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Hire Vladimir F.

Czech Republic

USD 40 /hr

Drug discovery chemist skilled in SAR analysis, metabolic optimization, and molecular design

Profile Summary

I am a medicinal chemist with a passion for translating chemical ideas into real therapeutic opportunities. My background combines synthetic organic chemistry, drug design, and biological insight, enabling me to approach problems holistically—from concept to synthesis and functional validation. I focus on the discovery and optimization of antimicrobial agents, with a strong emphasis on structure–activity relationship (SAR) expansion, metabolic stability improvement, and the design of synthetically feasible small molecules. Over the past years, I have contributed to multiple preclinical discovery projects targeting key mycobacterial transporters such as MmpL3 and DprE1, where I applied integrated medicinal chemistry and in silico modeling to design and refine novel scaffolds with enhanced potency and drug-like properties. My experience also includes developing derivatization methods for the detection of chemical warfare agent degradation products and designing fluorophores for advanced material applications. I bring a practical mindset to molecular design — always considering synthetic accessibility, precursor availability, and downstream scalability. Beyond laboratory work, I have strong experience in early-stage research ideation, proposal writing, and project management, with a track record of successfully initiating and leading grant-funded studies. I am skilled in advanced scientific visualization using ChemDraw and BioRender, which I use to communicate complex ideas effectively and align interdisciplinary teams around shared project goals. My approach combines creativity, analytical precision, and strategic thinking, aimed at transforming promising molecular concepts into viable, high-value assets for research and development.

Subject Matter Expertise

• ☆ Organic Chemistry
• ☆ Retrosynthesis
• ☆ Drug Discovery
• ☆ Medicinal Chemistry
• ☆ Pulmonology/Respiratory Disease
• ☆ Tuberculosis

Services

• Writing
• Research
• Consulting

Writing General Proofreading & Editing

Research Feasibility Study, Technology Scouting, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Work Experience

Research Scientist

Charles University in Prague

January 2024 - Present

Research Scientist

University Hospital Hradec Králové

January 2020 - Present

Postdoc (visiting)

University of Ljubljana

September 2025 - December 2025

PhD visiting student

Kings College London

March 2021 - September 2021

Education

Ph.D., Chemistry

Charles University Prague - Czech Republic

January 2025 - January 2025

M.Sc (Master of Science)

University of Pardubice - Czech Republic

September 2017 - June 2019

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Vladimir Finger, Ondrej Kovar, Martin Kufa, Ondrej Soukup, Martin Kratky, Carilyn Torruellas, Jaroslav Roh, Jan Korabecny (2025). Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies . Journal of Medicinal Chemistry.

Vladimir Finger, Martin Vrbicky, Lubica Muckova, Lukas Prchal, Martin Novak, Jan Marek, Ondrej Soukup, Michaela Hympanova, Ales Sorf, Marketa Benkova, et al. (2025). Novel antitubercular agents based on 2,4-disubstituted 5-(aryl-2-ylmethyl)-5H-pyrrolo[3,2-d]pyrimidines . Biomedicine & Pharmacotherapy.

Vladimir Finger, Jakub Opravil, Jaroslav Pejchal, Jan Korabecny, Tomas Rozsypal, Martina Hrabinova, Lubica Muckova, Vendula Hepnarova, Jan Konecny, Ondrej Soukup, et al. (2023). A-agents, misleadingly known as “Novichoks”: a narrative review . Archives of Toxicology.

Vladimir Finger, Barbora Svobodova, Lenka Pulkrabkova, Dawid Panek, Anna Misiachna, Marharyta Kolcheva, Rudolf Andrys, Jiri Handl, Jan Capek, Pavlina Nyvltova, et al. (2023). Structure-Guided Design of <i>N</i>-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer’s Disease . International Journal of Molecular Sciences.

PREPRINT

Vladimir Finger, Barbora Svobodova, Zuzana Moravcova, Anna Misiachna, Gabriela Novakova, Ales Marek, Jitka Odvarkova, Jaroslav Pejchal, Jana Karasova Zdarova, Jakub Netolicky, et al. (2025). Novel Tacrine-Based Compounds: Bridging Cholinesterase Inhibition and NMDAR Antagonism .