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Hire Dr. Vinod M.

United States

USD 100 /hr

Biomedical Researcher With 20+ Years of Experince

Profile Summary

I was born in India and obtained my Master of Science (MS) and Doctor of Philosophy (PhD) degree in Chemistry from University of Allahabad (allduniv.ac.in), Allahabad, India. I worked as a Research Associate in the Molecular Biophysics Unit of the Indian Institute of Science (mbu.iisc.ac.in), Bangalore, India, before my family and I moved to the United States in 1992 when I accepted a postdoctoral position in the Atherosclerosis Research Unit, Department of Medicine, UAB Medical Center (www.uab.edu), Birmingham, AL. I worked as a Research Assistant Professor in the Department of Medicine, UAB, from 1996 - 2001. In 2001, I accepted a position of Special Projects Manager in a biotechnology company specializing in antibodies. I returned to UAB in 2006 as an Assistant Professor in the Department of Medicine, UAB. I started teaching Chemistry in 2013 and joined Snead State Community College (SSCC) (www.snead.edu) as Chemistry Instructor in 2014. At SSCC, I teach both traditional as well as online Chemistry courses. My research experience includes studies of peptides, proteins, lipids, apolipoproteins, lipoproteins, and antibodies, using biochemical and biophysical methods and molecular modeling. Since 1992, I have authored and published 48 peer reviewed articles in high quality scientific Journals and two book chapters. Web of Science Researcher ID: S-1151-2019 ORCID ID: 0000-0002-4527-1512 Google Scholar: https://scholar.google.com/citations?user=SMVF-rMAAAAJ&hl=en&oi=ao ResearchGate: https://www.researchgate.net/profile/Vinod-Mishra-3

Subject Matter Expertise

• ★ Chemistry
• ★ Separation & Purification
• ★ Protein/Enzyme Engineering
• ☆ Molecular Modeling
• ☆ Structural Biology
• ☆ Lipidomics
• ☆ Biophysics
• ☆ Bioinformatics
• ☆ Antibody Engineering
• ☆ Science Education
• ☆ Liposomes

Services

• Writing
• Research
• Consulting
• Product Development

Work Experience

Instructor

Snead State Community College

2014 - Present

Assistant Professor

University of Alabama School of Medicine

2005 - 2013

Manager Special Projects

Southern Biotechnolgy Associates

2001 - 2005

Education

D.Phil. (Chemistry)

University of Allahabad

1983 - 1987

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Yang, Y., Mishra, V., Crasto, C.J., Chen, M., Dimmitt, R., Harmon, C.M.(2015). Third transmembrane domain of the Adrenocorticotropic Receptor Is Critical for Ligand Selectivity and Potency . Journal of Biological Chemistry. 290. (12). p. 7685-7692.

Sharifov, O.F., Xu, X., Gaggar, A., Grizzle, W.E., Mishra, V.K., Honavar, J., Litovsky, S.H., Palgunachari, M.N., White, C.R., Anantharamaiah, G.M., et al.(2013). Anti-Inflammatory Mechanisms of Apolipoprotein A-I Mimetic Peptide in Acute Respiratory Distress Syndrome Secondary to Sepsis . PLoS ONE. 8. (5).

Sharifov, O.F., Nayyar, G., Ternovoy, V.V., Mishra, V.K., Litovsky, S.H., Palgunachari, M.N., Garber, D.W., Anantharamaiah, G.M., Gupta, H.(2013). Cationic peptide mR18L with lipid lowering properties inhibits LPS-induced systemic and liver inflammation in rats . Biochemical and Biophysical Research Communications. 436. (4). p. 705-710.

Mishra, V.K., Palgunachari, M.N., McPherson, D.T., Anantharamaiah, G.M.(2013). Lipid complex of apolipoprotein A-I mimetic peptide 4F is a novel platform for paraoxonase-1 binding and enhancing its activity and stability . Biochemical and Biophysical Research Communications. 430. (3). p. 975-980.

