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USD 40 /hr

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Hire Dr. Vijayendar Y.

United Kingdom

USD 40 /hr

Medicinal Chemist with expertise in Computational Drug Design | CNS & TPD

Profile Summary

Ph.D.-level Medicinal Chemist with over 8 years of experience driving discovery programs, with a primary focus on Central Nervous System (CNS) therapeutics. I specialize in the design and development of Targeted Protein Degraders (TPD), offering deep expertise in PROTACs and molecular glue mechanisms to tackle "undruggable" targets. I bridge the gap between traditional synthetic chemistry and cutting-edge computational design. By leveraging AI-driven tools like Reinvent and molecular modeling suites (PyMol, ICM, AutoDock), I streamline the lead optimization process to reduce cycle times and improve compound potency. I am passionate about collaborating across multidisciplinary teams to translate complex biological challenges into viable drug candidates.

Subject Matter Expertise

• ☆ Molecular Modeling
• ☆ Organic Chemistry
• ☆ Drug Discovery
• ☆ High Throughput Screening (HTS)
• ☆ Hit-to-Lead & Lead Optimization
• ☆ Medicinal Chemistry
• ☆ Drug Design
• ☆ Combinatorial Chemistry
• ☆ Structure-Activity Relationship (SAR) Studies
• ☆ Drug Development
• ☆ Small Molecule Drug Development
• ☆ Preclinical ADME/PK/PD
• ☆ Pharmaceutical Management

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing, Copywriting, General Proofreading & Editing

Research Technology Scouting, Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting, Manufacturing Consulting

Data & AI Data Visualization, Data Cleaning, Data Processing

Work Experience

Medicinal Chemistry Lead

Eurofins discovery

December 2025 - Present

Senior Scientist

Eurofins discovery

September 2023 - Present

Senior Scientist

Sygnature Discovery

December 2019 - September 2023

Research Scientist

Symeres BV

January 2018 - November 2019

Education

PhD (Chemistry)

University of Hyderabad

July 2006 - March 2012

PhD

University of Hyderabad

July 2006 - February 2012

Certifications

• Data Science: R Basics

  coursera

  January 2020 - Present

Publications

JOURNAL ARTICLE

Abbas H. K. Al Temimi, Helene I. V. Amatdjais-Groenen, Y. Vijayendar Reddy, Richard H. Blaauw, Hong Guo, Ping Qian, Jasmin Mecinović (2019). The nucleophilic amino group of lysine is central for histone lysine methyltransferase catalysis . Communications Chemistry.

Yali Wang, Y. Vijayendar Reddy, Abbas H. K. Al Temimi, Hanka Venselaar, Frank H. T. Nelissen, Danny C. Lenstra, Jasmin Mecinović (2019). Investigating the active site of human trimethyllysine hydroxylase . Biochemical Journal.

Abbas H. K. Al Temimi, Y. Vijayendar Reddy, Paul B. White, Hong Guo, Ping Qian, Jasmin Mecinović (2017). Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis . Scientific Reports.

Y. Vijayendar Reddy, Abbas H. K. Al Temimi, Paul B. White, Jasmin Mecinović (2017). Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2<i>S</i>,3<i>S</i>)-3-Hydroxy-<i>N</i>^ε-trimethyllysine . Organic Letters.

Y. Vijayendar Reddy, Abbas H. K. Al Temimi, Jasmin Mecinović (2017). Fluorinated trimethyllysine as a¹⁹F NMR probe for trimethyllysine hydroxylase catalysis . Organic &amp; Biomolecular Chemistry.

Abbas H. K. Al Temimi, Bas J. G. E. Pieters, Y. Vijayendar Reddy, Paul B. White, Jasmin Mecinović (2016). Substrate scope for trimethyllysine hydroxylase catalysis . Chemical Communications.

Vijayendar R. Yedulla, Padmanava Pradhan, Lijia Yang, Mahesh K. Lakshman (2015). Cycloaddition of Arynes and Cyclic Enol Ethers as a Platform for Access to Stereochemically Defined 1,2‐Disubstituted Benzocyclobutenes . European Journal of Organic Chemistry.

Mahesh K Lakshman, Manish K Singh, Mukesh Kumar, Raghu Ram Chamala, Vijayender R Yedulla, Domenick Wagner, Evan Leung, Lijia Yang, Asha Matin, Sadia Ahmad (2014). Facile synthesis of 1-alkoxy-1<i>H</i>-benzo- and 7-azabenzotriazoles from peptide coupling agents, mechanistic studies, and synthetic applications . Beilstein Journal of Organic Chemistry.

Dhevalapally B. Ramachary, Chintalapudi Venkaiah, Y. Vijayendar Reddy (2014). High-yielding sequential one-pot synthesis of chiral and achiral α-substituted acrylates via a metal-free reductive coupling reaction . Org. Biomol. Chem.

Dhevalapally B. Ramachary, Y. Vijayendar Reddy (2012). Dienamine Catalysis: An Emerging Technology in Organic Synthesis . European Journal of Organic Chemistry.

Dhevalapally B. Ramachary, Y. Vijayendar Reddy, Atoshi Banerjee, Sharmistha Banerjee (2011). Design, synthesis and biological evaluation of optically pure functionalized spiro[5,5]undecane-1,5,9-triones as HIV-1 inhibitors . Organic &amp; Biomolecular Chemistry.

Dhevalapally B. Ramachary, Y. Vijayendar Reddy (2010). A General Approach to Chiral Building Blocks via Direct Amino Acid-Catalyzed Cascade Three-Component Reductive Alkylations: Formal Total Synthesis of HIV-1 Protease Inhibitors, Antibiotic Agglomerins, Brefeldin A, and (<i>R</i>)-γ-Hexanolide . The Journal of Organic Chemistry.

Dhevalapally B. Ramachary, Chintalapudi Venkaiah, Y. Vijayendar Reddy, Mamillapalli Kishor (2009). Multi-catalysis cascade reactions based on the methoxycarbonylketene platform: diversity-oriented synthesis of functionalized non-symmetrical malonates for agrochemicals and pharmaceuticals . Organic &amp; Biomolecular Chemistry.

Dhevalapally B. Ramachary, Mamillapalli Kishor, Y. Vijayendar Reddy (2008). Development of Pharmaceutical Drugs, Drug Intermediates and Ingredients by Using Direct Organo‐Click Reactions . European Journal of Organic Chemistry.

Dhevalapally B. Ramachary, Y. Vijayendar Reddy, B. Veda Prakash (2008). Double cascade reactions based on the Barbas dienamine platform: highly stereoselective synthesis of functionalized cyclohexanes for cardiovascular agents . Organic &amp; Biomolecular Chemistry.

Dhevalapally B. Ramachary, Y. Vijayendar Reddy, Mamillapalli Kishor (2008). Multi-catalysis reactions: direct organocatalytic sequential one-pot synthesis of highly functionalized cyclopenta[b]chromen-1-ones . Organic &amp; Biomolecular Chemistry.