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Hire Dr. Tara D.

United States

USD 200 /hr

Biophysics & Structural Biology Consultant | Cryo-EM & Crystallography | HTS

Profile Summary

Structural biologist and protein biochemist/biophysicist specializing in building and managing gene-to-structure pipelines to enable challenging targets. Experience in hiring, training, and motivating scientific teams and working with external collaborators/CROs to produce results. Academic: 15 publications, 40 depositions in the PDB, prior NIH funding, and a licensing agreement for ~500 expression vectors. Biotech/Pharma: successful scientist, manager, and consultant to pre-clinical and clinical stage companies in the US for 7 years.

Subject Matter Expertise

• ★ Crystallography
• ★ Structural Biology
• ★ Electron Microscopy
• ☆ Analytical Chemistry
• ☆ Biochemistry
• ☆ Biochemical Assays
• ☆ Binding Assays
• ☆ Biophysics
• ☆ Drug Discovery
• ☆ Hit-to-Lead & Lead Optimization

Services

• Writing
• Research
• Consulting

Writing General Proofreading & Editing

Research Feasibility Study, Technology Scouting, Fact Checking, Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Work Experience

Owner

TLDR Consultancy LLC

November 2023 - Present

Head of Strategic Accounts and Protein Science Consulting

NanoImaging Services

March 2021 - December 2023

Sr. Sci., structural biology

Civetta Therapeutics

August 2019 - March 2021

Sr. Sci., x-ray crystallography

Forma Therapeutics (United States)

August 2018 - March 2019

Assistant Professor

Drexel University College of Medicine

2012 - 2018

Postdoctoral fellow, Jurica Lab

University of California Santa Cruz

2009 - 2012

Postdoctoral Fellow, Dhe-Paganon Lab

Structural Genomics Consortium

2005 - 2009

Education

Ph.D.

University of Texas Southwestern Department of Biochemistry

1997 - 2004

B.S.

University of Texas at Austin

1991 - 1996

Certifications

• Certification details not provided.

Publications

REVIEW

Caroline Rajiv, Tara Davis (2018). Structural and Functional Insights into Human Nuclear Cyclophilins . Biomolecules.

JOURNAL ARTICLE

Gustafson, C. L., Parsley, N. C., Asimgil, H., Lee, H. W., Ahlbach, C., Michael, A. K., Xu, H., Williams, O. L., Davis, T. L., Liu, A. C., et al.(2017). A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms . Mol Cell. 66. (4). p. 447-457.e7.

Rajiv, C., Jackson, S. R., Cocklin, S., Eisenmesser, E. Z., Davis, T. L.(2017). The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding . Biochem J. 474. (21). p. 3689-3704.

Williams, P. A., Krug, M. S., McMillan, E. A., Peake, J. D., Davis, T. L., Cocklin, S., Strochlic, T. I.(2016). Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis . Mol Biol Cell. 27. (15). p. 2341-50.

Adams, B. M., Coates, M. N., Jackson, S. R., Jurica, M. S., Davis, T. L.(2015). Nuclear Cyclophilins Impact Spliceosome Assembly and Function In Vitro . Biochem J.

Nguyen, Thanh G., Honson, Nicolette S., Arns, Steven, Davis, Tara L., Dhe-Paganon, Sirano, Kovacic, Suzana, Kumar, Nag S., Pfeifer, Tom A., Young, Robert N.(2014). Development of Fluorescent Substrates and Assays for the Key Autophagy-Related Cysteine Protease Enzyme, ATG4B . Assay and Drug Development Technologies. 12. (3). p. 176-189.

Davis, T.L. and Walker, J.R. and Campagna-Slater, V. and Finerty, P.J. and Finerty Jr., P.J. and Paramanathan, R. and Bernstein, G. and Mackenzie, F. and Tempel, W. and Ouyang, H. and Lee, W.H. and Eisenmesser, E.Z. and Dhe-Paganon, S.(2010). Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases . PLoS Biology. 8. (7).

Littler, D.R. and Walker, J.R. and Davis, T. and Wybenga-Groot, L.E. and Finerty, P.J. and Newman, E. and MacKenzie, F. and Dhe-Paganon, S.(2010). A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation . Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 66. (2). p. 143-151.

Davis, T.L. and Walker, J.R. and Allali-Hassani, A. and Parker, S.A. and Turk, B.E. and Dhe-Paganon, S.(2009). Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases . FEBS Journal. 276. (16). p. 4395-4404.

Davis, T.L. and Walker, J.R. and Ouyang, H. and MacKenzie, F. and Butler-Cole, C. and Newman, E.M. and Eisenmesser, E.Z. and Dhe-Paganon, S.(2008). The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1) . FEBS Journal. 275. (9). p. 2283-2295.

Eydoux, C. and Spinelli, S. and Davis, T.L. and Walker, J.R. and Seitova, A. and Dhe-Paganon, S. and De Caro, A. and Cambillau, C. and Carrière, F.(2008). Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation . Biochemistry. 47. (36). p. 9553-9564.

Davis, T.L. and Walker, J.R. and Loppnau, P. and Butler-Cole, C. and Allali-Hassani, A. and Dhe-Paganon, S.(2008). Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3) . Structure. 16. (6). p. 873-884.

Thai, V. and Renesto, P. and Fowler, C.A. and Brown, D.J. and Davis, T. and Gu, W. and Pollock, D.D. and Kern, D. and Raoult, D. and Eisenmesser, E.Z.(2008). Structural, Biochemical, and in Vivo Characterization of the First Virally Encoded Cyclophilin from the Mimivirus . Journal of Molecular Biology. 378. (1). p. 71-86.

Davis, T.L. and Walker, J.R. and Finerty Jr., P.J. and Mackenzie, F. and Newman, E.M. and Dhe-Paganon, S.(2007). The Crystal Structures of Human Calpains 1 and 9 Imply Diverse Mechanisms of Action and Auto-inhibition . Journal of Molecular Biology. 366. (1). p. 216-229.

Davis, T.L. and Bonacci, T.M. and Sprang, S.R. and Smrcka, A.V.(2005). Structural and molecular characterization of a preferred protein interaction surface on G protein βγ subunits . Biochemistry. 44. (31). p. 10593-10604.