Profile Details

Create Project

★★★★★

☆☆☆☆☆

USD 100 /hr

★★★★★

☆☆☆☆☆

Hire {0}. {1}

United States

USD 100 /hr

Biomedical Researcher With 20+ Years of Experince

Profile Summary

I was born in India and obtained my Master of Science (MS) and Doctor of Philosophy (PhD) degree in Chemistry from University of Allahabad (allduniv.ac.in), Allahabad, India. I worked as a Research Associate in the Molecular Biophysics Unit of the Indian Institute of Science (mbu.iisc.ac.in), Bangalore, India, before my family and I moved to the United States in 1992 when I accepted a postdoctoral position in the Atherosclerosis Research Unit, Department of Medicine, UAB Medical Center (www.uab.edu), Birmingham, AL. I worked as a Research Assistant Professor in the Department of Medicine, UAB, from 1996 - 2001. In 2001, I accepted a position of Special Projects Manager in a biotechnology company specializing in antibodies. I returned to UAB in 2006 as an Assistant Professor in the Department of Medicine, UAB. I started teaching Chemistry in 2013 and joined Snead State Community College (SSCC) (www.snead.edu) as Chemistry Instructor in 2014. At SSCC, I teach both traditional as well as online Chemistry courses. My research experience includes studies of peptides, proteins, lipids, apolipoproteins, lipoproteins, and antibodies, using biochemical and biophysical methods and molecular modeling. Since 1992, I have authored and published 48 peer reviewed articles in high quality scientific Journals and two book chapters. Web of Science Researcher ID: S-1151-2019 ORCID ID: 0000-0002-4527-1512 Google Scholar: https://scholar.google.com/citations?user=SMVF-rMAAAAJ&hl=en&oi=ao ResearchGate: https://www.researchgate.net/profile/Vinod-Mishra-3

Subject Matter Expertise

• ★ Separation & Purification
• ★ Science Education
• ★ Liposomes
• ☆ Molecular Modeling
• ☆ Structural Biology
• ☆ Lipidomics
• ☆ Biophysics
• ☆ Bioinformatics
• ☆ Antibody Engineering

Services

• Writing
• Research
• Consulting
• Product Development

Work Experience

Instructor

Snead State Community College

2014 - Present

Assistant Professor

University of Alabama School of Medicine

2005 - 2013

Manager Special Projects

Southern Biotechnolgy Associates

2001 - 2005

Education

D.Phil. (Chemistry)

University of Allahabad

1983 - 1987

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Yang, Y., Mishra, V., Crasto, C.J., Chen, M., Dimmitt, R., Harmon, C.M.(2015). Third transmembrane domain of the Adrenocorticotropic Receptor Is Critical for Ligand Selectivity and Potency . Journal of Biological Chemistry. 290. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7685-7692.

Sharifov, O.F., Xu, X., Gaggar, A., Grizzle, W.E., Mishra, V.K., Honavar, J., Litovsky, S.H., Palgunachari, M.N., White, C.R., Anantharamaiah, G.M., et al.(2013). Anti-Inflammatory Mechanisms of Apolipoprotein A-I Mimetic Peptide in Acute Respiratory Distress Syndrome Secondary to Sepsis . PLoS ONE. 8. (5).

Sharifov, O.F., Nayyar, G., Ternovoy, V.V., Mishra, V.K., Litovsky, S.H., Palgunachari, M.N., Garber, D.W., Anantharamaiah, G.M., Gupta, H.(2013). Cationic peptide mR18L with lipid lowering properties inhibits LPS-induced systemic and liver inflammation in rats . Biochemical and Biophysical Research Communications. 436. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 705-710.

Mishra, V.K., Palgunachari, M.N., McPherson, D.T., Anantharamaiah, G.M.(2013). Lipid complex of apolipoprotein A-I mimetic peptide 4F is a novel platform for paraoxonase-1 binding and enhancing its activity and stability . Biochemical and Biophysical Research Communications. 430. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 975-980.

