaa, MN, Ibrahem, Reham A, Abdel-Rahman, Hamdy M, Abdel-Aziz, Mohamed, Abou El-Ella, Dalal A(2020). Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents. Bioorganic chemistry. 101. p. 103956. Elsevier

El-Sheref, Essmat M, Aly, Ashraf A, Alshammari, Mohammed B, Brown, Alan B, Abdel-Hafez, Sara Mohamed Naguib, Abdelzaher, Walaa Yehia, Br&#228;se, Stefan, Abdelhafez, ElShimaa MN(2020). Design, synthesis, molecular docking, antiapoptotic and caspase-3 inhibition of new 1, 2, 3-triazole/bis-2 (1 H)-quinolinone hybrids. Molecules. 25. (21). p. 5057. MDPI

Aly, Ashraf A., Braese, Stefan, Hassan, Alaa A., Mohamed, Nasr K., Abd El-Haleem, Lamiaa E., Nieger, Martin, Morsy, Nesrin M., Abdelhafez, Elshimaa M. N. (2020). New Paracyclophanylthiazoles with Anti-Leukemia Activity: Design, Synthesis, Molecular Docking, and Mechanistic Studies . Molecules.

Aly, Ashraf A, Br&#228;se, Stefan, Hassan, Alaa A, Mohamed, Nasr K, Abd El-Haleem, Lamiaa E, Nieger, Martin, Morsy, Nesrin M, Abdelhafez, Elshimaa MN(2020). New paracyclophanylthiazoles with anti-leukemia activity: Design, synthesis, molecular docking, and mechanistic studies. Molecules. 25. (13). p. 3089. MDPI

Aly, Ashraf A, Sayed, Samia M, Abdelhafez, El-Shimaa MN, Abdelhafez, Sara Mohamed Naguib, Abdelzaher, Walaa Yehia, Raslan, Mohamed A, Ahmed, Amira E, Thabet, Khaled, El-Reedy, Ahmed AM, Brown, Alan B, et al.(2020). New quinoline-2-one/pyrazole derivatives; design, synthesis, molecular docking, anti-apoptotic evaluation, and caspase-3 inhibition assay. Bioorganic Chemistry. 94. p. 103348. Academic Press

Aly, Ashraf A., Sayed, Samia M., Abdelhafez, El-Shimaa M. N., Abdelhafez, Sara Mohamed Naguib, Abdelzaher, Walaa Yehia, Raslan, Mohamed A., Ahmed, Amira E., Thabet, Khaled, El-Reedy, Ahmed A. M., Brown, Alan B., et al. (2020). New quinoline-2-one/pyrazole derivatives; design, synthesis, molecular docking, anti-apoptotic evaluation, and caspase-3 inhibition assay . Bioorganic Chemistry.

Morcoss, Martha M, Abdelhafez, El Shimaa, Abdel-Rahman, Hamdy M, Abdel-Aziz, Mohamed, El-Ella, Abou, Dalal, A(2020). Novel Benzimidazole/Hydrazone Derivatives as Promising Anticancer Lead Compounds: Design, Synthesis, and Molecular Docking Study. Journal of advanced Biomedical and Pharmaceutical Sciences. 3. (2). p. 45--52. Minia University, Faculty of Pharmacy

Maklad, Raed M., Abdelhafez, El-Shimaa M. N., Abdelhamid, Dalia, Aly, Omar M. (2020). Tubulin Inhibitors: Discovery of a New Scaffold Targeting Extra-binding Residues within the Colchicine Site through Anchoring Substituents Properly Adapted to their Pocket by a Semi-flexible Linker . Bioorganic Chemistry.

Maklad, Raed M, AbdelHafez, El-Shimaa MN, Abdelhamid, Dalia, Aly, Omar M(2020). Tubulin inhibitors: Discovery of a new scaffold targeting extra-binding residues within the colchicine site through anchoring substituents properly adapted to their pocket by a semi-flexible linker. Bioorganic Chemistry. 99. p. 103767. Academic Press

Hamada H. H. Mohammed, Samar H. Abbas, El-Shimaa M. N. Abdelhafez, James M. Berger, Satoshi Mitarai, Masayoshi Arai, Gamal El-Din A. A. Abuo-Rahma(2019). Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole/oxadiazole ciprofloxacin derivatives . Monatshefte für Chemie - Chemical Monthly. 150. (10). p. 1809--1824. Springer Science and Business Media {LLC}

Mohammed, Hamada H. H., Abbas, Samar H., Abdelhafez, El-Shimaa M. N., Berger, James M., Mitarai, Satoshi, Arai, Masayoshi, Abuo-Rahma, Gamal El-Din A. A. (2019). Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole/oxadiazole ciprofloxacin derivatives . Monatshefte für Chemie - Chemical Monthly.

