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USD 49 /hr

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☆☆☆☆☆

Hire Dr. Wei-Hua C.

United States

USD 49 /hr

Neurobiologist with 10+ years' experience of aniaml models of Parkinson's disease| Translational Research Advisor

Profile Summary

I am professional and efficient neurobiologist with 10+ years’ experience and knowledge of state-of-art translational research, focusing on biology, physiology, behavior, and histopathogy in clinical-relevant phenotype in small animal models of neurodegenerative diseases. My expertise is to choose and generate animal models to: 1. test compound and drugs efficacy and develop functional assay to evaluate the therapeutic effects; 2. investigate the symptom-relevant biological mechanisms for potential biomarkers and drug discovery.

Subject Matter Expertise

• ☆ Neuroscience
• ☆ Neurophysiology
• ☆ Behavioral Neuroscience
• ☆ Neuroanatomy
• ☆ Neuropharmacology
• ☆ Neurobiology
• ☆ Systems Neuroscience
• ☆ Biophysics
• ☆ Histology

Services

• Writing
• Research
• Consulting

Writing Technical Writing, General Proofreading & Editing, Translation

Research Feasibility Study, Scientific and Technical Research, Systematic Literature Review

Consulting Healthcare Consulting, Scientific and Technical Consulting

Work Experience

Research Scientist

NYU Langone Health

April 2020 - Present

Postdoctoral Researcher

Hebrew University Hadassah Medical School

February 2016 - February 2020

Education

Ph.D (Neurology)

Philipps University of Marburg

July 2008 - December 2013

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Katrin Sakreida, Wei-Hua Chiu, Juergen Dukart, Simon B. Eickhoff, Thomas Frodl, Christian Gaser, Michael Landgrebe, Berthold Langguth, Daniela Mirlach, I Sabina Rautu, et al.(2022). Disentangling dyskinesia from parkinsonism in motor structures of patients with schizophrenia . Brain Communications. 4. (4). Oxford University Press ({OUP})

Matschke, L.A., Komadowski, M.A., Stöhr, A., Lee, B., Henrich, M.T., Griesbach, M., Rinné, S., Geibl, F.F., Chiu, W.-H., Koprich, J.B., et al.(2022). Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease . Scientific Reports. 12. (1).

Wei-Hua Chiu, Lora Kovacheva, Ruth E. Musgrove, Hadar Arien-Zakay, James B. Koprich, Jonathan M. Brotchie, Rami Yaka, Danny Ben-Zvi, Menachem Hanani, Jochen Roeper, et al. (2021). α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms . Science Advances.

Chiu, W.-H., Kovacheva, L., Musgrove, R.E., Arien-Zakay, H., Koprich, J.B., Brotchie, J.M., Yaka, R., Ben-Zvi, D., Hanani, M., Roeper, J., et al.(2021). α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms . Science Advances. 7. (11).

Rotem Rehani, Yara Atamna, Lior Tiroshi, Wei-Hua Chiu, José de Jesús Aceves Buendía, Gabriela J. Martins, Gilad A. Jacobson, Joshua A. Goldberg (2019). Activity Patterns in the Neuropil of Striatal Cholinergic Interneurons in Freely Moving Mice Represent Their Collective Spiking Dynamics . eneuro.

Aceves Buendia, J.J., Tiroshi, L., Chiu, W.-H., Goldberg, J.A.(2019). Selective remodeling of glutamatergic transmission to striatal cholinergic interneurons after dopamine depletion . European Journal of Neuroscience. 49. (6). p. 824-833.

Thakur, P., Chiu, W.H., Roeper, J., Goldberg, J.A.(2019). α-Synuclein 2.0 — Moving towards Cell Type Specific Pathophysiology . Neuroscience. 412. p. 248-256.

Rehani, R., Atamna, Y., Tiroshi, L., Chiu, W.-H., Aceves Buendía, J.J., Martins, G.J., Jacobson, G.A., Goldberg, J.A.(2019). Activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics . eNeuro. 6. (1).

Henrich, M.T., Geibl, F.F., Lee, B., Chiu, W.-H., Koprich, J.B., Brotchie, J.M., Timmermann, L., Decher, N., Matschke, L.A., Oertel, W.H.(2018). A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia . Acta neuropathologica communications. 6. (1). p. 39.

Efrat Lasser-Katz, Alon Simchovitz, Wei-Hua Chiu, Wolfgang H. Oertel, Ronit Sharon, Hermona Soreq, Jochen Roeper, Joshua A. Goldberg (2017). Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease . The Journal of Neuroscience.

Efrat Lasser-Katz, Alon Simchovitz, Wei-Hua Chiu, Wolfgang H. Oertel, Ronit Sharon, Hermona Soreq, Jochen Roeper, Joshua A. Goldberg (2017). Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease . The Journal of Neuroscience.

Höllerhage, M., Moebius, C., Melms, J., Chiu, W.-H., Goebel, J.N., Chakroun, T., Koeglsperger, T., Oertel, W.H., Rösler, T.W., Bickle, M., et al.(2017). Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells . Scientific Reports. 7. (1).

Lasser-Katz, E., Simchovitz, A., Chiu, W.-H., Oertel, W.H., Sharon, R., Soreq, H., Roeper, J., Goldberg, J.A.(2017). Mutant α -synuclein overexpression induces stressless pacemaking in vagal motoneurons at risk in parkinson’s disease . Journal of Neuroscience. 37. (1). p. 47-57.

Klietz, M., Keber, U., Carlsson, T., Chiu, W.-H., Höglinger, G.U., Weihe, E., Schäfer, M.K.-H., Depboylu, C.(2016). L-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons . Neuroscience. 331. p. 120-133.

Chiu, W.-H., Depboylu, C., Hermanns, G., Maurer, L., Windolph, A., Oertel, W.H., Ries, V., Höglinger, G.U.(2015). Long-term treatment with l-DOPA or pramipexole affects adult neurogenesis and corresponding non-motor behavior in a mouse model of Parkinson's disease . Neuropharmacology. 95. p. 367-376.

Chiu, W.-H., Carlsson, T., Depboylu, C., Höglinger, G.U., Oertel, W.H., Ries, V.(2014). Selegiline normalizes, while l-DOPA sustains the increased number of dopamine neurons in the olfactory bulb in a 6-OHDA mouse model of Parkinson's disease . Neuropharmacology. 79. p. 212-221.

PREPRINT

Wei-Hua Chiu, Lora Kovacheva, Ruth E. Musgrove, Hadar Arien-Zakay, James B. Koprich, Jonathan M. Brotchie, Rami Yaka, Danny Ben-Zvi, Menachem Hanani, Jochen Roeper, et al. (2019). α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons causes non-motor parkinsonian symptoms .

OTHER

Rehani, R., Atamna, Y., Tiroshi, L., Chiu, W.-H., Aceves Buendía, J.D.J., Martins, G.J., Jacobson, G.A., Goldberg, J.A.(2018). Wave-like activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics . bioRxiv.

BOOK

Arias-Carrión, O., Yamada, E., Freundlieb, N., Djufri, M., Maurer, L., Hermanns, G., Ipach, B., Chiu, W.-H., Steiner, C., Oertel, W.H., et al.(2009). Neurogenesis in substantia nigra of Parkinsonian brains? . Journal of Neural Transmission, Supplementa. (73). p. 279-285.