Yang, Y., Mishra, V.K., Chen, M., Duffee, E., Dimmitt, R., Harmon, C.M.(2013). Molecular characterization of human melanocortin-5 receptor ligand-receptor interaction . Biochemistry. 52. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1737-1745.

Handattu, S.P., Nayyar, G., Garber, D.W., Palgunachari, M.N., Monroe, C.E., Keenum, T.D., Mishra, V.K., Datta, G., Anantharamaiah, G.M.(2013). Two apolipoprotein E mimetic peptides with similar cholesterol reducing properties exhibit differential atheroprotective effects in LDL-R null mice . Atherosclerosis. 227. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 58-64.

Singh, S.K., Thirumalai, A., Hammond Jr., D.J., Pangburn, M.K., Mishra, V.K., Johnson, D.A., Rusiñol, A.E., Agrawal, A.(2012). Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis . Journal of Biological Chemistry. 287. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3550-3558.

Gang, T.B., Hammond Jr., D.J., Singh, S.K., Ferguson Jr., D.A., Mishra, V.K., Agrawal, A.(2012). The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection . Journal of Biological Chemistry. 287. (51). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 43116-43125.

Nayyar, G., Garber, D.W., Palgunachari, M.N., Monroe, C.E., Keenum, T.D., Handattu, S.P., Mishra, V.K., Anantharamaiah, G.M.(2012). Apolipoprotein E mimetic is more effective than apolipoprotein A-I mimetic in reducing lesion formation in older female apo E null mice . Atherosclerosis. 224. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 326-331.

Nayyar, G., Mishra, V.K., Handattu, S.P., Palgunachari, M.N., Shin, R., McPherson, D.T., Deivanayagam, C.C.S., Garber, D.W., Segrest, J.P., Anantharamaiah, G.M.(2012). Sidedness of interfacial arginine residues and anti-atherogenicity of apolipoprotein A-I mimetic peptides . Journal of Lipid Research. 53. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 849-858.

Mishra, V.K., Palgunachari, M.N., Hudson, J.S., Shin, R., Keenum, T.D., Krishna, N.R., Anantharamaiah, G.M.(2011). Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G* apolipoprotein J peptide using solution NMR . Biochimica et Biophysica Acta - Biomembranes. 1808. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 498-507.

Yang, Y., Chen, M., McPherson, D., Mishra, V., Harmon, C.M.(2011). Structural insight into the role of the human melanocortin 3 receptor cysteine residues on receptor function . Peptides. 32. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2377-2383.

Sharifov, O.F., Nayyar, G., Garber, D.W., Handattu, S.P., Mishra, V.K., Goldberg, D., Anantharamaiah, G.M., Gupta, H.(2011). Apolipoprotein E mimetics and cholesterol-lowering properties . American Journal of Cardiovascular Drugs. 11. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 371-381.

Nayyar, G., Handattu, S.P., Monroe, C.E., Chaddha, M., Datta, G., Mishra, V.K., Keenum, T.D., Palgunachari, M.N., Garber, D.W., Anantharamaiah, G.M.(2010). Two adjacent domains (141-150 and 151-160) of apoE covalently linked to a class A amphipathic helical peptide exhibit opposite atherogenic effects . Atherosclerosis. 213. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 449-457.

Handattu, S.P., Datta, G., Epand, R.M., Epand, R.F., Palgunachari, M.N., Mishra, V.K., Monroe, C.E., Keenum, T.D., Chaddha, M., Anantharamaiah, G.M., et al.(2010). Oral administration of L-mR18L, a single domain cationic amphipathic helical peptide, inhibits lesion formation in ApoE null mice . Journal of Lipid Research. 51. (12). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 3491-3499.