Abdelhafez, El-Shimaa Mohamed Naguib, Ali, Sara Mohamed Naguib Abdelhafez, Hassan, Mohamed Ramadan Eisa, Abdel-Hakem, Adel Mohammed(2019). Apoptotic inhibitors as therapeutic targets for cell survival. Cytotoxicity-Definition, Identification, and Cytotoxic Compounds. p. 69. IntechOpen

Mohammed, Hamada H. H., Abuo-Rahma, Gamal El-Din A. A., Abbas, Samar H., Abdelhafez, El-Shimaa M. N. (2019). Current Trends and Future Directions of Fluoroquinolones . Current Medicinal Chemistry.

Mohammed, Hamada HH, Abuo-Rahma, Gamal El-Din AA, Abbas, Samar H, Abdelhafez, El-Shimaa(2019). Current trends and future directions of fluoroquinolones. Current Medicinal Chemistry. 26. (17). p. 3132--3149. Bentham Science Publishers

Mohammed, Hamada H. H., Abdelhafez, El-Shimaa M. N., Abbas, Samar H., Moustafa, Gamal A., I, Hauk, Glenn, Berger, James M., Mitarai, Satoshi, Arai, Masayoshi, Abd El-Baky, Rehab M., Abuo-Rahma, Gamal El-Din A. (2019). Design, synthesis and molecular docking of new <i>N</i>-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity . Bioorganic Chemistry.

Mohammed, Hamada HH, Abdelhafez, El-Shimaa MN, Abbas, Samar H, Moustafa, Gamal AI, Hauk, Glenn, Berger, James M, Mitarai, Satoshi, Arai, Masayoshi, Abd El-Baky, Rehab M, Abuo-Rahma, Gamal El-Din A(2019). Design, synthesis and molecular docking of new N-4-piperazinyl ciprofloxacin-triazole hybrids with potential antimicrobial activity. Bioorganic chemistry. 88. p. 102952. Academic Press

Hassan, Alaa A, Aly, Ashraf A, Mohamed, Nasr K, El Shaieb, Kamal M, Makhlouf, Maysa M, Abdelhafez, El-Shimaa MN, Br&#228;se, Stefan, Nieger, Martin, Dalby, Kevin N, Kaoud, Tamer S(2019). Design, synthesis, and DNA interaction studies of furo-imidazo [3.3. 3] propellane derivatives: Potential anticancer agents. Bioorganic chemistry. 85. p. 585--599. Academic Press

Hassan, Alaa A., Aly, Ashraf A., Mohamed, Nasr K., El Shaieb, Kamal M., Makhlouf, Maysa M., Abdelhafez, El-Shimaa M. N., Braese, Stefan, Nieger, Martin, Dalby, Kevin N., Kaoud, Tamer S. (2019). Design, synthesis, and DNA interaction studies of furo-imidazo[3.3.3] propellane derivatives: Potential anticancer agents . Bioorganic Chemistry.

Aly, Ashraf A, El-Sheref, Essmat M, Brown, Alan B, Br&#228;se, Stefan, Nieger, Martin, Abdelhafez, El-Shimaa MN(2019). New one-pot synthesis of 2-ylidenehydrazono-thiazoles. Journal of Sulfur Chemistry. 40. (6). p. 641--647. Taylor \& Francis

Aly, Ashraf A., El-Sheref, Essmat M., Brown, Alan B., Braese, Stefan, Nieger, Martin, Abdelhafez, El-Shinnaa M. N. (2019). New one-pot synthesis of 2-ylidenehydrazono-thiazoles . Journal of Sulfur Chemistry.

Mohammed, Hamada HH, Abbas, Samar H, Abdelhafez, El-Shimaa MN, Berger, James M, Mitarai, Satoshi, Arai, Masayoshi, Abuo-Rahma, Gamal El-Din AA(2019). Synthesis, molecular docking, antimicrobial evaluation, and DNA cleavage assay of new thiadiazole/oxadiazole ciprofloxacin derivatives. Monatshefte für Chemie-Chemical Monthly. 150. p. 1809--1824. Springer Vienna

Abdullah, Mohammed A. A., Abuo-Rahma, Gamal El-Din A. A., Abdelhafez, El-Shimaa M. N., Hassan, Heba A., Abd El-Baky, Rehab M. (2017). Design, synthesis, molecular docking, anti-<i>Proteus mirabilis</i> and urease inhibition of new fluoroquinolone carboxylic acid derivatives . Bioorganic Chemistry.

