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Experienced Research Scientist Specializing in Molecular Biology, Preclinical Models, and Biomarker Discovery.

Profile Summary

PhD-qualified research scientist with expertise in molecular biology, immunology, and preclinical models. Proven success in biomarker discovery, COPD, cancer, and neuroinflammation research, using cutting-edge techniques like RNAi, CRISPR-Cas9, and advanced histopathology. Published in high-impact journals, with a passion for applying innovative research to improve human health.

Subject Matter Expertise

• ☆ Molecular Biology
• ☆ Biomarkers
• ☆ Clinical Laboratory Science
• ☆ Histopathology
• ☆ Inflammation

Services

• Writing
• Research
• Consulting
• Data & AI

Writing Technical Writing, General Proofreading & Editing

Research Scientific and Technical Research, Systematic Literature Review

Consulting Scientific and Technical Consulting

Data & AI Statistical Analysis, Image Processing, Image Analysis

Work Experience

Assistant Scientist

Temple University

December 2023 - August 2024

Assistant Scientist/Postdoctoral Fellow

Temple University

August 2022 - October 2023

Assistant Research Scientist

The University of Texas Rio Grande Valley - Edinburg Campus

March 2020 - July 2023

post-Doctoral Fellow

Temple University

May 2018 - February 2020

Education

PhD (School of Biotechnology)

Gautam Buddha University

March 2012 - March 2018

Certifications

• Certification details not provided.

Publications

JOURNAL ARTICLE

Sudhir Kotnala, Partha Laskar, Anupam Dhasmana, Meena Jaggi, Murali Yallapu, Subhash C. Chauhan (2023). Glutathione-Responsive Tannic Acid-Assisted FRET Nanomedicine for Cancer Therapy . Pharmaceutics.

(2021). A topography of immunotherapies against gastrointestinal malignancies . Panminerva Medica.

Contribution of dipeptidyl peptidase 4 to non-typeable Haemophilus influenzae-induced lung inflammation in COPD @article{2021, doi = {10.1042/cs20210099}, url = {https://doi.org/10.1042%2Fcs20210099}, year = 2021, month = {sep}, publisher = {Portland Press Ltd.}, volume = {135}, number = {17}, pages = {2067--2083}, author = {Sudhir Kotnala and Yerin Kim and Charu Rajput and Hymavathi Reddyvari and Sudhir Bolla and Nathaniel~T. Marchetti and Beata Kosmider and Karim Bahmed and Umadevi~S. Sajjan}, title = {Contribution of dipeptidyl peptidase 4 to non-typeable Haemophilus influenzae-induced lung inflammation in {COPD}}} . Clinical Science.

Preliminary predictive criteria for COVID-19 cytokine storm @article{2020, doi = {10.1136/annrheumdis-2020-218323}, url = {https://doi.org/10.1136%2Fannrheumdis-2020-218323}, year = 2020, month = {sep}, publisher = {{BMJ}}, volume = {80}, number = {1}, pages = {88--95}, author = {Roberto Caricchio and Marcello Gallucci and Chandra Dass and Xinyan Zhang and Stefania Gallucci and David Fleece and Michael Bromberg and Gerard J Criner}, title = {Preliminary predictive criteria for {COVID}-19 cytokine storm}} . Annals of the Rheumatic Diseases.

Rali, P., O'Corragain, O., Oresanya, L., Yu, D., Sheriff, O., Weiss, R., Myers, C., Desai, P., Ali, N., Stack, A., et al.(2021). Incidence of venous thromboembolism in coronavirus disease 2019: An experience from a single large academic center . Journal of Vascular Surgery: Venous and Lymphatic Disorders. 9. (3). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 585-591.e2.

Kotnala, S., Dhasmana, A., Kashyap, V.K., Chauhan, S.C., Yallapu, M.M., Jaggi, M.(2021). A bird eye view on cystic fibrosis: An underestimated multifaceted chronic disorder . Life Sciences. 268.

Marron, R.M., Zheng, M., Romero, G.F., Zhao, H., Patel, R., Leopold, I., Thomas, A., Standiford, T., Kumaran, M., Stewart, N.P.J., et al.(2021). Impact of chronic obstructive pulmonary disease and emphysema on outcomes of hospitalized patients with COVID-19 pneumonia . Chronic Obstructive Pulmonary Diseases. 8. (2).

Kotnala, S., Kim, Y., Rajput, C., Reddyvari, H., Bolla, S., Marchetti, N.T., Kosmider, B., Bahmed, K., Sajjan, U.S.(2021). Contribution of dipeptidyl peptidase 4 to non-typeable Haemophilus influenzae-induced lung inflammation in COPD . Clinical Science. 135. (17). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 2067-2083.

Microarray analysis identifies defects in regenerative and immune response pathways in COPD airway basal cells @article{2020, doi = {10.1183/23120541.00656-2020}, url = {https://doi.org/10.1183%2F23120541.00656-2020}, year = 2020, month = {oct}, publisher = {European Respiratory Society ({ERS})}, volume = {6}, number = {4}, pages = {00656--2020}, author = {Fanny Pineau and Gabriella Shumyatsky and Nicole Owuor and Nisha Nalamala and Sudhir Kotnala and Sudhir Bolla and Nathaniel Marchetti and Steven Kelsen and Gerard J. Criner and Uma S. Sajjan}, title = {Microarray analysis identifies defects in regenerative and immune response pathways in {COPD} airway basal cells}} . ERJ Open Research.