Epand, R.F., Mishra, V.K., Palgunachari, M.N., Anantharamaiah, G.M., Epand, R.M.(2009). Anti-inflammatory peptides grab on to the whiskers of atherogenic oxidized lipids . Biochimica et Biophysica Acta - Biomembranes. 1788. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1967-1975.

Shin, R., Welch, D.R., Mishra, V.K., Nash, K.T., Hurst, D.R., Rama Krishna, N.(2009). Nuclear magnetic resonance and circular dichroism study of metastin (Kisspeptin-54) structure in solution . Clinical and Experimental Metastasis. 26. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 527-533.

Mishra, V.K., Palgunachari, M.N., Krishna, N.R., Glushka, J., Segrest, J.P., Anantharamaiah, G.M.(2008). Effect of leucine to phenylalanine substitution on the nonpolar face of a class A amphipathic helical peptide on its interaction with lipid: High resolution solution NMR studies of 4F-dimyristoylphosphatidylcholine discoidal complex . Journal of Biological Chemistry. 283. (49). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 34393-34402.

White, C.R., Datta, G., White, C.R., Datta, G., Zhang, Z., Gupta, H., Garber, D.W., Mishra, V.K., Palgunachari, M.N., Handattu, S.P., et al.(2008). HDL therapy for cardiovascular diseases: The road to HDL mimetics . Current Atherosclerosis Reports. 10. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 405-412.

Anantharamaiah, G.M., Mishra, V.K., Garber, D.W., Datta, G., Handattu, S.P., Palgunachari, M.N., Chaddha, M., Navab, M., Reddy, S.T., Segrest, J.P., et al.(2007). Structural requirements for antioxidative and anti-inflammatory properties of apolipoprotein A-I mimetic peptides . Journal of Lipid Research. 48. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1915-1923.

Handattu, S.P., Garber, D.W., Horn, D.C., Hughes, D.W., Berno, B., Bain, A.D., Mishra, V.K., Palgunachari, M.N., Datta, G., Anantharamaiah, G.M., et al.(2007). ApoA-I mimetic peptides with differing ability to inhibit atherosclerosis also exhibit differences in their interactions with membrane bilayers . Journal of Biological Chemistry. 282. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1980-1988.

Anantharamaiah, G.M., Navab, M., Reddy, S.T., Garber, D.W., Datta, G., Gupta, H., White, C.R., Handattu, S.P., Palgunachari, M.N., Chaddha, M., et al.(2006). Synthetic peptides: Managing lipid disorders . Current Opinion in Lipidology. 17. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 233-237.

Mishra, V.K., Anantharamaiah, G.M., Segrest, J.P., Palgunachari, M.N., Chaddha, M., Sham, S.W.S., Krishna, N.R.(2006). Association of a model class A (apolipoprotein) amphipathic α helical peptide with lipid: High resolution NMR studies of peptide-lipid discoidal complexes . Journal of Biological Chemistry. 281. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 6511-6519.

Garber, D.W., Handattu, S.P., Datta, G., Mishra, V.K., Gupta, H., White, C.R., Anantharamaiah, G.M.(2006). Atherosclerosis and vascular disease: Effects of peptide mimetics of apolilpoproteins . Current Pharmaceutical Biotechnology. 7. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 235-240.

Ajees, A.A., Anantharamaiah, G.M., Mishra, V.K., Hussain, M.M., Murthy, H.M.K.(2006). Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases . Proceedings of the National Academy of Sciences of the United States of America. 103. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2126-2131.

Navab, M., Anantharamaiah, G.M., Reddy, S.T., Hama, S., Hough, G., Frank, J.S., Grijalva, V.R., Ganesh, V.K., Mishra, V.K., Palgunachari, M.N., et al.(2005). Oral small peptides render HDL antiinflammatory in mice and monkeys and reduce atherosclerosis in ApoE null mice . Circulation Research. 97. (6). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 524-532.