Abdullah, Mohammed AA, Abuo-Rahma, Gamal El-Din AA, Abdelhafez, El-Shimaa MN, Hassan, Heba A, Abd El-Baky, Rehab M(2017). Design, synthesis, molecular docking, anti-Proteus mirabilis and urease inhibition of new fluoroquinolone carboxylic acid derivatives. Bioorganic Chemistry. 70. p. 1--11. Academic Press

Mustafa, Muhamad, Abdelhamid, Dalia, Abdelhafez, ElShimaa MN, Ibrahim, Mahmoud AA, Gamal-Eldeen, Amira M, Aly, Omar M(2017). Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1, 2, 4-triazoles as potential combretastatin analogues. European journal of medicinal chemistry. 141. p. 293--305. Elsevier Masson

Muhamad Mustafa and Dalia Abdelhamid and ElShimaa M.N. Abdelhafez and Mahmoud A.A. Ibrahim and Amira M. Gamal-Eldeen and Omar M. Aly(2017). Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues . European Journal of Medicinal Chemistry. 141. (Supplement C). p. 293 - 305.

Mustafa, Muhamad, Abdelhamid, Dalia, Abdelhafez, ElShimaa M. N., Ibrahim, Mahmoud A. A., Gamal-Eldeen, Amira M., Aly, Omar M. (2017). Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues . European Journal of Medicinal Chemistry.

Abdullah, MA, El-Baky, RMA, Hassan, Heba A, Abdelhafez, El-Shimaa MN, Abuo-Rahma, Gamal El-Din A(2016). Fluoroquinolones as urease inhibitors: anti-Proteus mirabilis activity and molecular docking studies. Am J Microbiol Res. 4. (3). p. 81--84.

Mohammed, Hamada HH, Abd El-Hafeez, Amer Ali, Abbas, Samar H, Abdelhafez, El-Shimaa MN, Abuo-Rahma, Gamal El-Din A(2016). New antiproliferative 7-(4-(N-substituted carbamoylmethyl) piperazin-1-yl) derivatives of ciprofloxacin induce cell cycle arrest at G2/M phase. Bioorganic & medicinal chemistry. 24. (19). p. 4636--4646. Pergamon

Hamada H.H. Mohammed and Amer Ali Abd El-Hafeez and Samar H. Abbas and El-Shimaa M.N. Abdelhafez and Gamal El-Din A. Abuo-Rahma(2016). New antiproliferative 7-(4-(N-substituted carbamoylmethyl)piperazin-1-yl) derivatives of ciprofloxacin induce cell cycle arrest at G2/M phase . Bioorganic & Medicinal Chemistry. 24. (19). p. 4636 - 4646.

Hamada H.H. Mohammed and Amer Ali Abd El-Hafeez and Samar H. Abbas and El-Shimaa M.N. Abdelhafez and Gamal El-Din A. Abuo-Rahma(2016). New antiproliferative 7-(4-(N-substituted carbamoylmethyl)piperazin-1-yl) derivatives of ciprofloxacin induce cell cycle arrest at G2/M phase . Bioorganic & Medicinal Chemistry. 24. (19). p. 4636 - 4646.

Mohammed, Hamada H. H., Abd El-Hafeez, Amer Ali, Abbas, Samar H., Abdelhafez, El-Shimaa M. N., Abuo-Rahma, Gamal El-Din A. (2016). New antiproliferative 7-(4-(<i>N</i>-substituted carbamoylmethyl)piperazin-1-yl) derivatives of ciprofloxacin induce cell cycle arrest at G₂/M phase . Bioorganic & Medicinal Chemistry.

AbdelHafez, El-Shimaa M. N., Aly, Omar M., Abuo-Rahma, Gamal El-Din A. A., King, S. Bruce (2014). Lossen Rearrangements under Heck Reaction Conditions . Advanced Synthesis & Catalysis.