Dhasmana, A., Kashyap, V.K., Dhasmana, S., Kotnala, S., Haque, S., Ashraf, G.M., Jaggi, M., Yallapu, M.M., Chauhan, S.C.(2020). Neutralization of sars-cov-2 spike protein via natural compounds: A multilayered high throughput virtual screening approach . Current Pharmaceutical Design. 26. (41). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 5300-5309.

Kashyap, V.K., Dhasmana, A., Massey, A., Kotnala, S., Zafar, N., Jaggi, M., Yallapu, M.M., Chauhan, S.C.(2020). Smoking and COVID-19: Adding fuel to the flame . International Journal of Molecular Sciences. 21. (18). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-22.

(2019). FOXO3a regulates rhinovirus-induced innate immune responses in airway epithelial cells . Scientific Reports.

(2019). Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis . Clinical science (London, England : 1979).

Gimenes, J.A., Srivastava, V., ReddyVari, H., Kotnala, S., Mishra, R., Farazuddin, M., Li, W., Sajjan, U.S.(2019). Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis . Clinical Science. 133. (8). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 983-996.

Gimenes-Junior, J., Owuar, N., Vari, H.R., Li, W., Xander, N., Kotnala, S., Sajjan, U.S.(2019). FOXO3a regulates rhinovirus-induced innate immune responses in airway epithelial cells . Scientific Reports. 9. (1).

Sudhir Kotnala, Amit Tyagi, Jai Prakash Muyal(2017). rHuKGF ameliorates protease/anti-protease imbalance in emphysematous mice . Pulmonary Pharmacology & Therapeutics. 45. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 124--135. Elsevier {BV}

Sudhir Kotnala, Swati Uniyal, Ekta Teotia, Rahul Kumar, Amit Tyagi, Jai Prakash Muyal(2017). ATRA modulates gluconeogenesis and triglyceride biosynthesis pathway of liver in elastase induced emphysematous rats . Journal of Experimental and Applied Animal Sciences. 2. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 109. Modern Science Publishers

Kotnala, S., Tyagi, A., Muyal, J.P.(2017). rHuKGF ameliorates protease/anti-protease imbalance in emphysematous mice . Pulmonary Pharmacology and Therapeutics. 45. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 124-135.

Sudhir Kotnala, Jai Prakash Muyal, Dhananjay Kumar, Vandana Muyal, Amit Kumar Tyagi(2015). El factor de crecimiento queratinocítico humano recombinante induce la progresión de la supervivencia celular mediada por Akt en ratones enfisematosos . Archivos de Bronconeumología. 51. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 328--337. Elsevier {BV}

Sudhir Kotnala, Jai Prakash Muyal, Dhananjay Kumar, Vandana Muyal, Amit Kumar Tyagi(2015). Recombinant Human Keratinocyte Growth Factor Induces Akt Mediated Cell Survival Progression in Emphysematous Mice . Archivos de Bronconeumología (English Edition). 51. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 328--337. Elsevier {BV}

Prakash Muyal, J., Kumar, D., Kotnala, S., Muyal, V., Kumar Tyagi, A.(2015). Recombinant Human Keratinocyte Growth Factor Induces Akt Mediated Cell Survival Progression in Emphysematous Mice,El factor de crecimiento queratinocítico humano recombinante induce la progresión de la supervivencia celular mediada por Akt en ratones enfisematosos . Archivos de Bronconeumologia. 51. (7). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 328-337.

Sudhir Kotnala, Jai Prakash Muyal, Harsh Bhardwaj, Amit Tyagi(2014). Effect of recombinant human keratinocyte growth factor in inducing Ras–Raf–Erk pathway-mediated cell proliferation in emphysematous mice lung . Inhalation Toxicology. 26. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 761--771. Informa {UK} Limited

Muyal, J.P., Kotnala, S., Bhardwaj, H., Tyagi, A.(2014). Effect of recombinant human keratinocyte growth factor in inducing Ras-Raf-Erk pathway-mediated cell proliferation in emphysematous mice lung . Inhalation Toxicology. 26. (13). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 761-771.

Muyal, J.P., Muyal, V., Kotnala, S., Kumar, D., Bhardwaj, H.(2013). Therapeutic potential of growth factors in pulmonary emphysematous condition . Lung. 191. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 147-163.

Sudhir Kotnala, Jai Prakash Muyal, Vandana Muyal, Dhananjay Kumar, Harsh Bhardwaj(2012). Therapeutic Potential of Growth Factors in Pulmonary Emphysematous Condition . Lung. 191. (2). Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 147--163. Springer Nature

BOOK CHAPTER

Dhasmana, A., Kotnala, S., Yallapu, M.M., Chauhan, S.C., Jaggi, M.(2021). Introduction: Structure and function . An Introduction to P-Glycoprotein. Microsoft.AspNetCore.Mvc.Localization.LocalizedHtmlString 1-21.