Navab, M., Anantharamaiah, G.M., Reddy, S.T., Van Lenten, B.J., Wagner, A.C., Hama, S., Hough, G., Bachini, E., Garber, D.W., Mishra, V.K., et al.(2005). An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice . Arteriosclerosis, Thrombosis, and Vascular Biology. 25. (9). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1932-1937.

Gupta, H., Dai, L., Datta, G., Garber, D.W., Grenett, H., Li, Y., Mishra, V., Palgunachari, M.N., Handattu, S., Gianturco, S.H., et al.(2005). Inhibition of lipopolysaccharide-induced inflammatory responses by an apolipoprotein AI mimetic peptide . Circulation Research. 97. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 236-243.

Li, L., Chen, J., Mishra, V.K., Kurtz, J.A., Cao, D., Klon, A.E., Harvey, S.C., Anantharamaiah, G.M., Segrest, J.P.(2004). Double belt structure of discoidal high density lipoproteins: Molecular basis for size heterogeneity . Journal of Molecular Biology. 343. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1293-1311.

Mishra, V.K., Palgunachari, M.N., Anantharamaiah, G.M., Jones, M.K., Segrest, J.P., Krishna, N.R.(2001). Solution NMR structure of a model class A (apolipoprotein) amphipathic α helical peptide . Peptides. 22. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 567-573.

Datta, G., Chaddha, M., Hama, S., Navab, M., Fogelman, A.M., Garber, D.W., Mishra, V.K., Epand, R.M., Epand, R.F., Lund-Katz, S., et al.(2001). Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide . Journal of Lipid Research. 42. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1096-1104.

Hristova, K., Wimley, W.C., Mishra, V.K., Anantharamiah, G.M., Segrest, J.P., White, S.H.(1999). An amphipathic α-helix at a membrane interface: A structural study using a novel X-ray diffraction method . Journal of Molecular Biology. 290. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 99-117.

Segrest, J.P., Jones, M.K., Mishra, V.K., Pierotti, V., Young, S.H., Borén, J., Innerarity, T.L., Dashti, N.(1998). Apolipoprotein B-100: Conservation of lipid-associating amphipathic secondary structural motifs in nine species of vertebrates . Journal of Lipid Research. 39. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 85-102.

Karle, I.L., Perozzo, M.A., Mishra, V.K., Balaram, P.(1998). Crystal structure of the channel-forming polypeptide antiamoebin in a membrane-mimetic environment . Proceedings of the National Academy of Sciences of the United States of America. 95. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5501-5504.

Mishra, V.K., Palgunachari, M.N., Datta, G., Phillips, M.C., Lund-Katz, S., Adeyeye, S.O., Segrest, J.P., Anantharamaiah, G.M., Mishra, V.K., Palgunachari, M.N., et al.(1998). Studies of synthetic peptides of human apolipoprotein A-I containing tandem amphipathic α-helixes . Biochemistry. 37. (28). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 10313-10324.

Polozov, I.V., Polozova, A.I., Mishra, V.K., Anantharamaiah, G.M., Segrest, J.P., Epand, R.M.(1998). Studies of kinetics and equilibrium membrane binding of class A and class L model amphipathic peptides . Biochimica et Biophysica Acta - Biomembranes. 1368. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 343-354.

Rogers, D.P., Brouillette, C.G., Engler, J.A., Tendian, S.W., Roberts, L., Mishra, V.K., Anantharamaiah, G.M., Lund-Katz, S., Phillips, M.C., Ray, M.J.(1997). Truncation of the amine terminus of human apolipoprotein A-I substantially alters only the lipid-free conformation . Biochemistry. 36. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 288-300.

Mishra, V.K., Palgunachari, M.N.(1996). Interaction of model class A1, class A2, and class Y amphipathic helical peptides with membranes . Biochemistry. 35. (34). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 11210-11220.