AbdelHafez, El-Shimaa MN, Aly, Omar M, Abuo-Rahma, Gamal El-Din AA, King, S Bruce(2014). Lossen rearrangements under Heck reaction conditions. Advanced Synthesis & Catalysis. 356. (16). p. 3456--3464. WILEY-VCH Verlag Weinheim

AbdelHafez, ElShimaa MN, Diamanduros, Andrew, Negureanu, Lacramioara, Luy, Yan, Bean, J Hayley, Zielke, Katherine, Crowe, Brittany, Vasilyeva, Aksana, Clodfelter, Jill E, Aly, Omar M, et al.(2013). Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment. Molecular cancer biology. 1. (1). NIH Public Access

Scarpinato, Karin Drotschmann, AbdelHafez, ElShimaa, Diamanduros, Andrew, Negureanu, Lacramioara, Lu, Yan, Bean, Jessica Hayley, Zielke, Katherine, Crowe, Brittany, Vasilyeva, Aksana, Clodfelter, Jill, et al.(2013). Improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment. eOpen Access Publishing

Abdel-Hafez, El-Shimaa MN, Abuo-Rahma, Gamal El-Din AA, Abdel-Aziz, Mohamed, Radwan, Mohamed F, Farag, Hassan H(2009). Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide. Bioorganic & medicinal chemistry. 17. (11). p. 3829--3837. Elsevier

Abdel-Hafez, El-Shimaa M. N., Abuo-Rahma, Gamal El-Din A. A., Abdel-Aziz, Mohamed, Radwan, Mohamed F., Farag, Hassan H. (2009). Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide . Bioorganic & Medicinal Chemistry.

Maklad, Raed M, Aly, Omar M, AbdelHafez, El-Shimaa MN, Abdelhamid, DaliaDesign, Synthesis and Cytotoxicity Measurement of Unsymmetrical Diacylhydrazine Derivatives as Potential Anticancer Agents.

Abdel-Hakem, Adel M, Abdelhafez, El-Shimaa MN, Abbas, Samar H, Aly, Omar MDocking Studies Of Some E-2-Phenyl-4-(2-Phenylhydrazineylidene) Oxazol-5 (4H)-One Derivatives As A Potential Caspase-8 Inhibitor.

Ali, Mohamed A, Abuo-Rahma, Gamal El-Din A, Abd El-baky, Rehab M, Abdelhafez, El-Shimaa MN, Hassan, Heba ANew Antibacterial Fluoroquinolone Hydroxamic Acids as Urease Inhibitors: Design, Synthesis and Molecular Docking Studies. infection. 4. p. 6.

AbdelHafez, EL-Shimaa MN, Diamanduros, Andrew, Aly, Omar M, Abuo-Rahma, Gamal El-Din AA, Scarpinato, Karin D, Jr, Freddie R Salsbury, King, S BruceSynthesis, Molecular Modeling and Anticancer Activity of New Rescinnamine Derivatives as MMR-Inducers.

OTHER

Elgemeie, Galal H, Azzam, Rasha A, Zaghary, Wafaa A, Aly, Ashraf A, Metwally, Nadia H, Sarhan, Mona O, Abdelhafez, Elshimaa M, Elsayed, Rasha E(2022). N-Sulfonated-N-Heterocycles: Synthesis, Chemistry, And Biological Applications. Elsevier

BOOK

Soloneski, Sonia, Larramendy, Marcelo L(2021). Genotoxicity and mutagenicity: Mechanisms and test methods. BoD--Books on Demand

Ila, Hasan Basri, Istifli, Erman Salih(2019). Cytotoxicity-Definition, Identification, and Cytotoxic Compounds. IntechOpen

BOOK CHAPTER

AbdelHakem, Adel M, Abdelhafez, El-Shimaa MN(2020). Current trends and future perspectives of antimutagenic agents. Genotoxicity and Mutagenicity-Mechanisms and Test Methods. IntechOpen

CONFERENCE PAPER

Mohammed, Hamada, Abdelhafez, El-Shimaa, Abbas, Samar, Abuo-Rahma, Gamal El-Din, Hauk, Glenn, Berger, James, Mitarai, Satoshi, Arai, Masayoshi, Dalby, Kevin, Kaoud, Tamer(2018). Design, synthesis, molecular docking and antimicrobial activity of New 7-(4-(2-((1, 2, 4-triazol-3-yl) thio) acetyl) piperazin-1-yl) derivatives of ciprofloxacin. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 255.

Ali, Mohammed, Abuo-Rahmaa, Gamal El-Din, Abdelbaky, Rehab, Hafez, El Shimaa Abdel, Hassan, Heba(2016). New fluoroquinolone hydroxamic acids as antibacterial and urease inhibitors: Design, synthesis and molecular docking studies. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 251.

DISSERTATION THESIS

Abdullah, Mohammed Abdullah Ali(2016). Design, Synthesis, Molecular Docking and Biological Investigation of New Hydroxamic Acid, Amide and Hydrazide Derivatives of Fluoroquinolones.