Yang, Y., Mishra, V.K., Chen, M., Duffee, E., Dimmitt, R., Harmon, C.M.(2013). Molecular characterization of human melanocortin-5 receptor ligand-receptor interaction . Biochemistry. 52. (10). p. 1737-1745.

Handattu, S.P., Nayyar, G., Garber, D.W., Palgunachari, M.N., Monroe, C.E., Keenum, T.D., Mishra, V.K., Datta, G., Anantharamaiah, G.M.(2013). Two apolipoprotein E mimetic peptides with similar cholesterol reducing properties exhibit differential atheroprotective effects in LDL-R null mice . Atherosclerosis. 227. (1). p. 58-64.

Singh, S.K., Thirumalai, A., Hammond Jr., D.J., Pangburn, M.K., Mishra, V.K., Johnson, D.A., Rusiñol, A.E., Agrawal, A.(2012). Exposing a hidden functional site of C-reactive protein by site-directed mutagenesis . Journal of Biological Chemistry. 287. (5). p. 3550-3558.

Gang, T.B., Hammond Jr., D.J., Singh, S.K., Ferguson Jr., D.A., Mishra, V.K., Agrawal, A.(2012). The phosphocholine-binding pocket on C-reactive protein is necessary for initial protection of mice against pneumococcal infection . Journal of Biological Chemistry. 287. (51). p. 43116-43125.

Nayyar, G., Garber, D.W., Palgunachari, M.N., Monroe, C.E., Keenum, T.D., Handattu, S.P., Mishra, V.K., Anantharamaiah, G.M.(2012). Apolipoprotein E mimetic is more effective than apolipoprotein A-I mimetic in reducing lesion formation in older female apo E null mice . Atherosclerosis. 224. (2). p. 326-331.

Nayyar, G., Mishra, V.K., Handattu, S.P., Palgunachari, M.N., Shin, R., McPherson, D.T., Deivanayagam, C.C.S., Garber, D.W., Segrest, J.P., Anantharamaiah, G.M.(2012). Sidedness of interfacial arginine residues and anti-atherogenicity of apolipoprotein A-I mimetic peptides . Journal of Lipid Research. 53. (5). p. 849-858.

Mishra, V.K., Palgunachari, M.N., Hudson, J.S., Shin, R., Keenum, T.D., Krishna, N.R., Anantharamaiah, G.M.(2011). Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G* apolipoprotein J peptide using solution NMR . Biochimica et Biophysica Acta - Biomembranes. 1808. (1). p. 498-507.

Yang, Y., Chen, M., McPherson, D., Mishra, V., Harmon, C.M.(2011). Structural insight into the role of the human melanocortin 3 receptor cysteine residues on receptor function . Peptides. 32. (12). p. 2377-2383.

Sharifov, O.F., Nayyar, G., Garber, D.W., Handattu, S.P., Mishra, V.K., Goldberg, D., Anantharamaiah, G.M., Gupta, H.(2011). Apolipoprotein E mimetics and cholesterol-lowering properties . American Journal of Cardiovascular Drugs. 11. (6). p. 371-381.

Nayyar, G., Handattu, S.P., Monroe, C.E., Chaddha, M., Datta, G., Mishra, V.K., Keenum, T.D., Palgunachari, M.N., Garber, D.W., Anantharamaiah, G.M.(2010). Two adjacent domains (141-150 and 151-160) of apoE covalently linked to a class A amphipathic helical peptide exhibit opposite atherogenic effects . Atherosclerosis. 213. (2). p. 449-457.

Handattu, S.P., Datta, G., Epand, R.M., Epand, R.F., Palgunachari, M.N., Mishra, V.K., Monroe, C.E., Keenum, T.D., Chaddha, M., Anantharamaiah, G.M., et al.(2010). Oral administration of L-mR18L, a single domain cationic amphipathic helical peptide, inhibits lesion formation in ApoE null mice . Journal of Lipid Research. 51. (12). p. 3491-3499.

