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Hire Viachaslau B.

United States

USD 35 /hr

Senior Research Chemist at Profusa

Profile Summary

Organic chemist with eight years of research experience in medicinal chemistry, chemical biology and fluorescent sensor development; demonstrated expertise in organic synthesis, purification and characterization of small molecules, oligomers, and conjugates; experienced in biochemistry and molecular biology techniques; demonstrated skills in complex experiment design, data analysis, and documentation in the form of SOP and weekly reports; coordination of collaborative projects and training of junior lab members; advanced two compounds to preclinical animal studies; developed glucose-sensing fluorescent dye that is currently in human trials

Subject Matter Expertise

• ★ Analytical Chemistry
• ★ Organic Chemistry
• ★ Medicinal Chemistry
• ☆ Separation & Purification
• ☆ Molecular Biology
• ☆ Data Analysis
• ☆ Chemical Biology

Services

• Writing
• Research
• Consulting
• Data & AI
• Product Development

Work Experience

Research Chemist

Profusa, Inc

June 2016 - Present

Research associate

The Scripps Research Institute

June 2014 - June 2016

Education

Dr. rer. Nat. (Natural science, Pharmaceutical chemistry)

Friedrich-Alexander-Universität Erlangen-Nürnberg

May 2010 - December 2013

Diploma (Chemistry department)

Belarusian State University

September 2004 - June 2009

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Manglik, A., Manglik, A., Lin, H., Aryal, D.K., McCorvy, J.D., Dengler, D., Corder, G., Levit, A., Kling, R.C., Bernat, V., et al.(2016). Structure-based discovery of opioid analgesics with reduced side effects . Nature. 537. (7619). p. 185-190.

(2016). Development of Photoactivatable Allosteric Modulators for the Chemokine Receptor CXCR3 . ChemMedChem. 11. (6). p. 575-584.

Schmidt, Denis and Bernat, Viachaslau and Brox, Regine and Tschammer, Nuska and Kolb, Peter(2015). Identifying Modulators of CXC Receptors 3 and 4 with Tailored Selectivity Using Multi-Target Docking . ACS Chem. Biol. 10. (3). p. 715--724.

Bernat, Viachaslau and Disney, Matthew D(2015). RNA Structures as Mediators of Neurological Diseases and as Drug Targets . Neuron. 87. (1). p. 28--46. Elsevier

Bernat, V., Disney, M.D.(2015). RNA Structures as Mediators of Neurological Diseases and as Drug Targets . Neuron. 87. (1). p. 28-46.

(2015). Identifying modulators of CXC receptors 3 and 4 with tailored selectivity using multi-target docking . ACS Chemical Biology. 10. (3). p. 715-724.

Bernat, V., Brox, R., Heinrich, M.R., Auberson, Y.P., Tschammer, N.(2015). Ligand-biased and probe-dependent modulation of chemokine receptor CXCR3 signaling by negative allosteric modulators . ChemMedChem. 10. (3). p. 566-574.

Bernat, Viachaslau and Brox, Regine and Heinrich, Markus R. and Auberson, Yves P. and Tschammer, Nuska(2015). Ligand-Biased and Probe-Dependent Modulation of Chemokine Receptor CXCR3 Signaling by Negative Allosteric Modulators . ChemMedChem. 10. p. 566--574.

(2014). Boronic Acids as Probes for Investigation of Allosteric Modulation of the Chemokine Receptor CXCR3 . ACS Chem. Biol. 9. (11). p. 2664--2677.

(2014). Boronic acids as probes for investigation of allosteric modulation of the chemokine receptor CXCR3 . ACS Chemical Biology. 9. (11). p. 2664-2677.

Bernat, Viachaslau and Heinrich, Markus R. and Baumeister, Paul and Buschauer, Armin and Tschammer, Nuska(2012). Synthesis and application of the first radioligand targeting the allosteric binding pocket of chemokine receptor CXCR3 . ChemMedChem. 7. (8). p. 1481--1489.

Bernat, V., Heinrich, M.R., Baumeister, P., Buschauer, A., Tschammer, N.(2012). Synthesis and Application of the First Radioligand Targeting the Allosteric Binding Pocket of Chemokine Receptor CXCR3 . ChemMedChem. 7. (8). p. 1481-1489.