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Hire Dr. Swayamsiddha K.

India

USD 25 /hr

Organic chemist, expert in Natural Products and Spectroscopy | Experienced modeler in drug design

Profile Summary

Scientific researcher with a PhD in Synthetic organic chemistry with expertise in Natural Products and computational chemistry. Experienced in analysing data, writing research proposals/grants and publishing scientific articles. My primary research: Novel spirobibenzopyrans, Novel benzopyrylium salts, Andrographolide and its derivatives. The key aspects of the research involving: Synthetic methodology, optimization of reaction conditions, Extensive characterization using: NMR, IR, UV-Vis and Mass spectrometry, Study of various structural features using single crystal X-Ray diffraction and 2- dimensional NMR and Study of their in silico and in vitro biological properties with associated mechanism of action.

Subject Matter Expertise

• ★ Spectroscopy
• ★ Organic Chemistry
• ★ Drug Design
• ☆ NMR Spectroscopy
• ☆ Technical & Scientific Writing
• ☆ Scientific Proofreading & Editing

Services

• Writing
• Research

Writing Technical Writing

Research Systematic Literature Review, Secondary Data Collection

Work Experience

Assistant Professor and Researcher

Sri Sathya Sai Institute of Higher Learning

January 2022 - Present

Assistant Professor

Sri Sathya Sai Institute of Higher Learning

January 2022 - Present

Senior Research Fellow

Sri Sathya Sai Institute of Higher Learning

September 2017 - November 2020

Exchange Scholar

Sankura Science exchange program, JAIST, Japan

August 2019 - August 2019

Internship student

Dr Reddy's Institute of Life Sciences

October 2018 - November 2018

Education

Doctor of Philosophy (Ph.D)

Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam Campus Department of Chemistry

July 2015 - November 2020

Master in Science (Chemistry)

Sri Sathya Sai Institute of Higher Learning

June 2013 - April 2015

Bachelor in Science (Hons.) (Chemistry)

Sri Sathya Sai Institute of Higher Learning

June 2010 - April 2013

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Swayamsiddha Kar, Gaurav Pawar, Shaikh Mohammad Ghouse, Swanand Vinayak Joshi, Preeti Rana, P. Mahesh Sarma, Srinivas Reddy Dannarm, Rajesh Sonti, Srinivas Nanduri(2022). Cu(I)‐Catalyzed Microwave‐Assisted Multicomponent Reaction Towards Synthesis of Diverse Fluorescent Quinazolino[4,3‐ <i>b</i> ]quinazolin‐8‐ones and Their Photophysical Study . ChemistrySelect. 7. (14). Wiley

Swayamsiddha Kar, Gaurav Pawar, Shaik Mahammad Ghouse, Sai Manohar Chelli, Srinivas Reddy Dannarm, Jitendra Gour, Rajesh Sonti, SRINIVAS NANDURI(2022). SmI2‐mediated C‐alkylation of Ketones with Alcohols in Microwave conditions: A Novel Route to Alkylated Ketones . Chemistry – An Asian Journal. Wiley

S. Skanda and P. S. J. Bharadwaj and Swayamsiddha Kar and V. Sai Muthukumar and B. S. Vijayakumar(2021). Bioremoval capacity of recalcitrant azo dye Congo red by soil fungus Aspergillus arcoverdensis SSSIHL-01 . Bioremediation Journal. p. 1--12. Informa {UK} Limited

Swayamsiddha Kar, Prashant Rai, Sai Manohar Chelli, Abdul Akhir, Naveen Shivalingegowda, Sidharth Chopra, Lokanath Neratur Krishnappagowda, Siva Kumar Belliraj, Nageswara Rao Golakoti(2021). Exploring the unexpected formation of spirobibenzopyrans and benzopyrylium salts and effect of Lewis acids on the Claisen-Schmidt reaction . Journal of Molecular Structure. 1240. p. 130598. Elsevier {BV}

Satyaveni Malasala, Anusha Polomoni, Chelli Sai Manohar, Dr. Swayamsiddha Kar, Y.V. Madhavi, SRINIVAS NANDURI(2021). A microwave-assisted copper-mediated tandem approach for fused quinazoline derivatives . Organic & biomolecular chemistry.

Synthesis, characterization and structure–activity relationship of non-linear optical response of chalcone derivatives with in silico insights @article{lens.org/088-336-125-418-390, author = {Prashant Rai and Prajal Chettri and Swayamsiddha Kar and Malhar Anupam Nagar and Shailesh Srivastava and Nageswara Rao Golakoti}, title = {Synthesis, characterization and structure–activity relationship of non-linear optical response of chalcone derivatives with in silico insights}, journal = {Chemical Papers}, month = {January}, doi = {10.1007/s11696-020-01487-6}, date = {2021-01-23}, note = "\url{https://link.springer.com/article/10.1007/s11696-020-01487-6}", url = {https://lens.org/088-336-125-418-390} } . Chemical Papers.