Epand, R.F., Mishra, V.K., Palgunachari, M.N., Anantharamaiah, G.M., Epand, R.M.(2009). Anti-inflammatory peptides grab on to the whiskers of atherogenic oxidized lipids . Biochimica et Biophysica Acta - Biomembranes. 1788. (9). p. 1967-1975.

Shin, R., Welch, D.R., Mishra, V.K., Nash, K.T., Hurst, D.R., Rama Krishna, N.(2009). Nuclear magnetic resonance and circular dichroism study of metastin (Kisspeptin-54) structure in solution . Clinical and Experimental Metastasis. 26. (6). p. 527-533.

Mishra, V.K., Palgunachari, M.N., Krishna, N.R., Glushka, J., Segrest, J.P., Anantharamaiah, G.M.(2008). Effect of leucine to phenylalanine substitution on the nonpolar face of a class A amphipathic helical peptide on its interaction with lipid: High resolution solution NMR studies of 4F-dimyristoylphosphatidylcholine discoidal complex . Journal of Biological Chemistry. 283. (49). p. 34393-34402.

White, C.R., Datta, G., White, C.R., Datta, G., Zhang, Z., Gupta, H., Garber, D.W., Mishra, V.K., Palgunachari, M.N., Handattu, S.P., et al.(2008). HDL therapy for cardiovascular diseases: The road to HDL mimetics . Current Atherosclerosis Reports. 10. (5). p. 405-412.

Anantharamaiah, G.M., Mishra, V.K., Garber, D.W., Datta, G., Handattu, S.P., Palgunachari, M.N., Chaddha, M., Navab, M., Reddy, S.T., Segrest, J.P., et al.(2007). Structural requirements for antioxidative and anti-inflammatory properties of apolipoprotein A-I mimetic peptides . Journal of Lipid Research. 48. (9). p. 1915-1923.

Handattu, S.P., Garber, D.W., Horn, D.C., Hughes, D.W., Berno, B., Bain, A.D., Mishra, V.K., Palgunachari, M.N., Datta, G., Anantharamaiah, G.M., et al.(2007). ApoA-I mimetic peptides with differing ability to inhibit atherosclerosis also exhibit differences in their interactions with membrane bilayers . Journal of Biological Chemistry. 282. (3). p. 1980-1988.

Anantharamaiah, G.M., Navab, M., Reddy, S.T., Garber, D.W., Datta, G., Gupta, H., White, C.R., Handattu, S.P., Palgunachari, M.N., Chaddha, M., et al.(2006). Synthetic peptides: Managing lipid disorders . Current Opinion in Lipidology. 17. (3). p. 233-237.

Mishra, V.K., Anantharamaiah, G.M., Segrest, J.P., Palgunachari, M.N., Chaddha, M., Sham, S.W.S., Krishna, N.R.(2006). Association of a model class A (apolipoprotein) amphipathic α helical peptide with lipid: High resolution NMR studies of peptide-lipid discoidal complexes . Journal of Biological Chemistry. 281. (10). p. 6511-6519.

Garber, D.W., Handattu, S.P., Datta, G., Mishra, V.K., Gupta, H., White, C.R., Anantharamaiah, G.M.(2006). Atherosclerosis and vascular disease: Effects of peptide mimetics of apolilpoproteins . Current Pharmaceutical Biotechnology. 7. (4). p. 235-240.

Ajees, A.A., Anantharamaiah, G.M., Mishra, V.K., Hussain, M.M., Murthy, H.M.K.(2006). Crystal structure of human apolipoprotein A-I: Insights into its protective effect against cardiovascular diseases . Proceedings of the National Academy of Sciences of the United States of America. 103. (7). p. 2126-2131.

Navab, M., Anantharamaiah, G.M., Reddy, S.T., Hama, S., Hough, G., Frank, J.S., Grijalva, V.R., Ganesh, V.K., Mishra, V.K., Palgunachari, M.N., et al.(2005). Oral small peptides render HDL antiinflammatory in mice and monkeys and reduce atherosclerosis in ApoE null mice . Circulation Research. 97. (6). p. 524-532.