Palgunachari, M.N., Mishra, V.K., Lund-Katz, S., Phillips, M.C., Adeyeye, S.O., Alluri, S., Anantharamaiah, G.M., Segrest, J.P.(1996). Only the two end helixes of eight tandem amphipathic helical domains of human Apo A-I have significant lipid affinity: Implications for HDL assembly . Arteriosclerosis, Thrombosis, and Vascular Biology. 16. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 328-338.

Chung, B.H., Palgunachari, M.N., Mishra, V.K., Chang, C.H., Segrest, J.P., Anantharamaiah, G.M.(1996). Probing structure and function of VLDL by synthetic amphipathic helical peptides . Journal of Lipid Research. 37. (5). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1099-1112.

Mishra, V.K., Palgunachari, M.N., Lund-Katz, S., Phillips, M.C., Segrest, J.P., Anantharamaiah, G.M.(1995). Effect of the arrangement of tandem repeating units of class A amphipathic α-helixes on lipid interaction . Journal of Biological Chemistry. 270. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1602-1611.

Lund-Katz, S., Phillips, M.C., Mishra, V.K., Segrest, J.P., Anantharamaiah, G.M.(1995). Microenvironments of Basic Amino Acids in Amphipathic a-Helices Bound to Phospholipid: ¹³C NMR Studies Using Selectively Labeled Peptides . Biochemistry. 34. (28). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 9219-9226.

Tytler, E.M., Anantharamaiah, G.M., Walker, D.E., Mishra, V.K., Palgunachari, M.N., Segrest, J.P.(1995). Molecular Basis for Prokaryotic Specificity of Magainin-Induced Lysis . Biochemistry. 34. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 4393-4401.

Mishra, V.K., Palgunachari, M.N., Segrest, J.P., Anantharamaiah, G.M.(1994). Interactions of synthetic peptide analogs of the class A amphipathic helix with lipids. Evidence for the snorkel hypothesis . Journal of Biological Chemistry. 269. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 7185-7191.

Segrest, J.P., Jones, M.K., Mishra, V.K., Anantharamaiah, G.M., Garber, D.W.(1994). ApoB-100 has a pentapartite structure composed of three amphipathic α-helical domains alternating with two amphipathic β-strand domains: Detection by the computer program LOCATE . Arteriosclerosis, Thrombosis, and Vascular Biology. 14. (10). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1674-1685.

Tytler, E.M., Segrest, J.P., Epand, R.M., Nie, S.-Q., Tytler, E.M., Segrest, J.P., Epand, R.M., Nie, S.-Q., Epand, R.F., Mishra, V.K., et al.(1993). Reciprocal effects of apolipoprotein and lytic peptide analogs on membranes. Cross-sectional molecular shapes of amphipathic α helixes control membrane stability . Journal of Biological Chemistry. 268. (29). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 22112-22118.

Sainani, M.N., Gupta, V.S., Mishra, V.K., Sainani, M.N., Gupta, V.S., Mishra, V.K., Lachke, A.H., Ranjekar, P.K., Pillay, D.T.N.(1993). Effect of chemical modification on some structural and functional properties of pennisetin, a major seed storage protein from pearl millet . Phytochemistry. 34. (4). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 919-925.

Sainani, M.N., Mishra, V.K., Gupta, V.S., Ranjekar, P.K.(1992). Circular dichroism and ¹³C nuclear magnetic resonance spectroscopy of pennisetin from pearl millet . Plant Science. 83. (1). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 15-22.

CONFERENCE PAPER

Wake, A.K., Datta, G., Palgunachari, M.N., Mishra, V.K., Anantharamaiah, G.M., White, C.R.(2009). Apolipoprotein A-I mimetic peptide retains function after oxidant exposure . Proceedings of the ASME Summer Bioengineering Conference, SBC2008. (PART A). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 171-172.

BOOK

Segrest, J.P., Jones, M.K., Mishra, V.K., Anantharamaiah, G.M.(2002). Experimental and computational studies of the interactions of amphipathic peptides with lipid surfaces . Current Topics in Membranes. 52. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 397-435.