Dr. Swayamsiddha Kar, Abdul Akhir, Sidharth Chopra, Shinya Ohki, Balasubramanyam Karanam, Nageswara Rao Golakoti(2021). Benzopyrylium salts as new anticancer, antibacterial, and antioxidant agents . Medicinal Chemistry Research.

Swayamsiddha Kar, Prashant Rai, Prajal Chettri, Malhar Anupam Nagar, Shailesh Srivastava, Nageswara Rao Golakoti(2021). Synthesis, characterization and structure–activity relationship of non-linear optical response of chalcone derivatives with in silico insights . Chemical Papers. Springer Science and Business Media {LLC}

Swayamsiddha Kar, Abdul Akhir, Sidharth Chopra, Shinya Ohki, Balasubramanyam Karanam, Nageswara Rao Golakoti(2021). Benzopyrylium salts as new anticancer, antibacterial, and antioxidant agents . Medicinal Chemistry Research. Springer Science and Business Media {LLC}

Satyaveni Malasala, Anusha Polomoni, Sai Manohar Chelli, Swayamsidda Kar, Y. V. Madhavi, Srinivas Nanduri(2021). A microwave-assisted copper-mediated tandem approach for fused quinazoline derivatives . Organic & Biomolecular Chemistry. Royal Society of Chemistry ({RSC})

Swayamsiddha Kar, Satyaveni Malasala, Anusha Polomani, Sai Manohar Chelli, Madhavi Venkata Yaddanapudi, Srinivas Nanduri(2021). Microwave-assisted Copper-mediated Tandem Approach for Fused Quinazoline Derivatives . Organic & Biomolecular Chemistry. Royal Society of Chemistry ({RSC})

Swayamsiddha Kar, Gayathri Ramamoorthy, Kartik Mitra, Naveen Shivalingegowda, Mahesha, Sai Kiran Mavileti, Lokanath Neratur Krishnappagowda, Mukesh Doble, Nageswara Rao Golakoti(2020). Synthesis of novel spirobibenzopyrans as potent anticancer leads inducing apoptosis in HeLa cells . Bioorganic & Medicinal Chemistry Letters. 30. (12). p. 127199. Elsevier {BV}

Dr. Swayamsiddha Kar, Gayathri Ramamoorthy, Kartik Mitra, Dr. Naveen S, Sai Kiran Mavileti, Lokanath Neratur Krishnappagowda, Mahesha, Nageswara Rao Golakoti(2020). Synthesis of novel spirobibenzopyrans as potent anticancer leads inducing apoptosis in HeLa cells . Bioorganic & medicinal chemistry letters.

Kar, S., Shivalingegowda, N., Krishnappagowda, L.N., Golakoti, N.R.(2019). SiCl<inf>4</inf> mediated one-pot synthesis of novel spirobibenzopyrans as potent anticancer agents . New Journal of Chemistry. 43. (12). p. 4669-4673.

Dr. Swayamsiddha Kar, Naveen Shivalingegowda, Lokanath Neratur Krishnappagowda, G Nageswara Rao(2019). SiCl4 mediated one-pot synthesis of novel spirobibenzopyrans as potent anticancer agents . New Journal of Chemistry.

Kar, S., Ramamoorthy, G., Sinha, S., Ramanan, M., Pola, J.K., Golakoti, N.R., Nanubolu, J.B., Sahoo, S.K., Dandamudi, R.B., Doble, M.(2019). Synthesis of diarylidenecyclohexanone derivatives as potential anti-inflammatory leads against COX-2/mPGES1 and 5-LOX . New Journal of Chemistry. 43. (23). p. 9012-9020.

Dr. Swayamsiddha Kar, Gayathri Ramamoorthy, shweta, Meera Ramanan, Pola Jeevan Kumar, G Nageswara Rao, Jagadeesh Babu Nanubolu, SURAJ SAHOO, RAJESH BABU DANDAMUDI, Mukeshd Doble(2019). Synthesis of diarylidenecyclohexanone derivatives as potential anti-inflammatory leads against COX-2/mPGES1 and 5-LOX . New Journal of Chemistry.