Navab, M., Anantharamaiah, G.M., Reddy, S.T., Van Lenten, B.J., Wagner, A.C., Hama, S., Hough, G., Bachini, E., Garber, D.W., Mishra, V.K., et al.(2005). An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice . Arteriosclerosis, Thrombosis, and Vascular Biology. 25. (9). p. 1932-1937.

Gupta, H., Dai, L., Datta, G., Garber, D.W., Grenett, H., Li, Y., Mishra, V., Palgunachari, M.N., Handattu, S., Gianturco, S.H., et al.(2005). Inhibition of lipopolysaccharide-induced inflammatory responses by an apolipoprotein AI mimetic peptide . Circulation Research. 97. (3). p. 236-243.

Li, L., Chen, J., Mishra, V.K., Kurtz, J.A., Cao, D., Klon, A.E., Harvey, S.C., Anantharamaiah, G.M., Segrest, J.P.(2004). Double belt structure of discoidal high density lipoproteins: Molecular basis for size heterogeneity . Journal of Molecular Biology. 343. (5). p. 1293-1311.

Mishra, V.K., Palgunachari, M.N., Anantharamaiah, G.M., Jones, M.K., Segrest, J.P., Krishna, N.R.(2001). Solution NMR structure of a model class A (apolipoprotein) amphipathic α helical peptide . Peptides. 22. (4). p. 567-573.

Datta, G., Chaddha, M., Hama, S., Navab, M., Fogelman, A.M., Garber, D.W., Mishra, V.K., Epand, R.M., Epand, R.F., Lund-Katz, S., et al.(2001). Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide . Journal of Lipid Research. 42. (7). p. 1096-1104.

Hristova, K., Wimley, W.C., Mishra, V.K., Anantharamiah, G.M., Segrest, J.P., White, S.H.(1999). An amphipathic α-helix at a membrane interface: A structural study using a novel X-ray diffraction method . Journal of Molecular Biology. 290. (1). p. 99-117.

Segrest, J.P., Jones, M.K., Mishra, V.K., Pierotti, V., Young, S.H., Borén, J., Innerarity, T.L., Dashti, N.(1998). Apolipoprotein B-100: Conservation of lipid-associating amphipathic secondary structural motifs in nine species of vertebrates . Journal of Lipid Research. 39. (1). p. 85-102.

Karle, I.L., Perozzo, M.A., Mishra, V.K., Balaram, P.(1998). Crystal structure of the channel-forming polypeptide antiamoebin in a membrane-mimetic environment . Proceedings of the National Academy of Sciences of the United States of America. 95. (10). p. 5501-5504.

Mishra, V.K., Palgunachari, M.N., Datta, G., Phillips, M.C., Lund-Katz, S., Adeyeye, S.O., Segrest, J.P., Anantharamaiah, G.M., Mishra, V.K., Palgunachari, M.N., et al.(1998). Studies of synthetic peptides of human apolipoprotein A-I containing tandem amphipathic α-helixes . Biochemistry. 37. (28). p. 10313-10324.

Polozov, I.V., Polozova, A.I., Mishra, V.K., Anantharamaiah, G.M., Segrest, J.P., Epand, R.M.(1998). Studies of kinetics and equilibrium membrane binding of class A and class L model amphipathic peptides . Biochimica et Biophysica Acta - Biomembranes. 1368. (2). p. 343-354.

Rogers, D.P., Brouillette, C.G., Engler, J.A., Tendian, S.W., Roberts, L., Mishra, V.K., Anantharamaiah, G.M., Lund-Katz, S., Phillips, M.C., Ray, M.J.(1997). Truncation of the amine terminus of human apolipoprotein A-I substantially alters only the lipid-free conformation . Biochemistry. 36. (2). p. 288-300.

Mishra, V.K., Palgunachari, M.N.(1996). Interaction of model class A1, class A2, and class Y amphipathic helical peptides with membranes . Biochemistry. 35. (34). p. 11210-11220.