Bishnu P. Joshi, Dinesh Mohanakrishnan, Garima Mittal, Dr. Swayamsiddha Kar, Jeevan Kumar Pola, Nageswara Rao Golakoti, Jagadeesh Babu Nanubolu, D Rajesh Babu, S Sai Suraj Kumar, Dinkar Sahal(2018). Synthesis, mechanistic and synergy studies of diarylidenecyclohexanone derivatives as new antiplasmodial pharmacophores . Medicinal Chemistry Research.

Microbial cyclic β-(1 → 3),(1 → 6)-glucans as potential drug carriers: Interaction studies between cyclic β-glucans isolated from Bradyrhizobium japonicum and betulinic acid @article{lens.org/049-969-001-041-427, author = {Naga Sai Visweswar Kambhampati and Swayamsiddha Kar and Sai Siva Kumar Pinnepalli and Janardhana Chelli and Mukesh Doble}, title = {Microbial cyclic β-(1 → 3),(1 → 6)-glucans as potential drug carriers: Interaction studies between cyclic β-glucans isolated from Bradyrhizobium japonicum and betulinic acid}, journal = {Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy}, month = {May}, doi = {10.1016/j.saa.2018.05.106}, date = {2018-05-28}, note = "\url{http://europepmc.org/abstract/MED/29898432} ; \url{https://www.ncbi.nlm.nih.gov/pubmed/29898432} ; \url{https://ui.adsabs.harvard.edu/abs/2018AcSpA.203..494K/abstract} ; \url{https://www.sciencedirect.com/science/article/pii/S1386142518305067}", url = {https://lens.org/049-969-001-041-427} } . Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

Dr. Swayamsiddha Kar, Rohit Kumar Mishra, Ashutosh Pathak, Anupam Dikshit, G Nageswara Rao(2018). In silico modeling and synthesis of phenyl and thienyl analogs of chalcones for potential leads as anti-bacterial agents . Journal of Molecular Structure.

Kar, S., Mishra, R.K., Pathak, A., Dikshit, A., Golakoti, N.R.(2018). In silico modeling and synthesis of phenyl and thienyl analogs of chalcones for potential leads as anti-bacterial agents . Journal of Molecular Structure. 1156. p. 433-440.

Joshi, B.P., Mohanakrishnan, D., Mittal, G., Kar, S., Pola, J.K., Golakoti, N.R., Nanubolu, J.B., D, R.B., S, S.S.K., Sahal, D.(2018). Synthesis, mechanistic and synergy studies of diarylidenecyclohexanone derivatives as new antiplasmodial pharmacophores . Medicinal Chemistry Research. 27. (10). p. 2312-2324.

Kambhampati, N.S.V., Kar, S., Pinnepalli, S.S.K., Chelli, J., Doble, M.(2018). Microbial cyclic β-(1 → 3),(1 → 6)-glucans as potential drug carriers: Interaction studies between cyclic β-glucans isolated from Bradyrhizobium japonicum and betulinic acid . Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 203. p. 494-500.

Dr. Swayamsiddha Kar, K.S. Adithya, Pruthvik Shankar, N. Jagadeesh Babu, Sailesh Srivastava, G Nageswara Rao(2017). Nonlinear optical studies and structure-activity relationship of chalcone derivatives with in silico insights . Journal of Molecular Structure.

(2017). In silico Modeling of New C-12 Substituted-14-DeoxyAndrographolide Derivatives as Potent Anticancer Leads. Journal of Pharmacology & Clinical Toxicology.

Kar, S., Adithya, K.S., Shankar, P., Jagadeesh Babu, N., Srivastava, S., Nageswara Rao, G.(2017). Nonlinear optical studies and structure-activity relationship of chalcone derivatives with in silico insights . Journal of Molecular Structure. 1139. p. 294-302.

DATA SET

Swayamsiddha Kar, Naveen Shivalingegowda, Lokanath Neratur Krishnappagowda, Nageswara Rao Golakoti (2019). CCDC 1504427: Experimental Crystal Structure Determination . Cambridge Crystallographic Data Centre.

Swayamsiddha Kar, Naveen Shivalingegowda, Lokanath Neratur Krishnappagowda, Nageswara Rao Golakoti (2019). CCDC 1504532: Experimental Crystal Structure Determination . Cambridge Crystallographic Data Centre.

Swayamsiddha Kar, K.S. Adithya, Pruthvik Shankar, N. Jagadeesh Babu, Sailesh Srivastava, G. Nageswara Rao (2017). CCDC 1453426: Experimental Crystal Structure Determination . Cambridge Crystallographic Data Centre.

PATENT

(2018). SPIROBIBENZOPYRANS AND ANALOGUES AS MULTITHERAPEUTIC AGENTS .

(2017). SPIROBIBENZOPYRANS AND ANALOGUES AS MULTITHERAPEUTIC AGENTS.