Palgunachari, M.N., Mishra, V.K., Lund-Katz, S., Phillips, M.C., Adeyeye, S.O., Alluri, S., Anantharamaiah, G.M., Segrest, J.P.(1996). Only the two end helixes of eight tandem amphipathic helical domains of human Apo A-I have significant lipid affinity: Implications for HDL assembly . Arteriosclerosis, Thrombosis, and Vascular Biology. 16. (2). p. 328-338.

Chung, B.H., Palgunachari, M.N., Mishra, V.K., Chang, C.H., Segrest, J.P., Anantharamaiah, G.M.(1996). Probing structure and function of VLDL by synthetic amphipathic helical peptides . Journal of Lipid Research. 37. (5). p. 1099-1112.

Mishra, V.K., Palgunachari, M.N., Lund-Katz, S., Phillips, M.C., Segrest, J.P., Anantharamaiah, G.M.(1995). Effect of the arrangement of tandem repeating units of class A amphipathic α-helixes on lipid interaction . Journal of Biological Chemistry. 270. (4). p. 1602-1611.

Lund-Katz, S., Phillips, M.C., Mishra, V.K., Segrest, J.P., Anantharamaiah, G.M.(1995). Microenvironments of Basic Amino Acids in Amphipathic a-Helices Bound to Phospholipid: ¹³C NMR Studies Using Selectively Labeled Peptides . Biochemistry. 34. (28). p. 9219-9226.

Tytler, E.M., Anantharamaiah, G.M., Walker, D.E., Mishra, V.K., Palgunachari, M.N., Segrest, J.P.(1995). Molecular Basis for Prokaryotic Specificity of Magainin-Induced Lysis . Biochemistry. 34. (13). p. 4393-4401.

Mishra, V.K., Palgunachari, M.N., Segrest, J.P., Anantharamaiah, G.M.(1994). Interactions of synthetic peptide analogs of the class A amphipathic helix with lipids. Evidence for the snorkel hypothesis . Journal of Biological Chemistry. 269. (10). p. 7185-7191.

Segrest, J.P., Jones, M.K., Mishra, V.K., Anantharamaiah, G.M., Garber, D.W.(1994). ApoB-100 has a pentapartite structure composed of three amphipathic α-helical domains alternating with two amphipathic β-strand domains: Detection by the computer program LOCATE . Arteriosclerosis, Thrombosis, and Vascular Biology. 14. (10). p. 1674-1685.

Tytler, E.M., Segrest, J.P., Epand, R.M., Nie, S.-Q., Tytler, E.M., Segrest, J.P., Epand, R.M., Nie, S.-Q., Epand, R.F., Mishra, V.K., et al.(1993). Reciprocal effects of apolipoprotein and lytic peptide analogs on membranes. Cross-sectional molecular shapes of amphipathic α helixes control membrane stability . Journal of Biological Chemistry. 268. (29). p. 22112-22118.

Sainani, M.N., Gupta, V.S., Mishra, V.K., Sainani, M.N., Gupta, V.S., Mishra, V.K., Lachke, A.H., Ranjekar, P.K., Pillay, D.T.N.(1993). Effect of chemical modification on some structural and functional properties of pennisetin, a major seed storage protein from pearl millet . Phytochemistry. 34. (4). p. 919-925.

Sainani, M.N., Mishra, V.K., Gupta, V.S., Ranjekar, P.K.(1992). Circular dichroism and ¹³C nuclear magnetic resonance spectroscopy of pennisetin from pearl millet . Plant Science. 83. (1). p. 15-22.

CONFERENCE PAPER

Wake, A.K., Datta, G., Palgunachari, M.N., Mishra, V.K., Anantharamaiah, G.M., White, C.R.(2009). Apolipoprotein A-I mimetic peptide retains function after oxidant exposure . Proceedings of the ASME Summer Bioengineering Conference, SBC2008. (PART A). p. 171-172.

BOOK

Segrest, J.P., Jones, M.K., Mishra, V.K., Anantharamaiah, G.M.(2002). Experimental and computational studies of the interactions of amphipathic peptides with lipid surfaces . Current Topics in Membranes. 52. p. 397-435.